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1508-76-5,MFCD00079236
Catalog No.:AA0031O4

1508-76-5 | 1-Pyrrolidinepropanol, α-cyclohexyl-α-phenyl-, hydrochloride (1:1)

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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0031O4
Chemical Name:
1-Pyrrolidinepropanol, α-cyclohexyl-α-phenyl-, hydrochloride (1:1)
CAS Number:
1508-76-5
Molecular Formula:
C19H30ClNO
Molecular Weight:
323.9006
MDL Number:
MFCD00079236
SMILES:
OC(c1ccccc1)(C1CCCCC1)CCN1CCCC1.Cl
NSC Number:
757293
Properties
Properties
 
MP:
224 - 226°C (dec.)  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
301  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  

Downstream Synthesis Route
Literature

Title: Two medical therapies very effective shortly after high levels of soman poisoning in rats, but only one with universal utility.

Journal: Toxicology 20131215

Title: Minimum effective drug concentrations of a transdermal patch system containing procyclidine and physostigmine for prophylaxis against soman poisoning in rhesus monkeys.

Journal: Environmental toxicology and pharmacology 20120101

Title: Enhanced efficacy of anticonvulsants when combined with levetiracetam in soman-exposed rats.

Journal: Neurotoxicology 20111201

Title: Target urinary analytes for the gas chromatographic- mass spectrometric detection of procyclidine and benzhexol in drug abuse cases.

Journal: Journal of analytical toxicology 20110301

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Behavioral side effects in rats treated with acetylcholinesterase inhibitors suggested used as prophylactics against nerve agents.

Journal: Pharmacology, biochemistry, and behavior 20100501

Title: Roles of perirhinal and posterior piriform cortices in control and generation of seizures: a microinfusion study in rats exposed to soman.

Journal: Neurotoxicology 20100101

Title: Fatalities associated with clozapine-related constipation and bowel obstruction: a literature review and two case reports.

Journal: Psychosomatics 20090101

Title: Enhanced cholinergic-mediated increase in the pro-inflammatory cytokine IL-6 in irritable bowel syndrome: role of muscarinic receptors.

Journal: The American journal of gastroenterology 20081001

Title: Stuttering priapism--a review of the therapeutic options.

Journal: International journal of clinical practice 20080801

Title: Antiparkinson drugs used as prophylactics for nerve agents: studies of cognitive side effects in rats.

Journal: Pharmacology, biochemistry, and behavior 20080601

Title: The combination of donepezil and procyclidine protects against soman-induced seizures in rats.

Journal: Toxicology and applied pharmacology 20070415

Title: Measurements with fluorescent probes in primary neural cultures; improved multiwell techniques.

Journal: Journal of pharmacological and toxicological methods 20070101

Title: Pharmacological therapies against soman-induced seizures in rats 30 min following onset and anticonvulsant impact.

Journal: European journal of pharmacology 20061024

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Abdominal pain with rigidity secondary to the anti-emetic drug metoclopramide.

Journal: The Journal of emergency medicine 20060501

Title: Efficacy of immediate and subsequent therapies against soman-induced seizures and lethality in rats.

Journal: Basic & clinical pharmacology & toxicology 20060201

Title: Protection by a transdermal patch containing physostigmine and procyclidine of soman poisoning in dogs.

Journal: European journal of pharmacology 20051121

Title: Lack of association between prepulse inhibition and antisaccadic deficits in chronic schizophrenia: implications for identification of schizophrenia endophenotypes.

Journal: Journal of psychiatric research 20050501

Title: Protection by sustained release of physostigmine and procyclidine of soman poisoning in rats.

Journal: European journal of pharmacology 20041128

Title: Development of a screening method for the most commonly abused anticholinergic drugs in Jordan; trihexyphenidyl, procyclidine and biperiden.

Journal: Legal medicine (Tokyo, Japan) 20041001

Title: Drug-human serum albumin binding studied by capillary electrophoresis with electrochemiluminescence detection.

Journal: Electrophoresis 20041001

Title: Protection against soman-induced seizures in rats: relationship among doses of prophylactics, soman, and adjuncts.

Journal: Toxicology and applied pharmacology 20040501

Title: Cognitive side effects in rats caused by pharmacological agents used to prevent soman-induced lethality.

