366789-02-8,MFCD11974010
Catalog No.:AA0035HT

366789-02-8 | 5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$6.00   $4.00
- +
5mg
98%
in stock  
$8.00   $6.00
- +
10mg
98%
in stock  
$11.00   $8.00
- +
50mg
98%
in stock  
$13.00   $9.00
- +
1g
98%
in stock  
$17.00   $12.00
- +
5g
98%
in stock  
$70.00   $49.00
- +
10g
98%
in stock  
$128.00   $90.00
- +
25g
98%
in stock  
$245.00   $171.00
- +
100g
98%
in stock  
$760.00 $532.00
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
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Technical Information
Catalog Number:
AA0035HT
Chemical Name:
5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide
CAS Number:
366789-02-8
Molecular Formula:
C19H18ClN3O5S
Molecular Weight:
435.8813
MDL Number:
MFCD11974010
SMILES:
O=C1O[C@H](CN1c1ccc(cc1)N1CCOCC1=O)CNC(=O)c1ccc(s1)Cl
Properties
Properties
 
BP:
732.6°C at 760 mmHg  
Form:
Solid  
MP:
228-229°C  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
645  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
2.5  

Downstream Synthesis Route

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Title: Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF.

Journal: The Lancet. Neurology 20120401

Title: New oral anticoagulants for atrial fibrillation: a review of clinical trials.

Journal: Clinical therapeutics 20120401

Title: Rivaroxaban: a new oral anticoagulant.

Journal: Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 20120401

Title: Preventing venous thromboembolic events after total hip arthroplasty: new developments in clinical practice.

Journal: Hospital practice (1995) 20120401

Title: Thromboprophylaxis in surgical and medical patients.

Journal: Seminars in respiratory and critical care medicine 20120401

Title: Beyond warfarin: the new generation of oral anticoagulants and their implications for the management of dental patients.

Journal: Oral surgery, oral medicine, oral pathology and oral radiology 20120401

Title: How I treat with anticoagulants in 2012: new and old anticoagulants, and when and how to switch.

Journal: Blood 20120329

Title: [Prophylaxis of stroke and embolisms in atrial fibrillation--what is new in the guidelines?].

Journal: MMW Fortschritte der Medizin 20120322

Title: Rivaroxaban vs. warfarin for stroke prevention in patients with nonvalvular atrial fibrillation.

Journal: American family physician 20120315

Title: Net clinical benefit of new oral anticoagulants (dabigatran, rivaroxaban, apixaban) versus no treatment in a 'real world' atrial fibrillation population: a modelling analysis based on a nationwide cohort study.

Journal: Thrombosis and haemostasis 20120301

Title: Old and new oral anticoagulants for venous thromboembolism and atrial fibrillation: a review of the literature.

Journal: Thrombosis research 20120301

Title: Utility of a physiologically-based pharmacokinetic (PBPK) modeling approach to quantitatively predict a complex drug-drug-disease interaction scenario for rivaroxaban during the drug review process: implications for clinical practice.

Journal: Biopharmaceutics & drug disposition 20120301

Title: What's the 'go to' anticoagulant for stroke prevention in atrial fibrillation?

Journal: Thrombosis and haemostasis 20120301

Title: New directions in anticoagulation.

Journal: The American journal of medicine 20120301

Title: A new generation of oral direct anticoagulants.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20120301

Title: Review of atrial fibrillation outcome trials of oral anticoagulant and antiplatelet agents.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20120301

Title: Highlights of the American Heart Association Scientific Sessions 2011: a focus on ATLAS-TIMI 51, TRACER and PALLAS.

Journal: Expert review of cardiovascular therapy 20120301

Title: Coagulopathies and thrombosis: usual and unusual causes and associations, part VI.

Journal: Seminars in thrombosis and hemostasis 20120301

Title: Determination of rivaroxaban in human plasma samples.

Journal: Seminars in thrombosis and hemostasis 20120301

Title: The efficacy and safety of postoperative autologous transfusion of filtered shed blood and anticoagulant prophylaxis in total knee arthroplasty patients.

Journal: Knee surgery & related research 20120301

Title: Oral direct factor Xa inhibitors for stroke prevention in atrial fibrillation.

Journal: Nature reviews. Cardiology 20120227

Title: Oral factor Xa inhibitors for the long-term management of ACS.

Journal: Nature reviews. Cardiology 20120221

Title: Heparin-induced thrombocytopenia: in vitro studies on the interaction of dabigatran, rivaroxaban, and low-sulfated heparin, with platelet factor 4 and anti-PF4/heparin antibodies.

Journal: Blood 20120202

Title: Anticoagulant management in the cardiovascular setting.

Journal: Fundamental & clinical pharmacology 20120201

Title: Pharmacodynamic and pharmacokinetic basics of rivaroxaban.

Journal: Fundamental & clinical pharmacology 20120201

Title: Rivaroxaban for the prevention and treatment of venous thromboembolism.

Journal: Fundamental & clinical pharmacology 20120201

Title: New anticoagulants for the prevention of stroke in atrial fibrillation.

Journal: Fundamental & clinical pharmacology 20120201

Title: Lack of an antagonist to reverse the action of dabigatran.

Journal: QJM : monthly journal of the Association of Physicians 20120201

Title: Management of coagulation: an Australian perspective.

Journal: Current opinion in anaesthesiology 20120201

Title: Evaluation of the anti-factor Xa chromogenic assay for the measurement of rivaroxaban plasma concentrations using calibrators and controls.

Journal: Thrombosis and haemostasis 20120201

Title: Cost effectiveness of rivaroxaban versus enoxaparin for prevention of post-surgical venous thromboembolism from a U.S. payer's perspective.

Journal: PharmacoEconomics 20120201

Title: Cost-effectiveness of pharmacologic and invasive therapies for stroke prophylaxis in atrial fibrillation.

Journal: Journal of cardiovascular medicine (Hagerstown, Md.) 20120201

Title: The year in Cardiothoracic and Vascular Anesthesia: selected highlights from 2011.

Journal: Journal of cardiothoracic and vascular anesthesia 20120201

Title: The king is dead (warfarin): direct thrombin and factor Xa inhibitors: the next Diadochian War?

Journal: International journal of stroke : official journal of the International Stroke Society 20120201

Title: Determination of the anticoagulant effects of new oral anticoagulants: an unmet need.

Journal: Expert review of hematology 20120201

Title: Rivaroxaban: a review of its use for the prophylaxis of venous thromboembolism after total hip or knee replacement surgery.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20120201

Title: Direct thrombin inhibitors and factor Xa inhibitors in patients with cerebrovascular disease.

Journal: Expert review of neurotherapeutics 20120201

Title: Active online assessment of patients using new oral anticoagulants: bleeding risk, compliance, and coagulation analysis.

Journal: Seminars in thrombosis and hemostasis 20120201

Title: Prevention of VTE in orthopedic surgery patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Journal: Chest 20120201

Title: Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Journal: Chest 20120201

Title: Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Journal: Chest 20120201

Title: [Expanded arsenal in atrial fibrillation: bye-bye marcumar?].

Journal: MMW Fortschritte der Medizin 20120119

Title: Rivaroxaban reduced stroke and systemic embolism compared with warfarin in nonvalvular AF.

Journal: Annals of internal medicine 20120117

Title: Rivaroxaban in patients with a recent acute coronary syndrome.

Journal: The New England journal of medicine 20120105

Title: A new era in secondary prevention after acute coronary syndrome.

Journal: The New England journal of medicine 20120105

Title: New anticoagulants - promising and failed developments.

Journal: British journal of pharmacology 20120101

Title: Novel oral anticoagulants: new challenges for anesthesiologists in bleeding patients.

Journal: Anesthesiology 20120101

Title: Optimisation of the assays for the measurement of clotting factor activity in the presence of rivaroxaban.

Journal: Thrombosis research 20120101

Title: Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model.

Journal: Anesthesiology 20120101

Title: Concerns about studies investigating new anticoagulant drugs for stroke prevention in atrial fibrillation.

Journal: Journal of neurology 20120101

Title: [Anticoagulation in atrial fibrillation: a new era has begun].

Journal: Hamostaseologie 20120101

Title: [Anticoagulation for atrial fibrillation : the future has begun].

Journal: Der Internist 20120101

Title: Meta-analysis of cause of death following total joint replacement using different thromboprophylaxis regimens.

Journal: The Journal of bone and joint surgery. British volume 20120101

Title: [Apixaban: pharmacology and action profile].

Journal: Deutsche medizinische Wochenschrift (1946) 20120101

Title: New frontiers for stroke prevention in atrial fibrillation.

Journal: Cerebrovascular diseases (Basel, Switzerland) 20120101

Title: [Summary of the article: Patel MR, Mahaffey KW, Garg J et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med, 2011; 365: 1557-1559].

Journal: Kardiologia polska 20120101

Title: ARISTOTLE RE-LYs on the ROCKET. What's new in stroke prevention in patients with atrial fibrillation?

Journal: Cardiology journal 20120101

Title: New antiplatelet and anticoagulant drugs.

Journal: General dentistry 20120101

Title: Anticoagulation prophylaxis in orthopedic surgery: an efficiency frontier approach.

Journal: Postgraduate medicine 20120101

Title: New oral antithrombotics: focus on dabigatran, an oral, reversible direct thrombin inhibitor for the prevention and treatment of venous and arterial thromboembolic disorders.

Journal: Vascular health and risk management 20120101

Title: I recently heard that there are alternative medications to the blood thinner warfarin. What are they, and how are they different?

Journal: DukeMedicine healthnews 20120101

Title: A new era for anticoagulation in atrial fibrillation. Which anticoagulant should we choose for long‑term prevention of thromboembolic complications in patients with atrial fibrillation?

Journal: Polskie Archiwum Medycyny Wewnetrznej 20120101

Title: Newer anticoagulants in cardiovascular disease: a systematic review of the literature.

Journal: Cardiology in review 20120101

Title: Upcoming oral factor Xa inhibitors for venous thromboembolism prophylaxis in patients undergoing major orthopedic surgery: rivaroxaban (Xarelto) and apixaban (Eliquis) review.

Journal: Connecticut medicine 20120101

Title: Improving prevention and treatment of venous thromboembolism: clinical trial results.

Journal: Journal of medical economics 20120101

Title: Evaluation of the prothrombin time for measuring rivaroxaban plasma concentrations using calibrators and controls: results of a multicenter field trial.

Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20120101

Title: The WATCHMAN left atrial appendage closure device for atrial fibrillation.

Journal: Journal of visualized experiments : JoVE 20120101

Title: Stroke Prevention in Atrial Fibrillation: Where are We Now?

Journal: Clinical Medicine Insights. Cardiology 20120101

Title: Focused 2012 update of the Canadian Cardiovascular Society atrial fibrillation guidelines: recommendations for stroke prevention and rate/rhythm control.

Journal: The Canadian journal of cardiology 20120101

Title: [Update on current care guidelines: atrial fibrillation].

Journal: Duodecim; laaketieteellinen aikakauskirja 20120101

Title: Medical cost reductions associated with the usage of novel oral anticoagulants vs warfarin among atrial fibrillation patients, based on the RE-LY, ROCKET-AF, and ARISTOTLE trials.

Journal: Journal of medical economics 20120101

Title: The Anticoagulation of Calf Thrombosis (ACT) project: study protocol for a randomized controlled trial.

Journal: Trials 20120101

Title: Cost-effectiveness of rivaroxaban in the prevention of venous thromboembolism: A Canadian analysis using the Ontario Ministry of Health Perspective.

Journal: Journal of medical economics 20120101

Title: Current status of new anticoagulants in the management of venous thromboembolism.

Journal: Advances in hematology 20120101

Title: Costs and clinical consequences of suboptimal atrial fibrillation management.

Journal: ClinicoEconomics and outcomes research : CEOR 20120101

Title: The Interface between Inflammation and Coagulation in Cardiovascular Disease.

Journal: International journal of inflammation 20120101

Title: Efficacy and safety of venous thromboembolism prophylaxis with apixaban in major orthopedic surgery.

Journal: Therapeutics and clinical risk management 20120101

Title: Oral anticoagulants. New oral anticoagulants for atrial fibrillation: the factor Xa inhibitors rivaroxaban and apixaban.

Journal: Reviews in cardiovascular medicine 20120101

Title: The economic impact of enoxaparin versus unfractionated heparin for prevention of venous thromboembolism in acute ischemic stroke patients.

Journal: ClinicoEconomics and outcomes research : CEOR 20120101

Title: Preventing stroke in atrial fibrillation patients - clinical utility of oral anticoagulants.

Journal: Journal of blood medicine 20120101

Title: Anticoagulant and antiplatelet therapy in patients with atrial fibrillation and coronary artery disease.

Journal: Thrombosis 20120101

Title: Acute-onset severe gastrointestinal tract hemorrhage in a postoperative patient taking rivaroxaban after total hip arthroplasty: a case report.

Journal: Journal of medical case reports 20120101

Title: [New antithrombotic drugs].

Journal: Duodecim; laaketieteellinen aikakauskirja 20120101

Title: Advances in the diagnosis and treatment of acute pulmonary embolism.

Journal: F1000 medicine reports 20120101

Title: Reviewing the medical literature: five notable articles in general internal medicine from 2010 and 2011.

Journal: Open medicine : a peer-reviewed, independent, open-access journal 20120101

Title: Therapeutic dosing of acenocoumarol: proposal of a population specific pharmacogenetic dosing algorithm and its validation in north Indians.

Journal: PloS one 20120101

Title: Dabigatran for stroke prevention in nonvalvular atrial fibrillation: answers to challenging 'real-world' questions.

Journal: Thrombosis 20120101

Title: Newer anticoagulants for the prevention of venous thromboembolism.

Journal: The National medical journal of India 20120101

Title: Emerging anticoagulants.

Journal: Current medicinal chemistry 20120101

Title: Dabigatran, rivaroxaban, or apixaban versus enoxaparin for thromboprophylaxis after total hip or knee replacement: systematic review, meta-analysis, and indirect treatment comparisons.

Journal: BMJ (Clinical research ed.) 20120101

Title: Rationale and design of XAMOS: noninterventional study of rivaroxaban for prophylaxis of venous thromboembolism after major hip and knee surgery.

Journal: Vascular health and risk management 20120101

Title: Health technology assessment and its role in the future development of the Indian healthcare sector.

Journal: Perspectives in clinical research 20120101

Title: [Rivaroxaban in the prevention and treatment of thromboembolic disorders].

Journal: Hamostaseologie 20120101

Title: [New anticoagulants: dabigatran, rivaroxaban and apixaban].

Journal: Gaceta medica de Mexico 20120101

Title: An evidence-based review of apixaban and its potential in the prevention of stroke in patients with atrial fibrillation.

Journal: Core evidence 20120101

Title: Emerging anticoagulant therapies for atrial fibrillation: new options, new challenges.

Journal: Current medicinal chemistry 20120101

Title: Perioperative stroke risk in nonvascular surgery.

Journal: Cerebrovascular diseases (Basel, Switzerland) 20120101

Title: Vitamin K antagonists. Ready to be replaced?

Journal: Hamostaseologie 20120101

Title: Understanding the new emerging oral anticoagulants for venous thromboembolism prophylaxis.

Journal: Orthopedic nursing 20120101

Title: Rivaroxaban in atrial fibrillation.

Journal: Vascular health and risk management 20120101

Title: Prevention of stroke and systemic embolization in atrial fibrillation: a Canadian perspective.

Journal: Polskie Archiwum Medycyny Wewnetrznej 20120101

Title: Stroke prevention in atrial fibrillation: understanding the new oral anticoagulants dabigatran, rivaroxaban, and apixaban.

Journal: Thrombosis 20120101

Title: [New oral anticoagulants for atrial fibrillation: a neurologist's view].

Journal: Nederlands tijdschrift voor geneeskunde 20120101

Title: Management of venous thromboembolism in patients with advanced gastrointestinal cancers: what is the role of novel oral anticoagulants?

Journal: Thrombosis 20120101

Title: Thromboembolic prophylaxis in total joint arthroplasty.

Journal: Thrombosis 20120101

Title: Coronary and mortality risk of novel oral antithrombotic agents: a meta-analysis of large randomised trials.

Journal: BMJ open 20120101

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Journal: Vnitrni lekarstvi 20120101

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Journal: Hamostaseologie 20120101

Title: Left atrial appendage exclusion for stroke prevention in atrial fibrillation.

Journal: Cardiology research and practice 20120101

Title: Rationalizing tight ligand binding through cooperative interaction networks.

Journal: Journal of chemical information and modeling 20111227

Title: Rivaroxaban versus warfarin in nonvalvular atrial fibrillation.

Journal: The New England journal of medicine 20111215

Title: Rivaroxaban versus warfarin in nonvalvular atrial fibrillation.

Journal: The New England journal of medicine 20111215

Title: Rivaroxaban versus warfarin in nonvalvular atrial fibrillation.

Journal: The New England journal of medicine 20111215

Title: Rivaroxaban versus warfarin in nonvalvular atrial fibrillation.

Journal: The New England journal of medicine 20111215

Title: Rivaroxaban (Xarelto) for acute coronary syndrome.

Journal: The Medical letter on drugs and therapeutics 20111212

Title: Discovery of N-[2-hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide (darexaban, YM150) as a potent and orally available factor Xa inhibitor.

Journal: Journal of medicinal chemistry 20111208

Title: Antiplatelet agents and anticoagulants for hypertension.

Journal: The Cochrane database of systematic reviews 20111207

Title: Drugs in traffic: the road to approval.

Journal: Nature medicine 20111206

Title: Effect of multiple doses of omeprazole on the pharmacokinetics, pharmacodynamics, and safety of a single dose of rivaroxaban.

Journal: Journal of cardiovascular pharmacology 20111201

Title: New anticoagulants: moving on from scientific results to clinical implementation.

Journal: Annals of medicine 20111201

Title: Determination of an international sensitivity index of thromboplastin reagents using a WHO thromboplastin as calibrator for plasma spiked with rivaroxaban.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20111201

Title: Arterial antithrombotic activity of rivaroxaban, an orally active factor Xa inhibitor, in a rat electrolytic carotid artery injury model of thrombosis.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20111201

Title: Intraarticular vs. extraarticular ropivacaine infusion following high-dose local infiltration analgesia after total knee arthroplasty: a randomized double-blind study.

Journal: Acta orthopaedica 20111201

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Journal: Operative Orthopadie und Traumatologie 20111201

Title: Laboratory testing of anticoagulants: the present and the future.

Journal: Pathology 20111201

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Journal: Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen 20111201

Title: Antithrombotic therapy in nonvalvular atrial fibrillation: a narrative review.

Journal: Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20111201

Title: Role of pharmacogenomics in the management of traditional and novel oral anticoagulants.

Journal: Pharmacotherapy 20111201

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Journal: Journal des maladies vasculaires 20111201

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Journal: Journal des maladies vasculaires 20111201

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Journal: MMW Fortschritte der Medizin 20111201

Title: [Rivaroxaban is not inferior compared with warfarin as an anticoagulant in patients with non-valvular atrial fibrillation].

Journal: Praxis 20111130

Title: Acute coronary syndromes: Rivaroxaban reduces serious CV events without increasing fatal bleeding in patients with a recent ACS.

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Title: FDA advisory decision highlights some problems inherent in pragmatic trials.

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Title: Bleeding, vertebral fractures and vascular calcifications in patients treated with warfarin: hope for lower risks with alternative therapies.

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Title: Comparison of unfractionated heparin, low-molecular-weight heparin, low-dose and high-dose rivaroxaban in preventing thrombus formation on mechanical heart valves: results of an in vitro study.

Journal: Journal of thrombosis and thrombolysis 20111101

Title: Rationale and current perspective for early rhythm control therapy in atrial fibrillation.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20111101

Title: Interference of rivaroxaban in one-stage and chromogenic factor VIII:C assays.

