54-92-2,MFCD00153819
Catalog No.:AA0034YH

54-92-2 | N'-(propan-2-yl)pyridine-4-carbohydrazide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
200mg
>96.0%(T)(HPLC)
in stock  
$70.00   $49.00
- +
1g
97%
in stock  
$123.00   $86.00
- +
5g
>97%
in stock  
$149.00   $105.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0034YH
Chemical Name:
N'-(propan-2-yl)pyridine-4-carbohydrazide
CAS Number:
54-92-2
Molecular Formula:
C9H13N3O
Molecular Weight:
179.2190
MDL Number:
MFCD00153819
SMILES:
CC(NNC(=O)c1ccncc1)C
Properties
Properties
 
Form:
Solid  
MP:
111-113°C  
Storage:
Light sensitive;Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
164  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
0.4  

Literature

Title: Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.

Journal: Chemical research in toxicology 20170515

Title: A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140101

Title: Hydroxycoumarins as selective MAO-B inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20120101

Title: 2D MI-DRAGON: a new predictor for protein-ligands interactions and theoretic-experimental studies of US FDA drug-target network, oxoisoaporphine inhibitors for MAO-A and human parasite proteins.

Journal: European journal of medicinal chemistry 20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Synthesis and study of a series of 3-arylcoumarins as potent and selective monoamine oxidase B inhibitors.

Journal: Journal of medicinal chemistry 20111027

Title: Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives.

Journal: European journal of medicinal chemistry 20111001

Title: Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors.

Journal: Journal of medicinal chemistry 20110728

Title: MAO inhibitory activity modulation: 3-Phenylcoumarins versus 3-benzoylcoumarins.

Journal: Bioorganic & medicinal chemistry letters 20110715

Title: Homoisoflavonoids: natural scaffolds with potent and selective monoamine oxidase-B inhibition properties.

Journal: Journal of medicinal chemistry 20110414

Title: Synthesis, human monoamine oxidase inhibitory activity and molecular docking studies of 3-heteroarylcoumarin derivatives.

Journal: European journal of medicinal chemistry 20110401

Title: Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20110115

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20101115

Title: Synthesis of new 3-aryl-4,5-dihydropyrazole-1-carbothioamide derivatives. An investigation on their ability to inhibit monoamine oxidase.

Journal: European journal of medicinal chemistry 20101001

Title: Serendipity and psychopharmacology.

Journal: Journal of psychosocial nursing and mental health services 20101001

Title: Synthesis, stereochemical separation, and biological evaluation of selective inhibitors of human MAO-B: 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines.

Journal: Journal of medicinal chemistry 20100909

Title: New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20100901

Title: Investigations on the 2-thiazolylhydrazyne scaffold: synthesis and molecular modeling of selective human monoamine oxidase inhibitors.

Journal: Bioorganic & medicinal chemistry 20100801

Title: Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors.

Journal: Bioorganic & medicinal chemistry 20100715

Title: Inhibition of monoamine oxidase activity by cannabinoids.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20100601

Title: Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B.

Journal: Bioorganic & medicinal chemistry letters 20100501

Title: Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors.

Journal: Bioorganic & medicinal chemistry 20100215

Title: A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors.

Journal: Bioorganic & medicinal chemistry 20100201

Title: Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers.

Journal: Neuro endocrinology letters 20100101

Title: Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20090901

Title: A new series of 3-phenylcoumarins as potent and selective MAO-B inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20090615

Title: Chalcones: a valid scaffold for monoamine oxidases inhibitors.

Journal: Journal of medicinal chemistry 20090514

Title: Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins.

Journal: Journal of medicinal chemistry 20090409

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Synthesis, stereochemical identification, and selective inhibitory activity against human monoamine oxidase-B of 2-methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones.

Journal: Journal of medicinal chemistry 20080828

Title: Metabolism of dopamine by the nasal mucosa.

Journal: Journal of pharmaceutical sciences 20061101

Title: (-)-Trans-epsilon-viniferin, a polyphenol present in wines, is an inhibitor of noradrenaline and 5-hydroxytryptamine uptake and of monoamine oxidase activity.

Journal: European journal of pharmacology 20060807

Title: Hydrazide derivatives produce active oxygen species as hydrazine.

Journal: Bioorganic chemistry 20051201

Title: Fast-flow EPR spectroscopic observation of the isoniazid, iproniazid, and phenylhydrazine hydrazyl radicals.

Journal: Chemical research in toxicology 20040201

Title: Open space swimming test to index antidepressant activity.

Journal: Journal of neuroscience methods 20030615

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Inhibition of type A monoamine oxidase by coptisine in mouse brain.

Journal: Life sciences 20011228

Title: A possible indirect sympathomimetic action of metformin in the arterial vessel wall of spontanously hypertensive rats.

