128-37-0,MFCD00011644
Catalog No.:AA0032Z9

128-37-0 | 2,6-Di-tert-butyl-4-methylphenol

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25g
98%
in stock  
$7.00   $5.00
- +
100g
98%
in stock  
$9.00   $7.00
- +
500g
98%
in stock  
$12.00   $8.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0032Z9
Chemical Name:
2,6-Di-tert-butyl-4-methylphenol
CAS Number:
128-37-0
Molecular Formula:
C15H24O
Molecular Weight:
220.3505
MDL Number:
MFCD00011644
SMILES:
Cc1cc(c(c(c1)C(C)(C)C)O)C(C)(C)C
FEMA Number:
2184
Properties
Properties
 
BP:
265°C at 760 mmHg  
Form:
Solid  
MP:
69-73 °C  
Refractive Index:
1.4859  
Solubility:
methanol: 0.1 g/mL, clear, colorless  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
207  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
5.3  

Upstream Synthesis Route

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Downstream Synthesis Route

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Title: The Kras mutational spectra of chemically induced lung tumors in different inbred mice mimics the spectra of KRAS mutations in adenocarcinomas in smokers versus nonsmokers.

Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20100201

Title: Antioxidative activity of ferrocenes bearing 2,6-di-tert-butylphenol moieties.

Journal: Bioinorganic chemistry and applications 20100101

Title: Oxidative stress and mitochondrial functions in the intestinal Caco-2/15 cell line.

Journal: PloS one 20100101

Title: Rapid modification of the insect elicitor N-linolenoyl-glutamate via a lipoxygenase-mediated mechanism on Nicotiana attenuata leaves.

Journal: BMC plant biology 20100101

Title: Shrinkage Stresses Generated during Resin-Composite Applications: A Review.

Journal: Journal of dental biomechanics 20100101

Title: Antioxidant machinery differs between melanic and light nestlings of two polymorphic raptors.

Journal: PloS one 20100101

Title: Uridine metabolism in HIV-1-infected patients: effect of infection, of antiretroviral therapy and of HIV-1/ART-associated lipodystrophy syndrome.

Journal: PloS one 20100101

Title: Comparison of the phenolic content and antioxidant activities of Apocynum venetum L. (Luo-Bu-Ma) and two of its alternative species.

Journal: International journal of molecular sciences 20100101

Title: Dosage of 2,6-bis (1.1-dimethylethyl)-4-methylphenol (BHT) in the plant extract Mesembryanthemum crystallinum.

Journal: Journal of biomedicine & biotechnology 20100101

Title: Effect of resin matrix composition on the translucency of experimental dental composite resins.

Journal: Dental materials : official publication of the Academy of Dental Materials 20091201

Title: Quantitative determination of TEGDMA, BHT, and DMABEE in eluates from polymerized resin-based dental restorative materials by use of GC/MS.

Journal: Archives of toxicology 20091201

Title: New potent DPPH radical scavengers from a marine-derived actinomycete strain USF-TC31.

Journal: Bioscience, biotechnology, and biochemistry 20091201

Title: Effects of n-3 Fatty Acids Supplementation on Plasma Phospholipids Fatty Acid Composition in Patients with Obstructive Jaundice- a Pilot Study.

Journal: Journal of clinical biochemistry and nutrition 20091101

Title: Indole derivatives from a marine sponge-derived yeast as DPPH radical scavengers.

Journal: Journal of natural products 20091101

Title: Epileptiform EEG spikes and their functional significance.

Journal: Clinical EEG and neuroscience 20091001

Title: Bond Strength of One-Step Adhesives under Different Substrate Moisture Conditions.

Journal: European journal of dentistry 20091001

Title: Use of natural antioxidants from lyophilized water extracts of Borago officinalis in dry fermented sausages enriched in ω-3 PUFA.

Journal: Meat science 20091001

Title: Antioxidant activity of 5,10-dihydroindeno[1,2-b]indoles containing substituents on dihydroindeno part.

Journal: Bioorganic & medicinal chemistry 20090915

Title: Simultaneous determination of three antioxidants in foods and cosmetics by flow injection coupled to an ultra-short monolithic column.

Journal: Journal of chromatographic science 20090701

Title: Lung tumor promotion by curcumin.

Journal: Carcinogenesis 20090601

Title: Cholestane-3beta,5alpha,6beta-triol-induced reactive oxygen species production promotes mitochondrial dysfunction in isolated mice liver mitochondria.

Journal: Chemico-biological interactions 20090515

Title: Carbonic anhydrase inhibitors. Inhibition of human erythrocyte isozymes I and II with a series of antioxidant phenols.