Journal: Thrombosis and haemostasis 20111101

Title: [New anticoagulants. Characteristics, monitoring and management of bleeding].

Journal: Medizinische Klinik, Intensivmedizin und Notfallmedizin 20111101

Title: A study of thromboprophylactic practices of Scottish orthopaedic surgeons in patients undergoing total hip replacements. Should practice change with new guidelines?

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Title: [Effect of rivaroxaban on risk of bleeding after total knee arthroplasty].

Journal: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 20111101

Title: [Current status and future of anti-Xa inhibitors].

Journal: Rinsho shinkeigaku = Clinical neurology 20111101

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Journal: La Revue du praticien 20111101

Title: Evaluating rivaroxaban for nonvalvular atrial fibrillation--regulatory considerations.

Journal: The New England journal of medicine 20111027

Title: Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects.

Journal: Circulation 20111004

Title: Reversal of new oral anticoagulants.

Journal: Circulation 20111004

Title: Oral rivaroxaban for acute DVT, or long term for VTE, is as effective as enoxaparin followed by a vitamin K antagonist for preventing recurrence, with no increase in bleeding complications.

Journal: Evidence-based medicine 20111001

Title: Inhibitors of propagation of coagulation: factors V and X.

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Title: A role for coagulation factor Xa in experimental pulmonary arterial hypertension.

Journal: Cardiovascular research 20111001

Title: New anticoagulants: how to deal with treatment failure and bleeding complications.

Journal: British journal of clinical pharmacology 20111001

Title: Impact of venous thromboembolism on clinical management and therapy after hip and knee arthroplasty.

Journal: Canadian journal of surgery. Journal canadien de chirurgie 20111001

Title: Effect of rivaroxaban, in contrast to heparin, is similar in neonatal and adult plasma.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 20111001

Title: Determination of rivaroxaban by different factor Xa specific chromogenic substrate assays: reduction of interassay variability.

Journal: Journal of thrombosis and thrombolysis 20111001

Title: Anticoagulating obese patients in the modern era.

Journal: British journal of haematology 20111001

Title: Prevention of stroke and systemic embolism with rivaroxaban compared with warfarin in patients with non-valvular atrial fibrillation and moderate renal impairment.

Journal: European heart journal 20111001

Title: RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome.

Journal: European heart journal 20111001

Title: Rivaroxaban: population pharmacokinetic analyses in patients treated for acute deep-vein thrombosis and exposure simulations in patients with atrial fibrillation treated for stroke prevention.

Journal: Clinical pharmacokinetics 20111001

Title: New and emerging anticoagulant therapy for atrial fibrillation and acute coronary syndrome.

Journal: Pharmacotherapy 20111001

Title: Novel oral anticoagulants for VTE prevention in orthopedic surgery: overview of phase 3 trials.

Journal: Orthopedics 20111001

Title: Cost-effectiveness of rivaroxaban versus heparins for prevention of venous thromboembolism after total hip or knee surgery in Sweden.

Journal: Expert review of pharmacoeconomics & outcomes research 20111001

Title: Dutch guideline on total hip prosthesis.

Journal: Acta orthopaedica 20111001

Title: The new oral anticoagulants.

Journal: Clinical medicine (London, England) 20111001

Title: Xarelto: a new drug for new joints. Hip and knee recipients can avoid postsurgical clots without undergoing painful injections.

Journal: The Johns Hopkins medical letter health after 50 20111001

Title: [New antithrombotic drugs for the treatment of venous thromboembolism].

Journal: Revue des maladies respiratoires 20111001

Title: [Atrial fibrillation: what the GP needs to know].

Journal: MMW Fortschritte der Medizin 20110922

Title: [Modern risk assessment and stroke prevention in atrial fibrillation].

Journal: Praxis 20110921

Title: A new era for anticoagulation in atrial fibrillation.

Journal: The New England journal of medicine 20110915

Title: Rivaroxaban versus warfarin in nonvalvular atrial fibrillation.

Journal: The New England journal of medicine 20110908

Title: New options in anticoagulation for atrial fibrillation.

Journal: The New England journal of medicine 20110908

Title: Safety and efficacy of rivaroxaban for thromboprophylaxis following lower limb surgery: an update.

Journal: Expert opinion on drug safety 20110901

Title: Emerging options in the treatment of deep vein thrombosis and pulmonary embolism.

Journal: Blood reviews 20110901

Title: Prevention of venous thromboembolism after major orthopedic surgery: indirect comparison of three new oral anticoagulants.

Journal: Journal of thrombosis and haemostasis : JTH 20110901

Title: Direct inhibitors of thrombin and factor Xa attenuate clot-induced mitogenesis and inflammatory gene expression in human vascular smooth muscle cells.

Journal: Thrombosis and haemostasis 20110901

Title: Update on anti-coagulation in atrial fibrillation.

Journal: QJM : monthly journal of the Association of Physicians 20110901

Title: [Thromboembolic prophylaxis 2011: is warfarin on the wane?].

Journal: Giornale italiano di cardiologia (2006) 20110901

Title: Rivaroxaban: direct factor Xa inhibition to treat acute deep vein thrombosis.

Journal: British journal of hospital medicine (London, England : 2005) 20110901

Title: Direct thrombin inhibitors for the treatment of venous thromboembolism: analysis of the Dabigatran versus Warfarin clinical trial.

Journal: Seminars in vascular surgery 20110901

Title: Rivaroxaban (Xarelto)--a new oral anticoagulant.

Journal: The Medical letter on drugs and therapeutics 20110822

Title: New antithrombotic drugs and European approval processes.

Journal: Lancet (London, England) 20110820

Title: Oral direct factor Xa inhibitor gets FDA's OK.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110815

Title: Polysulfated xanthones: multipathway development of a new generation of dual anticoagulant/antiplatelet agents.

Journal: Journal of medicinal chemistry 20110811

Title: [The new Anticoagulants - Relevant Facts for the GP].

Journal: Praxis 20110810

Title: [Rivaroxaban as therapy of deep venous thrombosis equally as effective as current anticoagulation with heparin and vitamin K antagonist].

Journal: Praxis 20110810

Title: ['Xa-tra-xa': opportunities and open questions about new anticoagulants].

Journal: Praxis 20110810

Title: Novel oral anticoagulants: focus on stroke prevention and treatment of venous thrombo-embolism.

Journal: European heart journal 20110801

Title: Incidence of chronic kidney disease in patients with atrial fibrillation and its relevance for prescribing new oral antithrombotic drugs.

Journal: Journal of thrombosis and haemostasis : JTH 20110801

Title: New anticoagulants for prevention of stroke in patients with atrial fibrillation.

Journal: Journal of cardiovascular electrophysiology 20110801

Title: Detection of lupus anticoagulant in the presence of rivaroxaban using Taipan snake venom time.

Journal: Journal of thrombosis and haemostasis : JTH 20110801

Title: Role of emerging antithrombotic therapy in the prevention of cardioembolic complications in patients with atrial fibrillation.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20110801

Title: New oral anticoagulants for venous thromboembolism (VTE) prophylaxis.

Journal: The Medical journal of Malaysia 20110801

Title: Novel oral anticoagulants in development: Dabigatran, Rivaroxaban, and Apixaban.

Journal: American journal of therapeutics 20110701

Title: In vitro and in vivo P-glycoprotein transport characteristics of rivaroxaban.

Journal: The Journal of pharmacology and experimental therapeutics 20110701

Title: Clinical trials of direct thrombin and factor Xa inhibitors in atrial fibrillation.

Journal: Current opinion in cardiology 20110701

Title: Rivaroxaban differentially influences ex vivo global coagulation assays based on the administration time.

Journal: Thrombosis and haemostasis 20110701

Title: Response to 'Role of orally available antagonists of factor Xa in the treatment and prevention of thromboembolic disease: focus on rivaroxaban'.

Journal: Journal of clinical pharmacology 20110701

Title: Practical aspects of the oral new anticoagulants.

Journal: American journal of hematology 20110701

Title: Treatment of risk factors to prevent stroke.

Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20110701

Title: Optimal duration of anticoagulation in patients with venous thromboembolism.

Journal: The Indian journal of medical research 20110701

Title: Oral rivaroxaban after symptomatic venous thromboembolism: the continued treatment study (EINSTEIN-extension study).

Journal: Expert review of cardiovascular therapy 20110701

Title: [New anticoagulants in the prevention and treatment of venous thromboembolism].

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Title: The mechanism of action of rivaroxaban--an oral, direct Factor Xa inhibitor--compared with other anticoagulants.

Journal: Thrombosis research 20110601

Title: Atrial fibrillation and percutaneous coronary intervention: stroke, thrombosis, and bleeding.

Journal: Current treatment options in cardiovascular medicine 20110601

Title: Treating arrhythmias: an expert opinion.

Journal: Expert opinion on pharmacotherapy 20110601

Title: A systematic review of rivaroxaban versus enoxaparin in the prevention of venous thromboembolism after hip or knee replacement.

Journal: Thrombosis research 20110601

Title: Rivaroxaban in the contemporary treatment of acute coronary syndromes.

Journal: Expert opinion on investigational drugs 20110601

Title: Review of an article: oral rivaroxaban for symptomatic venous thromboembolism. The EINSTEIN Investigators et al. N Engl J Med 2010; 363(26):2499-2510.

Journal: Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing 20110601

Title: Prophylaxis of venous thromboembolism: low molecular weight heparin compared to the selective anticoagulants rivaroxaban, dabigatran and fondaparinux.

Journal: International angiology : a journal of the International Union of Angiology 20110601

Title: Economic impact of venous thromboembolism after hip and knee arthroplasty: potential impact of rivaroxaban.

Journal: Expert review of pharmacoeconomics & outcomes research 20110601

Title: 4-(3-Fluoro-4-nitro-phen-yl)morpholin-3-one.

Journal: Acta crystallographica. Section E, Structure reports online 20110601

Title: [Is the era from the end of warfarin?].

Journal: Medizinische Monatsschrift fur Pharmazeuten 20110601

Title: ACP journal club. Rivaroxaban was noninferior to enoxaparin for preventing short-term recurrent VTE and superior to placebo in continued treatment.

Journal: Annals of internal medicine 20110517

Title: Update on pharmacologic approaches to prevent thromboembolism in atrial fibrillation: are thrombin and factor Xa inhibitors the ultimate answer?

Journal: Current vascular pharmacology 20110501

Title: Is there evidence to support the use of direct Factor Xa inhibitors in coronary artery disease?

Journal: Reviews on recent clinical trials 20110501

Title: Coagulation parameters in patients receiving dabigatran etexilate or rivaroxaban: two observational studies in patients undergoing total hip or total knee replacement.

Journal: Thrombosis research 20110501

Title: Laboratory assessment of new anticoagulants.

Journal: Clinical chemistry and laboratory medicine 20110501

Title: Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor.

Journal: Journal of thrombosis and thrombolysis 20110501

Title: Extended-duration rivaroxaban thromboprophylaxis in acutely ill medical patients: MAGELLAN study protocol.

Journal: Journal of thrombosis and thrombolysis 20110501

Title: Risk-benefit ratio assessment for stroke prevention in intermediate risk atrial fibrillation patients: will TEE-based aspirin treatment fill the gap?

Journal: Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 20110501

Title: Rationale and design of the Anti-Xa therapy to lower cardiovascular events in addition to standard therapy in subjects with acute coronary syndrome-thrombolysis in myocardial infarction 51 (ATLAS-ACS 2 TIMI 51) trial: a randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of rivaroxaban in subjects with acute coronary syndrome.

Journal: American heart journal 20110501

Title: [New oral anticoagulant drugs: dabigatran, rivaroxaban and apixaban. Present and future].

Journal: Medecine sciences : M/S 20110501

Title: Advances in cardiology: clinical trial update.

Journal: Future cardiology 20110501

Title: [The new anticoagulants].

Journal: Harefuah 20110501

Title: [Current and future therapies for prophylaxis of thromboembolism in atrial fibrillation].

Journal: MMW Fortschritte der Medizin 20110414

Title: Coagulation-induced shedding of platelet glycoprotein VI mediated by factor Xa.

Journal: Blood 20110407

Title: A phase I open-label study evaluating the cardiovascular safety of sorafenib in patients with advanced cancer.

Journal: Cancer chemotherapy and pharmacology 20110401

Title: The potential role of new oral anticoagulants in the prevention and treatment of thromboembolism.

Journal: Pharmacology & therapeutics 20110401

Title: Measuring the anticoagulant effect of direct factor Xa inhibitors. Is the anti-Xa assay preferable to the prothrombin time test?

Journal: Thrombosis and haemostasis 20110401

Title: What do the RE-LY, AVERROES and ROCKET-AF trials tell us for stroke prevention in atrial fibrillation?

Journal: Thrombosis and haemostasis 20110401

Title: New oral anticoagulants.

Journal: Journal of thrombosis and thrombolysis 20110401

Title: Drug and dietary interactions of warfarin and novel oral anticoagulants: an update.

Journal: Journal of thrombosis and thrombolysis 20110401

Title: Investigational factor Xa inhibitors for thrombosis and acute coronary syndromes.

Journal: Expert opinion on investigational drugs 20110401

Title: Clinical trials update from the American Heart Association meeting 2010: EMPHASIS-HF, RAFT, TIM-HF, Tele-HF, ASCEND-HF, ROCKET-AF, and PROTECT.

Journal: European journal of heart failure 20110401

Title: Preventing postsurgical venous thromboembolism: pharmacological approaches.

Journal: Seminars in thrombosis and hemostasis 20110401

Title: Oral rivaroxaban for symptomatic venous thromboembolism.

Journal: The New England journal of medicine 20110324

Title: Rivaroxaban for the prevention of venous thromboembolism after hip or knee arthroplasty. Pooled analysis of four studies.

Journal: Thrombosis and haemostasis 20110301

Title: Italian intersociety consensus statement on antithrombotic prophylaxis in hip and knee replacement and in femoral neck fracture surgery.

Journal: Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology 20110301

Title: Changing anticoagulant paradigms for atrial fibrillation: dabigatran, apixaban and rivaroxaban.

Journal: Expert opinion on pharmacotherapy 20110301

Title: Old and new anticoagulant drugs: a minireview.

Journal: Annals of medicine 20110301

Title: Use of low-molecular-weight heparins and new anticoagulants in elderly patients with renal impairment.

Journal: Drugs & aging 20110301

Title: Evaluation of drug-induced serious hepatotoxicity (eDISH): application of this data organization approach to phase III clinical trials of rivaroxaban after total hip or knee replacement surgery.

Journal: Drug safety 20110301

Title: The discovery and development of rivaroxaban.

Journal: Annals of the New York Academy of Sciences 20110301

Title: Pharmacokinetics and pharmacodynamics of rivaroxaban and its effect on biomarkers of hypercoagulability in patients with chronic heart failure.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20110201

Title: Rivaroxaban and false positive lupus anticoagulant testing.

Journal: Thrombosis and haemostasis 20110201

Title: New anticoagulant agents in acute coronary syndromes.

Journal: Heart (British Cardiac Society) 20110201

Title: Dabigatran and rivaroxaban for prevention of venous thromboembolism--systematic review and adjusted indirect comparison.

Journal: Journal of clinical pharmacy and therapeutics 20110201

Title: Novel anticoagulants: a discussion of clinical use in the treatment and prevention of venous thromboembolism.

Journal: Phlebology 20110201

Title: [New oral anticoagulants in atrial fibrillation].

Journal: Der Nervenarzt 20110201

Title: Association of warfarin use with valvular and vascular calcification: a review.

Journal: Clinical cardiology 20110201

Title: Old and new anticoagulants.

Journal: Hamostaseologie 20110201

Title: New anticoagulants: pharmacology and clinical studies.

Journal: Wiener medizinische Wochenschrift (1946) 20110201

Title: Direct thrombin and factor Xa inhibitors in children: a quest for new anticoagulants for children.

Journal: Wiener medizinische Wochenschrift (1946) 20110201

Title: New oral anticoagulants and outpatient prophylaxis of venous thromboembolism.

Journal: The American journal of managed care 20110201

Title: Cost-effectiveness of rivaroxaban after total hip or total knee arthroplasty.

Journal: The American journal of managed care 20110201

Title: Characteristics of novel anticoagulants and potential economic implications.

Journal: The American journal of managed care 20110201

Title: Venous thromboembolism after total hip arthroplasty and total knee arthroplasty: current and future perspectives. Epilogue.

Journal: The American journal of managed care 20110201

Title: Venous thromboembolism after total hip arthroplasty and total knee arthroplasty: current and future perspectives.

Journal: The American journal of managed care 20110201

Title: New oral anticoagulants for thromboprophylaxis in patients having hip or knee arthroplasty.

Journal: BMJ (Clinical research ed.) 20110118

Title: New alternative to warfarin may help reduce stroke risk in patients with AF.

Journal: JAMA 20110105

Title: The International Normalized Ratio calibrated for rivaroxaban has the potential to normalize prothrombin time results for rivaroxaban-treated patients: results of an in vitro study.

Journal: Journal of thrombosis and haemostasis : JTH 20110101

Title: Effects of the oral, direct factor Xa inhibitor rivaroxaban on commonly used coagulation assays.

Journal: Journal of thrombosis and haemostasis : JTH 20110101

Title: Combination of a two-step fluorescence assay and a two-step anti-Factor Xa assay for detection of heparin falsifications and protein in heparins.

Journal: Analytical and bioanalytical chemistry 20110101

Title: Novel anticoagulants: new evidence for emerging drugs and their potential application in major lower limb surgery.

Journal: Current vascular pharmacology 20110101

Title: The discovery and development of rivaroxaban, an oral, direct factor Xa inhibitor.

Journal: Nature reviews. Drug discovery 20110101

Title: Factor Xa and thrombin as targets for new oral anticoagulants.

Journal: Thrombosis research 20110101

Title: Return to theatre following total hip and knee replacement, before and after the introduction of rivaroxaban: a retrospective cohort study.

Journal: The Journal of bone and joint surgery. British volume 20110101

Title: Novel oral factor Xa and thrombin inhibitors in the management of thromboembolism.

Journal: Annual review of medicine 20110101

Title: New oral anticoagulants: should they replace heparins and warfarin?

Journal: Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20110101

Title: An indirect comparison, via enoxaparin, of rivaroxaban with dabigatran in the prevention of venous thromboembolism after hip or knee replacement.

Journal: Journal of medical economics 20110101

Title: Cardiac crossroads: deciding between mechanical or bioprosthetic heart valve replacement.

Journal: Patient preference and adherence 20110101

Title: [Perioperative venous thromboembolism prophylaxis].

Journal: La Revue du praticien 20110101

Title: Heparin-induced thrombocytopenia in the ICU: an overview.

Journal: Critical care (London, England) 20110101

Title: The pathology and treatment of cardiac arrhythmias: focus on atrial fibrillation.

Journal: Vascular health and risk management 20110101

Title: Evaluation of the efficacy and safety of rivaroxaban using a computer model for blood coagulation.

Journal: PloS one 20110101

Title: New oral anticoagulants for venous thromboembolism prophylaxis in orthopaedic surgery.

Journal: Instructional course lectures 20110101

Title: Left Atrial Appendage Closure in Atrial Fibrillation: A World without Anticoagulation?

Journal: Cardiology research and practice 20110101

Title: Study protocol: the DESPATCH study: delivering stroke prevention for patients with atrial fibrillation - a cluster randomised controlled trial in primary healthcare.

Journal: Implementation science : IS 20110101

Title: [Drug prevention of pulmonary embolism in orthopedic practice: traditional and novel approaches].

Journal: Kardiologiia 20110101

Title: Performance of stroke risk scores in older people with atrial fibrillation not taking warfarin: comparative cohort study from BAFTA trial.