Journal: European journal of pharmacology 20040112

Title: Effects of procyclidine on eye movements in schizophrenia.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20031201

Title: NMDA receptors might be involved in the impairing effects of procyclidine on cognition.

Journal: Journal of clinical psychopharmacology 20031201

Title: Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats.

Journal: Neuropharmacology 20030501

Title: Probable dystonic reaction after a single dose of cyclizine in a patient with a history of encephalitis.

Journal: Anaesthesia 20030301

Title: Effects of acute procyclidine administration on prepulse inhibition of the startle response in schizophrenia: a double-blind, placebo-controlled study.

Journal: Journal of psychopharmacology (Oxford, England) 20030301

Title: Effects of 10 mg and 15 mg oral procyclidine on critical flicker fusion threshold and cardiac functioning in healthy human subjects.

Journal: Journal of psychopharmacology (Oxford, England) 20020601

Title: Effects of oral procyclidine administration on cognitive functions in healthy subjects: implications for schizophrenia.

Journal: Journal of clinical psychopharmacology 20020401

Title: [Neutropenia in a patient treated with clozapine in combination with other psychotropic drugs].

Journal: L'Encephale 20020101

Title: Physostigmine as treatment for severe CNS anticholinergic toxicity.

Journal: Emergency medicine journal : EMJ 20010901

Title: Nasal absorption of procyclidine in rats and dogs.

Journal: Archives of pharmacal research 20010601

Title: Lessons to be learned: a case study approach. 'Spontaneous' intraperitoneal bladder rupture in a psychiatric patient--with diagnostic difficulties.

Journal: The journal of the Royal Society for the Promotion of Health 20010601

Title: Effects of procyclidine on prepulse inhibition of the acoustic startle response in healthy human volunteers.

Journal: Psychopharmacology 20010301

Title: Antipsychotic drug-induced dysphoria.

Journal: The British journal of psychiatry : the journal of mental science 19951001

Title: Urinary retention--an unusual dystonic reaction to continuous metoclopramide infusion.

Journal: DICP : the annals of pharmacotherapy 19910501

Title: Effects of mianserin in neuroleptic-induced parkinsonism.

Journal: Psychopharmacology 19860101

Title: [Experience with the use of new Bulgarian psychotropic drugs].

Journal: Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952) 19820101

Title: Ethopropazine and benztropine in neuroleptic-induced parkinsonism.

Journal: The Journal of clinical psychiatry 19790301

Title: A comparison of piribedil, procyclidine and placebo in the control of phenothiazine-induced parkinsonism.

Journal: The British journal of psychiatry : the journal of mental science 19770601

Title: [The extrapyramidal symptoms in the combination of lithium long-term lithium therapy with nortriptyline. A case report on the formation of a pathogenesis hypothesis].

Journal: Der Nervenarzt 19760101

Title: Abnormal involuntary movements induced by anticholinergic therapy.

Journal: Acta neurologica Scandinavica 19740101

Title: Letter: Delayed drug-induced dystonias.

Journal: British medical journal 19731020

Title: Development of extrapyramidal symptoms in hypertensive patients treated with diazoxide.

Journal: British medical journal 19730901

Title: Double-blind comparison of levodopa and procyclidine in parkinsonism, with illustrations of levodopa-induced movement disorders.

Journal: Neurology 19701201

Title: Double-blind comparison of levodopa and procyclidine in parkinsonism, with illustrations of levodopa-induced movement disorders.

Journal: Neurology 19701201

Title: Greater than recommended drug dosages--some effects.

Journal: The American journal of psychiatry 19700601

Title: Treatment of resistant schizophrenics with extreme high dosage fluphenazine hydrochloride.

Journal: Psychosomatics 19700101

Title: Yun-Bae Kim, et al. Effects of combinational prophylactics composed of physostigmine and procyclidine on soman-induced lethality, seizures and brain injuries. Environ Toxicol Pharmacol. 2002 Jan;11(1):15-21.

Title: Ulrich Ettinger, et al. Effects of procyclidine on eye movements in schizophrenia. Neuropsychopharmacology. 2003 Dec;28(12):2199-208.

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Tags:1508-76-5 Molecular Formula|1508-76-5 MDL|1508-76-5 SMILES|1508-76-5 1-Pyrrolidinepropanol, α-cyclohexyl-α-phenyl-, hydrochloride (1:1)