[1]CurrentPatentAssignee:THEUNIVERSITYOFTEXASSYSTEM-WO2020/163479,2020,A1
[2]CurrentPatentAssignee:SIPINGOUKAITECH-CN115677525,2023,A
[1]CurrentPatentAssignee:THEUNIVERSITYOFTEXASSYSTEM-WO2020/163479,2020,A1
[2]CurrentPatentAssignee:SIPINGOUKAITECH-CN115677525,2023,A
[1]CurrentPatentAssignee:THEUNIVERSITYOFTEXASSYSTEM-WO2020/163479,2020,A1
[1]CurrentPatentAssignee:THEUNIVERSITYOFTEXASSYSTEM-WO2020/163479,2020,A1
Title: The use of anti-spasmodics in the treatment of irritable bowel syndrome: focus on otilonium bromide.
Journal: European review for medical and pharmacological sciences 20120101
Title: Randomised clinical trial: otilonium bromide improves frequency of abdominal pain, severity of distention and time to relapse in patients with irritable bowel syndrome.
Journal: Alimentary pharmacology & therapeutics 20110801
Title: Effect of otilonium bromide and ibodutant on the internalization of the NK2 receptor in human colon.
Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20110101
Title: Determination of the unstable drug otilonium bromide in human plasma by LC-ESI-MS and its application to a pharmacokinetic study.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101015
Title: Effect of otilonium bromide on contractile patterns in the human sigmoid colon.
Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100601
Title: T-type Ca(2+) channel modulation by otilonium bromide.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20100501
Title: Increased paracellular absorption by bile salts and P-glycoprotein stimulated efflux of otilonium bromide in Caco-2 cells monolayers as a model of intestinal barrier.
Journal: Journal of pharmaceutical sciences 20080901
Title: Oral bioavailability and enterohepatic recirculation of otilonium bromide in rats.
Journal: Archives of pharmacal research 20080101
Title: Irritable bowel syndrome.
Journal: Clinical drug investigation 20070101
Title: Otilonium bromide inhibits calcium entry through L-type calcium channels in human intestinal smooth muscle.
Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20040401
Title: Otilonium bromide inhibits muscle contractions via L-type calcium channels in the rat colon.
Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20040401
Title: [New approaches to diagnosing and treating hyperkinetic biliary dyskinesia associated with chronic acalculous cholecystitis].
Journal: Klinicheskaia meditsina 20040101
Title: Quaternary ammonium derivatives as spasmolytics for irritable bowel syndrome.
Journal: Current pharmaceutical design 20040101
Title: The colon-selective spasmolytic otilonium bromide inhibits muscarinic M(3) receptor-coupled calcium signals in isolated human colonic crypts.
Journal: British journal of pharmacology 20021201
Title: Extended analysis of a double-blind, placebo-controlled, 15-week study with otilonium bromide in irritable bowel syndrome.
Journal: European journal of gastroenterology & hepatology 20021201
Title: Oesophageal motility disorders.
Journal: Lancet (London, England) 20020112
Title: Multicenter phase III clinical trial of otilonium bromide in irritable bowel syndrome.
Journal: Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 20020101
Title: Optimisation and validation of a capillary electrophoresis method for the simultaneous determination of diazepam and otilonium bromide.
Journal: The Analyst 20011001
Title: [Functional intestinal disorders and quality of life].
Journal: Gastroenterologie clinique et biologique 20010901
Title: Otilonium bromide enhances sensory thresholds of volume and pressure in patients with irritable bowel syndrome.
Journal: Journal of physiology, Paris 20010101
Title: Effects exerted by otilonium bromide administration on precipitated opioid withdrawal syndrome in rats.
Journal: Toxicology 19970926
Title: Battaglia, G., et al., Otilonium bromide in irritable bowel syndrome: a double-blind, placebo-controlled, 15-week study. Aliment Pharmacol Ther, 1998. 12(10): p. 1003-10.
Title: Clave, P., et al., Randomised clinical trial: otilonium bromide improves frequency of abdominal pain, severity of distention and time to relapse in patients with irritable bowel syndrome. Aliment Pharmacol Ther, 2011. 34(4): p. 432-42.
Title: Lindqvist, S., et al., The colon-selective spasmolytic otilonium bromide inhibits muscarinic M(3) receptor-coupled calcium signals in isolated human colonic crypts. Br J Pharmacol, 2002. 137(7): p. 1134-42.
Title: Gandia, L., et al., Otilonium: a potent blocker of neuronal nicotinic ACh receptors in bovine chromaffin cells. Br J Pharmacol, 1996. 117(3): p. 463-470.
