Home Nitro Compounds 145370-39-4
145370-39-4,MFCD22479198
Catalog No.:AA0033Z0

145370-39-4 | 2-(3-Methoxy-4-nitrophenyl)-4h-chromen-4-one

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100mg
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA0033Z0
Chemical Name:
2-(3-Methoxy-4-nitrophenyl)-4h-chromen-4-one
CAS Number:
145370-39-4
Molecular Formula:
C16H11NO5
Molecular Weight:
297.2622
MDL Number:
MFCD22479198
SMILES:
COc1cc(ccc1[N+](=O)[O-])c1cc(=O)c2c(o1)cccc2
Properties
Properties
 
BP:
494.0±45.0°C at 760 mmHg  
Form:
Solid  
MP:
>203ºC (dec.)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
483  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
5  
Rotatable Bond Count:
2  
XLogP3:
3.4  

Literature

Title: The highly bioactive molecule and signal substance 6-formylindolo[3,2-b]carbazole (FICZ) plays bi-functional roles in cell growth and apoptosis in vitro.

Journal: Archives of toxicology 20171001

Title: Aryl hydrocarbon receptor signaling modifies Toll-like receptor-regulated responses in human dendritic cells.

Journal: Archives of toxicology 20170501

Title: Environmental pollutants parathion, paraquat and bisphenol A show distinct effects towards nuclear receptors-mediated induction of xenobiotics-metabolizing cytochromes P450 in human hepatocytes.

Journal: Toxicology letters 20151001

Title: Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2).

Journal: Archives of toxicology 20150801

Title: Aryl hydrocarbon receptor-dependent cell cycle arrest in isolated mouse oval cells.

Journal: Toxicology letters 20131023

Title: Long interspersed element-1 is differentially regulated by food-borne carcinogens via the aryl hydrocarbon receptor.

Journal: Oncogene 20131010

Title: Regulation of estrogen sulfotransferase expression by confluence of MCF10A breast epithelial cells: role of the aryl hydrocarbon receptor.

Journal: The Journal of pharmacology and experimental therapeutics 20111101

Title: Suppression of WIF-1 through promoter hypermethylation causes accelerated proliferation of the aryl hydrocarbon receptor (AHR) overexpressing MCF10AT1 breast cancer cells.

Journal: Toxicology 20110729

Title: Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism.

Journal: The Journal of pharmacology and experimental therapeutics 20110701

Title: Activation of aryl hydrocarbon receptor induces vascular inflammation and promotes atherosclerosis in apolipoprotein E-/- mice.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20110601

Title: FRET analysis of protein tyrosine kinase c-Src activation mediated via aryl hydrocarbon receptor.

Journal: Biochimica et biophysica acta 20110401

Title: The AhR is constitutively activated and affects granulosa cell features in the human cell line KGN.

Journal: Molecular human reproduction 20110201

Title: Species-specific differential AhR expression protects human neural progenitor cells against developmental neurotoxicity of PAHs.

Journal: Environmental health perspectives 20101101

Title: CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20101001

Title: Cytochrome P450 1A1 gene regulation by UVB involves crosstalk between the aryl hydrocarbon receptor and nuclear factor kappaB.

Journal: Chemico-biological interactions 20100330

Title: Arylhydrocarbon receptor activation in NCI-H441 cells and C57BL/6 mice: possible mechanisms for lung dysfunction.

Journal: American journal of respiratory cell and molecular biology 20100201

Title: TCDD-induced cyclooxygenase-2 expression is mediated by the nongenomic pathway in mouse MMDD1 macula densa cells and kidneys.

Journal: Biochemical pharmacology 20100201

Title: Antagonism of aryl hydrocarbon receptor signaling by 6,2',4'-trimethoxyflavone.

Journal: The Journal of pharmacology and experimental therapeutics 20100101

Title: Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators.

Journal: Molecular endocrinology (Baltimore, Md.) 20100101

Title: The arylhydrocarbon receptor is only marginally involved in the antileukemic effects of its ligand curcumin.

Journal: Anticancer research 20091101

Title: The conversion of rapid TCCD nongenomic signals to persistent inflammatory effects via select protein kinases in MCF10A cells.

Journal: Molecular endocrinology (Baltimore, Md.) 20090401

Title: Characterization of MCF mammary epithelial cells overexpressing the Arylhydrocarbon receptor (AhR).

Journal: BMC cancer 20090101

Title: Significance of the nongenomic, inflammatory pathway in mediating the toxic action of TCDD to induce rapid and long-term cellular responses in 3T3-L1 adipocytes.

Journal: Biochemistry 20081230

Title: Aryl hydrocarbon receptor signaling mediates expression of indoleamine 2,3-dioxygenase.

