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309271-94-1,MFCD01819836
Catalog No.:AA0031LI

309271-94-1 | Inauhzin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$156.00   $109.00
- +
10mg
in stock  
$234.00   $164.00
- +
25mg
98% by HPLC
in stock  
$473.00   $331.00
- +
50mg
in stock  
$592.00   $414.00
- +
500mg
98% by HPLC
in stock  
$3,958.00   $2,771.00
- +
1000mg
98% by HPLC
in stock  
$6,295.00   $4,407.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0031LI
Chemical Name:
Inauhzin
CAS Number:
309271-94-1
Molecular Formula:
C25H19N5OS2
Molecular Weight:
469.5813
MDL Number:
MFCD01819836
SMILES:
CCC(C(=O)N1c2ccccc2Sc2c1cccc2)Sc1nnc2c(n1)[nH]c1c2cccc1
Properties
Computed Properties
 
Complexity:
690  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
1  
XLogP3:
5.6  

Literature

Title: Sirtuin1 and autophagy protect cells from fluoride-induced cell stress.

Journal: Biochimica et biophysica acta 20140201

Title: Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth.

Journal: Cancer biology & therapy 20120801

Title: A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53.

Journal: EMBO molecular medicine 20120401

Title: Zhang Q, et al. A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53. EMBO Mol Med. 2012 Apr;4(4):298-312.

Title: Zhang Y, et al. Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth. Cancer Biol Ther. 2012 Aug;13(10):915-24.

Title: Nguyen D, et al. Reviving the guardian of the genome: Small molecule activators of p53. Pharmacol Ther. 2017 Oct;178:92-108.

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