Journal: Life sciences 20010720

Title: [Depression in the elderly. Medical treatment].

Journal: Presse medicale (Paris, France : 1983) 20010224

Title: Drug-induced hepatitis associated with anticytoplasmic organelle autoantibodies.

Journal: Hepatology (Baltimore, Md.) 19850101

Title: Epilepsy as an adverse reaction to combined therapy of MAOIs and tricyclics.

Journal: Journal of the Royal Society of Medicine 19840401

Title: Iproclozide fulminant hepatitis. Possible role of enzyme induction.

Journal: Gastroenterology 19780901

Title: Procaine HCl (Gerovital H3): a weak, reversible, fully competitive inhibitor of monoamine oxidase.

Journal: Federation proceedings 19750101

Title: [Brain amines and apomorphine-induced intraspecific aggressive behavior in the rat (author's transl)].

Journal: Psychopharmacologia 19740111

Title: Effects of a hydrazine monoamine oxidase inhibitor (phenelzine) on isoproterenol-induced myocardiopathies in the rat.

Journal: The Journal of pharmacology and experimental therapeutics 19670901

Title: Effect of certain monoamine oxidase inhibitors on isoproterenol-induced cardiac necrosis in rats.

Journal: Proceedings of the Western Pharmacology Society 19660101

Title: The chemical approach to the control of tuberculosis.

Journal: Science (New York, N.Y.) 19520808

Title: Fagervall I, et al. Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors. Biochemical pharmacology 35 (8): 1381–1387

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SDS
Tags:54-92-2 Molecular Formula|54-92-2 MDL|54-92-2 SMILES|54-92-2 N'-(propan-2-yl)pyridine-4-carbohydrazide
Catalog No.: AA0034YH
54-92-2,MFCD00153819
54-92-2 | N'-(propan-2-yl)pyridine-4-carbohydrazide
Pack Size: 200mg
Purity: >96.0%(T)(HPLC)
in stock
$70.00 $49.00
Pack Size: 1g
Purity: 97%
in stock
$123.00 $86.00
Pack Size: 5g
Purity: >97%
in stock
$149.00 $105.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA0034YH
Chemical Name: N'-(propan-2-yl)pyridine-4-carbohydrazide
CAS Number: 54-92-2
Molecular Formula: C9H13N3O
Molecular Weight: 179.2190
MDL Number: MFCD00153819
SMILES: CC(NNC(=O)c1ccncc1)C
Properties
Form: Solid  
MP: 111-113°C  
Storage: Light sensitive;Inert atmosphere;-20 ℃;  
Complexity: 164  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 13  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 3  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 0.4  
Literature fold

Title: Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.

Journal: Chemical research in toxicology20170515

Title: A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20140101

Title: Hydroxycoumarins as selective MAO-B inhibitors.

Journal: Bioorganic & medicinal chemistry letters20120101

Title: 2D MI-DRAGON: a new predictor for protein-ligands interactions and theoretic-experimental studies of US FDA drug-target network, oxoisoaporphine inhibitors for MAO-A and human parasite proteins.

Journal: European journal of medicinal chemistry20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology20111201

Title: Synthesis and study of a series of 3-arylcoumarins as potent and selective monoamine oxidase B inhibitors.

Journal: Journal of medicinal chemistry20111027

Title: Synthesis and selective human monoamine oxidase inhibition of 3-carbonyl, 3-acyl, and 3-carboxyhydrazido coumarin derivatives.

Journal: European journal of medicinal chemistry20111001

Title: Chromone, a privileged scaffold for the development of monoamine oxidase inhibitors.

Journal: Journal of medicinal chemistry20110728

Title: MAO inhibitory activity modulation: 3-Phenylcoumarins versus 3-benzoylcoumarins.

Journal: Bioorganic & medicinal chemistry letters20110715

Title: Homoisoflavonoids: natural scaffolds with potent and selective monoamine oxidase-B inhibition properties.

Journal: Journal of medicinal chemistry20110414

Title: Synthesis, human monoamine oxidase inhibitory activity and molecular docking studies of 3-heteroarylcoumarin derivatives.

Journal: European journal of medicinal chemistry20110401

Title: Chromone 3-phenylcarboxamides as potent and selective MAO-B inhibitors.

Journal: Bioorganic & medicinal chemistry letters20110115

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals20101201

Title: Synthesis and molecular modelling studies of prenylated pyrazolines as MAO-B inhibitors.

Journal: Bioorganic & medicinal chemistry letters20101115

Title: Synthesis of new 3-aryl-4,5-dihydropyrazole-1-carbothioamide derivatives. An investigation on their ability to inhibit monoamine oxidase.

Journal: European journal of medicinal chemistry20101001

Title: Serendipity and psychopharmacology.

