Title: Computational studies of novel chymase inhibitors against cardiovascular and allergic diseases: mechanism and inhibition.
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Title: Exploration of ring size in a series of cyclic vicinal diamines with σ₁ receptor affinity.
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Title: Automated synthesis of a library of triazolated 1,2,5-thiadiazepane 1,1-dioxides via a double aza-Michael strategy.
Journal: ACS combinatorial science20120813
Title: Reaction of homopiperazine with endogenous formaldehyde: a carbon hydrogen addition metabolite/product identified in rat urine and blood.
Journal: Drug metabolism and disposition: the biological fate of chemicals20120801
Title: Evaluation of the behavioral and pharmacokinetic profile of SYA013, a homopiperazine analog of haloperidol in rats.
Journal: Pharmacology, biochemistry, and behavior20120801
Title: Synthesis and positive inotropic evaluation of N-(1-oxo-1,2,4,5-tetrahydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)acetamides bearing piperazine and 1,4-diazepane moieties.
Journal: Bioorganic & medicinal chemistry letters20120701
Title: 1,4-Ditosyl-1,4-diazepane.
Journal: Acta crystallographica. Section E, Structure reports online20120601
Title: Ethyl 2-(7-oxo-3,5-diphenyl-1,4-diaze-pan-2-yl)acetate.
Journal: Acta crystallographica. Section E, Structure reports online20120401
Title: Structure-activity relationship studies of SYA 013, a homopiperazine analog of haloperidol.
Journal: Bioorganic & medicinal chemistry20120301
Title: Activation of the c-Jun N-terminal kinase/activating transcription factor 3 (ATF3) pathway characterizes effective arylated diazeniumdiolate-based nitric oxide-releasing anticancer prodrugs.
Journal: Journal of medicinal chemistry20111124
Title: Methyl (9aR*,10S*,11R*,13aS*,13bS*)-9-oxo-6,7,9,9a,10,11-hexa-hydro-5H,13bH-11,13a-ep-oxy-pyrrolo-[2',1':3,4][1,4]diazepino[2,1-a]isoindole-10-carboxyl-ate.
Journal: Acta crystallographica. Section E, Structure reports online20111101
Title: N-substituted homopiperazine barbiturates as gelatinase inhibitors.
Journal: Bioorganic & medicinal chemistry20110815
Title: Homopiperazine-1,4-diium bis-[hexa-aqua-cobalt(II)] tris-ulfate.
Journal: Acta crystallographica. Section E, Structure reports online20110801
Title: Aryl 1,4-diazepane compounds as potent and selective CB2 agonists: optimization of drug-like properties and target independent parameters.
Journal: Bioorganic & medicinal chemistry letters20110715
Title: Synthesis and structure-activity relationship of tricyclic carboxylic acids as novel anti-histamines.
Journal: Bioorganic & medicinal chemistry20110501
Title: 1,4-Diazepane compounds as potent and selective CB2 agonists: optimization of metabolic stability.
Journal: Bioorganic & medicinal chemistry letters20110401
Title: Solution-phase parallel synthesis and SAR of homopiperazinyl analogs as positive allosteric modulators of mGlu₄.
Journal: ACS combinatorial science20110314
Title: Potent farnesyltransferase inhibitors with 1,4-diazepane scaffolds as novel destabilizing microtubule agents in hormone-resistant prostate cancer.
Journal: Journal of medicinal chemistry20110310
Title: Mechanistic insight into the reactivity of oxotransferases by novel asymmetric dioxomolybdenum(VI) model complexes.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany)20110110
Title: Lipopolysaccharide-Deficient Brucella Variants Arise Spontaneously during Infection.
Journal: Frontiers in microbiology20110101
Title: Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion.
Journal: PloS one20110101
Title: Insights into the complex formed by matrix metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations.
Journal: PloS one20110101
Title: A series of Cu(II)-azide polymers of Cu6 building units and the role of chelating diamine in controlling their dimensionality: synthesis, structures, and magnetic behavior.
Journal: Inorganic chemistry20101115
Title: Bis(homopiperazine-1,4-diium) cyclo-tetra-phosphate-telluric acid (1/2).
Journal: Acta crystallographica. Section E, Structure reports online20101101
Title: Synthesis of 2-(4-substituted benzyl-1,4-diazepan-1-yl)-N-(3,4-dihydro-3-oxo-2H-benzo[b][1,4]oxazin-7-yl)acetamides and their positive inotropic evaluation.
Journal: Bioorganic & medicinal chemistry letters20100801
Title: Synthesis of a histamine H(3) receptor antagonist-manipulation of hydroxyproline stereochemistry, desymmetrization of homopiperazine, and nonextractive sodium triacetoxyborohydride reaction workup.
Journal: The Journal of organic chemistry20100702
Title: Synthesis and biological evaluation of 1,4-diazepane derivatives as T-type calcium channel blockers.
Journal: Bioorganic & medicinal chemistry letters20100501
Title: Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists.
