Home Bromides 956014-19-0
956014-19-0,MFCD24387114
Catalog No.:AA0035Z9

956014-19-0 | 1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea

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Purity
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1mg
≥95%
in stock  
$46.00   $32.00
- +
5mg
≥95%
in stock  
$143.00   $100.00
- +
10mg
≥95%
in stock  
$219.00   $153.00
- +
50mg
95%
in stock  
$408.00   $286.00
- +
1000mg
98% by HPLC
in stock  
$6,710.00   $4,697.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0035Z9
Chemical Name:
1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea
CAS Number:
956014-19-0
Molecular Formula:
C16H9BrF6N6S
Molecular Weight:
511.2423
MDL Number:
MFCD24387114
SMILES:
S=C(Nc1ccc(cc1c1nn[nH]n1)Br)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Properties
Properties
 
Form:
Solid  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
586  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
4.8  

Literature

Title: Localization of large conductance calcium-activated potassium channels and their effect on calcitonin gene-related peptide release in the rat trigemino-neuronal pathway.

Journal: Neuroscience 20100602

Title: Synthesis and characterisation of NS13558: a new important tool for addressing KCa1.1 channel function ex vivo.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20100301

Title: BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20100201

Title: NS11021, a novel opener of large-conductance Ca(2+)-activated K(+) channels, enhances erectile responses in rats.

Journal: British journal of pharmacology 20091101

Title: Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury.

Journal: Pflugers Archiv : European journal of physiology 20090301

Title: The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels.

Journal: Molecular pharmacology 20071001

Title: Bo Hjorth Bentzen, et al. The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels. Mol Pharmacol. 2007 Oct;72(4):1033-44

Title: Cagil Coskun, et al. BK channel openers NS1619 and NS11021 reverse hydrogen peroxide-induced membrane potential changes in skeletal muscle. J Recept Signal Transduct Res. 2020 Oct;40(5):449-455.

Title: Stephen Shrum, et al. Specific BK Channel Activator NS11021 Protects Rat Renal Proximal Tubular Cells from Cold Storage-Induced Mitochondrial Injury In Vitro. Biomolecules. 2019 Dec 4;9(12):825.

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Tags:956014-19-0 Molecular Formula|956014-19-0 MDL|956014-19-0 SMILES|956014-19-0 1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)thiourea