Journal: Biochemical and biophysical research communications 20081024

Title: Roles of cytosolic phospholipase A2 and Src kinase in the early action of 2,3,7,8-tetrachlorodibenzo-p-dioxin through a nongenomic pathway in MCF10A cells.

Journal: Molecular pharmacology 20080701

Title: Molecular determinants of species-specific agonist and antagonist activity of a substituted flavone towards the aryl hydrocarbon receptor.

Journal: Archives of biochemistry and biophysics 20080415

Title: Pathogenesis of aryl hydrocarbon receptor-mediated development of lymphoma is associated with increased cyclooxygenase-2 expression.

Journal: The American journal of pathology 20071101

Title: Cigarette smoke condensate and dioxin suppress culture shock induced senescence in normal human oral keratinocytes.

Journal: Oral oncology 20070801

Title: beta-Naphthoflavone and 3'-methoxy-4'-nitroflavone exert ambiguous effects on Ah receptor-dependent cell proliferation and gene expression in rat liver 'stem-like' cells.

Journal: Biochemical pharmacology 20070515

Title: Identification of kaempferol as an inhibitor of cigarette smoke-induced activation of the aryl hydrocarbon receptor and cell transformation.

Journal: Carcinogenesis 20070301

Title: Lack of the aryl hydrocarbon receptor leads to impaired activation of AKT/protein kinase B and enhanced sensitivity to apoptosis induced via the intrinsic pathway.

Journal: The Journal of pharmacology and experimental therapeutics 20070101

Title: Impact of the arylhydrocarbon receptor on eugenol- and isoeugenol-induced cell cycle arrest in human immortalized keratinocytes (HaCaT).

Journal: Biological chemistry 20060901

Title: Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo[a]pyrene.

Journal: The Journal of biological chemistry 20060721

Title: Human endothelial progenitors constitute targets for environmental atherogenic polycyclic aromatic hydrocarbons.

Journal: Biochemical and biophysical research communications 20060317

Title: The ligand status of the aromatic hydrocarbon receptor modulates transcriptional activation of BRCA-1 promoter by estrogen.

Journal: Cancer research 20060215

Title: The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts.

Journal: American journal of physiology. Lung cellular and molecular physiology 20050901

Title: Human CD34-positive hematopoietic stem cells constitute targets for carcinogenic polycyclic aromatic hydrocarbons.

Journal: The Journal of pharmacology and experimental therapeutics 20050801

Title: Superinduction of CYP1A1 in MCF10A cultures by cycloheximide, anisomycin, and puromycin: a process independent of effects on protein translation and unrelated to suppression of aryl hydrocarbon receptor proteolysis by the proteasome.

Journal: Molecular pharmacology 20041001

Title: Dioxin-induced immortalization of normal human keratinocytes and silencing of p53 and p16INK4a.

Journal: The Journal of biological chemistry 20040625

Title: Presence and functional activity of the aryl hydrocarbon receptor in isolated murine cerebral vascular endothelial cells and astrocytes.

Journal: Neurotoxicology 20040601

Title: TCDD administration after the pro-adipogenic differentiation stimulus inhibits PPARgamma through a MEK-dependent process but less effectively suppresses adipogenesis.

Journal: Toxicology and applied pharmacology 20040401

Title: 3'-methoxy-4'-nitroflavone, a reported aryl hydrocarbon receptor antagonist, enhances Cyp1a1 transcription by a dioxin responsive element-dependent mechanism.

Journal: Archives of biochemistry and biophysics 20030801

Title: Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements.

Journal: Molecular pharmacology 20030401

Title: The aryl hydrocarbon receptor antagonist, 3'methoxy-4'nitroflavone, attenuates 2,3,7,8-tetrachlorodibenzo-p-dioxin-dependent regulation of growth factor signaling and apoptosis in the MCF-10A cell line.

Journal: Toxicology and applied pharmacology 20030401

Title: Involvement of a post-transcriptional mechanism in the inhibition of CYP1A1 expression by resveratrol in breast cancer cells.

Journal: Biochemical pharmacology 20011015

Title: In vivo antagonism of AhR-mediated gene induction by 3'-methoxy-4'-nitroflavone in TCDD-responsive lacZ mice.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20010601

Title: Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo.

Journal: Carcinogenesis 20010101

Title: Suppression of cell cycle progression by flavonoids: dependence on the aryl hydrocarbon receptor.

Journal: Carcinogenesis 19990801

Title: Substituted flavones as aryl hydrocarbon (Ah) receptor agonists and antagonists.

Journal: Biochemical pharmacology 19960426

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