Journal: Bioorganic & medicinal chemistry letters20100401
Title: Tertiary skipped diynes: a pluripotent building block for the modular and diversity-oriented synthesis of nitrogen heterocycles.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany)20100315
Title: A series of peroxomanganese(III) complexes supported by tetradentate aminopyridyl ligands: detailed spectroscopic and computational studies.
Journal: Journal of the American Chemical Society20100303
Title: Dramatic increase of selectivity for heavy lanthanide(III) cations by tuning the flexibility of polydentate chelators.
Journal: Inorganic chemistry20100118
Title: Synthesis and evaluation of (S,S)-N,N'-bis-[3-(2,2',6,6'-tetramethylbenzhydryloxy)-2-hydroxy-propyl]-ethylenediamine (S2824) analogs with anti-tuberculosis activity.
Journal: Bioorganic & medicinal chemistry letters20091101
Title: Expedite protocol for construction of chiral regioselectively N-protected monosubstituted piperazine, 1,4-diazepane, and 1,4-diazocane building blocks.
Journal: The Journal of organic chemistry20090807
Title: Synthesis of dimeric quinazolin-2-one, 1,4-benzodiazepin-2-one, and isoalloxazine compounds as inhibitors of amyloid peptides association.
Journal: Archiv der Pharmazie20090801
Title: Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in rats.
Journal: ChemMedChem20090701
Title: Synthesis and evaluation of piperazine and homopiperazine analogues of JS-K, an anti-cancer lead compound.
Journal: Bioorganic & medicinal chemistry letters20090515
Title: User-friendly stereoselective one-pot access to 1,4-diazepane derivatives by a cyclodehydrative three-component reaction with 1,3-dicarbonyls.
Journal: Organic & biomolecular chemistry20090507
Title: 1,4-Diazepanes derived from (S)-serine--homopiperazines with improved sigma(1) (sigma) receptor affinity and selectivity.
Journal: European journal of medicinal chemistry20090201
Title: Synthesis and biological evaluation of homopiperazine derivatives with beta-aminoacyl group as dipeptidyl peptidase IV inhibitors.
Journal: Bioorganic & medicinal chemistry letters20081215
Title: Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs.
Journal: Bioorganic & medicinal chemistry20081115
Title: Novel C-5 aminomethyl pyrrolotriazine dual inhibitors of EGFR and HER2 protein tyrosine kinases.
Journal: Bioorganic & medicinal chemistry letters20070515
Title: N, N -disubstituted piperazines and homopiperazines: synthesis and affinities at alpha4beta2* and alpha7* neuronal nicotinic acetylcholine receptors.
Journal: Journal of enzyme inhibition and medicinal chemistry20061201
Title: Identification of new diamine scaffolds with activity against Mycobacterium tuberculosis.
Journal: Journal of medicinal chemistry20060601
Title: Docking of 6-chloropyridazin-3-yl derivatives active on nicotinic acetylcholine receptors into molluscan acetylcholine binding protein (AChBP).
Journal: Farmaco (Societa chimica italiana : 1989)20050401
Title: [High throughput screening of pharmacokinetics and metabolism in drug discovery (II)--investigation on in vitro and in vivo correlation in drug metabolism screening].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan20050101
Title: Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives.
Journal: Bioorganic & medicinal chemistry letters20041101
Title: Orally active factor Xa inhibitor: synthesis and biological activity of masked amidines as prodrugs of novel 1,4-diazepane derivatives.
Journal: Bioorganic & medicinal chemistry20041015
Title: Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity.
Journal: Bioorganic & medicinal chemistry20040501
Title: Exploration of composition space in templated uranium sulfates.
Journal: Inorganic chemistry20031103
Title: A new class of spermidine-derived alkaloids.
Journal: Organic letters20030807
Title: Trypanocidal activity of conformationally restricted pentamidine congeners.
Journal: Journal of medicinal chemistry20030313
Title: Potent and selective inhibitors of PDGF receptor phosphorylation. 2. Synthesis, structure activity relationship, improvement of aqueous solubility, and biological effects of 4-[4-(N-substituted (thio)carbamoyl)-1-piperazinyl]-6,7-dimethoxyquinazoline derivatives.
Journal: Journal of medicinal chemistry20020926
Title: 6-Chloropyridazin-3-yl derivatives active as nicotinic agents: synthesis, binding, and modeling studies.
Journal: Journal of medicinal chemistry20020829
Title: New mu-opioid receptor agonists with piperazine moiety.
Journal: Chemical & pharmaceutical bulletin20011001
Title: Subtle bite-angle influences on N(2)S(2)Ni complexes.
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Title: Steric control of stereoselective interactions between the platinum(II) complex [PtCl2(1,4-diazacycloheptane)] and DNA: comparison with cis-[PtCl2(NH3)2] and [PtCl2(ethane-1,2-diamine)] using DNA binding and molecular modeling studies.
Journal: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry20010601
