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5451-40-1,MFCD09749894
Catalog No.:AA0032YJ

5451-40-1 | 2,6-Dichloropurine

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1g
97%
in stock  
$8.00   $5.00
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5g
97%
in stock  
$10.00   $7.00
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10g
98%
in stock  
$16.00   $11.00
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25g
95%
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$31.00   $22.00
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50g
95%
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$61.00   $43.00
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100g
98%
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$104.00   $73.00
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500g
98%
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$511.00   $358.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0032YJ
Chemical Name:
2,6-Dichloropurine
CAS Number:
5451-40-1
Molecular Formula:
C5H2Cl2N4
Molecular Weight:
189.0022
MDL Number:
MFCD09749894
SMILES:
Clc1nc(Cl)c2c(n1)nc[nH]2
NSC Number:
18395
Properties
Properties
 
BP:
405.4°C at 760 mmHg  
Form:
Solid  
MP:
184-186 °C  
Refractive Index:
1.6300 (estimate)  
Solubility:
soluble  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
155  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
XLogP3:
1.7  

Literature

Title: Two tautomeric polymorphs of 2,6-dichloropurine.

Journal: Acta crystallographica. Section C, Crystal structure communications 20111201

Title: Direct C-H arylation of purine on solid phase and its use for chemical libraries synthesis.

Journal: ACS combinatorial science 20110912

Title: Solid-phase synthesis of highly diverse purine-hydroxyquinolinone bisheterocycles.

Journal: Journal of combinatorial chemistry 20101108

Title: A class of novel conjugates of substituted purine and Gly-AA-OBzl: synthesis and evaluation of orally analgesic activity.

Journal: Bioorganic & medicinal chemistry letters 20101015

Title: Inhibition of human immunodeficiency virus type-1 by cdk inhibitors.

Journal: AIDS research and therapy 20100101

Title: UVC induced oxidation of chloropurines: excited singlet and triplet pathways for the photoreaction.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20080901

Title: Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways.

Journal: AIDS research and therapy 20080101

Title: New 2,6,9-trisubstituted adenines as adenosine receptor antagonists: a preliminary SAR profile.

Journal: Purinergic signalling 20070901

Title: Structure and synthesis of 6-(substituted-imidazol-1-yl)purines: versatile substrates for regiospecific alkylation and glycosylation at N9.

Journal: The Journal of organic chemistry 20060526

Title: Synthesis and Ca2+-mobilizing activity of purine-modified mimics of adenophostin A: a model for the adenophostin-Ins(1,4,5)P3 receptor interaction.

Journal: Journal of medicinal chemistry 20031106

Title: An efficient synthesis of 2-substituted 6-methylpurine bases and nucleosides by Fe- or Pd-catalyzed cross-coupling reactions of 2,6-dichloropurines.

Journal: The Journal of organic chemistry 20030711

Title: Purine and deazapurine nucleosides: synthetic approaches, molecular modelling and biological activity.

Journal: Farmaco (Societa chimica italiana : 1989) 20030301

Title: Nucleic acid related compounds. 118. Nonaqueous diazotization of aminopurine derivatives. Convenient access to 6-halo- and 2,6-dihalopurine nucleosides and 2'-deoxynucleosides with acyl or silyl halides.

Journal: The Journal of organic chemistry 20030124

Title: Catalysis of nucleophilic aromatic substitutions in the 2,6,8-trisubstituted purines and application in the synthesis of combinatorial libraries.

Journal: Molecular diversity 20030101

Title: Nucleic acid related compounds. 116. Nonaqueous diazotization of aminopurine nucleosides. Mechanistic considerations and efficient procedures with tert-butyl nitrite or sodium nitrite.

Journal: The Journal of organic chemistry 20020920

Title: Adenine and deazaadenine nucleoside and deoxynucleoside analogues: inhibition of viral replication of sheep MVV (in vitro model for HIV) and bovine BHV-1.

Journal: Bioorganic & medicinal chemistry 20020901

Title: 5'-O-alkyl ethers of N,2-substituted adenosine derivatives: partial agonists for the adenosine A1 and A3 receptors.

Journal: Journal of medicinal chemistry 20010830

Title: Synthesis and biological activity of 4'-C-hydroxymethyl-2'-fluoro-D-arabinofuranosylpurine nucleosides.

Journal: Nucleosides, nucleotides & nucleic acids 20010101

Title: Coupling of 2,6-disubstituted purines to ribose-modified sugars.

Journal: Nucleosides, nucleotides & nucleic acids 20010101

Title: Prevalence and characteristics of multinucleoside-resistant human immunodeficiency virus type 1 among European patients receiving combinations of nucleoside analogues.

Journal: Antimicrobial agents and chemotherapy 20000801

Title: A new point mutation (P157S) in the reverse transcriptase of human immunodeficiency virus type 1 confers low-level resistance to (-)-beta-2',3'-dideoxy-3'-thiacytidine.

Journal: Antimicrobial agents and chemotherapy 19990801

Title: Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii.

Journal: Biochemical pharmacology 19951109

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