Home Amines 26615-21-4
26615-21-4,MFCD00868143
Catalog No.:AA002TSA

26615-21-4 | Ethanamine, 2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethyl-

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98%(HPLC)
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10mg
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25mg
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50mg
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100mg
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500mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002TSA
Chemical Name:
Ethanamine, 2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethyl-
CAS Number:
26615-21-4
Molecular Formula:
C18H18ClNOS
Molecular Weight:
331.8596
MDL Number:
MFCD00868143
SMILES:
CN(CCOC1=Cc2ccccc2Sc2c1cc(Cl)cc2)C
Properties
Computed Properties
 
Complexity:
401  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
4.8  

Literature

Title: Improvement in QTc prolongation induced by zotepine following a switch to perospirone.

Journal: Psychiatry and clinical neurosciences 20120401

Title: Hyperhidrosis under combination of zotepine and haloperidol alleviated by aripiprazole.

Journal: Psychiatry and clinical neurosciences 20120401

Title: Valproate and high dosage of zotepine induced acute delirium: a case report.

Journal: British journal of clinical pharmacology 20120301

Title: Atypical antipsychotic-induced mania/hypomania: a review of recent case reports and clinical studies.

Journal: International journal of psychiatry in clinical practice 20120301

Title: Second-generation antipsychotic drugs and extrapyramidal side effects: a systematic review and meta-analysis of head-to-head comparisons.

Journal: Schizophrenia bulletin 20120101

Title: Genome-wide association study of treatment refractory schizophrenia in Han Chinese.

Journal: PloS one 20120101

Title: Recent advances in imaging of dopaminergic neurons for evaluation of neuropsychiatric disorders.

Journal: Journal of biomedicine & biotechnology 20120101

Title: Atypical antipsychotic drugs, schizophrenia, and metabolic syndrome in non-Euro-American societies.

Journal: Clinical neuropharmacology 20120101

Title: A self-limiting case of atypical neuroleptic malignant syndrome associated with zotepine.

Journal: Journal of clinical psychopharmacology 20111001

Title: Relationship between P-glycoprotein and second-generation antipsychotics.

Journal: Pharmacogenomics 20110801

Title: Review: clozapine shows some improved clinical efficacy over risperidone and zotepine in treatment of schizophrenia, but robust evidence is lacking.

Journal: Evidence-based mental health 20110501

Title: Newer molecules in the treatment of schizophrenia: A clinical update.

Journal: Indian journal of pharmacology 20110401

Title: Risperidone versus other atypical antipsychotics for schizophrenia.

Journal: The Cochrane database of systematic reviews 20110101

Title: Pharmacotherapy for treatment-resistant schizophrenia.

Journal: Neuropsychiatric disease and treatment 20110101

Title: Criterion and construct validity of the CogState Schizophrenia Battery in Japanese patients with schizophrenia.

Journal: PloS one 20110101

Title: Clinical utility of the risperidone formulations in the management of schizophrenia.

Journal: Neuropsychiatric disease and treatment 20110101

Title: [Hyperprolactinemia in mentally ill patients].

Journal: Acta medica portuguesa 20110101

Title: An open, large, 6-month naturalistic study of outcome in schizophrenic outpatients, treated with olanzapine.

Journal: Human psychopharmacology 20110101

Title: The effect of metformin on anthropometrics and insulin resistance in patients receiving atypical antipsychotic agents: a meta-analysis.

Journal: The Journal of clinical psychiatry 20101001

Title: Pharmacologic treatment of schizophrenia.

Journal: Dialogues in clinical neuroscience 20100901

Title: Safety evaluation of zotepine for the treatment of schizophrenia.

Journal: Expert opinion on drug safety 20100701

Title: Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like and antidepressant-like actions through its potent inhibition of norepinephrine reuptake.

Journal: The Journal of pharmacology and experimental therapeutics 20100601

Title: Prolonged withdrawal delirium in concomitant diphenhydramine and nefopam dependence: A case report.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20100530

Title: A single-blind, comparative study of zotepine versus haloperidol in combination with a mood stabilizer for patients with moderate-to-severe mania.

Journal: Psychiatry and clinical neurosciences 20100401

Title: QTc prolongation and antipsychotic medications in a sample of 1017 patients with schizophrenia.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20100317

Title: Gene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia.