Journal: Bioorganic & medicinal chemistry 20090415

Title: Sensitive, quantitative carbon-13 NMR spectra by mechanical sample translation.

Journal: Journal of magnetic resonance (San Diego, Calif. : 1997) 20090401

Title: Phenolic compounds protect cultured hippocampal neurons against ethanol-withdrawal induced oxidative stress.

Journal: International journal of molecular sciences 20090401

Title: Antioxidant and anticholinesterase activity evaluation of ent-kaurane diterpenoids from Sideritis arguta.

Journal: Journal of natural products 20090327

Title: Synthesis of novel benzo[h]quinolines: wound healing, antibacterial, DNA binding and in vitro antioxidant activity.

Journal: European journal of medicinal chemistry 20090301

Title: Identification of tumor promotion marker genes for predicting tumor promoting potential of chemicals in BALB/c 3T3 cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090201

Title: Mechanisms of cytotoxicity of 2- or 2,6-di-tert-butylphenols and 2-methoxyphenols in terms of inhibition rate constant and a theoretical parameter.

Journal: Chemosphere 20090201

Title: Searching for anthropogenic contaminants in human breast adipose tissues using gas chromatography-time-of-flight mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20090101

Title: Surugapyrroles A and B, two new N-hydroxypyrroles, as DPPH radical-scavengers from Streptomyces sp. USF-6280 strain.

Journal: Bioscience, biotechnology, and biochemistry 20090101

Title: Ascorbic acid pre-treated quartz stimulates TNF-alpha release in RAW 264.7 murine macrophages through ROS production and membrane lipid peroxidation.

Journal: Respiratory research 20090101

Title: Mechanism of PP2A-mediated IKK beta dephosphorylation: a systems biological approach.

Journal: BMC systems biology 20090101

Title: Ecology and geography of avian influenza (HPAI H5N1) transmission in the Middle East and northeastern Africa.

Journal: International journal of health geographics 20090101

Title: Use of dried blood for measurement of trans fatty acids.

Journal: Nutrition journal 20090101

Title: Deletion of Forkhead Box M1 transcription factor from respiratory epithelial cells inhibits pulmonary tumorigenesis.

Journal: PloS one 20090101

Title: Electrocardiographic changes in hiatal hernia: a case report.

Journal: Cases journal 20090101

Title: Transcriptomic analysis of pathways regulated by toll-like receptor 4 in a murine model of chronic pulmonary inflammation and carcinogenesis.

Journal: Molecular cancer 20090101

Title: Alleviation of high-fat diet-induced fatty liver damage in group IVA phospholipase A2-knockout mice.

Journal: PloS one 20090101

Title: Cigarette smoking blocks the protective expression of Nrf2/ARE pathway in peripheral mononuclear cells of young heavy smokers favouring inflammation.

Journal: PloS one 20090101

Title: Management of contact dermatitis due to nickel allergy: an update.

Journal: Clinical, cosmetic and investigational dermatology 20090101

Title: Effects of maté tea intake on ex vivo LDL peroxidation induced by three different pathways.

Journal: Nutrients 20090101

Title: Hepatic retention and toxicological responses during feeding and depuration periods in Atlantic salmon ( Salmo salar ) fed graded levels of the synthetic antioxidant, butylated hydroxytoluene.

Journal: Journal of agricultural and food chemistry 20081210

Title: S-alkenyl cysteine sulfoxide and its antioxidant properties from Allium cepa var. tropeana (red onion) seeds.

Journal: Journal of natural products 20081201

Title: New lipophilic tyrosyl esters. Comparative antioxidant evaluation with hydroxytyrosyl esters.

Journal: Journal of agricultural and food chemistry 20081126

Title: Synthesis and free radical scavenging activity of some new spiropyranocoumarins.

Journal: Bioorganic & medicinal chemistry letters 20081101

Title: Synthesis and recovery of high bioactive phenolics from table-olive brine process wastewater.

Journal: Bioorganic & medicinal chemistry 20081015

Title: 2,2'-Pyridoin derivatives protect HL-60 cells against oxidative stress.

Journal: Bioorganic & medicinal chemistry letters 20081001

Title: Temporal evolution of epithelial, vascular and interstitial lung injury in an experimental model of idiopathic pulmonary fibrosis induced by butyl-hydroxytoluene.

Journal: International journal of experimental pathology 20081001

Title: Characterization of the microsomal cytochrome P450 2B4 O2 activation intermediates by cryoreduction and electron paramagnetic resonance.