Journal: Journal of psychosocial nursing and mental health services20101001

Title: Synthesis, stereochemical separation, and biological evaluation of selective inhibitors of human MAO-B: 1-(4-arylthiazol-2-yl)-2-(3-methylcyclohexylidene)hydrazines.

Journal: Journal of medicinal chemistry20100909

Title: New halogenated 3-phenylcoumarins as potent and selective MAO-B inhibitors.

Journal: Bioorganic & medicinal chemistry letters20100901

Title: Investigations on the 2-thiazolylhydrazyne scaffold: synthesis and molecular modeling of selective human monoamine oxidase inhibitors.

Journal: Bioorganic & medicinal chemistry20100801

Title: Synthesis, semipreparative HPLC separation, biological evaluation, and 3D-QSAR of hydrazothiazole derivatives as human monoamine oxidase B inhibitors.

Journal: Bioorganic & medicinal chemistry20100715

Title: Inhibition of monoamine oxidase activity by cannabinoids.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20100601

Title: Chromone-2- and -3-carboxylic acids inhibit differently monoamine oxidases A and B.

Journal: Bioorganic & medicinal chemistry letters20100501

Title: Design of novel nicotinamides as potent and selective monoamine oxidase a inhibitors.

Journal: Bioorganic & medicinal chemistry20100215

Title: A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors.

Journal: Bioorganic & medicinal chemistry20100201

Title: Inhibition of monoamine oxidase activity by antidepressants and mood stabilizers.

Journal: Neuro endocrinology letters20100101

Title: Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitors.

Journal: Bioorganic & medicinal chemistry letters20090901

Title: A new series of 3-phenylcoumarins as potent and selective MAO-B inhibitors.

Journal: Bioorganic & medicinal chemistry letters20090615

Title: Chalcones: a valid scaffold for monoamine oxidases inhibitors.

Journal: Journal of medicinal chemistry20090514

Title: Synthesis, molecular modeling, and selective inhibitory activity against human monoamine oxidases of 3-carboxamido-7-substituted coumarins.

Journal: Journal of medicinal chemistry20090409

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry20081113

Title: Synthesis, stereochemical identification, and selective inhibitory activity against human monoamine oxidase-B of 2-methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones.

Journal: Journal of medicinal chemistry20080828

Title: Metabolism of dopamine by the nasal mucosa.

Journal: Journal of pharmaceutical sciences20061101

Title: (-)-Trans-epsilon-viniferin, a polyphenol present in wines, is an inhibitor of noradrenaline and 5-hydroxytryptamine uptake and of monoamine oxidase activity.

Journal: European journal of pharmacology20060807

Title: Hydrazide derivatives produce active oxygen species as hydrazine.

Journal: Bioorganic chemistry20051201

Title: Fast-flow EPR spectroscopic observation of the isoniazid, iproniazid, and phenylhydrazine hydrazyl radicals.

Journal: Chemical research in toxicology20040201

Title: Open space swimming test to index antidepressant activity.

Journal: Journal of neuroscience methods20030615

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

Title: Inhibition of type A monoamine oxidase by coptisine in mouse brain.

Journal: Life sciences20011228

Title: A possible indirect sympathomimetic action of metformin in the arterial vessel wall of spontanously hypertensive rats.

Journal: Life sciences20010720

Title: [Depression in the elderly. Medical treatment].

Journal: Presse medicale (Paris, France : 1983)20010224

Title: Drug-induced hepatitis associated with anticytoplasmic organelle autoantibodies.

Journal: Hepatology (Baltimore, Md.)19850101

Title: Epilepsy as an adverse reaction to combined therapy of MAOIs and tricyclics.

Journal: Journal of the Royal Society of Medicine19840401

Title: Iproclozide fulminant hepatitis. Possible role of enzyme induction.

Journal: Gastroenterology19780901

Title: Procaine HCl (Gerovital H3): a weak, reversible, fully competitive inhibitor of monoamine oxidase.

Journal: Federation proceedings19750101

Title: [Brain amines and apomorphine-induced intraspecific aggressive behavior in the rat (author's transl)].

Journal: Psychopharmacologia19740111

Title: Effects of a hydrazine monoamine oxidase inhibitor (phenelzine) on isoproterenol-induced myocardiopathies in the rat.

Journal: The Journal of pharmacology and experimental therapeutics19670901

Title: Effect of certain monoamine oxidase inhibitors on isoproterenol-induced cardiac necrosis in rats.

Journal: Proceedings of the Western Pharmacology Society19660101

Title: The chemical approach to the control of tuberculosis.

Journal: Science (New York, N.Y.)19520808

Title: Fagervall I, et al. Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors. Biochemical pharmacology 35 (8): 1381–1387

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