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29681-57-0,MFCD00010754
Catalog No.:AA002Z0K

29681-57-0 | tert-Butyldimethylsilane

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1g
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5g
95%
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002Z0K
Chemical Name:
tert-Butyldimethylsilane
CAS Number:
29681-57-0
Molecular Formula:
C6H16Si
Molecular Weight:
116.2767
MDL Number:
MFCD00010754
SMILES:
C[SiH](C(C)(C)C)C
Properties
Properties
 
BP:
81-83°C at 760 mmHg  
Form:
Liquid  
MP:
13℃  
Refractive Index:
n20/D 1.4(lit.)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
49.7  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
7  
Rotatable Bond Count:
1  

Literature

Title: Bis(tert-butyldimethylsilyl)(2,6-diisopropylphenyl)phosphane: the first structure of an organophosphane with two tert-butyldimethylsilyl (TBDMS) substituents.

Journal: Acta crystallographica. Section C, Crystal structure communications 20121001

Title: Identification and synthesis of a male-produced pheromone for the neotropical root weevil Diaprepes abbreviatus.

Journal: Journal of chemical ecology 20120401

Title: Postsynthetic on column RNA labeling via Stille coupling.

Journal: Bioconjugate chemistry 20120321

Title: N(3)-protection of thymidine with Boc for an easy synthetic access to sugar-alkylated nucleoside analogs.

Journal: Chemistry & biodiversity 20120301

Title: Integrating flux balance analysis into kinetic models to decipher the dynamic metabolism of Shewanella oneidensis MR-1.

Journal: PLoS computational biology 20120201

Title: Metabolic pathway confirmation and discovery through (13)C-labeling of proteinogenic amino acids.

Journal: Journal of visualized experiments : JoVE 20120101

Title: Discovery of inhibitors of Leishmania β-1,2-mannosyltransferases using a click-chemistry-derived guanosine monophosphate library.

Journal: PloS one 20120101

Title: Preparation of DNA containing 5-hydroxymethyl-2'-deoxycytidine modification through phosphoramidites with TBDMS as 5-hydroxymethyl protecting group.

Journal: Current protocols in nucleic acid chemistry 20111201

Title: [2,4-(13)C]β-hydroxybutyrate metabolism in astrocytes and C6 glioblastoma cells.

Journal: Neurochemical research 20110801

Title: A boost for the emerging field of RNA nanotechnology.

Journal: ACS nano 20110524

Title: Syntheses of two 5-hydroxymethyl-2'-deoxycytidine phosphoramidites with TBDMS as the 5-hydroxymethyl protecting group and their incorporation into DNA.

Journal: The Journal of organic chemistry 20110520

Title: Highly chemoselective esterification reactions and Boc/THP/TBDMS discriminating deprotections under samarium(III) catalysis.

Journal: Organic letters 20110415

Title: Synthesis of arabinofuranose branched galactofuran tetrasaccharides, constituents of mycobacterial arabinogalactan.

Journal: Organic & biomolecular chemistry 20110407

Title: Synthesis of a versatile building block for the preparation of 6-N-derivatized α-galactosyl ceramides: rapid access to biologically active glycolipids.

Journal: The Journal of organic chemistry 20110107

Title: Branched RNA: A New Architecture for RNA Interference.

Journal: Journal of nucleic acids 20110101

Title: Targeted metabolomic analyses of cellular models of pelizaeus-merzbacher disease reveal plasmalogen and myo-inositol solute carrier dysfunction.

Journal: Lipids in health and disease 20110101

Title: Conformationally constrained histidines in the design of peptidomimetics: strategies for the χ-space control.

Journal: International journal of molecular sciences 20110101

Title: Synthesis of specifically modified oligonucleotides for application in structural and functional analysis of RNA.

Journal: Journal of nucleic acids 20110101

Title: A highly efficient green synthesis of 1, 8-dioxo-octahydroxanthenes.