Journal: Biochemistry 20080909

Title: Transcriptome analysis provides new insights into liver changes induced in the rat upon dietary administration of the food additives butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080801

Title: Carbonyl reductase inactivation may contribute to mouse lung tumor promotion by electrophilic metabolites of butylated hydroxytoluene: protein alkylation in vivo and in vitro.

Journal: Chemical research in toxicology 20080801

Title: Transgenic expression of the forkhead box M1 transcription factor induces formation of lung tumors.

Journal: Oncogene 20080710

Title: PGK1 induction by a hydrogen peroxide treatment is suppressed by antioxidants in human colon carcinoma cells.

Journal: Bioscience, biotechnology, and biochemistry 20080701

Title: Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20080601

Title: Synthesis and antioxidant properties of novel N-methyl-1,3,4-thiadiazol-2-amine and 4-methyl-2H-1,2,4-triazole-3(4H)-thione derivatives of benzimidazole class.

Journal: Bioorganic & medicinal chemistry 20080415

Title: Resonance Raman studies of cytochrome P450 2B4 in its interactions with substrates and redox partners.

Journal: Biochemistry 20080325

Title: Mechanisms of butylated hydroxytoluene chemoprevention of aflatoxicosis--inhibition of aflatoxin B1 metabolism.

Journal: Toxicology and applied pharmacology 20080315

Title: Synthesis and antioxidant activities of 3,5-dialkoxy-4-hydroxycinnamamides.

Journal: Bioorganic & medicinal chemistry letters 20080301

Title: Outpatient pulmonary rehabilitation in patients with chronic obstructive pulmonary disease.

Journal: International journal of chronic obstructive pulmonary disease 20080301

Title: Synthesis and evaluation of 2'-hydroxyethyl trans-apovincaminate derivatives as antioxidant and cognitive enhancer agents.

Journal: Journal of medicinal chemistry 20080214

Title: Electron transfer between protonated and unprotonated phenoxyl radicals.

Journal: The Journal of organic chemistry 20080201

Title: Antioxidant activities of methanolic extract of Sapium ellipticum.

Journal: Pakistan journal of biological sciences : PJBS 20080201

Title: Bromophenols from the marine red alga Polysiphonia urceolata with DPPH radical scavenging activity.

Journal: Journal of natural products 20080101

Title: The NF-kappaB inhibitor curcumin blocks sepsis-induced muscle proteolysis.

Journal: Mediators of inflammation 20080101

Title: Target and nontarget screening of organic micropollutants in water by solid-phase microextraction combined with gas chromatography/high-resolution time-of-flight mass spectrometry.

Journal: Analytical chemistry 20071215

Title: A novel method to measure both the reductive and the radical scavenging activity in a linoleic acid model system.

Journal: Molecular nutrition & food research 20071201

Title: Biological role, protein expression, subcellular localization, and oxidative stress response of paraoxonase 2 in the intestine of humans and rats.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20071201

Title: Altered expression of splicing factor, heterogeneous nuclear ribonucleoprotein A2/B1, in mouse lung neoplasia.

Journal: Molecular carcinogenesis 20071101

Title: Natural bromophenols from the marine red alga Polysiphonia urceolata (Rhodomelaceae): structural elucidation and DPPH radical-scavenging activity.

Journal: Bioorganic & medicinal chemistry 20071101

Title: Alkaline saponification results in decomposition of tocopherols in milk and ovine blood plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015

Title: Enhancement of allergic responses in vivo and in vitro by butylated hydroxytoluene.

Journal: Toxicology and applied pharmacology 20070901

Title: Synthesis and pharmacochemical evaluation of novel aryl-acetic acid inhibitors of lipoxygenase, antioxidants, and anti-inflammatory agents.

Journal: Bioorganic & medicinal chemistry 20070901

Title: Antioxidant profile of ethoxyquin and some of its S, Se, and Te analogues.

Journal: The Journal of organic chemistry 20070803

Title: Role of reactive oxygen species in protein degradation in murine myotubes induced by proteolysis-inducing factor and angiotensin II.

Journal: Cellular signalling 20070801

Title: Amiodarone inhibits tocopherol-mediated human lipoprotein peroxidation.

Journal: Biochemical pharmacology 20070715

Title: MAO-A-induced mitogenic signaling is mediated by reactive oxygen species, MMP-2, and the sphingolipid pathway.

Journal: Free radical biology & medicine 20070701

Title: Highly brominated mono- and bis-phenols from the marine red alga Symphyocladia latiuscula with radical-scavenging activity.

