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254-60-4,MFCD00059751
Catalog No.:AA0032KU

254-60-4 | 1,8-Naphthyridine

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250mg
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1g
98%
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$19.00   $14.00
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5g
95%
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$71.00   $50.00
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10g
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25g
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0032KU
Chemical Name:
1,8-Naphthyridine
CAS Number:
254-60-4
Molecular Formula:
C8H6N2
Molecular Weight:
130.1466
MDL Number:
MFCD00059751
SMILES:
c1cnc2c(c1)cccn2
Properties
Properties
 
BP:
248.9°C at 760 mmHg  
Form:
Solid  
MP:
99.8-99.9 °C  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
102  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
2  
XLogP3:
1.5  

Literature

Title: Synthesis of a new series of pyridine and fused pyridine derivatives.

Journal: Molecules (Basel, Switzerland) 20120911

Title: Methyl 1-ethyl-7-methyl-4-oxo-1,4-di-hydro-1,8-naphthyridine-3-carboxyl-ate monohydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20120301

Title: Enhancement of affinity in molecular recognition via hydrogen bonds by POSS-core dendrimer and its application for selective complex formation between guanosine triphosphate and 1,8-naphthyridine derivatives.

Journal: Organic & biomolecular chemistry 20120107

Title: Selective G-quadruplex DNA stabilizing agents based on bisquinolinium and bispyridinium derivatives of 1,8-naphthyridine.

Journal: The Journal of organic chemistry 20120106

Title: Towards crystal structure prediction of complex organic compounds--a report on the fifth blind test.

Journal: Acta crystallographica. Section B, Structural science 20111201

Title: 1,8-Naphthyridine derivatives as cholinesterases inhibitors and cell Ca2+ regulators, a multitarget strategy for Alzheimer's disease.

Journal: Current topics in medicinal chemistry 20111101

Title: 7-Amino-1,8-naphthyridin-2(1H)-one monohydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20110901

Title: Hg2+ recognition by triptycene-derived heteracalixarenes: selectivity tuned by bridging heteroatoms and macrocyclic cavity.

Journal: Organic & biomolecular chemistry 20110821

Title: 2,6-Diamino-pyridinium tetra-phenyl-borate-1,2-bis-(5,7-dimethyl-1,8-naphthyridin-2-yl)diazene (1/1).

Journal: Acta crystallographica. Section E, Structure reports online 20110501

Title: Palladium(II) complexes based on 1,8-naphthyridine functionalized N-heterocyclic carbenes (NHC) and their catalytic activity.

Journal: Dalton transactions (Cambridge, England : 2003) 20110114

Title: A step further towards multitarget drugs for Alzheimer and neuronal vascular diseases: targeting the cholinergic system, amyloid-β aggregation and Ca(2+) dyshomeostasis.

Journal: Current medicinal chemistry 20110101

Title: Combined 3D-QSAR modeling and molecular docking studies on pyrrole-indolin-2-ones as Aurora A kinase inhibitors.

Journal: International journal of molecular sciences 20110101

Title: Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.

Journal: Bioorganic & medicinal chemistry letters 20100801

Title: Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.

Journal: Journal of medicinal chemistry 20100722

Title: Intense one- and two-photon excited fluorescent bis(BF2) core complex containing a 1,8-naphthyridine derivative.

Journal: Organic letters 20100702

Title: 2-Chloro-7-methyl-12-phenyldibenzo[b,g][1,8]naphthyridin-11(6H)-one.

Journal: Acta crystallographica. Section E, Structure reports online 20100701

Title: Synthesis, characterization, photoinduced isomerization, and spectroscopic properties of vinyl-1,8-naphthyridine derivatives and their copper(I) complexes.

Journal: Inorganic chemistry 20100517

Title: Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.

Journal: Journal of medicinal chemistry 20100422

Title: CoMFA and CoMSIA analyses on 4-oxo-1,4-dihydroquinoline and 4-oxo-1,4-dihydro-1,5-, -1,6- and -1,8-naphthyridine derivatives as selective CB2 receptor agonists.

Journal: Journal of molecular modeling 20100401

Title: [Molecular geometries and theoretical electronic spectra of four 1,8-naphthyridine derivatives].

Journal: Guang pu xue yu guang pu fen xi = Guang pu 20100301

Title: 2,7-Bis-(trichloro-meth-yl)-1,8-naphthyridine.

Journal: Acta crystallographica. Section E, Structure reports online 20100301

Title: Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II.