Journal: Chemistry Central journal 20110101

Title: Incorporation of 3-aminobenzanthrone into 2'-deoxyoligonucleotides and its impact on duplex stability.

Journal: Journal of nucleic acids 20110101

Title: Changes in transcript abundance in Chlamydomonas reinhardtii following nitrogen deprivation predict diversion of metabolism.

Journal: Plant physiology 20101201

Title: 13C-tracer and gas chromatography-mass spectrometry analyses reveal metabolic flux distribution in the oleaginous microalga Chlorella protothecoides.

Journal: Plant physiology 20101001

Title: Novel derivatisation technique for the determination of chlorophenoxy acid type herbicides by gas chromatography-mass spectrometry.

Journal: Analytical and bioanalytical chemistry 20100501

Title: Inhibition of Escherichia coli glycosyltransferase MurG and Mycobacterium tuberculosis Gal transferase by uridine-linked transition state mimics.

Journal: Bioorganic & medicinal chemistry 20100401

Title: Electronic signatures of all four DNA nucleosides in a tunneling gap.

Journal: Nano letters 20100310

Title: O-Silylated C3-halohydrins as a novel class of protected building blocks for total, regio- and stereocontrolled synthesis of glycerolipid frameworks.

Journal: Organic & biomolecular chemistry 20100121

Title: New automated and high-throughput quantitative analysis of urinary ketones by multifiber exchange-solid phase microextraction coupled to fast gas chromatography/negative chemical-electron ionization/mass spectrometry.

Journal: Journal of automated methods & management in chemistry 20100101

Title: A systematic investigation of Escherichia coli central carbon metabolism in response to superoxide stress.

Journal: BMC systems biology 20100101

Title: Central metabolism in Mycobacterium smegmatis during the transition from O2-rich to O2-poor conditions as studied by isotopomer-assisted metabolite analysis.

Journal: Biotechnology letters 20090801

Title: Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors.

Journal: Bioorganic & medicinal chemistry 20090501

Title: Uric acid is a mediator of the Plasmodium falciparum-induced inflammatory response.

Journal: PloS one 20090101

Title: Synthesis, Binding and Fluorescence Studies of Bis-2-amidopyrrole Receptors for Bis-carboxylate Anions.

Journal: Sensors (Basel, Switzerland) 20090101

Title: tert-Butyldimethylsilyl O-protected chitosan and chitooligosaccharides: useful precursors for N-modifications in common organic solvents.

Journal: Carbohydrate research 20081013

Title: Gas chromatographic-mass spectrometric analyses of cholesterol and its precursors in rat plasma as tert-butyldimethylsilyl derivatives.

Journal: Clinica chimica acta; international journal of clinical chemistry 20081001

Title: A simple gas chromatography-mass spectrometry procedure for the simultaneous determination of buprenorphine and norbuprenorphine in human urine.

Journal: Journal of analytical toxicology 20081001

Title: Variant synthetic pathway to glucuronic acid-containing di- and trisaccharide thioglycoside building blocks for continued synthesis of Cryptococcus neoformans capsular polysaccharide structures.

Journal: Carbohydrate research 20080811

Title: Protecting groups transfer: unusual method of removal of tr and tbdms groups by transetherification.

Journal: Nucleosides, nucleotides & nucleic acids 20080801

Title: Target metabolic profiling analysis of free amino acids in plasma as EOC/TBDMS derivatives by GC-SIM-MS.

Journal: Biomedical chromatography : BMC 20080401

Title: Selenium derivatization of nucleic acids for phase and structure determination in nucleic acid X-ray crystallography.

Journal: International journal of molecular sciences 20080301

Title: Optimized fluoride ions treatment for release of base-sensitive 2'-O-modified oligoribonucleotides from various solid supports.

Journal: Nucleic acids symposium series (2004) 20080101

Title: A short and efficient synthesis of the tRNA nucleosides PreQ0 and archaeosine.

Journal: Organic & biomolecular chemistry 20071207

Title: Synthesis of branched oligonucleotides with three different sequences using an oxidatively removable tritylthio group.