Journal: European archives of psychiatry and clinical neuroscience 20100301

Title: Zotepine versus other atypical antipsychotics for schizophrenia.

Journal: The Cochrane database of systematic reviews 20100120

Title: Amisulpride versus other atypical antipsychotics for schizophrenia.

Journal: The Cochrane database of systematic reviews 20100101

Title: Quetiapine versus other atypical antipsychotics for schizophrenia.

Journal: The Cochrane database of systematic reviews 20100101

Title: First-generation vs second-generation antipsychotic drugs: The ongoing saga.

Journal: Indian journal of psychiatry 20100101

Title: Olanzapine versus other atypical antipsychotics for schizophrenia.

Journal: The Cochrane database of systematic reviews 20100101

Title: Factors associated with dental caries among institutionalized residents with schizophrenia in Taiwan: a cross-sectional study.

Journal: BMC public health 20100101

Title: Effects of age of onset on clinical characteristics in schizophrenia spectrum disorders.

Journal: BMC psychiatry 20100101

Title: A 64-week, multicenter, open-label study of aripiprazole effectiveness in the management of patients with schizophrenia or schizoaffective disorder in a general psychiatric outpatient setting.

Journal: Annals of general psychiatry 20100101

Title: Emerging role of sertindole in the management of schizophrenia.

Journal: Neuropsychiatric disease and treatment 20100101

Title: Emerging treatments in the management of schizophrenia - focus on sertindole.

Journal: Drug design, development and therapy 20100101

Title: Profile of olanzapine long-acting injection for the maintenance treatment of adult patients with schizophrenia.

Journal: Neuropsychiatric disease and treatment 20100101

Title: Zotepine versus other atypical antipsychotics for schizophrenia.

Journal: The Cochrane database of systematic reviews 20100101

Title: Clozapine versus other atypical antipsychotics for schizophrenia.

Journal: The Cochrane database of systematic reviews 20100101

Title: A new strategy for antidepressant prescription.

Journal: Frontiers in neuroscience 20100101

Title: Huntington's disease: a clinical review.

Journal: Orphanet journal of rare diseases 20100101

Title: Weight-gain in psychiatric treatment: risks, implications, and strategies for prevention and management.

Journal: Mens sana monographs 20100101

Title: 11-[3-(Dimethyl-amino)prop-yl]-6,11-dihydro-dibenzo[b,e]thiepin-11-ol.

Journal: Acta crystallographica. Section E, Structure reports online 20100101

Title: Tolerability of zotepine in Indian patients: Preliminary experience.

Journal: Industrial psychiatry journal 20100101

Title: Increased D-amino acid oxidase expression in the bilateral hippocampal CA4 of schizophrenic patients: a post-mortem study.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20091201

Title: Dual acting norepinephrine reuptake inhibitors and 5-HT(2A) receptor antagonists: Identification, synthesis and activity of novel 4-aminoethyl-3-(phenylsulfonyl)-1H-indoles.

Journal: Bioorganic & medicinal chemistry 20091115

Title: Application of on-line electrochemistry/electrospray/tandem mass spectrometry to a quantification method for the antipsychotic drug zotepine in human serum.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20091001

Title: Effects of zotepine on extracellular levels of monoamine, GABA and glutamate in rat prefrontal cortex.

Journal: British journal of pharmacology 20090601

Title: Further characterization of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in C57BL/6 mice: role of 5-HT(2A) serotonergic and alpha (1) adrenergic antagonism.

Journal: Psychopharmacology 20090401

Title: Review of the efficacy of placebo in comparative clinical trials between typical and atypical antipsychotics.

Journal: Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20090301

Title: A meta-analysis of head-to-head comparisons of second-generation antipsychotics in the treatment of schizophrenia.

Journal: The American journal of psychiatry 20090201

Title: Zotepine: a clinical review.

Journal: Expert opinion on drug metabolism & toxicology 20090201

Title: Sertindole versus other atypical antipsychotics for schizophrenia.

Journal: The Cochrane database of systematic reviews 20090101

Title: Impaired prefrontal hemodynamic maturation in autism and unaffected siblings.

Journal: PloS one 20090101

Title: Aripiprazole versus other atypical antipsychotics for schizophrenia.

