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303727-31-3,MFCD12828750
Catalog No.:AA002ZU0

303727-31-3 | 2-Chloro-5-(2-phenyl-5-(pyridin-4-yl)-1h-imidazol-4-yl)phenol

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$9.00   $7.00
- +
5mg
98+%
in stock  
$22.00   $15.00
- +
10mg
98+%
in stock  
$32.00   $22.00
- +
25mg
98+%
in stock  
$52.00   $36.00
- +
50mg
98+%
in stock  
$87.00   $61.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002ZU0
Chemical Name:
2-Chloro-5-(2-phenyl-5-(pyridin-4-yl)-1h-imidazol-4-yl)phenol
CAS Number:
303727-31-3
Molecular Formula:
C20H14ClN3O
Molecular Weight:
347.7977
MDL Number:
MFCD12828750
SMILES:
Oc1cc(ccc1Cl)c1[nH]c(nc1c1ccncc1)c1ccccc1
Properties
Properties
 
Form:
Solid  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
425  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
4.2  

Literature

Title: The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20110215

Title: The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase.

Journal: Bioorganic & medicinal chemistry letters 20080801

Title: Pharmacophore identification of Raf-1 kinase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20080401

Title: The identification of potent and selective imidazole-based inhibitors of B-Raf kinase.

Journal: Bioorganic & medicinal chemistry letters 20060115

Title: Takle AK, et al. The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4373-6.

Title: Shelton JG, et al. Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation. Leukemia. 2003 Sep;17(9):1765-82.

Title: Berger A, et al. RAF inhibition overcomes resistance to TRAIL-induced apoptosis in melanoma cells. J Invest Dermatol. 2014 Feb;134(2):430-440.

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SDS
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Tags:303727-31-3 Molecular Formula|303727-31-3 MDL|303727-31-3 SMILES|303727-31-3 2-Chloro-5-(2-phenyl-5-(pyridin-4-yl)-1h-imidazol-4-yl)phenol