Journal: BMJ (Clinical research ed.) 20110101

Title: Evaluation of plaque stability of advanced atherosclerotic lesions in apo E-deficient mice after treatment with the oral factor Xa inhibitor rivaroxaban.

Journal: Mediators of inflammation 20110101

Title: Battle of oral anticoagulants in the field of atrial fibrillation scrutinized from a clinical practice (the real world) perspective.

Journal: Thrombosis journal 20110101

Title: Therapeutic potential of rivaroxaban in the prevention of venous thromboembolism following hip and knee replacement surgery: a review of clinical trial data.

Journal: Vascular health and risk management 20110101

Title: Antithrombotic medication for cardioembolic stroke prevention.

Journal: Stroke research and treatment 20110101

Title: Comparison of pharmacist managed anticoagulation with usual medical care in a family medicine clinic.

Journal: BMC family practice 20110101

Title: Strategies for diagnosis and prevention of venous thromboembolism during pregnancy.

Journal: Journal of pregnancy 20110101

Title: FDA approves rivaroxaban for prevention of deep-vein thrombosis in surgery.

Journal: Cardiovascular journal of Africa 20110101

Title: Evaluation of marine brown algae and sponges from Brazil as anticoagulant and antiplatelet products.

Journal: Marine drugs 20110101

Title: Anesthesia for joint replacement surgery: Issues with coexisting diseases.

Journal: Journal of anaesthesiology, clinical pharmacology 20110101

Title: Tissue factor, blood coagulation, and beyond: an overview.

Journal: International journal of inflammation 20110101

Title: Prophylaxis for deep vein thrombosis and pulmonary embolism in the surgical patient.

Journal: Advances in surgery 20110101

Title: [The new oral anticoagulants in surgery].

Journal: Revista medica del Instituto Mexicano del Seguro Social 20110101

Title: European Society of Cardiology congress 2011.

Journal: Cardiovascular journal of Africa 20110101

Title: Role of factor xa inhibitors in cancer-associated thrombosis: any new data?

Journal: Advances in hematology 20110101

Title: Cost and outcomes associated with rivaroxaban vs enoxaparin for the prevention of postsurgical venous thromboembolism from a US payer's perspective.

Journal: Journal of medical economics 20110101

Title: Emerging therapies for acute coronary syndromes.

Journal: Frontiers in pharmacology 20110101

Title: The effect of a new direct Factor Xa inhibitor on human osteoblasts: an in-vitro study comparing the effect of rivaroxaban with enoxaparin.

Journal: BMC musculoskeletal disorders 20110101

Title: Dabigatran etexilate versus warfarin in management of non-valvular atrial fibrillation in UK context: quantitative benefit-harm and economic analyses.

Journal: BMJ (Clinical research ed.) 20110101

Title: Rivaroxaban, ticagrelor, and fidaxomicin.

Journal: Journal of the American Pharmacists Association : JAPhA 20110101

Title: Urinary Prothrombin Fragment 1+2 in relation to Development of Non-Symptomatic and Symptomatic Venous Thromboembolic Events following Total Knee Replacement.

Journal: Thrombosis 20110101

Title: Venous thromboembolism: classification, risk factors, diagnosis, and management.

Journal: ISRN hematology 20110101

Title: Preoperative versus postoperative initiation of thromboprophylaxis following major orthopedic surgery: safety and efficacy of postoperative administration supported by recent trials of new oral anticoagulants.

Journal: Thrombosis journal 20110101

Title: Anticoagulants and the propagation phase of thrombin generation.

Journal: PloS one 20110101

Title: Gene-drug interaction in stroke.

Journal: Stroke research and treatment 20110101

Title: Raft of rivaroxaban good news from the USA, implications for South African clinical practice.

Journal: Cardiovascular journal of Africa 20110101

Title: Oral fondaparinux: use of lipid nanocapsules as nanocarriers and in vivo pharmacokinetic study.

Journal: International journal of nanomedicine 20110101

Title: Cardiac arrest caused by multiple recurrent pulmonary embolism.

Journal: Case reports in medicine 20110101

Title: Pharmacological basis and clinical evidence of dabigatran therapy.

Journal: Journal of hematology & oncology 20110101

Title: The case for an elderly targeted stroke management.

Journal: Frontiers in neurology 20110101

Title: Oral thromboprophylaxis following total hip or knee replacement: review and multicentre experience with dabigatran etexilate.

Journal: The open orthopaedics journal 20110101

Title: Deep vein thrombosis: a clinical review.

Journal: Journal of blood medicine 20110101

Title: Oral rivaroxaban for symptomatic venous thromboembolism.

Journal: The New England journal of medicine 20101223

Title: Therapeutic potential of oral factor Xa inhibitors.

Journal: The New England journal of medicine 20101223

Title: Engineered thrombin aims to take on heparin.

Journal: Chemistry & biology 20101222

Title: Novel anticoagulants for stroke prevention in atrial fibrillation: current clinical evidence and future developments.

Journal: Journal of the American College of Cardiology 20101214

Title: [Rivaroxaban at least as effective as marcumar in stroke prevention].

Journal: MMW Fortschritte der Medizin 20101202

Title: [New oral anticoagulants: better than vitamin K antagonists?].

Journal: Der Internist 20101201

Title: Assays for measuring rivaroxaban: their suitability and limitations.

Journal: Therapeutic drug monitoring 20101201

Title: The new oral anticoagulants, do they change the benefit vs. risk for thromboprophylaxis in association to ambulatory surgery?

Journal: Current opinion in anaesthesiology 20101201

Title: The impact of elective knee/hip replacement surgery and thromboprophylaxis with rivaroxaban or dalteparin on thrombin generation.

Journal: British journal of haematology 20101201

Title: Clinical laboratory measurement of direct factor Xa inhibitors: anti-Xa assay is preferable to prothrombin time assay.

Journal: Thrombosis and haemostasis 20101201

Title: New synthetic antithrombotic agents for venous thromboembolism: pentasaccharides, direct thrombin inhibitors, direct Xa inhibitors.

Journal: Clinics in chest medicine 20101201

Title: Recurrent venous thrombosis despite 'optimal anticoagulation therapy' for antiphospholipid syndrome--could new oral anticoagulants solve the problem?

Journal: Acta clinica Croatica 20101201

Title: Clinical pharmacology of direct and indirect factor Xa inhibitors.

Journal: Drugs 20101112

Title: Is there adequate provision of venous thromboembolism prophylaxis following hip arthroplasty? An audit and international survey.

Journal: Annals of the Royal College of Surgeons of England 20101101

Title: An optimised, rapid chromogenic assay, specific for measuring direct factor Xa inhibitors (rivaroxaban) in plasma.

Journal: Thrombosis and haemostasis 20101101

Title: Rivaroxaban versus enoxaparin for thromboprophylaxis after total hip or knee arthroplasty: a meta-analysis of randomized controlled trials.

Journal: European journal of clinical pharmacology 20101101

Title: Enoxaparin versus dabigatran or rivaroxaban for thromboprophylaxis after hip or knee arthroplasty: Results of separate pooled analyses of phase III multicenter randomized trials.

Journal: Circulation. Cardiovascular quality and outcomes 20101101

Title: Blood transfusion and the anaesthetist: management of massive haemorrhage.

Journal: Anaesthesia 20101101

Title: [Prophylaxis of thrombembolic diseases with rivaroxaban].

Journal: Deutsche medizinische Wochenschrift (1946) 20101101

Title: Effects of renal impairment on the pharmacokinetics, pharmacodynamics and safety of rivaroxaban, an oral, direct Factor Xa inhibitor.

Journal: British journal of clinical pharmacology 20101101

Title: Korean guidelines for the prevention of venous thromboembolism.

Journal: Journal of Korean medical science 20101101

Title: [Novel anticoagulants for stroke prevention in atrial fibrillation].

Journal: Deutsche medizinische Wochenschrift (1946) 20101101

Title: [New oral anticoagulants from the perspective of trauma surgery].

Journal: Der Unfallchirurg 20101101

Title: [Thromboembolism prophylaxis in trauma surgery: S3 guidelines and significance of the amendment for trauma surgeons].

Journal: Der Unfallchirurg 20101101

Title: [Recommendations for the administration of conventional and new antithrombotic agents from the perspective of anesthesiology].

Journal: Der Unfallchirurg 20101101

Title: [Two new anticoagulants available in 2010--Dabigatran Etexilate and Rivaroxaban: expected progresses--raised problems].

Journal: Annales pharmaceutiques francaises 20101101

Title: [New study findings in cardiology. The best is the enemy of the good].

Journal: Medizinische Monatsschrift fur Pharmazeuten 20101101

Title: New options for stroke prevention in atrial fibrillation.

Journal: The American journal of managed care 20101101

Title: Rivaroxaban: a novel anticoagulant.

Journal: Indian journal of medical sciences 20101101

Title: New antithrombotics for atrial fibrillation.

Journal: Cardiovascular therapeutics 20101001

Title: Emerging antithrombotic agents: what does the intensivist need to know?

Journal: Current opinion in critical care 20101001

Title: Cost-effectiveness of rivaroxaban versus enoxaparin for the prevention of postsurgical venous thromboembolism in Canada.

Journal: Thrombosis and haemostasis 20101001

Title: Low risk of thromboembolic complications after fast-track hip and knee arthroplasty.

Journal: Acta orthopaedica 20101001

Title: Rivaroxaban for thromboembolism prophylaxis after orthopaedic surgery.

Journal: Anaesthesia 20101001

Title: Factor Xa inhibitors: next-generation antithrombotic agents.

Journal: Journal of medicinal chemistry 20100909

Title: Role of orally available antagonists of factor Xa in the treatment and prevention of thromboembolic disease: focus on rivaroxaban.

Journal: Journal of clinical pharmacology 20100901

Title: [Oral prevention of thromboembolism with rivaroxaban and dabigatran: are the newly approved drugs innovations in orthopaedic and trauma surgery? ].

Journal: Zeitschrift fur Orthopadie und Unfallchirurgie 20100901

Title: New antithrombotic agents--insights from clinical trials.

Journal: Nature reviews. Cardiology 20100901

Title: Novel oral anticoagulants: implications in the perioperative setting.

Journal: Anesthesiology 20100901

Title: [Rivaroxaban and factor Xa inhibitors in clinical practice].

Journal: Vnitrni lekarstvi 20100901

Title: Antithrombotic and anticoagulant profiles of TAK-442, a novel factor Xa inhibitor, in a rabbit model of venous thrombosis.

Journal: Journal of cardiovascular pharmacology 20100801

Title: Anticoagulation by factor Xa inhibitors.

Journal: Journal of thrombosis and haemostasis : JTH 20100801

Title: Apixaban, a direct factor Xa inhibitor, inhibits tissue-factor induced human platelet aggregation in vitro: comparison with direct inhibitors of factor VIIa, XIa and thrombin.

Journal: Thrombosis and haemostasis 20100801

Title: Treatment of thromboembolism in cancer patients.

Journal: Expert opinion on pharmacotherapy 20100801

Title: Oral Xa inhibitors.

Journal: Hematology/oncology clinics of North America 20100801

Title: [Do orally active factor Xa (FXa) inhibitors have potential as innovative new anticoagulants? Future perspective from preclinical data].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20100801

Title: Oral factor Xa inhibitors for the prevention of stroke in atrial fibrillation.

Journal: Current opinion in cardiology 20100701

Title: New oral anticoagulant drugs in cardiovascular disease.

Journal: Thrombosis and haemostasis 20100701

Title: Clot prevention--common questions about medications.

Journal: Australian family physician 20100701

Title: [A new deal with new anticoagulants?].

Journal: Journal des maladies vasculaires 20100601

Title: Old versus new anticoagulants: focus on pharmacology.

Journal: Recent patents on cardiovascular drug discovery 20100601

Title: Anesthetic concerns for patients with coagulopathy.

Journal: Current opinion in anaesthesiology 20100601

Title: Rivaroxaban for thromboprophylaxis in patients undergoing major orthopedic surgery.

Journal: The Annals of pharmacotherapy 20100601

Title: Rivaroxaban for thromboembolism prophylaxis after orthopaedic surgery.

Journal: Anaesthesia 20100601

Title: Drug and dietary interactions of the new and emerging oral anticoagulants.

Journal: International journal of clinical practice 20100601

Title: Novel oral anticoagulants. Part II: direct thrombin inhibitors.

Journal: Expert review of hematology 20100601

Title: [New oral anticoagulants: prospects].

Journal: La Revue du praticien 20100520

Title: Emerging anticoagulants for venous thromboembolism prevention.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100515

Title: New anticoagulants for prevention and treatment of venous thromboembolism.

Journal: Current vascular pharmacology 20100501

Title: Rivaroxaban and dabigatran etexilate: two new oral anticoagulants for extended postoperative prevention of venous thromboembolism after elective total hip arthroplasty.

Journal: Archives of orthopaedic and trauma surgery 20100501

Title: New and emerging antiarrhythmic and anticoagulant agents for atrial fibrillation.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100501

Title: Primary prevention of venous thromboembolism in medical and surgical oncology patients.

Journal: British journal of cancer 20100413

Title: Assessment of laboratory assays to measure rivaroxaban--an oral, direct factor Xa inhibitor.

Journal: Thrombosis and haemostasis 20100401

Title: Facts and artefacts of coagulation assays for factor Xa inhibitors.

Journal: Thrombosis and haemostasis 20100401

Title: Antithrombotic treatment failures in antiphospholipid syndrome: the new anticoagulants?

Journal: Lupus 20100401

Title: Rivaroxaban vs dabigatran for thromboprophylaxis after joint-replacement surgery: exploratory indirect comparison based on meta-analysis of pivotal clinical trials.

Journal: Croatian medical journal 20100401

Title: VTE prophylaxis for the medical patient: where do we stand? - a focus on cancer patients.

Journal: Thrombosis research 20100401

Title: Potential of new anticoagulants in patients with cancer.

Journal: Thrombosis research 20100401

Title: Novel oral anticoagulants for prophylaxis and treatment of venous thromboembolism: part I (Factor Xa inhibitors).

Journal: Expert review of hematology 20100401

Title: Comparative efficacy and safety of the novel oral anticoagulants dabigatran, rivaroxaban and apixaban in preclinical and clinical development.

Journal: Thrombosis and haemostasis 20100301

Title: DVT: a new era in anticoagulant therapy.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20100301

Title: Rivaroxaban: a new oral factor Xa inhibitor.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20100301

Title: Antithrombotic drugs for patients with ischaemic stroke and transient ischaemic attack to prevent recurrent major vascular events.

Journal: The Lancet. Neurology 20100301

Title: Rivaroxaban-once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation: rationale and design of the ROCKET AF study.

Journal: American heart journal 20100301

Title: Oral rivaroxaban for the prevention of symptomatic venous thromboembolism after elective hip and knee replacement.

Journal: The Journal of bone and joint surgery. British volume 20100301

Title: Recent advances in the management of venous thromboembolism.

Journal: The Korean journal of hematology 20100301

Title: New oral anticoagulants: a practical guide for clinicians.

Journal: Journal of thrombosis and thrombolysis 20100201

Title: The ultimate anticoagulants?

Journal: Cardiovascular journal of Africa 20100201

Title: [Update on new antithrombotic treatments].

Journal: Revue medicale suisse 20100120

Title: The new oral anticoagulants.

Journal: Blood 20100107

Title: Factor Xa inhibitors in acute coronary syndromes and venous thromboembolism.

Journal: Current vascular pharmacology 20100101

Title: Safety, pharmacokinetics and pharmacodynamics of single doses of rivaroxaban - an oral, direct factor Xa inhibitor - in elderly Chinese subjects.

Journal: Thrombosis and haemostasis 20100101

Title: The potential benefits of low-molecular-weight heparins in cancer patients.

Journal: Journal of hematology & oncology 20100101

Title: [Prophylaxis of venous thromboembolism in orthopaedic surgery--trivial option, huge potential].

Journal: Zeitschrift fur Orthopadie und Unfallchirurgie 20100101

Title: Entering the era of non-basic p1 site groups: discovery of Xarelto (Rivaroxaban).

Journal: Current topics in medicinal chemistry 20100101

Title: New oral anticoagulants in development: potential for improved safety profiles.

Journal: Reviews in neurological diseases 20100101

Title: Forecasting drug utilization and expenditure in a metropolitan health region.

Journal: BMC health services research 20100101

Title: New options with dabigatran etexilate in anticoagulant therapy.

Journal: Vascular health and risk management 20100101

Title: New anticoagulants for the prevention of venous thromboembolism.

Journal: Drug design, development and therapy 20100101

Title: Deep vein thrombosis and pulmonary embolism - Prevention, management, and anaesthetic considerations.

Journal: Indian journal of anaesthesia 20100101

Title: Novel anticoagulant therapy: principle and practice.

Journal: Methods in molecular biology (Clifton, N.J.) 20100101

Title: Oral direct factor Xa inhibitors, with special emphasis on rivaroxaban.

Journal: Methods in molecular biology (Clifton, N.J.) 20100101

Title: [Anticoagulant therapy in cardiology: yesterday, today, tomorrow].

Journal: Kardiologiia 20100101

Title: Prevention strategies for cardioembolic stroke: present and future perspectives.

Journal: The open neurology journal 20100101

Title: Oral anticoagulants in pediatric cardiac practice: A systematic review of the literature.

Journal: Annals of pediatric cardiology 20100101

Title: Cost effectiveness of venous thromboembolism pharmacological prophylaxis in total hip and knee replacement: a systematic review.

Journal: PharmacoEconomics 20100101

Title: Further issues with new oral anticoagulants.

Journal: Current pharmaceutical design 20100101

Title: New anticoagulants for the prevention of thromboembolism.

Journal: Current pharmaceutical design 20100101

Title: Pharmacologic properties of the new oral anticoagulants: a clinician-oriented review with a focus on perioperative management.

Journal: Current pharmaceutical design 20100101

Title: Managing bleeding complications in patients treated with the old and the new anticoagulants.

Journal: Current pharmaceutical design 20100101

Title: Post-operative thromboprophylaxis: new oral thrombin and factor X inhibitors and their place in clinical practice.

Journal: F1000 medicine reports 20100101

Title: Effective single-drug approach is welcomed for deep-vein thrombosis treatment.

Journal: Cardiovascular journal of Africa 20100101

Title: Rivaroxaban equals warfarin treatment in atrial fibrillation patients at high risk of stroke.

Journal: Cardiovascular journal of Africa 20100101

Title: Development of new anticoagulant highly honoured: Bayer's Xarelto recognised with 2010 international Prix Galien award.

Journal: Cardiovascular journal of Africa 20100101

Title: Newer antithrombotic drugs.

Journal: Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 20100101

Title: Simplifying thromboprophylaxis could improve outcomes in orthopaedic surgery.

Journal: Thrombosis 20100101

Title: New oral anticoagulants for thromboprophylaxis after elective total hip and knee arthroplasty.

Journal: Thrombosis 20100101

Title: Emerging antithrombotic agents for thromboprophylaxis, clinical potential and patient considerations.

Journal: Journal of blood medicine 20100101

Title: Dabigatran or rivaroxaban versus other anticoagulants for thromboprophylaxis after major orthopedic surgery: systematic review of comparative clinical-effectiveness and safety.

Journal: CADTH technology overviews 20100101

Title: Rivaroxaban in orthopedic surgery--a change of paradigm?

Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20091201

Title: Oral factor Xa inhibitors for thromboprophylaxis in major orthopedic surgery: a review.

Journal: Internal and emergency medicine 20091201

Title: Will oral rivaroxaban improve clinically relevant outcomes and thromboprophylaxis management in the orthopedic patient?

Journal: Journal of thrombosis and haemostasis : JTH 20091201

Title: [New oral anticoagulants. Consequences for perioperative coagulation diagnostics and therapy].

Journal: Der Anaesthesist 20091201

Title: Rivaroxaban, the first oral, direct factor Xa inhibitor.

