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6192-52-5,MFCD00142137
Catalog No.:AA0035GL

6192-52-5 | P-Toluenesulfonic acid monohydrate

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5g
98.5%min.
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$24.00   $17.00
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25g
>98.0%(T)(HPLC)
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$24.00   $17.00
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500g
>98.0%(T)(HPLC)
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  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA0035GL
Chemical Name:
P-Toluenesulfonic acid monohydrate
CAS Number:
6192-52-5
Molecular Formula:
C7H10O4S
Molecular Weight:
190.2169
MDL Number:
MFCD00142137
SMILES:
Cc1ccc(cc1)S(=O)(=O)O.O
Properties
Properties
 
BP:
428.9°C at 760 mmHg  
Form:
Solid  
MP:
96-99 °C(lit.);  
Refractive Index:
1,382-1,384  
Solubility:
H2O: 0.1 g/mL, clear  
Stability:
Hygroscopic  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
206  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  

Literature

Title: Synthesis of Met-enkephalin by solution-phase peptide synthesis methodology utilizing para-toluene sulfonic acid as N-terminal masking of l-methionine amino acid.

Journal: Chemical biology & drug design 20161201

Title: Catalytic asymmetric construction of spiro(γ-butyrolactam-γ-butyrolactone) moieties through sequential reactions of cyclic imino esters with Morita-Baylis-Hillman bromides.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20121001

Title: Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria.

Journal: International journal of pharmaceutics 20120915

Title: Spectroscopic, thermal and mechanical studies on 4-methylanilinium p-toluenesulfonate - a new organic NLO single crystal.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120901

Title: Validation of a sequential extraction and liquid chromatography-tandem mass spectrometric method for determination of dihydrotestosterone, androstanediol and androstanediol-glucuronide in prostate tissues.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120801

Title: PTSA-catalyzed Mannich-type-cyclization-oxidation tandem reactions: one-pot synthesis of 1,3,5-substituted pyrazoles from aldehydes, hydrazines and alkynes.

Journal: Organic & biomolecular chemistry 20120628

Title: Coumarin-trioxane hybrids: synthesis and evaluation as a new class of antimalarial scaffolds.

Journal: Bioorganic & medicinal chemistry letters 20120615

Title: Enantiomeric resolution of p-toluenesulfonate of valine benzyl ester by preferential crystallizaion.

Journal: Chirality 20120201

Title: Rapid conversion of spirostans into furostan skeletons at room temperature.

Journal: Steroids 20120101

Title: Interactions of D-cellobiose with p-toluenesulfonic acid in aqueous solution: a (13)C NMR study.

Journal: Carbohydrate research 20111213

Title: Heterogeneous catalytic hydrogenation of unprotected indoles in water: a green solution to a long-standing challenge.

Journal: Organic letters 20111007

Title: Synthesis and contractile activity of substituted 1,2,3,4-tetrahydroisoquinolines.

Journal: Molecules (Basel, Switzerland) 20110816

Title: Mild C-H halogenation of anilides and the isolation of an unusual palladium(I)-palladium(II) species.

Journal: Angewandte Chemie (International ed. in English) 20110606

Title: Quantum chemical study of p-toluenesulfonic acid, p-toluenesulfonate anion and the water-p-toluenesulfonic acid complex. Comparison with experimental spectroscopic data.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110601

Title: Concentration and fractionation by isoelectric trapping in a micropreparative-scale multicompartmental electrolyzer having orthogonal pH gradients. Part 2.

Journal: Electrophoresis 20110601

Title: Why two are not enough: degradation of p-toluenesulfonate by a bacterial community from a pristine site in Moorea, French Polynesia.

Journal: FEMS microbiology letters 20110301

Title: Bis dihydropyrimidine: synthesis and antimycobacterial activity.

Journal: Journal of enzyme inhibition and medicinal chemistry 20110201

Title: Supported p-toluenesulfonic acid as a highly robust and eco-friendly isocyanide scavenger.

Journal: ACS combinatorial science 20110110

Title: Low-cost gas sensors produced by the graphite line-patterning technique applied to monitoring banana ripeness.

Journal: Sensors (Basel, Switzerland) 20110101

Title: Glucose oxidase-polypyrrole electrodes synthesized in p-toluenesulfonic acid and sodium p-toluenesulfonate.

Journal: Prikladnaia biokhimiia i mikrobiologiia 20110101

Title: Analysis of deprotonated acids with silicon nanoparticle-assisted laser desorption/ ionization mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20101201

Title: An efficient and chemoselective procedure for acylal synthesis.

Journal: Molecules (Basel, Switzerland) 20100916

Title: A practical synthesis of 5-lipoxygenase inhibitor MK-0633.

