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4005-51-0,MFCD00003107
Catalog No.:AA0032ZZ

4005-51-0 | 2-Amino-1,3,4-thiadiazole

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  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA0032ZZ
Chemical Name:
2-Amino-1,3,4-thiadiazole
CAS Number:
4005-51-0
Molecular Formula:
C2H3N3S
Molecular Weight:
101.1303
MDL Number:
MFCD00003107
SMILES:
Nc1nncs1
NSC Number:
4728
Properties
Properties
 
BP:
238.9°C at 760 mmHg  
Form:
Solid  
MP:
181-182 °C  
Refractive Index:
1.5800 (estimate)  
Solubility:
water: soluble25mg/mL, clear, colorless  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
48.1  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
6  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
XLogP3:
-0.6  

Literature

Title: 2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.

Journal: Bioorganic & medicinal chemistry letters 20120901

Title: 5-(Thio-phen-2-ylmeth-yl)-1,3,4-thia-diazol-2-amine.

Journal: Acta crystallographica. Section E, Structure reports online 20120501

Title: Investigation of trypanothione reductase inhibitory activity by 1,3,4-thiadiazolium-2-aminide derivatives and molecular docking studies.

Journal: Bioorganic & medicinal chemistry 20120301

Title: 4-(3,5-Dioxo-10-oxa-4-aza-tricyclo-[5.2.1.0]decan-4-yl)-10-oxa-4-aza-tricyclo-[5.2.1.0]decane-3,5-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20120201

Title: The in vivo activity of 1,3,4-thiadiazolium-2-aminide compounds in the treatment of cutaneous and visceral leishmaniasis.

Journal: The Journal of antimicrobial chemotherapy 20120101

Title: catena-Poly[(μ-2-amino-1,3,4-thia-diazole-κN:N)di-μ-chlorido-cadmium].

Journal: Acta crystallographica. Section E, Structure reports online 20110801

Title: Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase.

Journal: Journal of medicinal chemistry 20110113

Title: Spectroscopic studies of intramolecular proton transfer in 2-(4-fluorophenylamino)-5-(2,4-dihydroxybenzeno)-1,3,4-thiadiazole.

Journal: Journal of fluorescence 20110101

Title: The activity of a new 2-amino-1,3,4-thiadiazole derivative 4ClABT in cancer and normal cells.

Journal: Folia histochemica et cytobiologica 20110101

Title: (14)N NQR, (1)H NMR and DFT/QTAIM study of hydrogen bonding and polymorphism in selected solid 1,3,4-thiadiazole derivatives.

Journal: Physical chemistry chemical physics : PCCP 20101028

Title: Selective determination of homocysteine at physiological pH using nanostructured film of aminothiadiazole modified electrode.

Journal: Bioelectrochemistry (Amsterdam, Netherlands) 20101001

Title: catena-Poly[[diaqua-manganese(II)]-μ-7-oxabicyclo-[2.2.1]heptane-2,3-dicarboxyl-ato].

Journal: Acta crystallographica. Section E, Structure reports online 20100601

Title: Simultaneous determination of ascorbic acid, dopamine, uric acid and xanthine using a nanostructured polymer film modified electrode.

Journal: Talanta 20100315

Title: N,N-Bis(2,6-difluoro-benz-yl)-1,3,4-thia-diazol-2-amine.

Journal: Acta crystallographica. Section E, Structure reports online 20090901

Title: rac-7-Oxabicyclo-[2.2.1]heptane-2,3-dicarboxylic acid-2-amino-1,3,4-thia-diazole-water (1/1/1).

Journal: Acta crystallographica. Section E, Structure reports online 20090701

Title: Amide derivatives with pyrazole carboxylic acids of 5-amino-1,3,4-thiadiazole 2-sulfonamide as new carbonic anhydrase inhibitors: synthesis and investigation of inhibitory effects.

Journal: Journal of enzyme inhibition and medicinal chemistry 20081201

Title: 5,5'-Diethyl-2,2'-(triazene-1,3-di-yl)di-1,3,4-thia-diazole.

Journal: Acta crystallographica. Section E, Structure reports online 20081101

Title: Anticancer, neuroprotective activities and computational studies of 2-amino-1,3,4-thiadiazole based compound.

Journal: Bioorganic & medicinal chemistry 20070501

Title: [2-(2,4-Dihydroxyphenyl)-1,3,4-thiadiazole analogues: antifungal activity in vitro against Candida species].

Journal: Bioorganicheskaia khimiia 20070101

Title: Probing Aspergillus niger glucose oxidase with pentacyanoferrate(III) aza- and thia-complexes.

Journal: Journal of inorganic biochemistry 20061001

Title: Synthesis and spectroscopic studies of new Schiff bases.

Journal: Molecules (Basel, Switzerland) 20060317

Title: 2-Amino-5-trifluoromethyl-1,3,4-thiadiazole and a redetermination of 2-amino-1,3,4-thiadiazole, both at 120 K: chains of edge-fused R(2)(2)(8) and R(4)(4)(10) rings, and sheets of R(2)(2)(8) and R(6)(6)(20) rings.

Journal: Acta crystallographica. Section C, Crystal structure communications 20060101

Title: Spectrophotometric and electrical studies of charge transfer complexes of 2-amino-1,3,4-thiadiazole with pi-acceptors.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051101

Title: Cytotoxic effect of a new 1,3,4-thiadiazolium mesoionic compound (MI-D) on cell lines of human melanoma.

Journal: British journal of cancer 20040719

Title: Role of an aminothiazole derivative on ethanol- and thermally oxidized sunflower oil-induced toxicity.

Journal: Polish journal of pharmacology 20040101

Title: Antibacterial Role of SO(4), NO(3), C(2)O(4) and CH(3)CO(2) Anions on Cu(II) and Zn(II) Complexes of a Thiadiazole-derived Pyrrolyl Schiff Base.

Journal: Metal-based drugs 20020101

Title: 2-Amino-5-methyl-1,3,4-thiadiazole and 2-amino-5-ethyl-1,3,4-thiadiazole.

Journal: Acta crystallographica. Section C, Crystal structure communications 20011001

Title: Biological evaluation of hepatitis C virus helicase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20010709

Title: Antibacterial Co(II), Cu(II), Ni(II) and Zn(II) Complexes of Thiadiazoles Schiff Bases.

Journal: Metal-based drugs 20010101

Title: DNA synthesis inhibition, cytotoxicity and their relationship to teratogenesis following administration of a nicotinamide antagonist, aminothiadiazole, to pregnant rats.

Journal: Journal of embryology and experimental morphology 19730801

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