Journal: Expert opinion on pharmacotherapy 20091201

Title: Oral anticoagulation with Factor Xa and thrombin inhibitors: Is there an alternative to warfarin?

Journal: Discovery medicine 20091201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20091201

Title: Heparin-induced thrombocytopaenia/thrombosis: a clinicopathologic review.

Journal: East African medical journal 20091201

Title: Direct inhibitors of coagulation proteins - the end of the heparin and low-molecular-weight heparin era for anticoagulant therapy?

Journal: Thrombosis and haemostasis 20091101

Title: Thromboprophylaxis after multiple trauma: what treatment and for how long?

Journal: Injury 20091101

Title: [Pregnancy and venous thromboembolism. North-American and European guidelines. American College of Chest Physicians].

Journal: Journal des maladies vasculaires 20091101

Title: New agents for orthopaedic thromboprophylaxis: caution essential, but time will tell.

Journal: ANZ journal of surgery 20091101

Title: New antithrombotic drugs: potential for use in oncology.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091010

Title: Underestimation of the effect of bleeding in clinical trials.

Journal: Lancet (London, England) 20091003

Title: New anticoagulants and regional anesthesia.

Journal: Current opinion in anaesthesiology 20091001

Title: Anticoagulation with {blacktriangledown}dabigatran or{blacktriangledown}rivaroxaban.

Journal: Drug and therapeutics bulletin 20091001

Title: Rivaroxaban for the prevention of venous thromboembolism: a single technology appraisal.

Journal: Health technology assessment (Winchester, England) 20091001

Title: [Rivaroxaban (Xarelto): new anticoagulant inhibitor of factor Xa].

Journal: Revue medicale de Liege 20091001

Title: Oral anticoagulation with factor Xa and thrombin inhibitors: on the threshold of change.

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Title: Rivaroxaban versus enoxaparin after total knee arthroplasty.

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Title: Rivaroxaban versus enoxaparin after total knee arthroplasty.

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Title: Rivaroxaban versus enoxaparin after total knee arthroplasty.

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Title: Rivaroxaban versus enoxaparin after total knee arthroplasty.

Journal: Lancet (London, England) 20090829

Title: Favorable therapeutic index of the direct factor Xa inhibitors, apixaban and rivaroxaban, compared with the thrombin inhibitor dabigatran in rabbits.

Journal: Journal of thrombosis and haemostasis : JTH 20090801

Title: Recent developments in the use of oral anticoagulants.

Journal: Expert opinion on pharmacotherapy 20090801

Title: Novel anticoagulants in clinical development: focus on factor Xa and direct thrombin inhibitors.

Journal: Journal of cardiovascular medicine (Hagerstown, Md.) 20090801

Title: Use of emerging oral anticoagulants in clinical practice: translating results from clinical trials to orthopedic and general surgical patient populations.

Journal: Annals of surgery 20090801

Title: Factor Xa inhibitors--new anticoagulants for secondary haemostasis.

Journal: Hamostaseologie 20090801

Title: [Patients with oral anticoagulation--bridging anticoagulation in the perioperative phase].

Journal: Hamostaseologie 20090801

Title: Rivaroxaban: new drug. After hip or knee replacement surgery: LMWH is safer.

Journal: Prescrire international 20090801

Title: Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomised, double-blind, phase II trial.

Journal: Lancet (London, England) 20090704

Title: Rivaroxaban in acute coronary syndromes: too soon to know?

Journal: Lancet (London, England) 20090704

Title: New anticoagulants: focus on venous thromboembolism.

Journal: Current vascular pharmacology 20090701

Title: Safety, pharmacokinetics and pharmacodynamics of single/multiple doses of the oral, direct Factor Xa inhibitor rivaroxaban in healthy Chinese subjects.

Journal: British journal of clinical pharmacology 20090701

Title: New anticoagulants for atrial fibrillation.

Journal: Seminars in thrombosis and hemostasis 20090701

Title: [New agents for the prevention of venous thromboembolism].

Journal: Der Internist 20090601

Title: Rivaroxaban for the prevention of venous thromboembolism following major orthopedic surgery: the RECORD trials.

Journal: Expert review of cardiovascular therapy 20090601

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20090601

Title: 3-(3-Chloro-anilino)-1-(3,5-dimethyl-1H-pyrazol-1-yl)propan-1-one.

Journal: Acta crystallographica. Section E, Structure reports online 20090601

Title: Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial.

Journal: Lancet (London, England) 20090516

Title: The importance of VTE prevention after orthopaedic surgery.

Journal: Lancet (London, England) 20090516

Title: Rivaroxaban -- an oral, direct Factor Xa inhibitor: lessons from a broad clinical study programme.

Journal: European journal of haematology 20090501

Title: Metabolism and excretion of rivaroxaban, an oral, direct factor Xa inhibitor, in rats, dogs, and humans.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090501

Title: In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090501

Title: Oral rivaroxaban for the prevention of symptomatic venous thromboembolism after elective hip and knee replacement.

Journal: The Journal of bone and joint surgery. British volume 20090501

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20090501

Title: Rivaroxaban (xarelto) for the prevention of thromboembolic disease: an inside look at the oral direct factor xa inhibitor.

Journal: P & T : a peer-reviewed journal for formulary management 20090501

Title: [The new oral anticoagulant in the Netherlands].

Journal: Nederlands tijdschrift voor geneeskunde 20090418

Title: Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor.

Journal: Bioorganic & medicinal chemistry letters 20090415

Title: The direct factor Xa inhibitor rivaroxaban.

Journal: The Medical journal of Australia 20090406

Title: Rivaroxaban, a new, oral, direct factor Xa inhibitor for thromboprophylaxis after major joint arthroplasty.

Journal: Expert opinion on pharmacotherapy 20090401

Title: [New anticoagulants].

Journal: Deutsche medizinische Wochenschrift (1946) 20090401

Title: Should new oral anticoagulants replace low-molecular-weight heparin for thromboprophylaxis in orthopaedic surgery?

Journal: Archives of cardiovascular diseases 20090401

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20090401

Title: [Venous thromboembolism prophylaxis in orthopaedics and traumatology].

Journal: Vnitrni lekarstvi 20090301

Title: [Advances in antithrombotic treatment--antithrombotics with anti-Xa effect].

Journal: Vnitrni lekarstvi 20090301

Title: The novel anticoagulants: entering a new era.

Journal: Swiss medical weekly 20090207

Title: [The new antithrombotics in 2009].

Journal: Revue medicale suisse 20090204

Title: Rivaroxaban: a novel, oral, direct factor Xa inhibitor.

Journal: Pharmacotherapy 20090201

Title: New anticoagulants - towards the development of an 'ideal' anticoagulant.

Journal: VASA. Zeitschrift fur Gefasskrankheiten 20090201

Title: Laboratory monitoring of anticoagulation: where do we stand?

Journal: Seminars in thrombosis and hemostasis 20090201

Title: Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development.

Journal: Clinical pharmacokinetics 20090101

Title: Multinational development of a questionnaire assessing patient satisfaction with anticoagulant treatment: the 'Perception of Anticoagulant Treatment Questionnaire' (PACT-Q).

Journal: Health and quality of life outcomes 20090101

Title: In the pipeline: new oral anticoagulants for the prevention of venous thromboembolism.

Journal: Orthopedics 20090101

Title: New oral anticoagulants: not quite there yet.

Journal: Polskie Archiwum Medycyny Wewnetrznej 20090101

Title: Old and new anticoagulant agents for the prevention and treatment of patients with ischemic stroke.

Journal: Cerebrovascular diseases (Basel, Switzerland) 20090101

Title: Use of anticoagulants in elderly patients: practical recommendations.

Journal: Clinical interventions in aging 20090101

Title: Rivaroxaban: an oral direct factor Xa inhibitor for the prevention of thromboembolism.

Journal: Cardiology in review 20090101

Title: Interpretation of benefit-risk of enoxaparin as comparator in the RECORD program: rivaroxaban oral tablets (10 milligrams) for use in prophylaxis in deep vein thrombosis and pulmonary embolism in patients undergoing hip or knee replacement surgery.

Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20090101

Title: Selecting the optimal antithrombotic regimen for patients with acute coronary syndromes undergoing percutaneous coronary intervention.

Journal: Vascular health and risk management 20090101

Title: The prevention and treatment of venous thromboembolism with LMWHs and new anticoagulants.

Journal: Vascular health and risk management 20090101

Title: [Dabigatran and rivaroxaban, new oral anticoagulants for the treatment of venous thromboembolism].

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20090101

Title: [Pharmacokinetics and pharmacodynamics of the new oral anticoagulants dabigatran and rivaroxaban].

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20090101

Title: Rivaroxaban: a review of its use for the prevention of venous thromboembolism after total hip or knee replacement surgery.

Journal: Drugs 20090101

Title: [From old to new anticoagulants: the role of the biologist].

Journal: Annales de biologie clinique 20090101

Title: New anticoagulants for the prevention of deep venous thrombosis: time to consider cost effectiveness?

Journal: PharmacoEconomics 20090101

Title: A cost-effectiveness model comparing rivaroxaban and dabigatran etexilate with enoxaparin sodium as thromboprophylaxis after total hip and total knee replacement in the irish healthcare setting.

Journal: PharmacoEconomics 20090101

Title: Prevention and treatment of thromboembolic events in medical patients and new anticoagulants.

Journal: Acta clinica Belgica 20090101

Title: [Pharmacology of heparins and direct anticoagulants].

Journal: Hamostaseologie 20081201

Title: [Rivaroxaban: a decisive step forward in the management of postoperative thromboembolic disease?].

Journal: Annales francaises d'anesthesie et de reanimation 20081201

Title: [Rivaroxaban: clinical pharmacology].

Journal: Annales francaises d'anesthesie et de reanimation 20081201

Title: [Perioperative venous thromboembolism prophylaxis: short review and recommendations].

Journal: Annales francaises d'anesthesie et de reanimation 20081201

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Journal: Annales francaises d'anesthesie et de reanimation 20081201

Title: [Summary and perspectives. Rivaroxaban].

Journal: Annales francaises d'anesthesie et de reanimation 20081201

Title: [Rivaroxaban: mode of action].

Journal: Annales francaises d'anesthesie et de reanimation 20081201

Title: Emergence of new oral antithrombotics: a critical appraisal of their clinical potential.

Journal: Vascular health and risk management 20081201

Title: Rivaroxaban for thromboprophylaxis.

Journal: The New England journal of medicine 20081113

Title: Rivaroxaban for thromboprophylaxis.

Journal: The New England journal of medicine 20081113

Title: Rivaroxaban for thromboprophylaxis.

Journal: The New England journal of medicine 20081113

Title: Rivaroxaban for thromboprophylaxis.

Journal: The New England journal of medicine 20081113

Title: [Rivaroxaban. The first factor Xa inhibitor].

Journal: Medizinische Monatsschrift fur Pharmazeuten 20081101

Title: [Thromboembolic disease in orthopedic surgery].

Journal: Medicina clinica 20081101

Title: [Anaesthesia and thromboembolic disease].

Journal: Medicina clinica 20081101

Title: [New oral anticoagulants: molecular characteristics, mechanisms of action, pharmacokinetics and pharmacodynamics].

Journal: Medicina clinica 20081101

Title: Polyphosphate as a general procoagulant agent.

Journal: Journal of thrombosis and haemostasis : JTH 20081001

Title: Rivaroxaban--an oral, direct Factor Xa inhibitor--has potential for the management of patients with heparin-induced thrombocytopenia.

Journal: British journal of haematology 20081001

Title: Differences in urinary prothrombin fragment 1 + 2 levels after total hip replacement in relation to venous thromboembolism and bleeding events.

Journal: Journal of thrombosis and haemostasis : JTH 20081001

Title: Dose-escalation study of the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy elderly subjects.

Journal: Current medical research and opinion 20081001

Title: [Anticoagulation in atrial fibrillation].

Journal: Hamostaseologie 20081001

Title: [Prophylaxis of venous thromboembolism].

Journal: Hamostaseologie 20081001

Title: Rivaroxaban: future in anticoagulation practice?

Journal: Hematology (Amsterdam, Netherlands) 20081001

Title: More effective, simpler-to-use clot-buster is on the way. Clot-prevention drug could save lives after joint replacement.

Journal: DukeMedicine healthnews 20081001

Title: [Always more amputations in Germany?].

Journal: Deutsche medizinische Wochenschrift (1946) 20081001

Title: Orally administered factor xa inhibitor, rivaroxaban: a novel thromboembolic prophylaxis agent.

Journal: Neurosurgery 20081001

Title: A dose-ranging study evaluating once-daily oral administration of the factor Xa inhibitor rivaroxaban in the treatment of patients with acute symptomatic deep vein thrombosis: the Einstein-DVT Dose-Ranging Study.

Journal: Blood 20080915

Title: Determination of rivaroxaban--a novel, oral, direct Factor Xa inhibitor--in human plasma by high-performance liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080901

Title: Population pharmacokinetics and pharmacodynamics of once- and twice-daily rivaroxaban for the prevention of venous thromboembolism in patients undergoing total hip replacement.

Journal: Thrombosis and haemostasis 20080901

Title: New developments in anticoagulation for atrial fibrillation.

Journal: Current treatment options in cardiovascular medicine 20080901

Title: Rivaroxaban: an oral direct inhibitor of factor Xa.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080815

Title: Potent anticoagulants are associated with a higher all-cause mortality rate after hip and knee arthroplasty.

Journal: Clinical orthopaedics and related research 20080801

Title: New compounds in the management of venous thromboembolism after orthopedic surgery: focus on rivaroxaban.

Journal: Vascular health and risk management 20080801

Title: Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled trial.

Journal: Lancet (London, England) 20080705

Title: Selective factor Xa inhibition for thromboprophylaxis.

Journal: Lancet (London, England) 20080705

Title: Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty.

Journal: The New England journal of medicine 20080626

Title: Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty.

Journal: The New England journal of medicine 20080626

Title: New anticoagulants--the path from discovery to clinical practice.

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Journal: Deutsche medizinische Wochenschrift (1946) 20080601

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20080601

Title: Preventing venous thromboembolism through risk assessment approaches.

Journal: British journal of nursing (Mark Allen Publishing) 20080601

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20080401

Title: Potent anticoagulants are associated with a higher all-cause mortality rate after hip and knee arthroplasty.

Journal: Clinical orthopaedics and related research 20080301

Title: New anticoagulants for treatment of venous thromboembolism.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20080301

Title: Update on atrial fibrillation: part I.

Journal: Clinical cardiology 20080201

Title: [New anticoagulants].

Journal: Hamostaseologie 20080201

Title: Current and future prospects for anticoagulant therapy: inhibitors of factor Xa and factor IIa.

Journal: Seminars in thrombosis and hemostasis 20080201

Title: The laboratory diagnosis and clinical management of patients with heparin-induced thrombocytopenia: an update.

Journal: Seminars in thrombosis and hemostasis 20080201

Title: Randomized, double-blind, crossover study to investigate the effect of rivaroxaban on QT-interval prolongation.

Journal: Drug safety 20080101

Title: New oral anticoagulants in atrial fibrillation.

Journal: European heart journal 20080101

Title: Population pharmacokinetics and pharmacodynamics of rivaroxaban--an oral, direct factor Xa inhibitor--in patients undergoing major orthopaedic surgery.

Journal: Clinical pharmacokinetics 20080101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20080101

Title: Pharmacological strategies for inhibition of thrombin activity.

Journal: Current pharmaceutical design 20080101

Title: The top 4 advances in antithrombotic care in the last year.

Journal: Thrombosis research 20080101

Title: Brave new world: the current and future use of novel anticoagulants.

Journal: Thrombosis research 20080101

Title: Thromboprophylaxis with rivaroxaban or enoxaparin did not differ for major bleeding or other safety outcomes in hip arthroplasty.

Journal: ACP journal club 20080101

Title: Thromboprophylaxis with rivaroxaban or enoxaparin did not differ for major bleeding in knee arthroplasty.

Journal: ACP journal club 20080101

Title: Controversies in the antiphospholipid syndrome: can we ever stop warfarin?

Journal: Journal of autoimmune diseases 20080101

Title: New issues in oral anticoagulants.

Journal: Hematology. American Society of Hematology. Education Program 20080101

Title: Oral factor Xa inhibitors for venous thromboembolism prevention in major orthopedic surgery: a review.

Journal: Pathophysiology of haemostasis and thrombosis 20080101

Title: Effects of the oral, direct factor xa inhibitor rivaroxaban on platelet-induced thrombin generation and prothrombinase activity.

Journal: Journal of clinical pharmacology 20071101

Title: Development of oral anticoagulants.

Journal: British journal of clinical pharmacology 20070901

Title: Rivaroxaban. A novel, oral, direct factor Xa inhibitor in clinical development for the prevention and treatment of thromboembolic disorders.

Journal: Hamostaseologie 20070901

Title: Beyond unfractionated heparin and warfarin: current and future advances.

Journal: Circulation 20070731

Title: A replacement for warfarin: the search continues.

Journal: Circulation 20070710

Title: Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor rivaroxaban (BAY 59-7939): the ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in Patients With Acute Symptomatic Deep-Vein Thrombosis) study.

Journal: Circulation 20070710

Title: Ultrasound screening for asymptomatic deep vein thrombosis after major orthopaedic surgery: the VENUS study.

Journal: Journal of thrombosis and haemostasis : JTH 20070701

Title: Preclinical and clinical characteristics of rivaroxaban: a novel, oral, direct factor Xa inhibitor.

Journal: Seminars in thrombosis and hemostasis 20070701

Title: Oral, direct factor Xa inhibitors in development for the prevention and treatment of thromboembolic diseases.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20070601

Title: Rivaroxaban for thromboprophylaxis after orthopaedic surgery: pooled analysis of two studies.

Journal: Thrombosis and haemostasis 20070601

Title: Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban--an oral, direct factor xa inhibitor--in healthy subjects.

Journal: International journal of clinical pharmacology and therapeutics 20070601

Title: Rivaroxaban (BAY 59-7939)--an oral, direct Factor Xa inhibitor--has no clinically relevant interaction with naproxen.

Journal: British journal of clinical pharmacology 20070401

Title: Investigational treatments of venous thromboembolism.

Journal: Expert opinion on investigational drugs 20070401

Title: In vitro inhibition of thrombin generation, after tissue factor pathway activation, by the oral, direct factor Xa inhibitor rivaroxaban.

Journal: Journal of thrombosis and haemostasis : JTH 20070401

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20070401

Title: Prevention and treatment of experimental thrombosis in rabbits with rivaroxaban (BAY 597939)--an oral, direct factor Xa inhibitor.

Journal: Thrombosis and haemostasis 20070301

Title: Rivaroxaban.

Journal: Drugs of today (Barcelona, Spain : 1998) 20070301

Title: [New antitoagulants].

Journal: Annales pharmaceutiques francaises 20070301

Title: Drug evaluation: rivaroxaban, an oral, direct inhibitor of activated factor X.

Journal: Current opinion in investigational drugs (London, England : 2000) 20070301

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20070301

Title: Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects.

Journal: Journal of clinical pharmacology 20070201

Title: Dose-escalation study of rivaroxaban (BAY 59-7939)--an oral, direct Factor Xa inhibitor--for the prevention of venous thromboembolism in patients undergoing total hip replacement.

Journal: Thrombosis research 20070101

Title: Stroke in atrial fibrillation: update on pathophysiology, new antithrombotic therapies, and evolution of procedures and devices.

Journal: Annals of medicine 20070101

Title: Anithrombotic prevention in vascular disease: bases for a new strategy in antithrombotic therapy.

Journal: Thrombosis journal 20070101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20070101

Title: A once-daily, oral, direct Factor Xa inhibitor, rivaroxaban (BAY 59-7939), for thromboprophylaxis after total hip replacement.