Journal: Journal of natural products 20070701

Title: Impact of phenolic compounds on hydrothermal oxidation of cellulose.

Journal: Carbohydrate research 20070611

Title: Lowering effects of onion intake on oxidative stress biomarkers in streptozotocin-induced diabetic rats.

Journal: Journal of clinical biochemistry and nutrition 20070301

Title: Mechanistic basis for inflammation and tumor promotion in lungs of 2,6-di-tert-butyl-4-methylphenol-treated mice: electrophilic metabolites alkylate and inactivate antioxidant enzymes.

Journal: Chemical research in toxicology 20070201

Title: Development and validation of HPLC methods for the determination of potential extractables from elastomeric stoppers in the presence of a complex surfactant vehicle used in the preparation of parenteral drug products.

Journal: Journal of pharmaceutical and biomedical analysis 20070117

Title: Does immune stimulation or antioxidant therapy reduce MNU-induced placental damage via activation of Jak-STAT and NFkappaB signaling pathways?

Journal: Placenta 20070101

Title: Bioactive bibenzyl derivatives and fluorenones from Dendrobium nobile.

Journal: Journal of natural products 20070101

Title: Malignant hyperthermia.

Journal: Orphanet journal of rare diseases 20070101

Title: Accuracy of telepsychiatric assessment of new routine outpatient referrals.

Journal: BMC psychiatry 20070101

Title: Oxidative stress influences cholesterol efflux in THP-1 macrophages: role of ATP-binding cassette A1 and nuclear factors.

Journal: Cardiovascular research 20061201

Title: Regio- and stereoselective Ferrier reaction of O-1,3-dienyl acetals promoted by organoaluminum complexes.

Journal: Organic letters 20061123

Title: Synthesis and free radical scavenging activity of a novel metabolite from the fungus Colletotrichum gloeosporioides.

Journal: Bioorganic & medicinal chemistry letters 20061115

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: BHT blocks NF-kappaB activation and ethanol-induced brain damage.

Journal: Alcoholism, clinical and experimental research 20061101

Title: Free radical scavenging action of the natural polyamine spermine in rat liver mitochondria.

Journal: Free radical biology & medicine 20061015

Title: Quantitative analysis of early chemically-induced pulmonary lesions in mice of varying susceptibilities to lung tumorigenesis.

Journal: Cancer letters 20060928

Title: A new arthritis therapy with oxidative burst inducers.

Journal: PLoS medicine 20060901

Title: Phenolic glycosides with antioxidant activity from the stem bark of Populus davidiana.

Journal: Journal of natural products 20060901

Title: New analogues of butylated hydroxytoluene as anti-inflammatory and antioxidant agents.

Journal: Bioorganic & medicinal chemistry 20060815

Title: Enhancement of tumor invasion depends on transdifferentiation of skin fibroblasts mediated by reactive oxygen species.

Journal: Journal of cell science 20060701

Title: Synthesis and antioxidant activity of [60]fullerene-BHT conjugates.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20060602

Title: Attenuation of the pulmonary inflammatory response following butylated hydroxytoluene treatment of cytosolic phospholipase A2 null mice.

Journal: American journal of physiology. Lung cellular and molecular physiology 20060601

Title: Lipophilic hydroxytyrosyl esters. Antioxidant activity in lipid matrices and biological systems.

Journal: Journal of agricultural and food chemistry 20060531

Title: Evaluation of the antioxidant capacity of limonin, nomilin, and limonin glucoside.

Journal: Journal of agricultural and food chemistry 20060531

Title: NO-donor phenols: a new class of products endowed with antioxidant and vasodilator properties.

Journal: Journal of medicinal chemistry 20060518

Title: Cadmium-induced apoptosis in rat kidney epithelial cells involves decrease in nuclear factor-kappa B activity.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: An interlaboratory comparison of methods used to assess antioxidant potentials.

Journal: International journal of cosmetic science 20060401

Title: Beta-catenin in the fibroproliferative response to acute lung injury.

Journal: American journal of respiratory cell and molecular biology 20060301

Title: Evaluation of the antioxidant properties of diarylamines in the benzo[b]thiophene series by free radical scavenging activity and reducing power.

Journal: Bioorganic & medicinal chemistry letters 20060301

Title: Polypyrroles as antioxidants: kinetic studies on reactions of bilirubin and biliverdin dimethyl esters and synthetic model compounds with peroxyl radicals in solution. Chemical calculations on selected typical structures.

Journal: The Journal of organic chemistry 20060106

Title: Cytokine response to lipoprotein lipid loading in human monocyte-derived macrophages.

