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Title: Novel pyrazole derivatives as anticancer and radiosensitizing agents.
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Title: Poly[(μ(3)-rac-5-eth-oxy-carbonyl-6-hy-droxy-6-methyl-4-phenyl-4,5,6,7-tetra-hydro-benzo[c]isoxazol-3-olato)potassium].
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Title: 3D QSAR pharmacophore modeling, in silico screening, and density functional theory (DFT) approaches for identification of human chymase inhibitors.
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Title: Synthesis and Antimicrobial Activities of Some New Azetidin-2-ones and Thiazolidin-4-ones.
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Title: Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents.
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Title: Synthesis of chlorinated bicyclic C-fused tetrahydrofuro[3,2-c]azetidin-2-ones.
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Title: Ferrier-Petasis rearrangement of 4-(vinyloxy)azetidin-2-ones: an entry to carbapenams and carbacephams.
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Title: T-type calcium channel blockers: spiro-piperidine azetidines and azetidinones-optimization, design and synthesis.
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Title: Azetidinone-isothiazolidinones: stereoselective synthesis and antibacterial evaluation of new monocyclic beta-lactams.
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Title: Dietary phospholipids and intestinal cholesterol absorption.
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Title: Suppressed beta-effect of silicon in 3-silylated monocyclic beta-lactams: the role of antiaromaticity.
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Title: Design, synthesis and bioactivity of catechin/epicatechin and 2-azetidinone derived chimeric molecules.
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Title: 2-Azetidinone derivatives: design, synthesis, in vitro anti-microbial, cytotoxic activities and DNA cleavage study.
Journal: European journal of medicinal chemistry 20091201
Title: Azetidinones as zinc-binding groups to design selective HDAC8 inhibitors.
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Title: Molecular and crystalline structures of three (S)-4-alkoxycarbonyl-2-azetidinones containing long alkyl side chains from synchrotron X-ray powder diffraction data.
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Title: Potential of ezetimibe in memory deficits associated with dementia of Alzheimer's type in mice.
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Title: Lewis acid-assisted ene cyclization of 2-azetidinone-tethered enals: synthesis of enantiopure carbacepham derivatives.
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Title: (RS/SR)-2-Oxo-4-phenyl-azetidin-3-yl acetate.
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Title: Studies on the cytotoxic activity of synthetic 2H-azirine-2-azetidinone compounds.
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Title: Synthesis and antifungal activity of 2-azetidinonyl-5-(2-benzoylphenoxy)methyl-1,3,4-oxadiazoles against seed-borne pathogens of Eleusine coracana (L.) Gaertn.
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Title: Staudinger ketene-imine cycloaddition, RCM approach to macrocrocyclic bisazetidinones.
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Title: Large ring 1,3-bridged 2-azetidinones: experimental and theoretical studies.
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Title: 2-Azetidinone derivatives: design, synthesis and evaluation of cholesterol absorption inhibitors.
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Title: Spiro-piperidine azetidinones as potent TRPV1 antagonists.
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Title: Ring opening at N1-C2 bond of azetidin-2-ones by a molybdenum hydroxo-carbonyl complex: evidence from a computational study.
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Title: Deeper insight into the mechanism of the reaction of photogenerated metallaketenes and imines.
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Title: Beta-lactam type molecular scaffolds for antiproliferative activity: synthesis and cytotoxic effects in breast cancer cells.
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Title: Ezetimibe-related myopathy: A systematic review.
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Title: Base-induced sequential cyclization-rearrangement of enantioenriched 3-aminoalkanoates to five- and seven-membered lactams.
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Title: Drug delivery approaches to overcome bacterial resistance to beta-lactam antibiotics.
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Title: Novel syntheses of azetidines and azetidinones.
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Title: Ethyl 1'-[1-(4-methoxyphenyl)-3-phenoxy-4-phenylazetidin-1-yl]-1,3-dioxo-2',3',5',6',7',7a'-hexahydroindan-2-spiro-3'-1'H-pyrrolizine-2'-carboxylate.
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Title: Spectroscopic characterization of the 1-substituted 3,3-diphenyl-4-(2'-hydroxyphenyl)azetidin-2-ones: application of (13)C NMR, (1)H-(13)C COSY NMR and mass spectroscopy.
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Title: 3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors.
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Title: Indium-mediated 1,2,4,5-hexatetraen-3-ylation of 4-acetoxy-2-azetidinones and their applications to the Diels-Alder reactions for the synthesis of 2-azetidinone derivatives.
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Title: Total synthesis of (-)-kainic acid via intramolecular Michael addition: a second-generation route.
