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35212-22-7,MFCD00221719
Catalog No.:AA0034YG

35212-22-7 | 3-phenyl-7-(propan-2-yloxy)-4H-chromen-4-one

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50mg
98%
in stock  
$6.00   $4.00
- +
100mg
98%
in stock  
$8.00   $6.00
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250mg
98%
in stock  
$11.00   $8.00
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1g
98%
in stock  
$13.00   $9.00
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5g
98%
in stock  
$29.00   $21.00
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25g
98%
in stock  
$96.00   $68.00
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100g
98%
in stock  
$302.00   $212.00
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500g
98%
in stock  
$909.00   $636.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0034YG
Chemical Name:
3-phenyl-7-(propan-2-yloxy)-4H-chromen-4-one
CAS Number:
35212-22-7
Molecular Formula:
C18H16O3
Molecular Weight:
280.3178
MDL Number:
MFCD00221719
SMILES:
CC(Oc1ccc2c(c1)occ(c2=O)c1ccccc1)C
Properties
Properties
 
BP:
435.9°C at 760 mmHg  
Form:
Solid  
MP:
116-120 °C(lit.)  
Refractive Index:
1.4700 (estimate)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
407  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
4  

Upstream Synthesis Route

[1]JournalofLabelledCompoundsandRadiopharmaceuticals,1999,vol.42,#5,p.497-504

[2]BioorganicandMedicinalChemistry,2003,vol.11,#18,p.4069-4081

[3]Patent:WO2004/2470,2004,A1,.Locationinpatent:Page/Pagecolumn22-23

[4]Patent:US3949085,1976,A,

[1]Patent:US5973169,1999,A,

[1]PharmaceuticalChemistryJournal,1990,vol.24,#9,p.641-645

[2]Khimiko-FarmatsevticheskiiZhurnal,1990,vol.24,#9,p.38-41

[1]JournalofOrganicChemistry,2016,vol.81,#19,p.9422-9427

[1]SyntheticCommunications,2008,vol.38,#22,p.3875-3883

Downstream Synthesis Route

[1]PharmaceuticalChemistryJournal,1990,vol.24,p.641-645    Khimiko-FarmatsevticheskiiZhurnal,1990,vol.24,p.38-41

[1]Journaloflabelledcompoundsandradiopharmaceuticals,1999,vol.42,p.497-504

[2]BioorganicandMedicinalChemistry,2003,vol.11,p.4069-4081

[3]Patent:WO2004/2470,2004,A1.Locationinpatent:Page/Pagecolumn22-23

[4]Patent:US3949085,1976,A

[1]Journaloflabelledcompoundsandradiopharmaceuticals,1999,vol.42,p.497-504

[2]JournalofChemicalCrystallography,2005,vol.35,p.101-105

[1]EuropeanJournalofOrganicChemistry,2001,p.3911-3920

35212-22-7    13057-72-2    385817-63-0   
7-hydroxy-2',5'-diisopropylisoflavone 
 
7-hydroxy-3',5'-diisopropylisoflavone 

[1]EuropeanJournalofOrganicChemistry,2001,p.3911-3920

Literature

Title: Why are most phospholipidosis inducers also hERG blockers?

Journal: Archives of toxicology 20171201

Title: Mutagenicity of ipriflavone in vivo and in vitro.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120301

Title: Determination of ipriflavone in human plasma by LC-MS and its application in a pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20120101

Title: [Effect of ipriflavone on Wistar rats and their litters].

Journal: Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia 20120101

Title: Discovery of indeno[1,2-c]quinoline derivatives as inhibitors of osteoclastogenesis induced by receptor activator of NF-κB ligand (RANKL).

Journal: Journal of medicinal chemistry 20110428

Title: Identification of Hedgehog signaling inhibitors with relevant human exposure by small molecule screening.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20100801

Title: Effects of ipriflavone on postmenopausal syndrome and osteoporosis.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20100201

Title: Pharmacokinetics of ipriflavone and its two metabolites, M1 and M5, after the intravenous and oral administration of ipriflavone to rat model of diabetes mellitus induced by streptozotocin.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20091208

Title: Synthesis and anti-osteoporotic evaluation of certain 3-amino-2-hydroxypropoxyisoflavone derivatives.

Journal: European journal of medicinal chemistry 20090901

Title: [Effect of ipriflavone on growth and blood testosterone level in male rats].

Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20090501

Title: Determination of the anti-osteoporosis drug ipriflavone in pharmaceutical formulation by stripping voltammetric and chromatographic methods.

Journal: Journal of AOAC International 20090101

Title: Effects of phytoestrogen on mitochondrial structure and function of hippocampal CA1 region of ovariectomized rats.

Journal: Cellular and molecular neurobiology 20080901

Title: The combination of genistin and ipriflavone prevents mammary tumorigenesis and modulates lipid profile.

Journal: Clinical nutrition (Edinburgh, Scotland) 20080801

Title: Effects of estrogen and estrogenic compounds on cognition in ovariectomized rats.

Journal: Climacteric : the journal of the International Menopause Society 20080601

Title: Potential ipriflavone and warfarin interaction.

Journal: The American journal of medicine 20071201

Title: Characterization of cytochrome P450s mediating ipriflavone metabolism in human liver microsomes.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20070301

Title: Pharmacokinetic changes of ipriflavone in rats with acute renal failure induced by uranyl nitrate.

Journal: Biopharmaceutics & drug disposition 20061001

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous ipriflavone in rats.

Journal: The Journal of pharmacy and pharmacology 20060401

Title: Effects of methoxyisoflavone, ecdysterone, and sulfo-polysaccharide supplementation on training adaptations in resistance-trained males.

Journal: Journal of the International Society of Sports Nutrition 20060101

Title: The effect of two dietary and a synthetic phytoestrogen on transepithelial calcium transport in human intestinal-like Caco-2 cells.

Journal: European journal of nutrition 20050301

Title: Ipriflavone modulates IGF-I but is unable to restore bone in rats.

Journal: Phytotherapy research : PTR 20050201

Title: Induction of apoptosis in cultured rat gastric epithelial cells by ipriflavone: comparison with indomethacin.

Journal: Biological & pharmaceutical bulletin 20040501

Title: [Abnormality of bone mineral metabolism in type 2 diabetes mellitus].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20040201

Title: [Interaction between ipriflavone and other drugs in metabolism in vitro].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20040101

Title: Inhibition of COX isoforms by nutraceuticals.

Journal: Journal of herbal pharmacotherapy 20040101

Title: Promoting effect of kaempferol on the differentiation and mineralization of murine pre-osteoblastic cell line MC3T3-E1.

Journal: Bioscience, biotechnology, and biochemistry 20030601

Title: Use of alternative and complementary medicine in menopause.

Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20021201

Title: Ipriflavone inhibits osteolytic bone metastasis of human breast cancer cells in a nude mouse model.

Journal: International journal of cancer 20020801

Title: Complementary therapies for reducing the risk of osteoporosis in patients receiving luteinizing hormone-releasing hormone treatment/orchiectomy for prostate cancer: a review and assessment of the need for more research.

Journal: Urology 20020401

Title: [Comparative analyses on osteoporosis guidelines in Japan, EU and USA].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020301

Title: Effects of ipriflavone on bone augmentation within a titanium cap in rabbit calvaria.

Journal: Journal of oral science 20020301

Title: Pharmacokinetics of ipriflavone, an isoflavone derivative, after intravenous and oral administration to rats hepatic and intestinal first-pass effects.

Journal: Life sciences 20020201

Title: Clinical effects of phytoestrogens.

Journal: Clinical obstetrics and gynecology 20011201

Title: Rapid improvement of osteomalacia by treatment in a case with Sjögren's syndrome, rheumatoid arthritis and renal tubular acidosis type 1.

Journal: Internal medicine (Tokyo, Japan) 20010801

Title: Efficacy of ipriflavone in preventing adverse effects of leuprolide.

Journal: The Journal of clinical endocrinology and metabolism 20010701

Title: Ipriflavone in the treatment of postmenopausal osteoporosis: a randomized controlled trial.

Journal: JAMA 20010321

Title: Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.

Journal: Endocrinology 19981001

Title: Iisaki T, et al. Ipriflavone inhibits osteolytic bone metastasis of human breast cancer cells in a nude mouse model. Int J Cancer. 2002 Aug 1;100(4):381-7.

Title: Hagiwara H, et al. Ipriflavone down-regulates endothelin receptor levels during differentiation of rat calvarial osteoblast-like cells. J Biochem. 1999 Jul;126(1):168-73.

Title: Civitelli R, et al. Ipriflavone improves bone density and biomechanical properties of adult male rat bones. Calcif Tissue Int. 1995 Mar;56(3):215-9.

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