Journal: PloS one 20100101

Title: Molecular modeling studies of 4,5-dihydro-1H-pyrazolo[4,3-h] quinazoline derivatives as potent CDK2/Cyclin a inhibitors using 3D-QSAR and docking.

Journal: International journal of molecular sciences 20100101

Title: N'-[(E)-Benzyl-idene]-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide.

Journal: Acta crystallographica. Section E, Structure reports online 20091201

Title: Anticancer and immunomodulatory activities of novel 1,8-naphthyridine derivatives.

Journal: Journal of enzyme inhibition and medicinal chemistry 20091001

Title: Synthesis and in-vitro antitumour activity of new naphthyridine derivatives on human pancreatic cancer cells.

Journal: The Journal of pharmacy and pharmacology 20090801

Title: 2,7-Dimethyl-1,8-naphthyridine.

Journal: Acta crystallographica. Section E, Structure reports online 20090801

Title: Synthesis and cytotoxic activity of 5,6-heteroaromatically annulated pyridine-2,4-diamines.

Journal: Bioorganic & medicinal chemistry 20090701

Title: 2,2',4,4'-Tetra-methyl-7,7'-diazenediylbis(1,8-naphthyridin-1-ium) bis-(perchlorate).

Journal: Acta crystallographica. Section E, Structure reports online 20090701

Title: μ-Bis(5,7-dimethyl-1,8-naphthyridin-2-yl)diazene]bis-[difluoridoboron(III).

Journal: Acta crystallographica. Section E, Structure reports online 20090701

Title: 1-Ethyl-N'-[(E)-4-hydroxy-benzyl-idene]-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide.

Journal: Acta crystallographica. Section E, Structure reports online 20090401

Title: 7-(2,2-Dimethylpropanamido)-2-methyl-1,8-naphthyridin-1-ium chloride monohydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20090201

Title: A 1,8-naphthyridine-based fluorescent chemodosimeter for the rapid detection of Zn2+ and Cu2+.

Journal: Organic letters 20081120

Title: Synthesis of binuclear platinum complexes containing the ligands 8-naphthyridine, 2-aminopyridine, and 7-azaindolate. An experimental study of the steric hindrance of the bulky pentafluorophenyl ligands in the synthesis of binuclear complexes.

Journal: Inorganic chemistry 20081006

Title: 2,2'-Dimethyl-7,7'-(methyl-enediimino)di-1,8-naphthyridin-1-ium bis-(perchlorate).

Journal: Acta crystallographica. Section E, Structure reports online 20080901

Title: Allosteric inhibitors of Akt1 and Akt2: a naphthyridinone with efficacy in an A2780 tumor xenograft model.

Journal: Bioorganic & medicinal chemistry letters 20080601

Title: Quantitative structure-activity relationship study on affinity profile of a series of 1,8-naphthyridine antagonists toward bovine adenosine receptors.

Journal: Journal of enzyme inhibition and medicinal chemistry 20080601

Title: Naphthyridine-based helical foldamers and macrocycles: synthesis, cation binding, and supramolecular assemblies.

Journal: The Journal of organic chemistry 20080404

Title: cis,trans-Dicarbonyl-dichlorido[2-(2-pyrid-yl)-1,8-naphthyridine-κN,N]ruthenium(II).

Journal: Acta crystallographica. Section E, Structure reports online 20080301

Title: One-pot solvent free synthesis and DNA binding studies of thieno[2,3-b]-1,8-naphthyridines.

Journal: Preparative biochemistry & biotechnology 20080101

Title: Effect of an alkyl amino group on the binding of 1,8-naphthyridines to AP site-containing DNA duplexes.

Journal: Nucleic acids symposium series (2004) 20080101

Title: Dichloridobis(7-amino-2,4-dimethyl-1,8-naphthyridine-κN,N')cobalt(II) methanol disolvate.

Journal: Acta crystallographica. Section E, Structure reports online 20080101

Title: Bis(7-amino-2,4-dimethyl-1,8-naphthyridine)dinitratocadmium(II).

Journal: Acta crystallographica. Section E, Structure reports online 20080101

Title: 7-Acetyl-amino-2,4-dimethyl-1,8-naphthyridine.

Journal: Acta crystallographica. Section E, Structure reports online 20080101

Title: 7-[4-(5,7-Dimethyl-1,8-naphthyridin-2-yl-oxy)phen-oxy]-2,4-dimethyl-1,8-naphthyridine methanol disolvate.

Journal: Acta crystallographica. Section E, Structure reports online 20080101

Title: New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists.