Journal: Lipids in health and disease 20060101

Title: Monitoring of BHT-quinone and BHT-CHO in the gas of capsules of Asclepias physocarpa.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20060101

Title: Manganese superoxide dismutase protects from TNF-alpha-induced apoptosis by increasing the steady-state production of H2O2.

Journal: Antioxidants & redox signaling 20060101

Title: Molecular epidemiology of clinical and carrier strains of methicillin resistant Staphylococcus aureus (MRSA) in the hospital settings of north India.

Journal: Annals of clinical microbiology and antimicrobials 20060101

Title: Scavenging of dpph* radicals by vitamin E is accelerated by its partial ionization: the role of sequential proton loss electron transfer.

Journal: Organic letters 20051027

Title: Quantitative determination of volatile organic compounds in indoor dust using gas chromatography-UV spectrometry.

Journal: Environment international 20051001

Title: Iron-ascorbic acid-induced oxidant stress and its quenching by paraoxonase 1 in HDL and the liver: comparison between humans and rats.

Journal: Journal of cellular biochemistry 20051001

Title: Effect of inducers of DT-diaphorase on the haemolytic activity and nephrotoxicity of 2-amino-1,4-naphthoquinone in rats.

Journal: Chemico-biological interactions 20050815

Title: Method development and validation for monitoring in vivo oxidative stress: evaluation of lipid peroxidation and fat-soluble vitamin status by HPLC in rat plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050805

Title: 2,1,3-Benzothiadiazine derivatives: synthesis and screening versus PDE4 enzyme.

Journal: Farmaco (Societa chimica italiana : 1989) 20050801

Title: Antioxidant constituents of the aerial parts of Globularia alypum growing in Morocco.

Journal: Journal of natural products 20050801

Title: A labdane diterpene glucoside from the rhizomes of Curcuma mangga.

Journal: Journal of natural products 20050701

Title: Radical scavenging activity of protein from tentacles of jellyfish Rhopilema esculentum.

Journal: Bioorganic & medicinal chemistry letters 20050516

Title: [Determination of quercetin in apples by reversed-phase high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20050501

Title: Synthesis, biological evaluation and molecular modelling studies on benzothiadiazine derivatives as PDE4 selective inhibitors.

Journal: Bioorganic & medicinal chemistry 20050215

Title: TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibition.

Journal: Brain research 20050209

Title: Synthesis and characterization of BHT-derived tert-butyl dendrons.

Journal: The Journal of organic chemistry 20050204

Title: Single-site anionic polymerization. Monomeric ester enolaluminate propagator synthesis, molecular structure, and polymerization mechanism.

Journal: Journal of the American Chemical Society 20050126

Title: Identification and antioxidant potential of flavonoids and low molecular weight phenols in olive cultivar chemlali growing in Tunisia.

Journal: Journal of agricultural and food chemistry 20050126

Title: Anticancer properties of propofol-docosahexaenoate and propofol-eicosapentaenoate on breast cancer cells.

Journal: Breast cancer research : BCR 20050101

Title: [Activation of deoxyribonucleotide synthesis by radioprotectants and antioxidants as a key stage in formation of body resistance to DNA-damaging factors].

Journal: Izvestiia Akademii nauk. Seriia biologicheskaia 20050101

Title: Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants.

Journal: Bioorganic & medicinal chemistry letters 20041220

Title: Relative amounts of antagonistic splicing factors, hnRNP A1 and ASF/SF2, change during neoplastic lung growth: implications for pre-mRNA processing.

Journal: Molecular carcinogenesis 20041201

Title: Inhibition of glutathione S-transferase P1-1 in mouse lung epithelial cells by the tumor promoter 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone (BHT-quinone methide): protein adducts investigated by electrospray mass spectrometry.

Journal: Chemical research in toxicology 20041201

Title: New acylated iridoid glucosides from Vitex altissima.

Journal: Journal of natural products 20041201

Title: Relative antioxidant capacities of propofol and its main metabolites.

Journal: Archives of toxicology 20041101

Title: Vanadium-catalyzed sulfenylation of indoles and 2-naphthols with thiols under molecular oxygen.

Journal: The Journal of organic chemistry 20041029

Title: Mononuclear, five-coordinate lanthanide amido and aryloxide complexes bearing tetradentate (N2O2) Schiff bases.

Journal: Inorganic chemistry 20041004

Title: Optimization of a high-performance liquid chromatography system by artificial neural networks for separation and determination of antioxidants.

Journal: Journal of separation science 20041001

Title: Chemical constituents of Morinda citrifolia fruits inhibit copper-induced low-density lipoprotein oxidation.

