Catalog No.:AA0032K4

4752-10-7 | 1,4-Dichlorophthalazine

Name: Name:1,4-Dichlorophthalazine
Brand: AABLOCKS
SKU: AA0032K4
Availability: InStock
Rating: 90 (10 reviews)

Pack Size

Purity

Availability

Price(USD)

Quantity

95%

in stock

$7.00 $5.00

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100g

95%

in stock

$67.00 $47.00

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Technical Information
Properties
Upstream Synthesis Route
Downstream Synthesis Route
Literature
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Technical Information
Properties
Upstream Synthesis Route
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA0032K4

Chemical Name:

1,4-Dichlorophthalazine

CAS Number:

4752-10-7

Molecular Formula:

C8H4Cl2N2

Molecular Weight:

199.0368

MDL Number:

MFCD00006909

SMILES:

Clc1nnc(c2c1cccc2)Cl

Properties

Form:

Solid

MP:

160 - 162 °C

Stability:

Moisture Sensitive

Storage:

Inert atmosphere;-20 ℃;

Computed Properties

Complexity:

147

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

XLogP3:

3.5

Upstream Synthesis Route

1445-69-8

4752-10-7

[1]BioorganicandMedicinalChemistryLetters,2014,vol.24,#4,p.1236-1238

[2]EuropeanJournalofMedicinalChemistry,2014,vol.85,p.235-244

[3]ChemicalBiologyandDrugDesign,2013,vol.81,#5,p.591-599

[4]NewJournalofChemistry,2016,vol.40,#7,p.6070-6076

[5]BioorganicandMedicinalChemistryLetters,2016,vol.26,#6,p.1576-1579

[6]JournalofNaturalProducts,2009,vol.72,#11,p.2072-2075

[7]EuropeanJournalofMedicinalChemistry,2010,vol.45,#11,p.4807-4812

[8]AsianJournalofChemistry,2011,vol.23,#1,p.127-131

[9]OrganicProcessResearchandDevelopment,2011,vol.15,#5,p.1149-1162

[10]BioorganicandMedicinalChemistryLetters,2013,vol.23,#7,p.2007-2013

[11]JournalofOrganicChemistry,1993,vol.58,#4,p.844-849

[12]Patent:WO2006/74223,2006,A2,.Locationinpatent:Page/Pagecolumn59

[13]Patent:EP2799435,2014,A1,.Locationinpatent:Paragraph0050;0072;0073

[14]Patent:US2015/51211,2015,A1,.Locationinpatent:Paragraph0098;0099

[15]JournaloftheChemicalSociety,1937,p.16,25

[16]JournaloftheIndianChemicalSociety,1990,vol.67,#9,p.779-780

[17]Arzneimittel-Forschung/DrugResearch,2010,vol.60,#6,p.289-292

[18]LettersinDrugDesignandDiscovery,2012,vol.9,#4,p.409-414

[19]JournalofEnzymeInhibitionandMedicinalChemistry,2013,vol.28,#4,p.792-800

[20]BioorganicandMedicinalChemistryLetters,2014,vol.24,#7,p.1737-1741

[21]Patent:US2015/374705,2015,A1,.Locationinpatent:Paragraph0289;0290

[22]Patent:CN104016986,2016,B,.Locationinpatent:Paragraph0037

[23]Patent:CN103694244,2016,B,.Locationinpatent:Paragraph0044

[24]ArchivderPharmazie,2017,vol.350,#12,

1445-69-8

4752-10-7

[1]OrganicandBiomolecularChemistry,2012,vol.10,#36,p.7313-7320

[2]AustralianJournalofChemistry,1985,vol.38,#11,p.1685-1691

[3]Patent:WO2003/99274,2003,A1,.Locationinpatent:Page277-278

253-52-1

5784-45-2

4752-10-7

[1]BioorganicandMedicinalChemistryLetters,2016,vol.26,#14,p.3300-3306

85-44-9

4752-10-7

[1]JournaloftheChemicalSociety,1937,p.16,25

[2]JournaloftheChemicalSociety,1937,p.16,25

[3]JournaloftheChemicalSociety,1937,p.16,25

[4]JournaloftheChemicalSociety,1937,p.16,25

[5]JournaloftheChemicalSociety,1937,p.16,25

[6]OrganicandBiomolecularChemistry,2012,vol.10,#36,p.7313-7320

[7]BioorganicandMedicinalChemistryLetters,2014,vol.24,#4,p.1236-1238

[8]BioorganicandMedicinalChemistryLetters,2014,vol.24,#7,p.1737-1741

[9]EuropeanJournalofMedicinalChemistry,2014,vol.85,p.235-244

[10]Patent:EP2799435,2014,A1,

[11]Patent:US2015/51211,2015,A1,

[12]NewJournalofChemistry,2016,vol.40,#7,p.6070-6076

[13]Patent:CN104016986,2016,B,

[14]Patent:CN103694244,2016,B,

[15]ArchivderPharmazie,2017,vol.350,#12,

1875-48-5

4752-10-7

[1]BulletindelaSocieteChimiquedeFrance,1925,vol.<4>37,p.889

[2]JournaloftheChemicalSociety,1937,p.16,25

[3]JournaloftheChemicalSociety,1937,p.16,25

[4]Fortschr.Teerfarbenfabr.Verw.Industriezweige,vol.16,p.541

Downstream Synthesis Route

4752-10-7

62-53-3

87166-49-2

[1]Medda,Federico;Sells,Earlphia;Chang,Hui-Hua;Dietrich,Justin;Chappeta,Shashi;Smith,Breland;Gokhale,Vijay;Meuillet,EmmanuelleJ.;Hulme,Christopher[BioorganicandMedicinalChemistryLetters,2013,vol.23,#2,p.528-531]