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Title: 1-(4-Methoxy-phen-yl)-7-phenyl-3-(phenyl-selenylmeth-yl)perhydro-isoxazolo[2',3':1,2]pyrrolo[3,4-b]azetidine-6-spiro-2'-chroman-2,4'-dione.
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Title: 2-[1-(4-Ethoxy-phen-yl)-2-oxo-4-styryl-azetidin-3-yl]isoindoline-1,3-dione.
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Title: Identification of novel cannabinoid CB1 receptor antagonists by using virtual screening with a pharmacophore model.
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Title: Discovery of azetidinone acids as conformationally-constrained dual PPARalpha/gamma agonists.
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Title: Anti-tubercular and anti-inflammatory activities of azetidin-2-one derivatives and their effects on the activity of Phospholipase A2.
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Title: New regiocontrolled synthesis of functionalized pyrroles from 2-azetidinone-tethered allenols.
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Title: Synthesis and Pharmacological Evaluation of Azetidin-2-ones and Thiazolidin-4-ones Encompassing Benzothiazole.
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Title: Antibacterial Activity of Barringtonia acutangula against Selected Urinary Tract Pathogens.
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Title: Synthesis and biological activity of N-substituted-3-chloro-2-azetidinones.
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Title: Synthesis of novel N-(4-ethoxyphenyl) azetidin-2-ones and their oxidative N-deprotection by ceric ammonium nitrate.
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Title: A minimalistic approach to identify substrate binding features in B1 Metallo-beta-lactamases.
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Title: Inhibitory effect by new monocyclic 4-alkyliden-beta-lactam compounds on human platelet activation.
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Title: Synthesis of 3-[4'-(p-chlorophenyl)-thiazol-2'-yl]-2-[(substituted azetidinone/thiazolidinone)-aminomethyl]-6-bromoquinazolin-4-ones as anti-inflammatory agent.
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Title: Interaction of beta-lactam carbenes with aryl isonitriles: an unprecedented rearrangement of 2-azetidinonylidene indoles to delta-carbolinones.
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Title: Azetidinones as vasopressin V1a antagonists.
Journal: Bioorganic & medicinal chemistry 20070301
Title: Two new antifungal alkaloids produced by Streptoverticillium morookaense.
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Title: In vivo responsiveness to ezetimibe correlates with niemann-pick C1 like-1 (NPC1L1) binding affinity: Comparison of multiple species NPC1L1 orthologs.
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Title: Ezetimibe analogs with a reorganized azetidinone ring: Design, synthesis, and evaluation of cholesterol absorption inhibitions.
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Title: Indium-mediated selective introduction of a 1,3-butadien-2-yl group at the C4-position in 2-azetidinones and application of 1,3-diene-tethered 2-azetidinones in the Diels-Alder reaction.
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Title: A theoretical proposal for the synthesis of carbapenems from 4-(2-propynyl)azetidinones promoted by [W(CO)5] as an alternative to the Ag+-assisted process.
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Title: A theoretical study of rhodium(I) catalyzed carbonylative ring expansion of aziridines to beta-lactams: crucial activation of the breaking C-N bond by hyperconjugation.
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Title: Structures of (S)-(-)-4-oxo-2-azetidinecarboxylic acid and 3-azetidinecarboxylic acid from powder synchrotron diffraction data.
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Title: An ab initio study on the allene-isocyanic acid and ketene-vinylimine [2 + 2] cycloaddition reaction paths.
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Title: Synthesis of strained tricyclic beta-lactams by intramolecular [2+2] cycloaddition reactions of 2-azetidinone-tethered enallenols: control of regioselectivity by selective alkene substitution.
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Title: The polymer-supported and combinatorial synthesis of beta-lactam compounds: an update.
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Title: Rabbit small intestine does not contain an annexin II/caveolin 1 complex as a target for 2-azetidinone cholesterol absorption inhibitors.
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Title: Nitrenium ion azaspirocyclization-spirodienone cleavage: a new synthetic strategy for the stereocontrolled preparation of highly substituted lactams and N-hydroxy lactams.
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Title: Synthesis of 2-azetidinones from 2-diazo-1, 2-diarylethanones and N-(2-thienylidene)imines as possible antimicrobial agents.
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Title: The indium-mediated selective introduction of allenyl and propargyl groups at the C4-position of 2-azetidinones and the AuCl3-catalyzed cyclization of 4-allenyl-2-azetidinones.
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Title: 3,4-disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P3 elements for potency and selectivity.