Journal: Bioorganic & medicinal chemistry letters 20071201

Title: Synthesis and structure-activity relationships of potent antitumor active quinoline and naphthyridine derivatives.

Journal: Anti-cancer agents in medicinal chemistry 20071101

Title: Photochromism of photoenolizable ketones in quinoline and 1,8-naphthyridine series studied by time-resolved absorption spectroscopy.

Journal: The journal of physical chemistry. A 20070315

Title: Oxacalixarenes and oxacyclophanes containing 1,8-naphthyridines: a new class of molecular tweezers with concave-surface functionality.

Journal: Chemical communications (Cambridge, England) 20070314

Title: Synthesis and spectral investigations of manganese(II), cobalt(II), nickel(II), copper(II) and zinc(II) complexes of new polydentate ligands containing a 1,8-naphthyridine moiety.

Journal: Molecules (Basel, Switzerland) 20061221

Title: Effects of anti-inflammatory [1, 2, 4]triazolo[4, 3-a] [1, 8]naphthyridine derivatives on human stimulated PMN and endothelial cells: an in vitro study.

Journal: Journal of inflammation (London, England) 20060101

Title: 1,8-Naphthyridin-4-one derivatives as new ligands of A2A adenosine receptors.

Journal: Bioorganic & medicinal chemistry letters 20051015

Title: Structure-phototoxicity relationship in Balb/c mice treated with fluoroquinolone derivatives, followed by ultraviolet-A irradiation.

Journal: Toxicology letters 20050704

Title: Tetrakis(mu(2)-1,8-naphthyridine)-1:2kappa(4)N:N';3:4kappa(4)N:N'-bis(mu(2)-salicylato)-1:4kappa(2)O:O';2:3kappa(2)O:O'-tetrakis(salicylic acid)-1kappaO,2kappaO,3kappaO,4kappaO-tetrasilver(I)(4 Ag-Ag).

Journal: Acta crystallographica. Section C, Crystal structure communications 20050601

Title: Part 3: synthesis and biological evaluation of some analogs of the antitumor agents, 2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid, and 2-{4-[(7-bromo-2-quinolinyl)oxy]phenoxy}propionic acid.

Journal: Bioorganic & medicinal chemistry 20050215

Title: Synthesis and structure-activity relationships of 3-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridines as novel antitumor agents.

Journal: Bioorganic & medicinal chemistry letters 20040621

Title: Novel inhibitors of bacterial protein synthesis: structure-activity relationships for 1,8-naphthyridine derivatives incorporating position 3 and 4 variants.

Journal: Bioorganic & medicinal chemistry letters 20040621

Title: Study on affinity profile toward native human and bovine adenosine receptors of a series of 1,8-naphthyridine derivatives.

Journal: Journal of medicinal chemistry 20040603

Title: Synthesis and biological evaluation of 1,8-naphthyridin-4(1H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptors.

Journal: Bioorganic & medicinal chemistry 20040415

Title: Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 2.

Journal: Journal of medicinal chemistry 20040408

Title: Syntheses and EGFR kinase inhibitory activity of 6-substituted-4-anilino [1,7] and [1,8] naphthyridine-3-carbonitriles.

Journal: Bioorganic & medicinal chemistry letters 20040322

Title: Modeling the syn disposition of nitrogen donors at the active sites of carboxylate-bridged diiron enzymes. Enforcing dinuclearity and kinetic stability with a 1,2-diethynylbenzene-based ligand.

Journal: Inorganic chemistry 20031229

Title: Synthesis and beta-blocking activity of (R,S)-(E)-oximeethers of 2,3-dihydro-1,8-naphthyridine and 2,3-dihydrothiopyrano[2,3-b]pyridine: identification of beta 3-antagonists.

Journal: Bioorganic & medicinal chemistry 20031117

Title: Synthesis of 3- or 4-phenyl-1,8-naphthyridine derivatives and evaluation of antimycobacterial and antimicrobial activity.

Journal: Farmaco (Societa chimica italiana : 1989) 20030901

Title: Synthesis of variously substituted 1,8-naphthyridine derivatives and evaluation of their antimycobacterial activity.

Journal: Farmaco (Societa chimica italiana : 1989) 20020801

Title: Synthesis and pharmacological activities of 1,8-naphthyridine derivatives.

Journal: Biological & pharmaceutical bulletin 20020601

Title: Synthesis and evaluation of antihypertensive activity of 1,8-naphthyridine derivatives. Part X.

Journal: European journal of medicinal chemistry 20010101

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