[2]Bollenbach,Maud;Lugnier,Claire;Kremer,Mélanie;Salvat,Eric;Megat,Salim;Bihel,Frédéric;Bourguignon,Jean-Jacques;Barrot,Michel;Schmitt,Martine[EuropeanJournalofMedicinalChemistry,2019,vol.177,p.269-290]

[3]Haworth;Robinson[JournaloftheChemicalSociety,1948,p.777,781]

[4]Piatnitski,EvgueniL.;Duncton,MatthewA.J.;Kiselyov,AlexanderS.;Katoch-Rouse,Reeti;Sherman,Dan;Milligan,DanielL.;Balagtas,Chris;Wong,WaiC.;Kawakami,Joel;Doody,JacquelineF.[BioorganicandMedicinalChemistryLetters,2005,vol.15,#21,p.4696-4698]

4752-10-7

88-99-3

2257-69-4

[1]Drew;Hatt[JournaloftheChemicalSociety,1937,p.16,25]

[2]Drew;Hatt[JournaloftheChemicalSociety,1937,p.16,25]

4752-10-7

2257-69-4

[1]Lu,Dong;Liu,Jianan;Zhang,Yunzhe;Liu,Feifei;Zeng,Limin;Peng,Runze;Yang,Li;Ying,Huazhou;Tang,Wei;Chen,Wuhong;Zuo,Jianping;Tong,Xiankun;Liu,Tao;Hu,Youhong[EuropeanJournalofMedicinalChemistry,2018,vol.145,p.328-337]

[2]CurrentPatentAssignee:ShanghaiInstituteofMateriaMedica(in:CAS);CHINESEACADEMYOFSCIENCES-CN109134429,2019,ALocationinpatent:Paragraph0106;0108;0109;0110

[3]CurrentPatentAssignee:CHINESEACADEMYOFSCIENCES;ShanghaiInstituteofMateriaMedica(in:CAS)-CN109384727,2019,ALocationinpatent:Paragraph0092-0094

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[5]CurrentPatentAssignee:ShanghaiInstituteofMateriaMedica(in:CAS);CHINESEACADEMYOFSCIENCES-CN112125881,2020,ALocationinpatent:Paragraph0098-0101

1445-69-8

4752-10-7

[1]CurrentPatentAssignee:SINOCHEMHOLDINGSCORPORATIONLTD-CN110305068,2019,ALocationinpatent:Paragraph0007;0023-0027

[3]Zhang,Qiu-Rong;Xue,Deng-Qi;He,Peng;Shao,Kun-Peng;Chen,Peng-Ju;Gu,Yi-Fei;Ren,Jing-Li;Shan,Li-Hong;Liu,Hong-Min[BioorganicandMedicinalChemistryLetters,2014,vol.24,#4,p.1236-1238]

[4]Xue,Deng-Qi;Zhang,Xu-Yao;Wang,Chao-Jie;Ma,Li-Ying;Zhu,Nan;He,Peng;Shao,Kun-Peng;Chen,Peng-Ju;Gu,Yi-Fei;Zhang,Xiao-Song;Wang,Cai-Feng;Ji,Cong-Hui;Zhang,Qiu-Rong;Liu,Hong-Min[EuropeanJournalofMedicinalChemistry,2014,vol.85,p.235-244]

[5]Abulkhair,HamadaS.;Ahmed,HanyE.A.;Bayoumi,AshrafH.;Ghiaty,Adel;Turky,Abdallah[BioorganicChemistry,2020,vol.100]

[6]Turky,Abdallah;Bayoumi,AshrafH.;Ghiaty,Adel;El-Azab,AdelS.;A.-M.Abdel-Aziz,Alaa;Abulkhair,HamadaS.[BioorganicChemistry,2020,vol.101]

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[9]CurrentPatentAssignee:SHANDONGFIRSTMEDICALUNIVERSITY&SHANDONGACADAMYOFMEDICALSCIENCES-CN114014814,2022,ALocationinpatent:Paragraph0073;0080-0081

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[13]Liu,Da-Chuan;Gong,Guo-Hua;Wei,Cheng-Xi;Jin,Xue-Jun;Quan,Zhe-Shan[BioorganicandMedicinalChemistryLetters,2016,vol.26,#6,p.1576-1579]

[14]Luniwal,Amarjit;Khupse,RahulS.;Reese,Michael;Fang,Lei;Erhardt,PaulW.[JournalofNaturalProducts,2009,vol.72,#11,p.2072-2075]

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[16]Locationinpatent:experimentalpartCheng-Xi,Wei;Zhou,Guo;Fu-Nan,Li;Zhe-Shan,Quan[AsianJournalofChemistry,2011,vol.23,#1,p.127-131]

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4752-10-7

35212-85-2

134878-70-9

[1]JournalofHeterocyclicChemistry,1991,vol.28,p.545-548

Literature

Title: Aluminum chloride-induced heteroarylation of arenes and heteroarenes. 2. A new synthesis of 4-substituted phthalazin-1(2H)-ones.

Journal: The Journal of organic chemistry 20030822

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