Journal: The Cochrane database of systematic reviews 20090101

Title: Ziprasidone versus other atypical antipsychotics for schizophrenia.

Journal: The Cochrane database of systematic reviews 20090101

Title: Zotepine-induced spontaneous ejaculation.

Journal: International journal of clinical pharmacology and therapeutics 20081101

Title: Zotepine-induced QTc prolongation.

Journal: Journal of clinical psychopharmacology 20081001

Title: A pharmacoeconomic analysis of atypical antipsychotics and haloperidol in first-episode schizophrenic patients in taiwan.

Journal: Journal of clinical psychopharmacology 20080601

Title: Acute and long-term treatment of mania.

Journal: Dialogues in clinical neuroscience 20080601

Title: [Atypical antipsychotics in first-episode psychosis: a review].

Journal: L'Encephale 20080401

Title: Treatment of clozapine-associated tardive dyskinesia.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20080215

Title: Cardiac side effects of psychiatric drugs.

Journal: Human psychopharmacology 20080101

Title: Typical and atypical antipsychotics--the misleading dichotomy. Results from the Working Group 'Drugs in Psychiatry' (AGATE).

Journal: Neuropsychobiology 20080101

Title: The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913).

Journal: BMC psychiatry 20080101

Title: Differences in the effect of second-generation antipsychotics on prolactinaemia: six weeks open-label trial in female in-patients.

Journal: Neuro endocrinology letters 20071201

Title: Current therapeutic options for Alzheimer's disease.

Journal: Current genomics 20071201

Title: Early prediction of clinical response in schizophrenia patients receiving the atypical antipsychotic zotepine.

Journal: The Journal of clinical psychiatry 20071001

Title: Pharmacological causes of hyperprolactinemia.

Journal: Therapeutics and clinical risk management 20071001

Title: Atypical antipsychotic drugs: current issues of safety and efficacy in the management of schizophrenia.

Journal: Current opinion in investigational drugs (London, England : 2000) 20070701

Title: Simultaneous prescribing of atypical antipsychotics, conventional antipsychotics and anticholinergics-a European study.

Journal: Pharmacy world & science : PWS 20070601

Title: Hypothermia following antipsychotic drug use.

Journal: European journal of clinical pharmacology 20070601

Title: Risk of extrapyramidal syndrome in schizophrenic patients treated with antipsychotics: a population-based study.

Journal: Clinical pharmacology and therapeutics 20070401

Title: Second-generation antipsychotic agents in the treatment of acute mania: a systematic review and meta-analysis of randomized controlled trials.

Journal: Archives of general psychiatry 20070401

Title: Long-acting risperidone injection: efficacy, safety, and cost-effectiveness of the first long-acting atypical antipsychotic.

Journal: Neuropsychiatric disease and treatment 20070201

Title: Are there any differences in the efficacy among second generation antipsychotics in the treatment of schizophrenia and related disorders?

Journal: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20070101

Title: Atypical antipsychotics to treat the neuropsychiatric symptoms of dementia.

Journal: Neuropsychiatric disease and treatment 20061201

Title: Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061020

Title: Zotepine for schizophrenia.

Journal: The Cochrane database of systematic reviews 20061018

Title: Efficacy and safety of zotepine for patients with treatment-resistant schizophrenia.

Journal: Schizophrenia research 20061001

Title: [Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations].

Journal: No to shinkei = Brain and nerve 20060601

Title: Investigation of the electrochemical oxidation products of zotepine and their fragmentation using on-line electrochemistry/electrospray ionization mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20060501

Title: Perazine for schizophrenia.

Journal: The Cochrane database of systematic reviews 20060419

Title: The effects of zotepine in treating psychotic patients with hyperuricaemia: a case series.

Journal: The international journal of neuropsychopharmacology 20060401

Title: The effectiveness of atypical antipsychotics for the treatment of aggression and psychosis in Alzheimer's disease.

Journal: The Cochrane database of systematic reviews 20060125

Title: Adverse effects of atypical antipsychotics in the elderly: a review.

Journal: Drugs & aging 20060101

Title: Effect of zotepine on dopamine, serotonin and noradrenaline release in rat prefrontal cortex.

Journal: European journal of pharmacology 20051228

Title: Schizophrenia.