Journal: Journal of agricultural and food chemistry 20040922

Title: Malondialdehyde, a lipoperoxidation-derived aldehyde, can bring about secondary oxidative damage to proteins.

Journal: The journals of gerontology. Series A, Biological sciences and medical sciences 20040901

Title: Novel dual inhibitors of calpain and lipid peroxidation.

Journal: Bioorganic & medicinal chemistry letters 20040716

Title: Radical-scavenging activity of butylated hydroxytoluene (BHT) and its metabolites.

Journal: Chemistry and physics of lipids 20040701

Title: Effect of thiabendazole on some rat hepatic xenobiotic metabolising enzymes.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040601

Title: Inhibitory effects of organic acid salts on growth of Clostridium perfringens from spore inocula during chilling of marinated ground turkey breast.

Journal: International journal of food microbiology 20040601

Title: Inactivation of endoplasmic reticulum bound Ca2+-independent phospholipase A2 in renal cells during oxidative stress.

Journal: Journal of the American Society of Nephrology : JASN 20040601

Title: Effect of storage and packaging on fatty acid composition and oxidation in dry fermented sausages made with added olive oil and antioxidants.

Journal: Meat science 20040601

Title: [Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations].

Journal: Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20040501

Title: Recovery of phenolic antioxidants from wine industry by-products.

Journal: Bioresource technology 20040401

Title: [Inhibitory effect of zinc on beta-hexosaminidase release from RBL-2H3 cells by synthetic chemicals].

Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20040401

Title: In vitro estrogenicity of resin composites.

Journal: Journal of dental research 20040301

Title: Measurement of anti-HIV activity of marketed vaginal products and excipients using a PBMC-based in vitro assay.

Journal: Sexually transmitted diseases 20040301

Title: Mitochondrial permeability transition induced by reactive oxygen species is independent of cholesterol-regulated membrane fluidity.

Journal: FEBS letters 20040227

Title: A critical evaluation of the factors determining the effect of intramolecular hydrogen bonding on the O-H bond dissociation enthalpy of catechol and of flavonoid antioxidants.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20040220

Title: Monitoring of the antioxidant BHT and its metabolite BHT-CHO in German river water and ground water.

Journal: The Science of the total environment 20040205

Title: Structure and generation mechanism of a novel degradation product formed by oxidatively induced coupling of miconazole nitrate with butylated hydroxytoluene in a topical ointment studied by HPLC-ESI-MS and organic synthesis.

Journal: Journal of pharmaceutical sciences 20040201

Title: Analysis of insecticidal Azadirachta indica A. Juss. fractions.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101

Title: Antioxidizing potency of phenol compounds in olive oil mill wastewater.

Journal: Journal of agricultural and food chemistry 20031217

Title: Screening chemical composition and in vitro antioxidant and antimicrobial activities of the essential oils from Origanum syriacum L. growing in Turkey.

Journal: Biological & pharmaceutical bulletin 20031201

Title: A proposed sequence of events for cadmium-induced mitochondrial impairment.

Journal: Journal of inorganic biochemistry 20031101

Title: Ubiquitous expression of the forkhead box M1B transgene accelerates proliferation of distinct pulmonary cell types following lung injury.

Journal: The Journal of biological chemistry 20030926

Title: Antioxidative meroterpenoids from the brown alga Cystoseira crinita.

Journal: Journal of natural products 20030701

Title: Free radical-induced protein modification and inhibition of Ca2+-ATPase of cardiac sarcoplasmic reticulum.

Journal: Molecular and cellular biochemistry 20030601

Title: Effects of dietary butylated hydroxytoluene on aflatoxin B1-relevant metabolic enzymes in turkeys.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20030501

Title: Two new xanthone derivatives from the algicolous marine fungus Wardomyces anomalus.

Journal: Journal of natural products 20030501

Title: Reactive oxygen species mediate the down-regulation of mitochondrial transcripts and proteins by tumour necrosis factor-alpha in L929 cells.

Journal: The Biochemical journal 20030301

Title: Control of Clostridium perfringens germination and outgrowth by buffered sodium citrate during chilling of roast beef and injected pork.

Journal: Journal of food protection 20030301

Title: Sequestering ability of butylated hydroxytoluene, propyl gallate, resveratrol, and vitamins C and E against ABTS, DPPH, and hydroxyl free radicals in chemical and biological systems.

Journal: Journal of agricultural and food chemistry 20030212

Title: Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein.

Journal: Journal of lipid research 20030201

Title: Novel inhibitors of neuronal nitric oxide synthase with potent antioxidant properties.