Journal: The Journal of organic chemistry 20071026

Title: Synthesis and biological evaluation of phosphate prodrugs of 4-phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase.

Journal: ChemMedChem 20070813

Title: Derivatization of organophosphorus nerve agent degradation products for gas chromatography with ICPMS and TOF-MS detection.

Journal: Analytical and bioanalytical chemistry 20070601

Title: Regioselective silylation of N-phthaloylchitosan with TBDMS and TBDPS groups.

Journal: Biomacromolecules 20070601

Title: Mechanism for the regioselective asymmetric addition of grignard reagents to malimides: A computational exploration.

Journal: The Journal of organic chemistry 20070105

Title: Removal of acid-labile protecting groups on carbohydrates using water-tolerant and recoverable vanadyl triflate catalyst.

Journal: The Journal of organic chemistry 20070105

Title: Study on roles of anaplerotic pathways in glutamate overproduction of Corynebacterium glutamicum by metabolic flux analysis.

Journal: Microbial cell factories 20070101

Title: [Substituted 16alpha,17alpha-cyclohexanopregnanes: the anionic oxy-Cope rearrangement of 3beta-tert-butyldimethylsilyloxy-19-hydroxy-19-vinyl-16alpha,17alpha-cyclohexapregn-5-en-20-one].

Journal: Bioorganicheskaia khimiia 20070101

Title: Synthesis of a guanosine phosphoramidite derivative containing a photocleavable protecting group at the O6 position via regioselective protection of the 2'-hydroxy group with a TBDMS group.

Journal: Nucleic acids symposium series (2004) 20070101

Title: Aqueous phosphoric acid as a mild reagent for deprotection of tert-butyl carbamates, esters, and ethers.

Journal: The Journal of organic chemistry 20061124

Title: Total synthesis of (+/-)-symbioimine.

Journal: Organic letters 20061123

Title: Determination of ethylene oxide-hemoglobin adduct by silylation and gas chromatography-electron impact-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061107

Title: Determination of nitrogen mustard hydrolysis products, ethanolamines by gas chromatography-mass spectrometry after tert-butyldimethylsilyl derivatization.

Journal: Journal of chromatography. A 20060728

Title: Divergent synthesis of L-sugars and L-iminosugars from D-sugars.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20060724

Title: Efficient method for the deprotection of tert-butyldimethylsilyl ethers with TiCl4-Lewis base complexes: application to the synthesis of 1beta-methylcarbapenems.

Journal: The Journal of organic chemistry 20060707

Title: 29Si-13C spin-spin couplings over Si-O-Carom link.

Journal: Magnetic resonance in chemistry : MRC 20060701

Title: Unprecedented lability of the 5'-O-tert-butyldimethylsilyl group from 3'-spiro-5''-(4''-acylamino-1'',2''-oxathiole-2'',2''-dioxide) nucleoside derivatives via neighboring group participation of the 4''-acylamino residue.

Journal: The Journal of organic chemistry 20060217

Title: Neurochemical analysis of amino acids, polyamines and carboxylic acids: GC-MS quantitation of tBDMS derivatives using ammonia positive chemical ionization.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060202

Title: Colchitaxel, a coupled compound made from microtubule inhibitors colchicine and paclitaxel.

Journal: Beilstein journal of organic chemistry 20060101

Title: A general method for the synthesis of 2'-O-cyanoethylated oligoribonucleotides having promising hybridization affinity for DNA and RNA and enhanced nuclease resistance.

Journal: The Journal of organic chemistry 20051209

Title: Semisynthesis of human ghrelin: condensation of a Boc-protected recombinant peptide with a synthetic O-acylated fragment.

Journal: Biopolymers 20051205

Title: The tert-butyl dimethyl silyl group as an enhancer of drug cytotoxicity against human tumor cells.

Journal: Bioorganic & medicinal chemistry letters 20050801

Title: P(i-BuNCH2CH2)3N: an efficient promoter for the nucleophilic aromatic substitution reaction of aryl fluorides with aryl TBDMS (or TMS) ethers.