Journal: Circulation 20061128

Title: The scientific community's quest to identify optimal targets for anticoagulant pharmacotherapy.

Journal: Circulation 20061128

Title: Safety, tolerability, pharmacodynamics, and pharmacokinetics of rivaroxaban--an oral, direct factor Xa inhibitor--are not affected by aspirin.

Journal: Journal of clinical pharmacology 20060901

Title: Novel factor Xa inhibitors for prevention and treatment of thromboembolic diseases.

Journal: Expert opinion on investigational drugs 20060801

Title: Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct factor Xa inhibitor, in healthy subjects.

Journal: Journal of clinical pharmacology 20060501

Title: [Haemostasis and antithrombotic drugs: pharmacology and novel therapeutic approaches].

Journal: Hamostaseologie 20060501

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20060401

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Journal: JAMA 20060215

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Journal: Journal of thrombosis and haemostasis : JTH 20060101

Title: Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939--an oral, direct Factor Xa inhibitor--after multiple dosing in healthy male subjects.

Journal: European journal of clinical pharmacology 20051201

Title: BAY 59-7939: an oral, direct factor Xa inhibitor for the prevention of venous thromboembolism in patients after total knee replacement. A phase II dose-ranging study.

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Title: Pharmacokinetics of BAY 59-7939--an oral, direct Factor Xa inhibitor--in rats and dogs.

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Tags:366789-02-8 Molecular Formula|366789-02-8 MDL|366789-02-8 SMILES|366789-02-8 5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide
Catalog No.: AA0035HT
366789-02-8,MFCD11974010
366789-02-8 | 5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide
Pack Size: 1mg
Purity: 98%
in stock
$6.00 $4.00
Pack Size: 5mg
Purity: 98%
in stock
$8.00 $6.00
Pack Size: 10mg
Purity: 98%
in stock
$11.00 $8.00
Pack Size: 50mg
Purity: 98%
in stock
$13.00 $9.00
Pack Size: 1g
Purity: 98%
in stock
$17.00 $12.00
Pack Size: 5g
Purity: 98%
in stock
$70.00 $49.00
Pack Size: 10g
Purity: 98%
in stock
$128.00 $90.00
Pack Size: 25g
Purity: 98%
in stock
$245.00 $171.00
Pack Size: 100g
Purity: 98%
in stock
$760.00 $532.00
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Technical Information
Catalog Number: AA0035HT
Chemical Name: 5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide
CAS Number: 366789-02-8
Molecular Formula: C19H18ClN3O5S
Molecular Weight: 435.8813
MDL Number: MFCD11974010
SMILES: O=C1O[C@H](CN1c1ccc(cc1)N1CCOCC1=O)CNC(=O)c1ccc(s1)Cl
Properties
BP: 732.6°C at 760 mmHg  
Form: Solid  
MP: 228-229°C  
Storage: Inert atmosphere;2-8℃;  
Complexity: 645  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 1  
Heavy Atom Count: 29  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 1  
Rotatable Bond Count: 5  
XLogP3: 2.5  
Downstream Synthesis Route
446292-10-0    42518-98-9    366789-02-8 

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Title: The king is dead (warfarin): direct thrombin and factor Xa inhibitors: the next Diadochian War?

Journal: International journal of stroke : official journal of the International Stroke Society20120201

Title: Determination of the anticoagulant effects of new oral anticoagulants: an unmet need.

Journal: Expert review of hematology20120201

Title: Rivaroxaban: a review of its use for the prophylaxis of venous thromboembolism after total hip or knee replacement surgery.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions20120201

Title: Direct thrombin inhibitors and factor Xa inhibitors in patients with cerebrovascular disease.

Journal: Expert review of neurotherapeutics20120201

Title: Active online assessment of patients using new oral anticoagulants: bleeding risk, compliance, and coagulation analysis.

Journal: Seminars in thrombosis and hemostasis20120201

Title: Prevention of VTE in orthopedic surgery patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Journal: Chest20120201

Title: Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Journal: Chest20120201

Title: Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.

Journal: Chest20120201

Title: [Expanded arsenal in atrial fibrillation: bye-bye marcumar?].

Journal: MMW Fortschritte der Medizin20120119

Title: Rivaroxaban reduced stroke and systemic embolism compared with warfarin in nonvalvular AF.

Journal: Annals of internal medicine20120117

Title: Rivaroxaban in patients with a recent acute coronary syndrome.

Journal: The New England journal of medicine20120105

Title: A new era in secondary prevention after acute coronary syndrome.

Journal: The New England journal of medicine20120105

Title: New anticoagulants - promising and failed developments.

Journal: British journal of pharmacology20120101

Title: Novel oral anticoagulants: new challenges for anesthesiologists in bleeding patients.

Journal: Anesthesiology20120101

Title: Optimisation of the assays for the measurement of clotting factor activity in the presence of rivaroxaban.

Journal: Thrombosis research20120101

Title: Evaluation of prothrombin complex concentrate and recombinant activated factor VII to reverse rivaroxaban in a rabbit model.

Journal: Anesthesiology20120101

Title: Concerns about studies investigating new anticoagulant drugs for stroke prevention in atrial fibrillation.

Journal: Journal of neurology20120101

Title: [Anticoagulation in atrial fibrillation: a new era has begun].

Journal: Hamostaseologie20120101

Title: [Anticoagulation for atrial fibrillation : the future has begun].

Journal: Der Internist20120101

Title: Meta-analysis of cause of death following total joint replacement using different thromboprophylaxis regimens.

Journal: The Journal of bone and joint surgery. British volume20120101

Title: [Apixaban: pharmacology and action profile].

Journal: Deutsche medizinische Wochenschrift (1946)20120101

Title: New frontiers for stroke prevention in atrial fibrillation.

Journal: Cerebrovascular diseases (Basel, Switzerland)20120101

Title: [Summary of the article: Patel MR, Mahaffey KW, Garg J et al. Rivaroxaban versus warfarin in nonvalvular atrial fibrillation. N Engl J Med, 2011; 365: 1557-1559].

Journal: Kardiologia polska20120101

Title: ARISTOTLE RE-LYs on the ROCKET. What's new in stroke prevention in patients with atrial fibrillation?

Journal: Cardiology journal20120101

Title: New antiplatelet and anticoagulant drugs.

Journal: General dentistry20120101

Title: Anticoagulation prophylaxis in orthopedic surgery: an efficiency frontier approach.

Journal: Postgraduate medicine20120101

Title: New oral antithrombotics: focus on dabigatran, an oral, reversible direct thrombin inhibitor for the prevention and treatment of venous and arterial thromboembolic disorders.

Journal: Vascular health and risk management20120101

Title: I recently heard that there are alternative medications to the blood thinner warfarin. What are they, and how are they different?

Journal: DukeMedicine healthnews20120101

Title: A new era for anticoagulation in atrial fibrillation. Which anticoagulant should we choose for long‑term prevention of thromboembolic complications in patients with atrial fibrillation?

Journal: Polskie Archiwum Medycyny Wewnetrznej20120101

Title: Newer anticoagulants in cardiovascular disease: a systematic review of the literature.

Journal: Cardiology in review20120101

Title: Upcoming oral factor Xa inhibitors for venous thromboembolism prophylaxis in patients undergoing major orthopedic surgery: rivaroxaban (Xarelto) and apixaban (Eliquis) review.

Journal: Connecticut medicine20120101

Title: Improving prevention and treatment of venous thromboembolism: clinical trial results.

Journal: Journal of medical economics20120101

Title: Evaluation of the prothrombin time for measuring rivaroxaban plasma concentrations using calibrators and controls: results of a multicenter field trial.

Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis20120101

Title: The WATCHMAN left atrial appendage closure device for atrial fibrillation.

Journal: Journal of visualized experiments : JoVE20120101

Title: Stroke Prevention in Atrial Fibrillation: Where are We Now?

Journal: Clinical Medicine Insights. Cardiology20120101

Title: Focused 2012 update of the Canadian Cardiovascular Society atrial fibrillation guidelines: recommendations for stroke prevention and rate/rhythm control.

Journal: The Canadian journal of cardiology20120101

Title: [Update on current care guidelines: atrial fibrillation].

Journal: Duodecim; laaketieteellinen aikakauskirja20120101

Title: Medical cost reductions associated with the usage of novel oral anticoagulants vs warfarin among atrial fibrillation patients, based on the RE-LY, ROCKET-AF, and ARISTOTLE trials.

Journal: Journal of medical economics20120101

Title: The Anticoagulation of Calf Thrombosis (ACT) project: study protocol for a randomized controlled trial.

Journal: Trials20120101

Title: Cost-effectiveness of rivaroxaban in the prevention of venous thromboembolism: A Canadian analysis using the Ontario Ministry of Health Perspective.

Journal: Journal of medical economics20120101

Title: Current status of new anticoagulants in the management of venous thromboembolism.

Journal: Advances in hematology20120101

Title: Costs and clinical consequences of suboptimal atrial fibrillation management.

Journal: ClinicoEconomics and outcomes research : CEOR20120101

Title: The Interface between Inflammation and Coagulation in Cardiovascular Disease.

Journal: International journal of inflammation20120101

Title: Efficacy and safety of venous thromboembolism prophylaxis with apixaban in major orthopedic surgery.

Journal: Therapeutics and clinical risk management20120101

Title: Oral anticoagulants. New oral anticoagulants for atrial fibrillation: the factor Xa inhibitors rivaroxaban and apixaban.

Journal: Reviews in cardiovascular medicine20120101

Title: The economic impact of enoxaparin versus unfractionated heparin for prevention of venous thromboembolism in acute ischemic stroke patients.

Journal: ClinicoEconomics and outcomes research : CEOR20120101

Title: Preventing stroke in atrial fibrillation patients - clinical utility of oral anticoagulants.

Journal: Journal of blood medicine20120101

Title: Anticoagulant and antiplatelet therapy in patients with atrial fibrillation and coronary artery disease.

Journal: Thrombosis20120101

Title: Acute-onset severe gastrointestinal tract hemorrhage in a postoperative patient taking rivaroxaban after total hip arthroplasty: a case report.

Journal: Journal of medical case reports20120101

Title: [New antithrombotic drugs].

Journal: Duodecim; laaketieteellinen aikakauskirja20120101

Title: Advances in the diagnosis and treatment of acute pulmonary embolism.

Journal: F1000 medicine reports20120101

Title: Reviewing the medical literature: five notable articles in general internal medicine from 2010 and 2011.

Journal: Open medicine : a peer-reviewed, independent, open-access journal20120101

Title: Therapeutic dosing of acenocoumarol: proposal of a population specific pharmacogenetic dosing algorithm and its validation in north Indians.

Journal: PloS one20120101

Title: Dabigatran for stroke prevention in nonvalvular atrial fibrillation: answers to challenging 'real-world' questions.

Journal: Thrombosis20120101

Title: Newer anticoagulants for the prevention of venous thromboembolism.

Journal: The National medical journal of India20120101

Title: Emerging anticoagulants.

Journal: Current medicinal chemistry20120101

Title: Dabigatran, rivaroxaban, or apixaban versus enoxaparin for thromboprophylaxis after total hip or knee replacement: systematic review, meta-analysis, and indirect treatment comparisons.

Journal: BMJ (Clinical research ed.)20120101

Title: Rationale and design of XAMOS: noninterventional study of rivaroxaban for prophylaxis of venous thromboembolism after major hip and knee surgery.

Journal: Vascular health and risk management20120101

Title: Health technology assessment and its role in the future development of the Indian healthcare sector.

Journal: Perspectives in clinical research20120101

Title: [Rivaroxaban in the prevention and treatment of thromboembolic disorders].

Journal: Hamostaseologie20120101

Title: [New anticoagulants: dabigatran, rivaroxaban and apixaban].

Journal: Gaceta medica de Mexico20120101

Title: An evidence-based review of apixaban and its potential in the prevention of stroke in patients with atrial fibrillation.

Journal: Core evidence20120101

Title: Emerging anticoagulant therapies for atrial fibrillation: new options, new challenges.

Journal: Current medicinal chemistry20120101

Title: Perioperative stroke risk in nonvascular surgery.

Journal: Cerebrovascular diseases (Basel, Switzerland)20120101

Title: Vitamin K antagonists. Ready to be replaced?

Journal: Hamostaseologie20120101

Title: Understanding the new emerging oral anticoagulants for venous thromboembolism prophylaxis.

Journal: Orthopedic nursing20120101

Title: Rivaroxaban in atrial fibrillation.

Journal: Vascular health and risk management20120101

Title: Prevention of stroke and systemic embolization in atrial fibrillation: a Canadian perspective.

Journal: Polskie Archiwum Medycyny Wewnetrznej20120101

Title: Stroke prevention in atrial fibrillation: understanding the new oral anticoagulants dabigatran, rivaroxaban, and apixaban.

Journal: Thrombosis20120101

Title: [New oral anticoagulants for atrial fibrillation: a neurologist's view].

Journal: Nederlands tijdschrift voor geneeskunde20120101

Title: Management of venous thromboembolism in patients with advanced gastrointestinal cancers: what is the role of novel oral anticoagulants?

Journal: Thrombosis20120101

Title: Thromboembolic prophylaxis in total joint arthroplasty.

Journal: Thrombosis20120101

Title: Coronary and mortality risk of novel oral antithrombotic agents: a meta-analysis of large randomised trials.

Journal: BMJ open20120101

Title: [Therapeutic approach to the bleeding in association with 'old' and 'new' anticoagulants].

Journal: Vnitrni lekarstvi20120101

Title: [Risk of bleeding and haemorrhagic complication with rivaroxaban--periprocedural management of haemostasis].

Journal: Hamostaseologie20120101

Title: Left atrial appendage exclusion for stroke prevention in atrial fibrillation.

Journal: Cardiology research and practice20120101

Title: Rationalizing tight ligand binding through cooperative interaction networks.

Journal: Journal of chemical information and modeling20111227

Title: Rivaroxaban versus warfarin in nonvalvular atrial fibrillation.

Journal: The New England journal of medicine20111215

Title: Rivaroxaban versus warfarin in nonvalvular atrial fibrillation.

Journal: The New England journal of medicine20111215

Title: Rivaroxaban versus warfarin in nonvalvular atrial fibrillation.

Journal: The New England journal of medicine20111215

Title: Rivaroxaban versus warfarin in nonvalvular atrial fibrillation.

Journal: The New England journal of medicine20111215

Title: Rivaroxaban (Xarelto) for acute coronary syndrome.

Journal: The Medical letter on drugs and therapeutics20111212

Title: Discovery of N-[2-hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide (darexaban, YM150) as a potent and orally available factor Xa inhibitor.

Journal: Journal of medicinal chemistry20111208

Title: Antiplatelet agents and anticoagulants for hypertension.

Journal: The Cochrane database of systematic reviews20111207

Title: Drugs in traffic: the road to approval.

Journal: Nature medicine20111206

Title: Effect of multiple doses of omeprazole on the pharmacokinetics, pharmacodynamics, and safety of a single dose of rivaroxaban.

Journal: Journal of cardiovascular pharmacology20111201

Title: New anticoagulants: moving on from scientific results to clinical implementation.

Journal: Annals of medicine20111201

Title: Determination of an international sensitivity index of thromboplastin reagents using a WHO thromboplastin as calibrator for plasma spiked with rivaroxaban.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis20111201

Title: Arterial antithrombotic activity of rivaroxaban, an orally active factor Xa inhibitor, in a rat electrolytic carotid artery injury model of thrombosis.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis20111201

Title: Intraarticular vs. extraarticular ropivacaine infusion following high-dose local infiltration analgesia after total knee arthroplasty: a randomized double-blind study.

Journal: Acta orthopaedica20111201

Title: [Stabilization of inter- and subtrochanteric femoral fractures with the PFNΑ®].

Journal: Operative Orthopadie und Traumatologie20111201

Title: Laboratory testing of anticoagulants: the present and the future.

Journal: Pathology20111201

Title: [Thrombosis prophylaxis in surgery. What is the evidence?].

Journal: Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen20111201

Title: Antithrombotic therapy in nonvalvular atrial fibrillation: a narrative review.

Journal: Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology20111201

Title: Role of pharmacogenomics in the management of traditional and novel oral anticoagulants.

Journal: Pharmacotherapy20111201

Title: [Pharmacologic heterogeneity of new anticoagulants].

Journal: Journal des maladies vasculaires20111201

Title: [New treatments for venous thromboembolic disease].

Journal: Journal des maladies vasculaires20111201

Title: [Secondary prevention of myocardial infarct. A new anticoagulant improves survival prospects].

Journal: MMW Fortschritte der Medizin20111201

Title: [Rivaroxaban is not inferior compared with warfarin as an anticoagulant in patients with non-valvular atrial fibrillation].

Journal: Praxis20111130

Title: Acute coronary syndromes: Rivaroxaban reduces serious CV events without increasing fatal bleeding in patients with a recent ACS.

Journal: Nature reviews. Cardiology20111129

Title: FDA advisory decision highlights some problems inherent in pragmatic trials.

Journal: JAMA20111102

Title: Bleeding, vertebral fractures and vascular calcifications in patients treated with warfarin: hope for lower risks with alternative therapies.

Journal: Current vascular pharmacology20111101

Title: Comparison of unfractionated heparin, low-molecular-weight heparin, low-dose and high-dose rivaroxaban in preventing thrombus formation on mechanical heart valves: results of an in vitro study.

Journal: Journal of thrombosis and thrombolysis20111101

Title: Rationale and current perspective for early rhythm control therapy in atrial fibrillation.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology20111101

Title: Interference of rivaroxaban in one-stage and chromogenic factor VIII:C assays.

Journal: Thrombosis and haemostasis20111101

Title: [New anticoagulants. Characteristics, monitoring and management of bleeding].

Journal: Medizinische Klinik, Intensivmedizin und Notfallmedizin20111101

Title: A study of thromboprophylactic practices of Scottish orthopaedic surgeons in patients undergoing total hip replacements. Should practice change with new guidelines?

Journal: Scottish medical journal20111101

Title: [Effect of rivaroxaban on risk of bleeding after total knee arthroplasty].

Journal: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery20111101

Title: [Current status and future of anti-Xa inhibitors].

Journal: Rinsho shinkeigaku = Clinical neurology20111101

Title: [New anticoagulants].

Journal: La Revue du praticien20111101

Title: Evaluating rivaroxaban for nonvalvular atrial fibrillation--regulatory considerations.

Journal: The New England journal of medicine20111027

Title: Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects.

Journal: Circulation20111004

Title: Reversal of new oral anticoagulants.

Journal: Circulation20111004

Title: Oral rivaroxaban for acute DVT, or long term for VTE, is as effective as enoxaparin followed by a vitamin K antagonist for preventing recurrence, with no increase in bleeding complications.

Journal: Evidence-based medicine20111001

Title: Inhibitors of propagation of coagulation: factors V and X.

Journal: British journal of clinical pharmacology20111001

Title: A role for coagulation factor Xa in experimental pulmonary arterial hypertension.

Journal: Cardiovascular research20111001

Title: New anticoagulants: how to deal with treatment failure and bleeding complications.

Journal: British journal of clinical pharmacology20111001

Title: Impact of venous thromboembolism on clinical management and therapy after hip and knee arthroplasty.

Journal: Canadian journal of surgery. Journal canadien de chirurgie20111001

Title: Effect of rivaroxaban, in contrast to heparin, is similar in neonatal and adult plasma.

Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis20111001

Title: Determination of rivaroxaban by different factor Xa specific chromogenic substrate assays: reduction of interassay variability.

Journal: Journal of thrombosis and thrombolysis20111001

Title: Anticoagulating obese patients in the modern era.

Journal: British journal of haematology20111001

Title: Prevention of stroke and systemic embolism with rivaroxaban compared with warfarin in patients with non-valvular atrial fibrillation and moderate renal impairment.

Journal: European heart journal20111001

Title: RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome.