Journal: The Journal of organic chemistry 20100618

Title: Synthesis, characterization and biodegradation of functionalized amino acid-based poly(ester amide)s.

Journal: Biomaterials 20100501

Title: Structural studies on the full-length LysR-type regulator TsaR from Comamonas testosteroni T-2 reveal a novel open conformation of the tetrameric LTTR fold.

Journal: Molecular microbiology 20100301

Title: Back-to-back dinuclear platinum terpyridyl complexes: synthesis and photophysical studies.

Journal: Inorganic chemistry 20100215

Title: Chemoenzymatic synthesis of feruloylated monoacyl- and diacyl-glycerols in ionic liquids.

Journal: Biotechnology letters 20091201

Title: Promoting neurite outgrowth from spiral ganglion neuron explants using polypyrrole/BDNF-coated electrodes.

Journal: Journal of biomedical materials research. Part A 20091001

Title: PTSA-ZnCl2: an efficient catalyst for the synthesis of 1,2,4-oxadiazoles from amidoximes and organic nitriles.

Journal: The Journal of organic chemistry 20090807

Title: A novel three-component reaction for the synthesis of 3-aryl-4H-benzo [1,4] oxazin-2-amine.

Journal: Molecular diversity 20090801

Title: Quasi-equilibrium analysis of the ion-pair mediated membrane transport of low-permeability drugs.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20090701

Title: Microwave driven wood liquefaction with glycols.

Journal: Bioresource technology 20090601

Title: A novel class of extended pi-conjugated systems: one-pot synthesis of bis-3-aminoimidazo[1,2-a]pyridines, pyrimidines and pyrazines.

Journal: Molecular diversity 20090501

Title: Use of the sulfide mineral pyrite as electrochemical sensor in non-aqueous solutions: potentiometric titration of weak acids in acetonitrile, propionitrile and benzonitrile.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20090301

Title: New one-pot four-component synthesis of disubstituted pyrido[2,3-d]pyrimidine-6-carboxamide derivatives.

Journal: Journal of combinatorial chemistry 20090101

Title: Assessing ocular irritation potential using a modified ex vivo rabbit eye test.

Journal: Cutaneous and ocular toxicology 20090101

Title: New lipophilic tyrosyl esters. Comparative antioxidant evaluation with hydroxytyrosyl esters.

Journal: Journal of agricultural and food chemistry 20081126

Title: P-TSA catalyzed facile and efficient synthesis of polyhydroquinoline derivatives through hantzsch multi-component condensation.

Journal: Chemical & pharmaceutical bulletin 20080701

Title: Versatile acetylation of carbohydrate substrates with bench-top sulfonic acids and application to one-pot syntheses of peracetylated thioglycosides.

Journal: Carbohydrate research 20080407

Title: A convenient iodination method for alcohols using cesium iodide/methanesulfonic acid and its comparison using cesium iodide/p-toluenesulfonic acid or cesium iodide/aluminium chloride.

Journal: Natural product research 20080101

Title: A novel isocyanide-based three-component reaction: synthesis of highly substituted 1,6-dihydropyrazine-2,3-dicarbonitrile derivatives.

Journal: The Journal of organic chemistry 20070803

Title: Solid-supported acids as mild and versatile reagents for the deprotection of aromatic ethers.

Journal: Organic letters 20070705

Title: A new synthesis of lysophosphatidylcholines and related derivatives. Use of p-toluenesulfonate for hydroxyl group protection.

Journal: The Journal of organic chemistry 20070302

Title: Glycosylation in room temperature ionic liquid using unprotected and unactivated donors.

Journal: Carbohydrate research 20070226

Title: Heterogeneous photocatalytic degradation of p-toluenesulfonic acid using concentrated solar radiation in slurry photoreactor.

Journal: Journal of hazardous materials 20070209

Title: Calibration by NMR for quantitative analysis: p-toluenesulfonic acid as a reference substance.

Journal: Journal of chromatography. A 20070105

Title: The effect of polypyrrole with incorporated neurotrophin-3 on the promotion of neurite outgrowth from auditory neurons.

Journal: Biomaterials 20070101

Title: Analysis of steroid estrogens in water using liquid chromatography/tandem mass spectrometry with chemical derivatizations.

Journal: Rapid communications in mass spectrometry : RCM 20070101

Title: Limited role of inducible nitric oxide synthase in blood-brain barrier function after experimental subarachnoid hemorrhage.

Journal: Journal of neurotrauma 20061201

Title: [Hydroxy(tosyloxy)iodo]benzene mediated alpha-azidation of ketones.

Journal: Molecules (Basel, Switzerland) 20060714

Title: Low level determination of p-toluenesulfonate and benzenesulfonate esters in drug substance by high performance liquid chromatography/mass spectrometry.

