154229-18-2,MFCD00934213
Catalog No.:AA0035ZS

154229-18-2 | Abiraterone Acetate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
99%
in stock  
$9.00   $6.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0035ZS
Chemical Name:
Abiraterone Acetate
CAS Number:
154229-18-2
Molecular Formula:
C26H33NO2
Molecular Weight:
391.5457
MDL Number:
MFCD00934213
SMILES:
CC(=O)O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC=C2c2cccnc2)C)C1)C
Properties
Properties
 
BP:
506.7°C at 760 mmHg  
Form:
Solid  
MP:
127-130°C  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
739  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
5.2  

Literature

Title: Differential response to abiraterone acetate and di-n-butyl phthalate in an androgen-sensitive human fetal testis xenograft bioassay.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140301

Title: Changing paradigms in management of metastatic Castration Resistant Prostate Cancer (mCRPC).

Journal: BMC urology 20140101

Title: Urologists and oncologists: adapting to a new treatment paradigm in castration-resistant prostate cancer (CRPC).

Journal: BJU international 20120801

Title: Effect of abiraterone acetate plus prednisone on the QT interval in patients with metastatic castration-resistant prostate cancer.

Journal: Cancer chemotherapy and pharmacology 20120801

Title: Abiraterone inhibits 3β-hydroxysteroid dehydrogenase: a rationale for increasing drug exposure in castration-resistant prostate cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120701

Title: Discovery of potent and orally bioavailable 17β-hydroxysteroid dehydrogenase type 3 inhibitors.

Journal: Bioorganic & medicinal chemistry 20120515

Title: Novel molecular targets for the therapy of castration-resistant prostate cancer.

Journal: European urology 20120501

Title: Beyond castration-defining future directions in the hormonal treatment of prostate cancer.

Journal: Hormones & cancer 20120401

Title: Abiraterone acetate: redefining hormone treatment for advanced prostate cancer.

Journal: Drug discovery today 20120301

Title: Advances in the management of high-risk localised and metastatic prostate cancer.

Journal: BJU international 20120301

Title: Abiraterone acetate: a guide to its use in metastatic castration-resistant prostate cancer.

Journal: Drugs & aging 20120301

Title: The 5α-androstanedione pathway to dihydrotestosterone in castration-resistant prostate cancer.

Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20120201

Title: Development and clinical utility of abiraterone acetate as an androgen synthesis inhibitor.

Journal: Clinical pharmacology and therapeutics 20120101

Title: Abiraterone acetate, a first-in-class CYP17 inhibitor, establishes a new treatment paradigm in castration-resistant prostate cancer.

Journal: Expert review of anticancer therapy 20120101

Title: Abiraterone acetate: oral androgen biosynthesis inhibitor for treatment of castration-resistant prostate cancer.

Journal: Drug design, development and therapy 20120101

Title: Optimizing outcomes of advanced prostate cancer: drug sequencing and novel therapeutic approaches.

Journal: Oncology (Williston Park, N.Y.) 20120101

Title: Successful Treatment of Advanced Metastatic Prostate Cancer following Chemotherapy Based on Molecular Profiling.

Journal: Case reports in oncology 20120101

Title: Drugs in traffic: the road to approval.

Journal: Nature medicine 20111206

Title: TMPRSS2-ERG status in circulating tumor cells as a predictive biomarker of sensitivity in castration-resistant prostate cancer patients treated with abiraterone acetate.

Journal: European urology 20111101

Title: Circulating tumour cells as surrogate biomarkers in castration-resistant prostate cancer trials.

Journal: European urology 20111101

Title: Clinical implications of the 5α-androstanedione pathway for castration-resistant prostate cancer.

Journal: Future oncology (London, England) 20111101

Title: Abiraterone acetate: in metastatic castration-resistant prostate cancer.

Journal: Drugs 20111022

Title: Flushing oral oncology drugs down the toilet.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20111020

Title: Abiraterone acetate for prostate cancer: a new era of hormonal therapies.

Journal: Asian journal of andrology 20110901

Title: Phase II study of abiraterone acetate in chemotherapy-naive metastatic castration-resistant prostate cancer displaying bone flare discordant with serologic response.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110715

Title: [The trend toward development of novel agents based on the mechanism of prostate cancer progression].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20110601

Title: CYP17 inhibitors for prostate cancer therapy.

Journal: The Journal of steroid biochemistry and molecular biology 20110501

Title: Roflumilast, indacaterol maleate, and abiraterone acetate.

Journal: Journal of the American Pharmacists Association : JAPhA 20110101

Title: Abiraterone acetate.

Journal: Drugs in R&D 20101101

Title: CYP17 inhibition as a hormonal strategy for prostate cancer.