Journal: European heart journal20111001

Title: Rivaroxaban: population pharmacokinetic analyses in patients treated for acute deep-vein thrombosis and exposure simulations in patients with atrial fibrillation treated for stroke prevention.

Journal: Clinical pharmacokinetics20111001

Title: New and emerging anticoagulant therapy for atrial fibrillation and acute coronary syndrome.

Journal: Pharmacotherapy20111001

Title: Novel oral anticoagulants for VTE prevention in orthopedic surgery: overview of phase 3 trials.

Journal: Orthopedics20111001

Title: Cost-effectiveness of rivaroxaban versus heparins for prevention of venous thromboembolism after total hip or knee surgery in Sweden.

Journal: Expert review of pharmacoeconomics & outcomes research20111001

Title: Dutch guideline on total hip prosthesis.

Journal: Acta orthopaedica20111001

Title: The new oral anticoagulants.

Journal: Clinical medicine (London, England)20111001

Title: Xarelto: a new drug for new joints. Hip and knee recipients can avoid postsurgical clots without undergoing painful injections.

Journal: The Johns Hopkins medical letter health after 5020111001

Title: [New antithrombotic drugs for the treatment of venous thromboembolism].

Journal: Revue des maladies respiratoires20111001

Title: [Atrial fibrillation: what the GP needs to know].

Journal: MMW Fortschritte der Medizin20110922

Title: [Modern risk assessment and stroke prevention in atrial fibrillation].

Journal: Praxis20110921

Title: A new era for anticoagulation in atrial fibrillation.

Journal: The New England journal of medicine20110915

Title: Rivaroxaban versus warfarin in nonvalvular atrial fibrillation.

Journal: The New England journal of medicine20110908

Title: New options in anticoagulation for atrial fibrillation.

Journal: The New England journal of medicine20110908

Title: Safety and efficacy of rivaroxaban for thromboprophylaxis following lower limb surgery: an update.

Journal: Expert opinion on drug safety20110901

Title: Emerging options in the treatment of deep vein thrombosis and pulmonary embolism.

Journal: Blood reviews20110901

Title: Prevention of venous thromboembolism after major orthopedic surgery: indirect comparison of three new oral anticoagulants.

Journal: Journal of thrombosis and haemostasis : JTH20110901

Title: Direct inhibitors of thrombin and factor Xa attenuate clot-induced mitogenesis and inflammatory gene expression in human vascular smooth muscle cells.

Journal: Thrombosis and haemostasis20110901

Title: Update on anti-coagulation in atrial fibrillation.

Journal: QJM : monthly journal of the Association of Physicians20110901

Title: [Thromboembolic prophylaxis 2011: is warfarin on the wane?].

Journal: Giornale italiano di cardiologia (2006)20110901

Title: Rivaroxaban: direct factor Xa inhibition to treat acute deep vein thrombosis.

Journal: British journal of hospital medicine (London, England : 2005)20110901

Title: Direct thrombin inhibitors for the treatment of venous thromboembolism: analysis of the Dabigatran versus Warfarin clinical trial.

Journal: Seminars in vascular surgery20110901

Title: Rivaroxaban (Xarelto)--a new oral anticoagulant.

Journal: The Medical letter on drugs and therapeutics20110822

Title: New antithrombotic drugs and European approval processes.

Journal: Lancet (London, England)20110820

Title: Oral direct factor Xa inhibitor gets FDA's OK.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists20110815

Title: Polysulfated xanthones: multipathway development of a new generation of dual anticoagulant/antiplatelet agents.

Journal: Journal of medicinal chemistry20110811

Title: [The new Anticoagulants - Relevant Facts for the GP].

Journal: Praxis20110810

Title: [Rivaroxaban as therapy of deep venous thrombosis equally as effective as current anticoagulation with heparin and vitamin K antagonist].

Journal: Praxis20110810

Title: ['Xa-tra-xa': opportunities and open questions about new anticoagulants].

Journal: Praxis20110810

Title: Novel oral anticoagulants: focus on stroke prevention and treatment of venous thrombo-embolism.

Journal: European heart journal20110801

Title: Incidence of chronic kidney disease in patients with atrial fibrillation and its relevance for prescribing new oral antithrombotic drugs.

Journal: Journal of thrombosis and haemostasis : JTH20110801

Title: New anticoagulants for prevention of stroke in patients with atrial fibrillation.

Journal: Journal of cardiovascular electrophysiology20110801

Title: Detection of lupus anticoagulant in the presence of rivaroxaban using Taipan snake venom time.

Journal: Journal of thrombosis and haemostasis : JTH20110801

Title: Role of emerging antithrombotic therapy in the prevention of cardioembolic complications in patients with atrial fibrillation.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions20110801

Title: New oral anticoagulants for venous thromboembolism (VTE) prophylaxis.

Journal: The Medical journal of Malaysia20110801

Title: Novel oral anticoagulants in development: Dabigatran, Rivaroxaban, and Apixaban.

Journal: American journal of therapeutics20110701

Title: In vitro and in vivo P-glycoprotein transport characteristics of rivaroxaban.

Journal: The Journal of pharmacology and experimental therapeutics20110701

Title: Clinical trials of direct thrombin and factor Xa inhibitors in atrial fibrillation.

Journal: Current opinion in cardiology20110701

Title: Rivaroxaban differentially influences ex vivo global coagulation assays based on the administration time.

Journal: Thrombosis and haemostasis20110701

Title: Response to 'Role of orally available antagonists of factor Xa in the treatment and prevention of thromboembolic disease: focus on rivaroxaban'.

Journal: Journal of clinical pharmacology20110701

Title: Practical aspects of the oral new anticoagulants.

Journal: American journal of hematology20110701

Title: Treatment of risk factors to prevent stroke.

Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics20110701

Title: Optimal duration of anticoagulation in patients with venous thromboembolism.

Journal: The Indian journal of medical research20110701

Title: Oral rivaroxaban after symptomatic venous thromboembolism: the continued treatment study (EINSTEIN-extension study).

Journal: Expert review of cardiovascular therapy20110701

Title: [New anticoagulants in the prevention and treatment of venous thromboembolism].

Journal: Orvosi hetilap20110619

Title: The mechanism of action of rivaroxaban--an oral, direct Factor Xa inhibitor--compared with other anticoagulants.

Journal: Thrombosis research20110601

Title: Atrial fibrillation and percutaneous coronary intervention: stroke, thrombosis, and bleeding.

Journal: Current treatment options in cardiovascular medicine20110601

Title: Treating arrhythmias: an expert opinion.

Journal: Expert opinion on pharmacotherapy20110601

Title: A systematic review of rivaroxaban versus enoxaparin in the prevention of venous thromboembolism after hip or knee replacement.

Journal: Thrombosis research20110601

Title: Rivaroxaban in the contemporary treatment of acute coronary syndromes.

Journal: Expert opinion on investigational drugs20110601

Title: Review of an article: oral rivaroxaban for symptomatic venous thromboembolism. The EINSTEIN Investigators et al. N Engl J Med 2010; 363(26):2499-2510.

Journal: Journal of vascular nursing : official publication of the Society for Peripheral Vascular Nursing20110601

Title: Prophylaxis of venous thromboembolism: low molecular weight heparin compared to the selective anticoagulants rivaroxaban, dabigatran and fondaparinux.

Journal: International angiology : a journal of the International Union of Angiology20110601

Title: Economic impact of venous thromboembolism after hip and knee arthroplasty: potential impact of rivaroxaban.

Journal: Expert review of pharmacoeconomics & outcomes research20110601

Title: 4-(3-Fluoro-4-nitro-phen-yl)morpholin-3-one.

Journal: Acta crystallographica. Section E, Structure reports online20110601

Title: [Is the era from the end of warfarin?].

Journal: Medizinische Monatsschrift fur Pharmazeuten20110601

Title: ACP journal club. Rivaroxaban was noninferior to enoxaparin for preventing short-term recurrent VTE and superior to placebo in continued treatment.

Journal: Annals of internal medicine20110517

Title: Update on pharmacologic approaches to prevent thromboembolism in atrial fibrillation: are thrombin and factor Xa inhibitors the ultimate answer?

Journal: Current vascular pharmacology20110501

Title: Is there evidence to support the use of direct Factor Xa inhibitors in coronary artery disease?

Journal: Reviews on recent clinical trials20110501

Title: Coagulation parameters in patients receiving dabigatran etexilate or rivaroxaban: two observational studies in patients undergoing total hip or total knee replacement.

Journal: Thrombosis research20110501

Title: Laboratory assessment of new anticoagulants.

Journal: Clinical chemistry and laboratory medicine20110501

Title: Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor.

Journal: Journal of thrombosis and thrombolysis20110501

Title: Extended-duration rivaroxaban thromboprophylaxis in acutely ill medical patients: MAGELLAN study protocol.

Journal: Journal of thrombosis and thrombolysis20110501

Title: Risk-benefit ratio assessment for stroke prevention in intermediate risk atrial fibrillation patients: will TEE-based aspirin treatment fill the gap?

Journal: Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation20110501

Title: Rationale and design of the Anti-Xa therapy to lower cardiovascular events in addition to standard therapy in subjects with acute coronary syndrome-thrombolysis in myocardial infarction 51 (ATLAS-ACS 2 TIMI 51) trial: a randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of rivaroxaban in subjects with acute coronary syndrome.

Journal: American heart journal20110501

Title: [New oral anticoagulant drugs: dabigatran, rivaroxaban and apixaban. Present and future].

Journal: Medecine sciences : M/S20110501

Title: Advances in cardiology: clinical trial update.

Journal: Future cardiology20110501

Title: [The new anticoagulants].

Journal: Harefuah20110501

Title: [Current and future therapies for prophylaxis of thromboembolism in atrial fibrillation].

Journal: MMW Fortschritte der Medizin20110414

Title: Coagulation-induced shedding of platelet glycoprotein VI mediated by factor Xa.

Journal: Blood20110407

Title: A phase I open-label study evaluating the cardiovascular safety of sorafenib in patients with advanced cancer.

Journal: Cancer chemotherapy and pharmacology20110401

Title: The potential role of new oral anticoagulants in the prevention and treatment of thromboembolism.

Journal: Pharmacology & therapeutics20110401

Title: Measuring the anticoagulant effect of direct factor Xa inhibitors. Is the anti-Xa assay preferable to the prothrombin time test?

Journal: Thrombosis and haemostasis20110401

Title: What do the RE-LY, AVERROES and ROCKET-AF trials tell us for stroke prevention in atrial fibrillation?

Journal: Thrombosis and haemostasis20110401

Title: New oral anticoagulants.

Journal: Journal of thrombosis and thrombolysis20110401

Title: Drug and dietary interactions of warfarin and novel oral anticoagulants: an update.

Journal: Journal of thrombosis and thrombolysis20110401

Title: Investigational factor Xa inhibitors for thrombosis and acute coronary syndromes.

Journal: Expert opinion on investigational drugs20110401

Title: Clinical trials update from the American Heart Association meeting 2010: EMPHASIS-HF, RAFT, TIM-HF, Tele-HF, ASCEND-HF, ROCKET-AF, and PROTECT.

Journal: European journal of heart failure20110401

Title: Preventing postsurgical venous thromboembolism: pharmacological approaches.

Journal: Seminars in thrombosis and hemostasis20110401

Title: Oral rivaroxaban for symptomatic venous thromboembolism.

Journal: The New England journal of medicine20110324

Title: Rivaroxaban for the prevention of venous thromboembolism after hip or knee arthroplasty. Pooled analysis of four studies.

Journal: Thrombosis and haemostasis20110301

Title: Italian intersociety consensus statement on antithrombotic prophylaxis in hip and knee replacement and in femoral neck fracture surgery.

Journal: Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology20110301

Title: Changing anticoagulant paradigms for atrial fibrillation: dabigatran, apixaban and rivaroxaban.

Journal: Expert opinion on pharmacotherapy20110301

Title: Old and new anticoagulant drugs: a minireview.

Journal: Annals of medicine20110301

Title: Use of low-molecular-weight heparins and new anticoagulants in elderly patients with renal impairment.

Journal: Drugs & aging20110301

Title: Evaluation of drug-induced serious hepatotoxicity (eDISH): application of this data organization approach to phase III clinical trials of rivaroxaban after total hip or knee replacement surgery.

Journal: Drug safety20110301

Title: The discovery and development of rivaroxaban.

Journal: Annals of the New York Academy of Sciences20110301

Title: Pharmacokinetics and pharmacodynamics of rivaroxaban and its effect on biomarkers of hypercoagulability in patients with chronic heart failure.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation20110201

Title: Rivaroxaban and false positive lupus anticoagulant testing.

Journal: Thrombosis and haemostasis20110201

Title: New anticoagulant agents in acute coronary syndromes.

Journal: Heart (British Cardiac Society)20110201

Title: Dabigatran and rivaroxaban for prevention of venous thromboembolism--systematic review and adjusted indirect comparison.

Journal: Journal of clinical pharmacy and therapeutics20110201

Title: Novel anticoagulants: a discussion of clinical use in the treatment and prevention of venous thromboembolism.

Journal: Phlebology20110201

Title: [New oral anticoagulants in atrial fibrillation].

Journal: Der Nervenarzt20110201

Title: Association of warfarin use with valvular and vascular calcification: a review.

Journal: Clinical cardiology20110201

Title: Old and new anticoagulants.

Journal: Hamostaseologie20110201

Title: New anticoagulants: pharmacology and clinical studies.

Journal: Wiener medizinische Wochenschrift (1946)20110201

Title: Direct thrombin and factor Xa inhibitors in children: a quest for new anticoagulants for children.

Journal: Wiener medizinische Wochenschrift (1946)20110201

Title: New oral anticoagulants and outpatient prophylaxis of venous thromboembolism.

Journal: The American journal of managed care20110201

Title: Cost-effectiveness of rivaroxaban after total hip or total knee arthroplasty.

Journal: The American journal of managed care20110201

Title: Characteristics of novel anticoagulants and potential economic implications.

Journal: The American journal of managed care20110201

Title: Venous thromboembolism after total hip arthroplasty and total knee arthroplasty: current and future perspectives. Epilogue.

Journal: The American journal of managed care20110201

Title: Venous thromboembolism after total hip arthroplasty and total knee arthroplasty: current and future perspectives.

Journal: The American journal of managed care20110201

Title: New oral anticoagulants for thromboprophylaxis in patients having hip or knee arthroplasty.

Journal: BMJ (Clinical research ed.)20110118

Title: New alternative to warfarin may help reduce stroke risk in patients with AF.

Journal: JAMA20110105

Title: The International Normalized Ratio calibrated for rivaroxaban has the potential to normalize prothrombin time results for rivaroxaban-treated patients: results of an in vitro study.

Journal: Journal of thrombosis and haemostasis : JTH20110101

Title: Effects of the oral, direct factor Xa inhibitor rivaroxaban on commonly used coagulation assays.

Journal: Journal of thrombosis and haemostasis : JTH20110101

Title: Combination of a two-step fluorescence assay and a two-step anti-Factor Xa assay for detection of heparin falsifications and protein in heparins.

Journal: Analytical and bioanalytical chemistry20110101

Title: Novel anticoagulants: new evidence for emerging drugs and their potential application in major lower limb surgery.

Journal: Current vascular pharmacology20110101

Title: The discovery and development of rivaroxaban, an oral, direct factor Xa inhibitor.

Journal: Nature reviews. Drug discovery20110101

Title: Factor Xa and thrombin as targets for new oral anticoagulants.

Journal: Thrombosis research20110101

Title: Return to theatre following total hip and knee replacement, before and after the introduction of rivaroxaban: a retrospective cohort study.

Journal: The Journal of bone and joint surgery. British volume20110101

Title: Novel oral factor Xa and thrombin inhibitors in the management of thromboembolism.

Journal: Annual review of medicine20110101

Title: New oral anticoagulants: should they replace heparins and warfarin?

Journal: Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese20110101

Title: An indirect comparison, via enoxaparin, of rivaroxaban with dabigatran in the prevention of venous thromboembolism after hip or knee replacement.

Journal: Journal of medical economics20110101

Title: Cardiac crossroads: deciding between mechanical or bioprosthetic heart valve replacement.

Journal: Patient preference and adherence20110101

Title: [Perioperative venous thromboembolism prophylaxis].

Journal: La Revue du praticien20110101

Title: Heparin-induced thrombocytopenia in the ICU: an overview.

Journal: Critical care (London, England)20110101

Title: The pathology and treatment of cardiac arrhythmias: focus on atrial fibrillation.

Journal: Vascular health and risk management20110101

Title: Evaluation of the efficacy and safety of rivaroxaban using a computer model for blood coagulation.

Journal: PloS one20110101

Title: New oral anticoagulants for venous thromboembolism prophylaxis in orthopaedic surgery.

Journal: Instructional course lectures20110101

Title: Left Atrial Appendage Closure in Atrial Fibrillation: A World without Anticoagulation?

Journal: Cardiology research and practice20110101

Title: Study protocol: the DESPATCH study: delivering stroke prevention for patients with atrial fibrillation - a cluster randomised controlled trial in primary healthcare.

Journal: Implementation science : IS20110101

Title: [Drug prevention of pulmonary embolism in orthopedic practice: traditional and novel approaches].

Journal: Kardiologiia20110101

Title: Performance of stroke risk scores in older people with atrial fibrillation not taking warfarin: comparative cohort study from BAFTA trial.

Journal: BMJ (Clinical research ed.)20110101

Title: Evaluation of plaque stability of advanced atherosclerotic lesions in apo E-deficient mice after treatment with the oral factor Xa inhibitor rivaroxaban.

Journal: Mediators of inflammation20110101

Title: Battle of oral anticoagulants in the field of atrial fibrillation scrutinized from a clinical practice (the real world) perspective.

Journal: Thrombosis journal20110101

Title: Therapeutic potential of rivaroxaban in the prevention of venous thromboembolism following hip and knee replacement surgery: a review of clinical trial data.

Journal: Vascular health and risk management20110101

Title: Antithrombotic medication for cardioembolic stroke prevention.

Journal: Stroke research and treatment20110101

Title: Comparison of pharmacist managed anticoagulation with usual medical care in a family medicine clinic.

Journal: BMC family practice20110101

Title: Strategies for diagnosis and prevention of venous thromboembolism during pregnancy.

Journal: Journal of pregnancy20110101

Title: FDA approves rivaroxaban for prevention of deep-vein thrombosis in surgery.

Journal: Cardiovascular journal of Africa20110101

Title: Evaluation of marine brown algae and sponges from Brazil as anticoagulant and antiplatelet products.

Journal: Marine drugs20110101

Title: Anesthesia for joint replacement surgery: Issues with coexisting diseases.

Journal: Journal of anaesthesiology, clinical pharmacology20110101

Title: Tissue factor, blood coagulation, and beyond: an overview.

Journal: International journal of inflammation20110101

Title: Prophylaxis for deep vein thrombosis and pulmonary embolism in the surgical patient.

Journal: Advances in surgery20110101

Title: [The new oral anticoagulants in surgery].

Journal: Revista medica del Instituto Mexicano del Seguro Social20110101

Title: European Society of Cardiology congress 2011.

Journal: Cardiovascular journal of Africa20110101

Title: Role of factor xa inhibitors in cancer-associated thrombosis: any new data?

Journal: Advances in hematology20110101

Title: Cost and outcomes associated with rivaroxaban vs enoxaparin for the prevention of postsurgical venous thromboembolism from a US payer's perspective.

Journal: Journal of medical economics20110101

Title: Emerging therapies for acute coronary syndromes.

Journal: Frontiers in pharmacology20110101

Title: The effect of a new direct Factor Xa inhibitor on human osteoblasts: an in-vitro study comparing the effect of rivaroxaban with enoxaparin.