Journal: Organic letters 20050721

Title: Simultaneous retention index analysis of urinary amino acids and carboxylic acids for graphic recognition of abnormal state.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050705

Title: The synthesis of oligomers of oxetane-based dipeptide isosteres derived from L-rhamnose or D-xylose.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20050601

Title: A facile, catalytic, and environmentally benign method for selective deprotection of tert-butyldimethylsilyl ether mediated by phosphomolybdic acid supported on silica gel.

Journal: The Journal of organic chemistry 20050527

Title: Determination of 14 benzodiazepines and hydroxy metabolites, zaleplon and zolpidem as tert-butyldimethylsilyl derivatives compared with other common silylating reagents in whole blood by gas chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050425

Title: Controlled delivery of paclitaxel from stent coatings using poly(hydroxystyrene-b-isobutylene-b-hydroxystyrene) and its acetylated derivative.

Journal: Biomacromolecules 20050101

Title: Synthesis and glycosidase inhibitory activity of new hexa-substituted C8-glycomimetics.

Journal: Beilstein journal of organic chemistry 20050101

Title: Determination of thiodiglycol, a mustard gas hydrolysis product by gas chromatography-mass spectrometry after tert-butyldimethylsilylation.

Journal: Journal of chromatography. A 20041224

Title: Synthesis of nonracemic allylic hydroxy phosphonates via alkene cross metathesis.

Journal: The Journal of organic chemistry 20041210

Title: A multiresidue method for the analysis of phenols and nitrophenols in the atmosphere.

Journal: Journal of environmental monitoring : JEM 20041201

Title: New chiral selectors: design and synthesis of 6-TBDMS-2,3-methyl beta-cyclodextrin 2-2' thioureido dimer and 6-TBDMS-2,3-methyl (or 2-methyl-3-acetyl) beta-cyclodextrin bearing an (R) Mosher acid moiety.

Journal: Chirality 20041001

Title: Allyl, methallyl, prenyl, and methylprenyl ethers as protected alcohols: their selective cleavage with diphenyldisulfone under neutral conditions.

Journal: Organic letters 20040805

Title: Analysis of heterocyclic aromatic amines in foods by gas chromatography-mass spectrometry as their tert.-butyldimethylsilyl derivatives.

Journal: Journal of chromatography. A 20040618

Title: Synthesis of 6I-amino-6I-deoxy-2I-VII,3I-VII-tetradeca-O-methyl-cyclomaltoheptaose.

Journal: Carbohydrate research 20040517

Title: Production of Se-methylselenocysteine in transgenic plants expressing selenocysteine methyltransferase.

Journal: BMC plant biology 20040101

Title: Stereoselective synthesis of 4'-carbon-substituted xylofuranosyladenines.

Journal: Nucleic acids symposium series (2004) 20040101

Title: Discriminative determination of alkyl methylphosphonates and methylphosphonate in blood plasma and urine by gas chromatography-mass spectrometry after tert.-butyldimethylsilylation.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030925

Title: Combined isobutoxycarbonylation and tert-butyldimethylsilylation for the GC/MS-SIM detection of alkylphenols, chlorophenols and bisphenol A in mackerel samples.

Journal: Archives of pharmacal research 20030901

Title: Sensitive method for the quantification of urinary pyrimidine metabolites in healthy adults by gas chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030705

Title: Comprehensive chemical derivatization for gas chromatography-mass spectrometry-based multi-targeted profiling of the major phytohormones.

Journal: Journal of chromatography. A 20030418

Title: A remarkable solvent effect toward the Pd/C-catalyzed cleavage of silyl ethers.

Journal: Chemical communications (Cambridge, England) 20030307

Title: Zinc triflate-benzoyl bromide: a versatile reagent for the conversion of ether into benzoate protecting groups and ether glycosides into glycosyl bromides.