Journal: Bioorganic & medicinal chemistry letters 20050301
Title: Synthesis and anti-tubulin activity of a 3'-(4-azidophenyl)-3'-dephenylpaclitaxel photoaffinity probe.
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Title: Ketopyrrolidines and ketoazetidines as potent dipeptidyl peptidase IV (DPP IV) inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20041115
Title: Ezetimibe--a new cholesterol-lowering drug.
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Title: Beta-lactams as versatile synthetic intermediates for the preparation of heterocycles of biological interest.
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Title: Kinetics and mechanism of hydrolysis of N-acyloxymethyl derivatives of azetidin-2-one.
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Title: Examination of the 1,4-disubstituted azetidinone ring system as a template for combretastatin A-4 conformationally restricted analogue design.
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Title: Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20040503
Title: Regioselective Baeyer-Villiger oxidation in 4-carbonyl-2-azetidinone series: a revisited route toward carbapenem precursor.
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Title: Functionalized macrocycles from functionalized tetra-amines: pendent-arm macrocycles derived from dichloropivalic acid.
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Title: Synthesis of optically pure highly functionalized gamma-lactams via 2-azetidinone-tethered iminophosphoranes.
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Title: Synthesis of antitumor 6-alkylidenepenicillanate sulfones and related 3-alkylidene-2-azetidinones.
Journal: Bioorganic & medicinal chemistry letters 20040105
Title: Synthesis and evaluation of N1/C4-substituted beta-lactams as PPE and HLE inhibitors.
Journal: Bioorganic & medicinal chemistry 20040102
Title: Synthesis of cryptophycins via an N-acyl-beta-lactam macrolactonization.
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Title: Design of beta-lactams with mechanism based nonantibacterial activities.
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Title: Ezetimibe for management of hypercholesterolemia.
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Title: Crystal structure of 3,3-dichloro-N-p-methoxyphenyl-4-(2-phenylstryl)-2-azetidinone.
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Title: Synthesis of a biotin-tagged photoaffinity probe of 2-azetidinone cholesterol absorption inhibitors.
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Title: Catalysts with mixed ligands on immobilized supports. Electronic and steric advantages.
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Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20030101
Title: Exploring solid-phase approaches for the preparation of new beta-lactams from amino acids.
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Title: beta-Lactam allergenic determinants: fine structural recognition of a cross-reacting determinant on benzylpenicillin and cephalothin.
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Title: Efficient and highly stereoselective synthesis of a beta-lactam inhibitor of the serine protease prostate-specific antigen.
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Title: A stereoselective synthesis of BMS-262084, an azetidinone-based tryptase inhibitor.
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Title: General approach for the stereocontrolled construction of the beta-lactam ring in amino acid-derived 4-alkyl-4-carboxy-2-azetidinones.
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Title: SmI(2)-mediated cyclizations of derivatized beta-lactams for the highly diastereoselective construction of functionalized prolines.
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Title: Water-assisted alkaline hydrolysis of monobactams: a theoretical study.
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Title: Synthesis of iodinated biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors.
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Title: Synthesis of fluorescent biochemical tools related to the 2-azetidinone class of cholesterol absorption inhibitors.
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Title: Cholesterol absorption inhibitors for the treatment of hypercholesterolaemia.
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Title: Synthesis of ferrocene-substituted 2-azetidinones.
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Title: Design, synthesis and pharmacological evaluation of 3-benzylazetidine-2-one-based human chymase inhibitors.
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Title: beta-Lactam derivatives as enzyme inhibitors: derivatives of (E)-2-[(RS)-1-(4-methoxyphenyl)-2-oxo-4-phenylazetidin-3-ylidene]propionic acid.
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Title: Metal-promoted allylation, propargylation, or allenylation of azetidine-2,3-diones in aqueous and anhydrous media. Application to the asymmetric synthesis of densely functionalized 3-substituted 3-hydroxy-beta-lactams.
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Title: Crystal structure of 3,3-dichloro-N-p-methoxyphenyl-4-(2-phenylstryl)-2-azetidinone.
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Title: Entry to new conformationally constrained amino acids. First synthesis of 3-unsubstituted 4-alkyl-4-carboxy-2-azetidinone derivatives via an intramolecular N(alpha)-C(alpha)-cyclization strategy.
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Title: Design, synthesis, and proposed active site binding analysis of monocyclic 2-azetidinone inhibitors of prostate specific antigen.
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Title: Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors.
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Title: Fine structural recognition specificities of IgE antibodies distinguishing amoxicilloyl and amoxicillanyl determinants in allergic subjects.
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Title: Synthesis of trans-4-aryl-3-(omega-chloroalkyl) -2-azetidinones.
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