Journal: BMC musculoskeletal disorders20110101

Title: Dabigatran etexilate versus warfarin in management of non-valvular atrial fibrillation in UK context: quantitative benefit-harm and economic analyses.

Journal: BMJ (Clinical research ed.)20110101

Title: Rivaroxaban, ticagrelor, and fidaxomicin.

Journal: Journal of the American Pharmacists Association : JAPhA20110101

Title: Urinary Prothrombin Fragment 1+2 in relation to Development of Non-Symptomatic and Symptomatic Venous Thromboembolic Events following Total Knee Replacement.

Journal: Thrombosis20110101

Title: Venous thromboembolism: classification, risk factors, diagnosis, and management.

Journal: ISRN hematology20110101

Title: Preoperative versus postoperative initiation of thromboprophylaxis following major orthopedic surgery: safety and efficacy of postoperative administration supported by recent trials of new oral anticoagulants.

Journal: Thrombosis journal20110101

Title: Anticoagulants and the propagation phase of thrombin generation.

Journal: PloS one20110101

Title: Gene-drug interaction in stroke.

Journal: Stroke research and treatment20110101

Title: Raft of rivaroxaban good news from the USA, implications for South African clinical practice.

Journal: Cardiovascular journal of Africa20110101

Title: Oral fondaparinux: use of lipid nanocapsules as nanocarriers and in vivo pharmacokinetic study.

Journal: International journal of nanomedicine20110101

Title: Cardiac arrest caused by multiple recurrent pulmonary embolism.

Journal: Case reports in medicine20110101

Title: Pharmacological basis and clinical evidence of dabigatran therapy.

Journal: Journal of hematology & oncology20110101

Title: The case for an elderly targeted stroke management.

Journal: Frontiers in neurology20110101

Title: Oral thromboprophylaxis following total hip or knee replacement: review and multicentre experience with dabigatran etexilate.

Journal: The open orthopaedics journal20110101

Title: Deep vein thrombosis: a clinical review.

Journal: Journal of blood medicine20110101

Title: Oral rivaroxaban for symptomatic venous thromboembolism.

Journal: The New England journal of medicine20101223

Title: Therapeutic potential of oral factor Xa inhibitors.

Journal: The New England journal of medicine20101223

Title: Engineered thrombin aims to take on heparin.

Journal: Chemistry & biology20101222

Title: Novel anticoagulants for stroke prevention in atrial fibrillation: current clinical evidence and future developments.

Journal: Journal of the American College of Cardiology20101214

Title: [Rivaroxaban at least as effective as marcumar in stroke prevention].

Journal: MMW Fortschritte der Medizin20101202

Title: [New oral anticoagulants: better than vitamin K antagonists?].

Journal: Der Internist20101201

Title: Assays for measuring rivaroxaban: their suitability and limitations.

Journal: Therapeutic drug monitoring20101201

Title: The new oral anticoagulants, do they change the benefit vs. risk for thromboprophylaxis in association to ambulatory surgery?

Journal: Current opinion in anaesthesiology20101201

Title: The impact of elective knee/hip replacement surgery and thromboprophylaxis with rivaroxaban or dalteparin on thrombin generation.

Journal: British journal of haematology20101201

Title: Clinical laboratory measurement of direct factor Xa inhibitors: anti-Xa assay is preferable to prothrombin time assay.

Journal: Thrombosis and haemostasis20101201

Title: New synthetic antithrombotic agents for venous thromboembolism: pentasaccharides, direct thrombin inhibitors, direct Xa inhibitors.

Journal: Clinics in chest medicine20101201

Title: Recurrent venous thrombosis despite 'optimal anticoagulation therapy' for antiphospholipid syndrome--could new oral anticoagulants solve the problem?

Journal: Acta clinica Croatica20101201

Title: Clinical pharmacology of direct and indirect factor Xa inhibitors.

Journal: Drugs20101112

Title: Is there adequate provision of venous thromboembolism prophylaxis following hip arthroplasty? An audit and international survey.

Journal: Annals of the Royal College of Surgeons of England20101101

Title: An optimised, rapid chromogenic assay, specific for measuring direct factor Xa inhibitors (rivaroxaban) in plasma.

Journal: Thrombosis and haemostasis20101101

Title: Rivaroxaban versus enoxaparin for thromboprophylaxis after total hip or knee arthroplasty: a meta-analysis of randomized controlled trials.

Journal: European journal of clinical pharmacology20101101

Title: Enoxaparin versus dabigatran or rivaroxaban for thromboprophylaxis after hip or knee arthroplasty: Results of separate pooled analyses of phase III multicenter randomized trials.

Journal: Circulation. Cardiovascular quality and outcomes20101101

Title: Blood transfusion and the anaesthetist: management of massive haemorrhage.

Journal: Anaesthesia20101101

Title: [Prophylaxis of thrombembolic diseases with rivaroxaban].

Journal: Deutsche medizinische Wochenschrift (1946)20101101

Title: Effects of renal impairment on the pharmacokinetics, pharmacodynamics and safety of rivaroxaban, an oral, direct Factor Xa inhibitor.

Journal: British journal of clinical pharmacology20101101

Title: Korean guidelines for the prevention of venous thromboembolism.

Journal: Journal of Korean medical science20101101

Title: [Novel anticoagulants for stroke prevention in atrial fibrillation].

Journal: Deutsche medizinische Wochenschrift (1946)20101101

Title: [New oral anticoagulants from the perspective of trauma surgery].

Journal: Der Unfallchirurg20101101

Title: [Thromboembolism prophylaxis in trauma surgery: S3 guidelines and significance of the amendment for trauma surgeons].

Journal: Der Unfallchirurg20101101

Title: [Recommendations for the administration of conventional and new antithrombotic agents from the perspective of anesthesiology].

Journal: Der Unfallchirurg20101101

Title: [Two new anticoagulants available in 2010--Dabigatran Etexilate and Rivaroxaban: expected progresses--raised problems].

Journal: Annales pharmaceutiques francaises20101101

Title: [New study findings in cardiology. The best is the enemy of the good].

Journal: Medizinische Monatsschrift fur Pharmazeuten20101101

Title: New options for stroke prevention in atrial fibrillation.

Journal: The American journal of managed care20101101

Title: Rivaroxaban: a novel anticoagulant.

Journal: Indian journal of medical sciences20101101

Title: New antithrombotics for atrial fibrillation.

Journal: Cardiovascular therapeutics20101001

Title: Emerging antithrombotic agents: what does the intensivist need to know?

Journal: Current opinion in critical care20101001

Title: Cost-effectiveness of rivaroxaban versus enoxaparin for the prevention of postsurgical venous thromboembolism in Canada.

Journal: Thrombosis and haemostasis20101001

Title: Low risk of thromboembolic complications after fast-track hip and knee arthroplasty.

Journal: Acta orthopaedica20101001

Title: Rivaroxaban for thromboembolism prophylaxis after orthopaedic surgery.

Journal: Anaesthesia20101001

Title: Factor Xa inhibitors: next-generation antithrombotic agents.

Journal: Journal of medicinal chemistry20100909

Title: Role of orally available antagonists of factor Xa in the treatment and prevention of thromboembolic disease: focus on rivaroxaban.

Journal: Journal of clinical pharmacology20100901

Title: [Oral prevention of thromboembolism with rivaroxaban and dabigatran: are the newly approved drugs innovations in orthopaedic and trauma surgery? ].

Journal: Zeitschrift fur Orthopadie und Unfallchirurgie20100901

Title: New antithrombotic agents--insights from clinical trials.

Journal: Nature reviews. Cardiology20100901

Title: Novel oral anticoagulants: implications in the perioperative setting.

Journal: Anesthesiology20100901

Title: [Rivaroxaban and factor Xa inhibitors in clinical practice].

Journal: Vnitrni lekarstvi20100901

Title: Antithrombotic and anticoagulant profiles of TAK-442, a novel factor Xa inhibitor, in a rabbit model of venous thrombosis.

Journal: Journal of cardiovascular pharmacology20100801

Title: Anticoagulation by factor Xa inhibitors.

Journal: Journal of thrombosis and haemostasis : JTH20100801

Title: Apixaban, a direct factor Xa inhibitor, inhibits tissue-factor induced human platelet aggregation in vitro: comparison with direct inhibitors of factor VIIa, XIa and thrombin.

Journal: Thrombosis and haemostasis20100801

Title: Treatment of thromboembolism in cancer patients.

Journal: Expert opinion on pharmacotherapy20100801

Title: Oral Xa inhibitors.

Journal: Hematology/oncology clinics of North America20100801

Title: [Do orally active factor Xa (FXa) inhibitors have potential as innovative new anticoagulants? Future perspective from preclinical data].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica20100801

Title: Oral factor Xa inhibitors for the prevention of stroke in atrial fibrillation.

Journal: Current opinion in cardiology20100701

Title: New oral anticoagulant drugs in cardiovascular disease.

Journal: Thrombosis and haemostasis20100701

Title: Clot prevention--common questions about medications.

Journal: Australian family physician20100701

Title: [A new deal with new anticoagulants?].

Journal: Journal des maladies vasculaires20100601

Title: Old versus new anticoagulants: focus on pharmacology.

Journal: Recent patents on cardiovascular drug discovery20100601

Title: Anesthetic concerns for patients with coagulopathy.

Journal: Current opinion in anaesthesiology20100601

Title: Rivaroxaban for thromboprophylaxis in patients undergoing major orthopedic surgery.

Journal: The Annals of pharmacotherapy20100601

Title: Rivaroxaban for thromboembolism prophylaxis after orthopaedic surgery.

Journal: Anaesthesia20100601

Title: Drug and dietary interactions of the new and emerging oral anticoagulants.

Journal: International journal of clinical practice20100601

Title: Novel oral anticoagulants. Part II: direct thrombin inhibitors.

Journal: Expert review of hematology20100601

Title: [New oral anticoagulants: prospects].

Journal: La Revue du praticien20100520

Title: Emerging anticoagulants for venous thromboembolism prevention.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists20100515

Title: New anticoagulants for prevention and treatment of venous thromboembolism.

Journal: Current vascular pharmacology20100501

Title: Rivaroxaban and dabigatran etexilate: two new oral anticoagulants for extended postoperative prevention of venous thromboembolism after elective total hip arthroplasty.

Journal: Archives of orthopaedic and trauma surgery20100501

Title: New and emerging antiarrhythmic and anticoagulant agents for atrial fibrillation.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists20100501

Title: Primary prevention of venous thromboembolism in medical and surgical oncology patients.

Journal: British journal of cancer20100413

Title: Assessment of laboratory assays to measure rivaroxaban--an oral, direct factor Xa inhibitor.

Journal: Thrombosis and haemostasis20100401

Title: Facts and artefacts of coagulation assays for factor Xa inhibitors.

Journal: Thrombosis and haemostasis20100401

Title: Antithrombotic treatment failures in antiphospholipid syndrome: the new anticoagulants?

Journal: Lupus20100401

Title: Rivaroxaban vs dabigatran for thromboprophylaxis after joint-replacement surgery: exploratory indirect comparison based on meta-analysis of pivotal clinical trials.

Journal: Croatian medical journal20100401

Title: VTE prophylaxis for the medical patient: where do we stand? - a focus on cancer patients.

Journal: Thrombosis research20100401

Title: Potential of new anticoagulants in patients with cancer.

Journal: Thrombosis research20100401

Title: Novel oral anticoagulants for prophylaxis and treatment of venous thromboembolism: part I (Factor Xa inhibitors).

Journal: Expert review of hematology20100401

Title: Comparative efficacy and safety of the novel oral anticoagulants dabigatran, rivaroxaban and apixaban in preclinical and clinical development.

Journal: Thrombosis and haemostasis20100301

Title: DVT: a new era in anticoagulant therapy.

Journal: Arteriosclerosis, thrombosis, and vascular biology20100301

Title: Rivaroxaban: a new oral factor Xa inhibitor.

Journal: Arteriosclerosis, thrombosis, and vascular biology20100301

Title: Antithrombotic drugs for patients with ischaemic stroke and transient ischaemic attack to prevent recurrent major vascular events.

Journal: The Lancet. Neurology20100301

Title: Rivaroxaban-once daily, oral, direct factor Xa inhibition compared with vitamin K antagonism for prevention of stroke and Embolism Trial in Atrial Fibrillation: rationale and design of the ROCKET AF study.

Journal: American heart journal20100301

Title: Oral rivaroxaban for the prevention of symptomatic venous thromboembolism after elective hip and knee replacement.

Journal: The Journal of bone and joint surgery. British volume20100301

Title: Recent advances in the management of venous thromboembolism.

Journal: The Korean journal of hematology20100301

Title: New oral anticoagulants: a practical guide for clinicians.

Journal: Journal of thrombosis and thrombolysis20100201

Title: The ultimate anticoagulants?

Journal: Cardiovascular journal of Africa20100201

Title: [Update on new antithrombotic treatments].

Journal: Revue medicale suisse20100120

Title: The new oral anticoagulants.

Journal: Blood20100107

Title: Factor Xa inhibitors in acute coronary syndromes and venous thromboembolism.

Journal: Current vascular pharmacology20100101

Title: Safety, pharmacokinetics and pharmacodynamics of single doses of rivaroxaban - an oral, direct factor Xa inhibitor - in elderly Chinese subjects.

Journal: Thrombosis and haemostasis20100101

Title: The potential benefits of low-molecular-weight heparins in cancer patients.

Journal: Journal of hematology & oncology20100101

Title: [Prophylaxis of venous thromboembolism in orthopaedic surgery--trivial option, huge potential].

Journal: Zeitschrift fur Orthopadie und Unfallchirurgie20100101

Title: Entering the era of non-basic p1 site groups: discovery of Xarelto (Rivaroxaban).

Journal: Current topics in medicinal chemistry20100101

Title: New oral anticoagulants in development: potential for improved safety profiles.

Journal: Reviews in neurological diseases20100101

Title: Forecasting drug utilization and expenditure in a metropolitan health region.

Journal: BMC health services research20100101

Title: New options with dabigatran etexilate in anticoagulant therapy.

Journal: Vascular health and risk management20100101

Title: New anticoagulants for the prevention of venous thromboembolism.

Journal: Drug design, development and therapy20100101

Title: Deep vein thrombosis and pulmonary embolism - Prevention, management, and anaesthetic considerations.

Journal: Indian journal of anaesthesia20100101

Title: Novel anticoagulant therapy: principle and practice.

Journal: Methods in molecular biology (Clifton, N.J.)20100101

Title: Oral direct factor Xa inhibitors, with special emphasis on rivaroxaban.

Journal: Methods in molecular biology (Clifton, N.J.)20100101

Title: [Anticoagulant therapy in cardiology: yesterday, today, tomorrow].

Journal: Kardiologiia20100101

Title: Prevention strategies for cardioembolic stroke: present and future perspectives.

Journal: The open neurology journal20100101

Title: Oral anticoagulants in pediatric cardiac practice: A systematic review of the literature.

Journal: Annals of pediatric cardiology20100101

Title: Cost effectiveness of venous thromboembolism pharmacological prophylaxis in total hip and knee replacement: a systematic review.

Journal: PharmacoEconomics20100101

Title: Further issues with new oral anticoagulants.

Journal: Current pharmaceutical design20100101

Title: New anticoagulants for the prevention of thromboembolism.

Journal: Current pharmaceutical design20100101

Title: Pharmacologic properties of the new oral anticoagulants: a clinician-oriented review with a focus on perioperative management.

Journal: Current pharmaceutical design20100101

Title: Managing bleeding complications in patients treated with the old and the new anticoagulants.

Journal: Current pharmaceutical design20100101

Title: Post-operative thromboprophylaxis: new oral thrombin and factor X inhibitors and their place in clinical practice.

Journal: F1000 medicine reports20100101

Title: Effective single-drug approach is welcomed for deep-vein thrombosis treatment.

Journal: Cardiovascular journal of Africa20100101

Title: Rivaroxaban equals warfarin treatment in atrial fibrillation patients at high risk of stroke.

Journal: Cardiovascular journal of Africa20100101

Title: Development of new anticoagulant highly honoured: Bayer's Xarelto recognised with 2010 international Prix Galien award.

Journal: Cardiovascular journal of Africa20100101

Title: Newer antithrombotic drugs.

Journal: Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine20100101

Title: Simplifying thromboprophylaxis could improve outcomes in orthopaedic surgery.

Journal: Thrombosis20100101

Title: New oral anticoagulants for thromboprophylaxis after elective total hip and knee arthroplasty.

Journal: Thrombosis20100101

Title: Emerging antithrombotic agents for thromboprophylaxis, clinical potential and patient considerations.

Journal: Journal of blood medicine20100101

Title: Dabigatran or rivaroxaban versus other anticoagulants for thromboprophylaxis after major orthopedic surgery: systematic review of comparative clinical-effectiveness and safety.

Journal: CADTH technology overviews20100101

Title: Rivaroxaban in orthopedic surgery--a change of paradigm?

Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis20091201

Title: Oral factor Xa inhibitors for thromboprophylaxis in major orthopedic surgery: a review.

Journal: Internal and emergency medicine20091201

Title: Will oral rivaroxaban improve clinically relevant outcomes and thromboprophylaxis management in the orthopedic patient?

Journal: Journal of thrombosis and haemostasis : JTH20091201

Title: [New oral anticoagulants. Consequences for perioperative coagulation diagnostics and therapy].

Journal: Der Anaesthesist20091201

Title: Rivaroxaban, the first oral, direct factor Xa inhibitor.

Journal: Expert opinion on pharmacotherapy20091201

Title: Oral anticoagulation with Factor Xa and thrombin inhibitors: Is there an alternative to warfarin?

Journal: Discovery medicine20091201

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20091201

Title: Heparin-induced thrombocytopaenia/thrombosis: a clinicopathologic review.

Journal: East African medical journal20091201

Title: Direct inhibitors of coagulation proteins - the end of the heparin and low-molecular-weight heparin era for anticoagulant therapy?

Journal: Thrombosis and haemostasis20091101

Title: Thromboprophylaxis after multiple trauma: what treatment and for how long?

Journal: Injury20091101

Title: [Pregnancy and venous thromboembolism. North-American and European guidelines. American College of Chest Physicians].

Journal: Journal des maladies vasculaires20091101

Title: New agents for orthopaedic thromboprophylaxis: caution essential, but time will tell.

Journal: ANZ journal of surgery20091101

Title: New antithrombotic drugs: potential for use in oncology.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20091010

Title: Underestimation of the effect of bleeding in clinical trials.

Journal: Lancet (London, England)20091003

Title: New anticoagulants and regional anesthesia.

Journal: Current opinion in anaesthesiology20091001

Title: Anticoagulation with {blacktriangledown}dabigatran or{blacktriangledown}rivaroxaban.

Journal: Drug and therapeutics bulletin20091001

Title: Rivaroxaban for the prevention of venous thromboembolism: a single technology appraisal.

Journal: Health technology assessment (Winchester, England)20091001

Title: [Rivaroxaban (Xarelto): new anticoagulant inhibitor of factor Xa].

Journal: Revue medicale de Liege20091001

Title: Oral anticoagulation with factor Xa and thrombin inhibitors: on the threshold of change.

Journal: Current opinion in hematology20090901

Title: A logical approach to surgical thromboprophylaxis.

Journal: Current opinion in hematology20090901

Title: [Orthopedic patients with or without thrombophilia. Diagnostic, therapy and peri-operative strategies].

Journal: Der Orthopade20090901

Title: [New developments in antithrombotic care].

Journal: Revue medicale de Bruxelles20090901

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20090901

Title: Rivaroxaban versus enoxaparin after total knee arthroplasty.

Journal: Lancet (London, England)20090829

Title: Rivaroxaban versus enoxaparin after total knee arthroplasty.

Journal: Lancet (London, England)20090829

Title: Rivaroxaban versus enoxaparin after total knee arthroplasty.