Journal: Bioorganic & medicinal chemistry letters 20030120

Title: Reactive oxygen species are involved in the stimulation of the mitochondrial permeability transition by dihydrolipoate.

Journal: Biochemical pharmacology 20030101

Title: Trapping effect of synthetic sex pheromone of Acleris fimbriana (Lepidoptera: Tortricidae) in Chinese northern orchard.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101

Title: Cholesterol oxidation: health hazard and the role of antioxidants in prevention.

Journal: Biological research 20030101

Title: Cytotoxicity and apoptosis induction by butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT).

Journal: Anticancer research 20030101

Title: Ammonia-induced heme oxygenase-1 expression in cultured rat astrocytes and rat brain in vivo.

Journal: Glia 20021201

Title: Prodrug and covalent linker strategies for the solubilization of dual-action antioxidants/iron chelators.

Journal: Bioorganic & medicinal chemistry letters 20021118

Title: New antioxidant hydroquinone derivatives from the algicolous marine fungus Acremonium sp.

Journal: Journal of natural products 20021101

Title: Celecoxib reduces pulmonary inflammation but not lung tumorigenesis in mice.

Journal: Carcinogenesis 20021001

Title: Synthesis and evaluation of 4-hydroxyphenylacetic acid amides and 4-hydroxycinnamamides as antioxidants.

Journal: Bioorganic & medicinal chemistry letters 20020916

Title: Contact allergy to the monomers in p-tert-butylphenol-formaldehyde resin.

Journal: Contact dermatitis 20020901

Title: Practical synthesis of chiral emopamil left hand as a bioactive motif.

Journal: The Journal of organic chemistry 20020823

Title: Lung toxicity and tumor promotion by hydroxylated derivatives of 2,6-di-tert-butyl-4-methylphenol (BHT) and 2-tert-butyl-4-methyl-6-iso-propylphenol: correlation with quinone methide reactivity.

Journal: Chemical research in toxicology 20020801

Title: The mouse rasH2/BHT model as an in vivo rapid assay for lung carcinogens.

Journal: Japanese journal of cancer research : Gann 20020801

Title: Hydrogen bonding between phenols and fatty acid esters: (1)H NMR study and ab initio calculations.

Journal: Organic letters 20020711

Title: Reduced glutathione depletion causes necrosis and sensitization to tumor necrosis factor-alpha-induced apoptosis in cultured mouse hepatocytes.

Journal: Hepatology (Baltimore, Md.) 20020701

Title: [Determination of 2,6-di-tertbutyl-4-methylphenol in an aviation jet fuel by high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20020701

Title: Molecular profiling of genes up-regulated during promotion by phenobarbital treatment in a medium-term rat liver bioassay.

Journal: Carcinogenesis 20020601

Title: A convenient method for determination of the C20-22 PUFA composition of glycerolipids in blood and breast milk.

Journal: Lipids 20020501

Title: Design and synthesis of 2,6-diprenyl-4-iodophenol TX-1952 with a novel and potent anti-peroxidative activity.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20020501

Title: Analysis of the antioxidant butylated hydroxytoluene (BHT) in water by means of solid phase extraction combined with GC/MS.

Journal: Water research 20020501

Title: Development and validation of oxygen radical absorbance capacity assay for lipophilic antioxidants using randomly methylated beta-cyclodextrin as the solubility enhancer.

Journal: Journal of agricultural and food chemistry 20020327

Title: Quantitative trait loci that regulate susceptibility to both butylated hydroxytoluene-induced pulmonary inflammation and lung tumor promotion in CXB recombinant inbred mice.

Journal: Chest 20020301

Title: A lipoxygenase inhibitor from Aspergillus niger.

Journal: Applied microbiology and biotechnology 20020301

Title: The uptake of tocopherols by RAW 264.7 macrophages.

Journal: Nutrition journal 20020101

Title: The lung tumor promoter, butylated hydroxytoluene (BHT), causes chronic inflammation in promotion-sensitive BALB/cByJ mice but not in promotion-resistant CXB4 mice.

Journal: Toxicology 20011201

Title: Heteropteris aphrodisiaca O. Machado : effects of extract BST 0298 on the oxidative stress of young and old rat brains.

Journal: Phytotherapy research : PTR 20011101

Title: Butylhydroxytoluene (BHT) increases susceptibility of transgenic rasH2 mice to lung carcinogenesis.

Journal: Journal of cancer research and clinical oncology 20011001

Title: Use of an automated on-line SPE-HPLC method to monitor caffeine and selected aniline and phenol compounds in aquatic systems of Macedonia-Thrace, Greece.