Journal: Clinical evidence 20051201

Title: Effects of zotepine and olanzapine on noradrenaline transporter in cultured bovine adrenal medullary cells.

Journal: Human psychopharmacology 20051001

Title: Zotepine loading in acute and severely manic patients: a pilot study.

Journal: Bipolar disorders 20051001

Title: [The serotonin syndrome].

Journal: Psychiatrische Praxis 20051001

Title: Trace analysis of zotepine and its active metabolite in plasma by capillary electrophoresis with solid phase extraction and head-column field-amplified sample stacking.

Journal: Journal of chromatography. A 20050916

Title: Zotepine-induced catatonia as a precursor in the progression to neuroleptic malignant syndrome.

Journal: Pharmacotherapy 20050801

Title: Antipsychotic and antidepressive effects of second generation antipsychotics: two different pharmacological mechanisms?

Journal: European archives of psychiatry and clinical neuroscience 20050601

Title: Stable expression of constitutively activated mutant h5HT6 and h5HT7 serotonin receptors: inverse agonist activity of antipsychotic drugs.

Journal: Psychopharmacology 20050501

Title: The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating.

Journal: Pharmacology, biochemistry, and behavior 20050401

Title: Unbiased descriptor and parameter selection confirms the potential of proteochemometric modelling.

Journal: BMC bioinformatics 20050101

Title: Second-generation (atypical) antipsychotics and metabolic effects: a comprehensive literature review.

Journal: CNS drugs 20050101

Title: Atypical properties of several classes of antipsychotic drugs on the basis of differential induction of Fos-like immunoreactivity in the rat brain.

Journal: Life sciences 20041126

Title: Zotepine versus placebo in the treatment of schizophrenic patients with stable primary negative symptoms: a randomized double-blind multicenter trial.

Journal: Pharmacopsychiatry 20041101

Title: Possible induction of mania or hypomania by atypical antipsychotics: an updated review of reported cases.

Journal: The Journal of clinical psychiatry 20041101

Title: Care maps: atypical antipsychotics. Introduction.

Journal: Nursing standard (Royal College of Nursing (Great Britain) : 1987) 20040501

Title: Selective optimization of side activities: another way for drug discovery.

Journal: Journal of medicinal chemistry 20040311

Title: Atypical antipsychotics: pharmacokinetics, therapeutic drug monitoring and pharmacological interactions.

Journal: Current medicinal chemistry 20040201

Title: Stimulus properties of the 'atypical' antipsychotic zotepine in rats: comparisons with clozapine and quetiapine.

Journal: Pharmacology, biochemistry, and behavior 20040101

Title: Zotepine for behavioural and psychological symptoms in dementia: an open-label study.

Journal: CNS drugs 20040101

Title: [Atypical antipsychotics in therapy refractory schizophrenia].

Journal: Der Nervenarzt 20040101

Title: Adverse metabolic effects associated with atypical antipsychotics: literature review and clinical implications.

Journal: Drugs 20040101

Title: Impact of atypical antipsychotics on quality of life in patients with schizophrenia.

Journal: CNS drugs 20040101

Title: Zotepine for behavioural and psychological symptoms in dementia: an open-label study.

Journal: CNS drugs 20040101

Title: Schizophrenia.

Journal: Clinical evidence 20031201

Title: Two case studies of hypothermia induced by an increased dosage of zotepine in a combination therapy.

Journal: Psychiatry and clinical neurosciences 20030801

Title: A meta-analysis of the efficacy of second-generation antipsychotics.

Journal: Archives of general psychiatry 20030601

Title: New generation antipsychotics versus low-potency conventional antipsychotics: a systematic review and meta-analysis.

Journal: Lancet (London, England) 20030510

Title: Zotepine in Huntington's disease.

Journal: Human psychopharmacology 20030401

Title: Screening, library-assisted identification and validated quantification of fifteen neuroleptics and three of their metabolites in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization.

Journal: Journal of mass spectrometry : JMS 20030301

Title: Protective effect of the antipsychotic drug zotepine on dizocilpine-induced neuropathological changes in rat retrosplenial cortex.

Journal: European journal of pharmacology 20030214

Title: New generation antipsychotics for first episode schizophrenia.

Journal: The Cochrane database of systematic reviews 20030101

Title: [Hyperlipidemia--side-effect of the treatment with an atypical antipsychotic (zotepine)?].