Journal: Lancet (London, England)20090829

Title: Rivaroxaban versus enoxaparin after total knee arthroplasty.

Journal: Lancet (London, England)20090829

Title: Favorable therapeutic index of the direct factor Xa inhibitors, apixaban and rivaroxaban, compared with the thrombin inhibitor dabigatran in rabbits.

Journal: Journal of thrombosis and haemostasis : JTH20090801

Title: Recent developments in the use of oral anticoagulants.

Journal: Expert opinion on pharmacotherapy20090801

Title: Novel anticoagulants in clinical development: focus on factor Xa and direct thrombin inhibitors.

Journal: Journal of cardiovascular medicine (Hagerstown, Md.)20090801

Title: Use of emerging oral anticoagulants in clinical practice: translating results from clinical trials to orthopedic and general surgical patient populations.

Journal: Annals of surgery20090801

Title: Factor Xa inhibitors--new anticoagulants for secondary haemostasis.

Journal: Hamostaseologie20090801

Title: [Patients with oral anticoagulation--bridging anticoagulation in the perioperative phase].

Journal: Hamostaseologie20090801

Title: Rivaroxaban: new drug. After hip or knee replacement surgery: LMWH is safer.

Journal: Prescrire international20090801

Title: Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomised, double-blind, phase II trial.

Journal: Lancet (London, England)20090704

Title: Rivaroxaban in acute coronary syndromes: too soon to know?

Journal: Lancet (London, England)20090704

Title: New anticoagulants: focus on venous thromboembolism.

Journal: Current vascular pharmacology20090701

Title: Safety, pharmacokinetics and pharmacodynamics of single/multiple doses of the oral, direct Factor Xa inhibitor rivaroxaban in healthy Chinese subjects.

Journal: British journal of clinical pharmacology20090701

Title: New anticoagulants for atrial fibrillation.

Journal: Seminars in thrombosis and hemostasis20090701

Title: [New agents for the prevention of venous thromboembolism].

Journal: Der Internist20090601

Title: Rivaroxaban for the prevention of venous thromboembolism following major orthopedic surgery: the RECORD trials.

Journal: Expert review of cardiovascular therapy20090601

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20090601

Title: 3-(3-Chloro-anilino)-1-(3,5-dimethyl-1H-pyrazol-1-yl)propan-1-one.

Journal: Acta crystallographica. Section E, Structure reports online20090601

Title: Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial.

Journal: Lancet (London, England)20090516

Title: The importance of VTE prevention after orthopaedic surgery.

Journal: Lancet (London, England)20090516

Title: Rivaroxaban -- an oral, direct Factor Xa inhibitor: lessons from a broad clinical study programme.

Journal: European journal of haematology20090501

Title: Metabolism and excretion of rivaroxaban, an oral, direct factor Xa inhibitor, in rats, dogs, and humans.

Journal: Drug metabolism and disposition: the biological fate of chemicals20090501

Title: In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans.

Journal: Drug metabolism and disposition: the biological fate of chemicals20090501

Title: Oral rivaroxaban for the prevention of symptomatic venous thromboembolism after elective hip and knee replacement.

Journal: The Journal of bone and joint surgery. British volume20090501

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20090501

Title: Rivaroxaban (xarelto) for the prevention of thromboembolic disease: an inside look at the oral direct factor xa inhibitor.

Journal: P & T : a peer-reviewed journal for formulary management20090501

Title: [The new oral anticoagulant in the Netherlands].

Journal: Nederlands tijdschrift voor geneeskunde20090418

Title: Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor.

Journal: Bioorganic & medicinal chemistry letters20090415

Title: The direct factor Xa inhibitor rivaroxaban.

Journal: The Medical journal of Australia20090406

Title: Rivaroxaban, a new, oral, direct factor Xa inhibitor for thromboprophylaxis after major joint arthroplasty.

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Title: [New anticoagulants].

Journal: Deutsche medizinische Wochenschrift (1946)20090401

Title: Should new oral anticoagulants replace low-molecular-weight heparin for thromboprophylaxis in orthopaedic surgery?

Journal: Archives of cardiovascular diseases20090401

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20090401

Title: [Venous thromboembolism prophylaxis in orthopaedics and traumatology].

Journal: Vnitrni lekarstvi20090301

Title: [Advances in antithrombotic treatment--antithrombotics with anti-Xa effect].

Journal: Vnitrni lekarstvi20090301

Title: The novel anticoagulants: entering a new era.

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Title: [The new antithrombotics in 2009].

Journal: Revue medicale suisse20090204

Title: Rivaroxaban: a novel, oral, direct factor Xa inhibitor.

Journal: Pharmacotherapy20090201

Title: New anticoagulants - towards the development of an 'ideal' anticoagulant.

Journal: VASA. Zeitschrift fur Gefasskrankheiten20090201

Title: Laboratory monitoring of anticoagulation: where do we stand?

Journal: Seminars in thrombosis and hemostasis20090201

Title: Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development.

Journal: Clinical pharmacokinetics20090101

Title: Multinational development of a questionnaire assessing patient satisfaction with anticoagulant treatment: the 'Perception of Anticoagulant Treatment Questionnaire' (PACT-Q).

Journal: Health and quality of life outcomes20090101

Title: In the pipeline: new oral anticoagulants for the prevention of venous thromboembolism.

Journal: Orthopedics20090101

Title: New oral anticoagulants: not quite there yet.

Journal: Polskie Archiwum Medycyny Wewnetrznej20090101

Title: Old and new anticoagulant agents for the prevention and treatment of patients with ischemic stroke.

Journal: Cerebrovascular diseases (Basel, Switzerland)20090101

Title: Use of anticoagulants in elderly patients: practical recommendations.

Journal: Clinical interventions in aging20090101

Title: Rivaroxaban: an oral direct factor Xa inhibitor for the prevention of thromboembolism.

Journal: Cardiology in review20090101

Title: Interpretation of benefit-risk of enoxaparin as comparator in the RECORD program: rivaroxaban oral tablets (10 milligrams) for use in prophylaxis in deep vein thrombosis and pulmonary embolism in patients undergoing hip or knee replacement surgery.

Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis20090101

Title: Selecting the optimal antithrombotic regimen for patients with acute coronary syndromes undergoing percutaneous coronary intervention.

Journal: Vascular health and risk management20090101

Title: The prevention and treatment of venous thromboembolism with LMWHs and new anticoagulants.

Journal: Vascular health and risk management20090101

Title: [Dabigatran and rivaroxaban, new oral anticoagulants for the treatment of venous thromboembolism].

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria20090101

Title: [Pharmacokinetics and pharmacodynamics of the new oral anticoagulants dabigatran and rivaroxaban].

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria20090101

Title: Rivaroxaban: a review of its use for the prevention of venous thromboembolism after total hip or knee replacement surgery.

Journal: Drugs20090101

Title: [From old to new anticoagulants: the role of the biologist].

Journal: Annales de biologie clinique20090101

Title: New anticoagulants for the prevention of deep venous thrombosis: time to consider cost effectiveness?

Journal: PharmacoEconomics20090101

Title: A cost-effectiveness model comparing rivaroxaban and dabigatran etexilate with enoxaparin sodium as thromboprophylaxis after total hip and total knee replacement in the irish healthcare setting.

Journal: PharmacoEconomics20090101

Title: Prevention and treatment of thromboembolic events in medical patients and new anticoagulants.

Journal: Acta clinica Belgica20090101

Title: [Pharmacology of heparins and direct anticoagulants].

Journal: Hamostaseologie20081201

Title: [Rivaroxaban: a decisive step forward in the management of postoperative thromboembolic disease?].

Journal: Annales francaises d'anesthesie et de reanimation20081201

Title: [Rivaroxaban: clinical pharmacology].

Journal: Annales francaises d'anesthesie et de reanimation20081201

Title: [Perioperative venous thromboembolism prophylaxis: short review and recommendations].

Journal: Annales francaises d'anesthesie et de reanimation20081201

Title: [Rivaroxaban (Xarelto): efficacy and safety].

Journal: Annales francaises d'anesthesie et de reanimation20081201

Title: [Summary and perspectives. Rivaroxaban].

Journal: Annales francaises d'anesthesie et de reanimation20081201

Title: [Rivaroxaban: mode of action].

Journal: Annales francaises d'anesthesie et de reanimation20081201

Title: Emergence of new oral antithrombotics: a critical appraisal of their clinical potential.

Journal: Vascular health and risk management20081201

Title: Rivaroxaban for thromboprophylaxis.

Journal: The New England journal of medicine20081113

Title: Rivaroxaban for thromboprophylaxis.

Journal: The New England journal of medicine20081113

Title: Rivaroxaban for thromboprophylaxis.

Journal: The New England journal of medicine20081113

Title: Rivaroxaban for thromboprophylaxis.

Journal: The New England journal of medicine20081113

Title: [Rivaroxaban. The first factor Xa inhibitor].

Journal: Medizinische Monatsschrift fur Pharmazeuten20081101

Title: [Thromboembolic disease in orthopedic surgery].

Journal: Medicina clinica20081101

Title: [Anaesthesia and thromboembolic disease].

Journal: Medicina clinica20081101

Title: [New oral anticoagulants: molecular characteristics, mechanisms of action, pharmacokinetics and pharmacodynamics].

Journal: Medicina clinica20081101

Title: Polyphosphate as a general procoagulant agent.

Journal: Journal of thrombosis and haemostasis : JTH20081001

Title: Rivaroxaban--an oral, direct Factor Xa inhibitor--has potential for the management of patients with heparin-induced thrombocytopenia.

Journal: British journal of haematology20081001

Title: Differences in urinary prothrombin fragment 1 + 2 levels after total hip replacement in relation to venous thromboembolism and bleeding events.

Journal: Journal of thrombosis and haemostasis : JTH20081001

Title: Dose-escalation study of the pharmacokinetics and pharmacodynamics of rivaroxaban in healthy elderly subjects.

Journal: Current medical research and opinion20081001

Title: [Anticoagulation in atrial fibrillation].

Journal: Hamostaseologie20081001

Title: [Prophylaxis of venous thromboembolism].

Journal: Hamostaseologie20081001

Title: Rivaroxaban: future in anticoagulation practice?

Journal: Hematology (Amsterdam, Netherlands)20081001

Title: More effective, simpler-to-use clot-buster is on the way. Clot-prevention drug could save lives after joint replacement.

Journal: DukeMedicine healthnews20081001

Title: [Always more amputations in Germany?].

Journal: Deutsche medizinische Wochenschrift (1946)20081001

Title: Orally administered factor xa inhibitor, rivaroxaban: a novel thromboembolic prophylaxis agent.

Journal: Neurosurgery20081001

Title: A dose-ranging study evaluating once-daily oral administration of the factor Xa inhibitor rivaroxaban in the treatment of patients with acute symptomatic deep vein thrombosis: the Einstein-DVT Dose-Ranging Study.

Journal: Blood20080915

Title: Determination of rivaroxaban--a novel, oral, direct Factor Xa inhibitor--in human plasma by high-performance liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20080901

Title: Population pharmacokinetics and pharmacodynamics of once- and twice-daily rivaroxaban for the prevention of venous thromboembolism in patients undergoing total hip replacement.

Journal: Thrombosis and haemostasis20080901

Title: New developments in anticoagulation for atrial fibrillation.

Journal: Current treatment options in cardiovascular medicine20080901

Title: Rivaroxaban: an oral direct inhibitor of factor Xa.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists20080815

Title: Potent anticoagulants are associated with a higher all-cause mortality rate after hip and knee arthroplasty.

Journal: Clinical orthopaedics and related research20080801

Title: New compounds in the management of venous thromboembolism after orthopedic surgery: focus on rivaroxaban.

Journal: Vascular health and risk management20080801

Title: Extended duration rivaroxaban versus short-term enoxaparin for the prevention of venous thromboembolism after total hip arthroplasty: a double-blind, randomised controlled trial.

Journal: Lancet (London, England)20080705

Title: Selective factor Xa inhibition for thromboprophylaxis.

Journal: Lancet (London, England)20080705

Title: Rivaroxaban versus enoxaparin for thromboprophylaxis after hip arthroplasty.

Journal: The New England journal of medicine20080626

Title: Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty.

Journal: The New England journal of medicine20080626

Title: New anticoagulants--the path from discovery to clinical practice.

Journal: The New England journal of medicine20080626

Title: Rivaroxaban, an oral direct factor Xa inhibitor.

Journal: Expert opinion on investigational drugs20080601

Title: [Hematology 2008].

Journal: Deutsche medizinische Wochenschrift (1946)20080601

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20080601

Title: Preventing venous thromboembolism through risk assessment approaches.

Journal: British journal of nursing (Mark Allen Publishing)20080601

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20080401

Title: Potent anticoagulants are associated with a higher all-cause mortality rate after hip and knee arthroplasty.

Journal: Clinical orthopaedics and related research20080301

Title: New anticoagulants for treatment of venous thromboembolism.

Journal: Arteriosclerosis, thrombosis, and vascular biology20080301

Title: Update on atrial fibrillation: part I.

Journal: Clinical cardiology20080201

Title: [New anticoagulants].

Journal: Hamostaseologie20080201

Title: Current and future prospects for anticoagulant therapy: inhibitors of factor Xa and factor IIa.

Journal: Seminars in thrombosis and hemostasis20080201

Title: The laboratory diagnosis and clinical management of patients with heparin-induced thrombocytopenia: an update.

Journal: Seminars in thrombosis and hemostasis20080201

Title: Randomized, double-blind, crossover study to investigate the effect of rivaroxaban on QT-interval prolongation.

Journal: Drug safety20080101

Title: New oral anticoagulants in atrial fibrillation.

Journal: European heart journal20080101

Title: Population pharmacokinetics and pharmacodynamics of rivaroxaban--an oral, direct factor Xa inhibitor--in patients undergoing major orthopaedic surgery.

Journal: Clinical pharmacokinetics20080101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20080101

Title: Pharmacological strategies for inhibition of thrombin activity.

Journal: Current pharmaceutical design20080101

Title: The top 4 advances in antithrombotic care in the last year.

Journal: Thrombosis research20080101

Title: Brave new world: the current and future use of novel anticoagulants.

Journal: Thrombosis research20080101

Title: Thromboprophylaxis with rivaroxaban or enoxaparin did not differ for major bleeding or other safety outcomes in hip arthroplasty.

Journal: ACP journal club20080101

Title: Thromboprophylaxis with rivaroxaban or enoxaparin did not differ for major bleeding in knee arthroplasty.

Journal: ACP journal club20080101

Title: Controversies in the antiphospholipid syndrome: can we ever stop warfarin?

Journal: Journal of autoimmune diseases20080101

Title: New issues in oral anticoagulants.

Journal: Hematology. American Society of Hematology. Education Program20080101

Title: Oral factor Xa inhibitors for venous thromboembolism prevention in major orthopedic surgery: a review.

Journal: Pathophysiology of haemostasis and thrombosis20080101

Title: Effects of the oral, direct factor xa inhibitor rivaroxaban on platelet-induced thrombin generation and prothrombinase activity.

Journal: Journal of clinical pharmacology20071101

Title: Development of oral anticoagulants.

Journal: British journal of clinical pharmacology20070901

Title: Rivaroxaban. A novel, oral, direct factor Xa inhibitor in clinical development for the prevention and treatment of thromboembolic disorders.

Journal: Hamostaseologie20070901

Title: Beyond unfractionated heparin and warfarin: current and future advances.

Journal: Circulation20070731

Title: A replacement for warfarin: the search continues.

Journal: Circulation20070710

Title: Treatment of proximal deep-vein thrombosis with the oral direct factor Xa inhibitor rivaroxaban (BAY 59-7939): the ODIXa-DVT (Oral Direct Factor Xa Inhibitor BAY 59-7939 in Patients With Acute Symptomatic Deep-Vein Thrombosis) study.

Journal: Circulation20070710

Title: Ultrasound screening for asymptomatic deep vein thrombosis after major orthopaedic surgery: the VENUS study.

Journal: Journal of thrombosis and haemostasis : JTH20070701

Title: Preclinical and clinical characteristics of rivaroxaban: a novel, oral, direct factor Xa inhibitor.

Journal: Seminars in thrombosis and hemostasis20070701

Title: Oral, direct factor Xa inhibitors in development for the prevention and treatment of thromboembolic diseases.

Journal: Arteriosclerosis, thrombosis, and vascular biology20070601

Title: Rivaroxaban for thromboprophylaxis after orthopaedic surgery: pooled analysis of two studies.

Journal: Thrombosis and haemostasis20070601

Title: Population model of the pharmacokinetics and pharmacodynamics of rivaroxaban--an oral, direct factor xa inhibitor--in healthy subjects.

Journal: International journal of clinical pharmacology and therapeutics20070601

Title: Rivaroxaban (BAY 59-7939)--an oral, direct Factor Xa inhibitor--has no clinically relevant interaction with naproxen.

Journal: British journal of clinical pharmacology20070401

Title: Investigational treatments of venous thromboembolism.

Journal: Expert opinion on investigational drugs20070401

Title: In vitro inhibition of thrombin generation, after tissue factor pathway activation, by the oral, direct factor Xa inhibitor rivaroxaban.

Journal: Journal of thrombosis and haemostasis : JTH20070401

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20070401

Title: Prevention and treatment of experimental thrombosis in rabbits with rivaroxaban (BAY 597939)--an oral, direct factor Xa inhibitor.

Journal: Thrombosis and haemostasis20070301

Title: Rivaroxaban.

Journal: Drugs of today (Barcelona, Spain : 1998)20070301

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Journal: Annales pharmaceutiques francaises20070301

Title: Drug evaluation: rivaroxaban, an oral, direct inhibitor of activated factor X.

Journal: Current opinion in investigational drugs (London, England : 2000)20070301

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20070301

Title: Body weight has limited influence on the safety, tolerability, pharmacokinetics, or pharmacodynamics of rivaroxaban (BAY 59-7939) in healthy subjects.

Journal: Journal of clinical pharmacology20070201

Title: Dose-escalation study of rivaroxaban (BAY 59-7939)--an oral, direct Factor Xa inhibitor--for the prevention of venous thromboembolism in patients undergoing total hip replacement.

Journal: Thrombosis research20070101

Title: Stroke in atrial fibrillation: update on pathophysiology, new antithrombotic therapies, and evolution of procedures and devices.

Journal: Annals of medicine20070101

Title: Anithrombotic prevention in vascular disease: bases for a new strategy in antithrombotic therapy.

Journal: Thrombosis journal20070101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology20070101

Title: A once-daily, oral, direct Factor Xa inhibitor, rivaroxaban (BAY 59-7939), for thromboprophylaxis after total hip replacement.

Journal: Circulation20061128

Title: The scientific community's quest to identify optimal targets for anticoagulant pharmacotherapy.

Journal: Circulation20061128

Title: Safety, tolerability, pharmacodynamics, and pharmacokinetics of rivaroxaban--an oral, direct factor Xa inhibitor--are not affected by aspirin.

Journal: Journal of clinical pharmacology20060901

Title: Novel factor Xa inhibitors for prevention and treatment of thromboembolic diseases.

Journal: Expert opinion on investigational drugs20060801

Title: Effect of food, an antacid, and the H2 antagonist ranitidine on the absorption of BAY 59-7939 (rivaroxaban), an oral, direct factor Xa inhibitor, in healthy subjects.

Journal: Journal of clinical pharmacology20060501

Title: [Haemostasis and antithrombotic drugs: pharmacology and novel therapeutic approaches].

Journal: Hamostaseologie20060501

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Title: Safety, pharmacodynamics, and pharmacokinetics of BAY 59-7939--an oral, direct Factor Xa inhibitor--after multiple dosing in healthy male subjects.

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Title: BAY 59-7939: an oral, direct factor Xa inhibitor for the prevention of venous thromboembolism in patients after total knee replacement. A phase II dose-ranging study.

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