Journal: Fresenius' journal of analytical chemistry 20011001

Title: Thermochemical and kinetic studies of a bisphenol antioxidant.

Journal: The Journal of organic chemistry 20010810

Title: Separation of hydrophobic polymer additives by microemulsion electrokinetic chromatography.

Journal: Journal of chromatography. A 20010713

Title: Antioxidant principles from Bauhinia tarapotensis.

Journal: Journal of natural products 20010701

Title: Synthetic derivatives of abietic acid with radical scavenging activity.

Journal: Journal of natural products 20010601

Title: Differential expression of forkhead box transcription factors following butylated hydroxytoluene lung injury.

Journal: American journal of physiology. Lung cellular and molecular physiology 20010401

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Journal: The British journal of nutrition 19970901

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Journal: The Journal of clinical investigation 19951101

Title: Down-regulation by butylated hydroxytoluene of the number and function of gap junctions in epithelial cell lines derived from mouse lung and rat liver.

Journal: Carcinogenesis 19951001

Title: Copper-induced tissue factor expression in human monocytic THP-1 cells and its inhibition by antioxidants.

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SDS
Tags:128-37-0 Molecular Formula|128-37-0 MDL|128-37-0 SMILES|128-37-0 2,6-Di-tert-butyl-4-methylphenol
Catalog No.: AA0032Z9
128-37-0,MFCD00011644
128-37-0 | 2,6-Di-tert-butyl-4-methylphenol
Pack Size: 25g
Purity: 98%
in stock
$7.00 $5.00
Pack Size: 100g
Purity: 98%
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$9.00 $7.00
Pack Size: 500g
Purity: 98%
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Technical Information
Catalog Number: AA0032Z9
Chemical Name: 2,6-Di-tert-butyl-4-methylphenol
CAS Number: 128-37-0
Molecular Formula: C15H24O
Molecular Weight: 220.3505
MDL Number: MFCD00011644
SMILES: Cc1cc(c(c(c1)C(C)(C)C)O)C(C)(C)C
FEMA Number: 2184
Properties
BP: 265°C at 760 mmHg  
Form: Solid  
MP: 69-73 °C  
Refractive Index: 1.4859  
Solubility: methanol: 0.1 g/mL, clear, colorless  
Storage: Inert atmosphere;Room Temperature;  
Complexity: 207  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 16  
Hydrogen Bond Acceptor Count: 1  
Hydrogen Bond Donor Count: 1  
Rotatable Bond Count: 2  
XLogP3: 5.3  
Upstream Synthesis Route
128-37-0    1310558-97-4    6858-01-1    28230-32-2 

[1]JournalofOrganicChemistry,2014,vol.79,#11,p.5209-5218

128-39-2    292638-85-8    128-37-0    86860-74-4    6386-38-5 

[1]BulletinoftheAcademyofSciencesoftheUSSR,DivisionofChemicalScience(EnglishTranslation),1991,vol.40,#5.1,p.877-883

[2]IzvestiyaAkademiiNaukSSSR,SeriyaKhimicheskaya,1991,#5,p.989-996

128-37-0    95-48-7    98-27-1    2409-55-4    2219-82-1    616-55-7 

[1]Recueil:JournaloftheRoyalNetherlandsChemicalSociety,1983,vol.102,#4,p.206-209

[2]Recueil:JournaloftheRoyalNetherlandsChemicalSociety,1983,vol.102,#4,p.206-209

128-37-0    95-48-7    106-44-5    98-27-1    2409-55-4    2219-82-1 

[1]Recueil:JournaloftheRoyalNetherlandsChemicalSociety,1983,vol.102,#4,p.206-209

128-37-0    118-82-1    955-01-1    1879-09-0 

[1]Patent:US4308407,1981,A,

Downstream Synthesis Route
75-91-2    128-37-0    13154-57-9 

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128-37-0    719-22-2 

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128-37-0    10396-80-2 

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128-37-0    809-73-4 

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128-37-0    1620-98-0 

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[25]Hayashi,Naoto;Nakagawa,Hiroyuki;Sugiyama,Yuko;Yoshino,Junro;Higuchi,Hiroyuki[ChemistryLetters,2013,vol.42,#4,p.398-400]

[26]Liang,Cheng;Li,Xuefeng;Su,Diefeng;Ma,Qiyi;Mao,Jianyong;Chen,Zhirong;Wang,Yong;Yao,Jia;Li,Haoran[Molecularcatalysis,2018,vol.453,p.121-131]

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