Journal: Journal of chromatography. A 20060630

Title: Solid-state NMR and the thermal polymerization of 2,4-hexadiyne-1,6-diol bis-(p-toluenesulfonate).

Journal: Solid state nuclear magnetic resonance 20060601

Title: Rapid and efficient synthesis of poly-substituted quinolines assisted by p-toluene sulphonic acid under solvent-free conditions: comparative study of microwave irradiation versus conventional heating.

Journal: Organic & biomolecular chemistry 20060107

Title: UV-vis spectroscopy for following the kinetics of homogeneous polymerization of diphenylamine in p-toluene sulphonic acid.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051101

Title: Determination of methyl and ethyl esters of methanesulfonic, benzenesulfonic and p-toluenesulfonic acids in active pharmaceutical ingredients by solid-phase microextraction (SPME) coupled to GC/SIM-MS.

Journal: Journal of pharmaceutical and biomedical analysis 20050915

Title: Practical enantioselective synthesis of beta-substituted-beta-amino esters.

Journal: The Journal of organic chemistry 20050708

Title: Crystal structure of alpha-hordothionin at 1.9 Angstrom resolution.

Journal: FEBS letters 20050425

Title: [Degradation of p-toluenesulfonate by immobilized Comamonas testosteroni BS1310 (pBS1010) cells].

Journal: Prikladnaia biokhimiia i mikrobiologiia 20050101

Title: A novel outer-membrane anion channel (porin) as part of a putatively two-component transport system for 4-toluenesulphonate in Comamonas testosteroni T-2.

Journal: The Biochemical journal 20041001

Title: Raman spectroscopy of benzenesulfonic and 4-toluenesulfonic acids dissolved in dimethylsulfoxide.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20040601

Title: Solid-phase synthesis of a library of hydroxyproline derivatives.

Journal: Journal of combinatorial chemistry 20040101

Title: An additional regulator, TsaQ, is involved with TsaR in regulation of transport during the degradation of p-toluenesulfonate in Comamonas testosteroni T-2.

Journal: Archives of microbiology 20031101

Title: Generating diverse skeletons of small molecules combinatorially.

Journal: Science (New York, N.Y.) 20031024

Title: Thiyl radical reaction with thymine: absolute rate constant for hydrogen abstraction and comparison to benzylic C-H bonds.

Journal: Chemical research in toxicology 20030901

Title: [Methanogenic sarcina from an anaerobic microbial community degrading p-toluene sulfonate].

Journal: Mikrobiologiia 20030101

Title: [Analysis of the anaerobic microbial community capable of degrading p-toluene sulphonate].

Journal: Mikrobiologiia 20030101

Title: Modification of the swern oxidation: use of a recyclable, polystyrene bound sulfoxide.

Journal: Bioorganic & medicinal chemistry letters 20020722

Title: Sonochemical bromination of acetophenones using p-toluenesulfonic acid-N-bromosuccinimide.

Journal: Ultrasonics sonochemistry 20020301

Title: Microwave induced synthesis of ribonucleosides on solid support.

Journal: Nucleosides, nucleotides & nucleic acids 20020101

Title: Preparation of and tissue response to DNA-lipid films.

Journal: Journal of dental research 20010801

Title: Synthesis and antiperoxidant activity of new phenolic O-glycosides.

Journal: Carbohydrate research 20010227

Title: Degradative pathways for p-toluenecarboxylate and p-toluenesulfonate and their multicomponent oxygenases in Comamonas testosteroni strains PSB-4 and T-2.

Journal: Microbiology (Reading, England) 19960901

Title: 3-Sulphocatechol 2,3-dioxygenase and other dioxygenases (EC 1.13.11.2 and EC 1.14.12.-) in the degradative pathways of 2-aminobenzenesulphonic, benzenesulphonic and 4-toluenesulphonic acids in Alcaligenes sp. strain O-1.

Journal: Microbiology (Reading, England) 19940701

Title: 4-Toluene sulfonate methyl-monooxygenase from Comamonas testosteroni T-2: purification and some properties of the oxygenase component.

Journal: Journal of bacteriology 19910601

Title: Tashiro S, et al. Non-covalent immobilisation of p-toluenesulfonic acid in a porous molecular crystal for size-specific acid-catalysed reactions. Chem Commun (Camb). 2016 Jun 8;52(49):7657-60.

Title: Quan XJ, et al. p-Toluenesulfonic acid mediated 1,3-dipolar cycloaddition of nitroolefins with NaN3 for synthesis of 4-aryl-NH-1,2,3-triazoles. Org Lett. 2014 Nov 7;16(21):5728-31.

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