Journal: Carbohydrate research 20030214

Title: Determination of acidic drugs in sewage water by gas chromatography-mass spectrometry as tert.-butyldimethylsilyl derivatives.

Journal: Journal of chromatography. A 20030124

Title: Synthesis of new 3'-, 5-, and N(4)-modified 2'-O-methylcytidine libraries on solid support.

Journal: Journal of combinatorial chemistry 20030101

Title: Electron ionization and atmospheric pressure photochemical ionization in gas chromatography-mass spectrometry analysis of amino acids.

Journal: European journal of mass spectrometry (Chichester, England) 20030101

Title: Determination of endogenous levels of GHB in human hair. Are there possibilities for the identification of GHB administration through hair analysis in cases of drug-facilitated sexual assault?

Journal: Journal of analytical toxicology 20030101

Title: Retention of carbon and alteration of expected 13C-tracer enrichments by silylated derivatives using continuous-flow combustion-isotope ratio mass spectrometry.

Journal: Analytical chemistry 20021215

Title: Improved tert-butyldimethylsilylation gas chromatographic/mass spectrometric detection of nerve gas hydrolysis products from soils by pretreatment of aqueous alkaline extraction and strong anion-exchange solid-phase extraction.

Journal: Analytical chemistry 20020915

Title: Bulk and compound specific analysis of stool lipid confirm that the 'missing' 13C in the mixed triacylglycerol breath test is not in the stool.

Journal: Food and nutrition bulletin 20020901

Title: Silazanes/catalytic bases: mild, powerful and chemoselective agents for the preparation of enol silyl ethers from ketones and aldehydes.

Journal: Chemical communications (Cambridge, England) 20020807

Title: Determination of S-methyl-, S-propyl-, and S-propenyl-L-cysteine sulfoxides by gas chromatography-mass spectrometry after tert-butyldimethylsilylation.

Journal: Journal of agricultural and food chemistry 20020731

Title: Analysis of 13C-mixed triacylglycerol in stool by bulk (EA-IRMS) and compound specific (GC/MS) methods.

Journal: Isotopes in environmental and health studies 20020601

Title: Selective oxidation of allylic sulfides by hydrogen peroxide with the trirutile-type solid oxide catalyst LiNbMoO(6).

Journal: The Journal of organic chemistry 20011130

Title: Delta9-tetrahydrocannabivarin as a marker for the ingestion of marijuana versus Marinol: results of a clinical study.

Journal: Journal of analytical toxicology 20011001

Title: Simultaneous analysis of the di(2-ethylhexyl)phthalate metabolites 2-ethylhexanoic acid, 2-ethyl-3-hydroxyhexanoic acid and 2-ethyl-3-oxohexanoic acid in urine by gas chromatography-mass spectrometry.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010715

Title: Gas chromatography-mass spectrometry method for the simultaneous determination of wood extractive compounds in quaking aspen.

Journal: Journal of chromatography. A 20010713

Title: Effect of pedological characteristics on aqueous soil extraction recovery and tert-butyldimethylsilylation yield for gas chromatography-mass spectrometry of nerve gas hydrolysis products from soils.

Journal: Environmental science & technology 20010501

Title: Oligoribonucleotides with 2'-O-(tert-butyldimethylsilyl) groups.

Journal: Current protocols in nucleic acid chemistry 20010501

Title: Artifact-free matrix-assisted laser desorption ionization time-of-flight mass spectra of tert.-butyldimethylsilyl ether derivatives of cyclodextrins used for the synthesis of single-isomer, chiral resolving agents for capillary electrophoresis.

Journal: Journal of chromatography. A 20010420

Title: The measurement of muscle protein synthesis in broilers with a flooding dose technique: use of 15N-labelled phenylalanine, GC-MS and GC-C-IRMS.

Journal: Isotopes in environmental and health studies 20010101

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Tags:29681-57-0 Molecular Formula|29681-57-0 MDL|29681-57-0 SMILES|29681-57-0 tert-Butyldimethylsilane