Journal: Psychiatrische Praxis 20021101

Title: Effects of zotepine on excitatory synaptic responses in the perforant path-dentate gyrus pathway in chronically prepared rabbits.

Journal: European journal of pharmacology 20021025

Title: Effect of zotepine, olanzapine and risperidone on hostility in schizophrenic patients.

Journal: Schizophrenia research 20021001

Title: New antipsychotic agents for schizophrenia: pharmacokinetics and metabolism update.

Journal: Current opinion in investigational drugs (London, England : 2000) 20020701

Title: Comparing the efficacy of atypical antipsychotics in open uncontrolled versus double-blind controlled trials in schizophrenia.

Journal: Psychopharmacology 20020601

Title: Striatal dopamine-2 receptor occupancy as measured with [123I]iodobenzamide and SPECT predicted the occurrence of EPS in patients treated with atypical antipsychotics and haloperidol.

Journal: Psychopharmacology 20020601

Title: Variations in prescribing atypical antipsychotic drugs in primary care: cross-sectional study.

Journal: Pharmacoepidemiology and drug safety 20020601

Title: The effects of neuroleptics on the GABA-induced Cl- current in rat dorsal root ganglion neurons: differences between some neuroleptics.

Journal: British journal of pharmacology 20020301

Title: Schizophrenia: genesis, receptorology and current therapeutics.

Journal: Current medicinal chemistry 20020301

Title: Perazine for schizophrenia.

Journal: The Cochrane database of systematic reviews 20020101

Title: The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia.

Journal: BMC psychiatry 20020101

Title: Strategy for structure elucidation of drug metabolites derived from protonated molecules and (MS)n fragmentation of zotepine, tiaramide and their metabolites.

Journal: Drug metabolism and pharmacokinetics 20020101

Title: HPLC-ESI-MS/MS determination of zuclopenthixol in a fatal intoxication during psychiatric therapy.

Journal: Forensic science international 20011201

Title: Efficacy and safety of zotepine for the treatment of Taiwanese schizophrenic patients: a double-blind comparison with haloperidol.

Journal: Journal of the Formosan Medical Association = Taiwan yi zhi 20011201

Title: [Antipsychotics and phospholipid metabolism in schizophrenia].

Journal: Fortschritte der Neurologie-Psychiatrie 20011101

Title: In vivo (123)I IBZM SPECT imaging of striatal dopamine 2 receptor occupancy in schizophrenic patients.

Journal: Psychopharmacology 20010901

Title: Zotepine in the treatment of acute hospitalized schizophrenic episodes.

Journal: International clinical psychopharmacology 20010501

Title: Current and novel approaches to the drug treatment of schizophrenia.

Journal: Journal of medicinal chemistry 20010215

Title: Screening for detection of new antidepressants, neuroleptics, hypnotics, and their metabolites in urine by GC-MS developed using rat liver microsomes.

Journal: Therapeutic drug monitoring 20010201

Title: Atypical antipsychotics: new directions and new challenges in the treatment of schizophrenia.

Journal: Annual review of medicine 20010101

Title: Bodyweight gain with atypical antipsychotics. A comparative review.

Journal: Drug safety 20010101

Title: Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors.

Journal: The Journal of pharmacology and experimental therapeutics 20001001

Title: Further evidence that behavioral tests and neuropeptide mRNA and tissue level alterations can differentiate between typical and atypical antipsychotic drugs.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20000701

Title: Two cases of deep vein thrombosis associated with a combined paroxetine and zotepine therapy.

Journal: Pharmacopsychiatry 19970501

Title: Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding.

Journal: Psychopharmacology 19960301

Title: BMY-14802 reversed the sigma receptor agonist-induced neck dystonia in rats.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 19960101

Title: Zotepine in levodopa-induced Psychosis.

Journal: Movement disorders : official journal of the Movement Disorder Society 19951101

Title: Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.

Journal: The Journal of pharmacology and experimental therapeutics 19940301

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Tags:26615-21-4 Molecular Formula|26615-21-4 MDL|26615-21-4 SMILES|26615-21-4 Ethanamine, 2-[(8-chlorodibenzo[b,f]thiepin-10-yl)oxy]-N,N-dimethyl-