Journal: Nature clinical practice. Urology 20081101

Title: Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge.

Journal: Bioorganic & medicinal chemistry 20080815

Title: Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure.

Journal: Bioorganic & medicinal chemistry 20080215

Title: Hormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer.

Journal: British journal of cancer 20040614

Title: Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer.

Journal: Journal of medicinal chemistry 19950623

Title: Stein MN, et al. Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer. Asian J Androl. 2014 May-Jun;16(3):387-400.

Title: Richards J, et al. Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100. Cancer Res. 2012 May 1;72(9):2176-82.

Title: Li R, et al. Abiraterone inhibits 3β-hydroxysteroid dehydrogenase: a rationale for increasing drug exposure in castration-resistant prostate cancer. Clin Cancer Res. 2012 Jul 1;18(13):3571-9.

Title: Lee GT, et al. Intracrine androgen biosynthesis in renal cell carcinoma. Br J Cancer. 2017 Mar 28;116(7):937-943.

Title: A O'Donnell, et al. Hormonal impact of the 17α-hydroxylase/C17,20-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer. British Journal of Cancervolume 90, pages2317–2325 (2004)

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:154229-18-2 Molecular Formula|154229-18-2 MDL|154229-18-2 SMILES|154229-18-2 Abiraterone Acetate
Catalog No.: AA0035ZS
154229-18-2,MFCD00934213
154229-18-2 | Abiraterone Acetate
Pack Size: 250mg
Purity: 99%
in stock
$9.00 $6.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA0035ZS
Chemical Name: Abiraterone Acetate
CAS Number: 154229-18-2
Molecular Formula: C26H33NO2
Molecular Weight: 391.5457
MDL Number: MFCD00934213
SMILES: CC(=O)O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC=C2c2cccnc2)C)C1)C
Properties
BP: 506.7°C at 760 mmHg  
Form: Solid  
MP: 127-130°C  
Storage: Keep in dry area;-20 ℃;  
Complexity: 739  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 6  
Heavy Atom Count: 29  
Hydrogen Bond Acceptor Count: 3  
Rotatable Bond Count: 3  
XLogP3: 5.2  
Literature fold

Title: Differential response to abiraterone acetate and di-n-butyl phthalate in an androgen-sensitive human fetal testis xenograft bioassay.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20140301

Title: Changing paradigms in management of metastatic Castration Resistant Prostate Cancer (mCRPC).

Journal: BMC urology20140101

Title: Urologists and oncologists: adapting to a new treatment paradigm in castration-resistant prostate cancer (CRPC).

Journal: BJU international20120801

Title: Effect of abiraterone acetate plus prednisone on the QT interval in patients with metastatic castration-resistant prostate cancer.

Journal: Cancer chemotherapy and pharmacology20120801

Title: Abiraterone inhibits 3β-hydroxysteroid dehydrogenase: a rationale for increasing drug exposure in castration-resistant prostate cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20120701

Title: Discovery of potent and orally bioavailable 17β-hydroxysteroid dehydrogenase type 3 inhibitors.

Journal: Bioorganic & medicinal chemistry20120515

Title: Novel molecular targets for the therapy of castration-resistant prostate cancer.

Journal: European urology20120501

Title: Beyond castration-defining future directions in the hormonal treatment of prostate cancer.

Journal: Hormones & cancer20120401

Title: Abiraterone acetate: redefining hormone treatment for advanced prostate cancer.

Journal: Drug discovery today20120301

Title: Advances in the management of high-risk localised and metastatic prostate cancer.

Journal: BJU international20120301

Title: Abiraterone acetate: a guide to its use in metastatic castration-resistant prostate cancer.

Journal: Drugs & aging20120301

Title: The 5α-androstanedione pathway to dihydrotestosterone in castration-resistant prostate cancer.

Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research20120201

Title: Development and clinical utility of abiraterone acetate as an androgen synthesis inhibitor.

Journal: Clinical pharmacology and therapeutics20120101

Title: Abiraterone acetate, a first-in-class CYP17 inhibitor, establishes a new treatment paradigm in castration-resistant prostate cancer.

Journal: Expert review of anticancer therapy20120101

Title: Abiraterone acetate: oral androgen biosynthesis inhibitor for treatment of castration-resistant prostate cancer.

Journal: Drug design, development and therapy20120101

Title: Optimizing outcomes of advanced prostate cancer: drug sequencing and novel therapeutic approaches.

Journal: Oncology (Williston Park, N.Y.)20120101

Title: Successful Treatment of Advanced Metastatic Prostate Cancer following Chemotherapy Based on Molecular Profiling.

Journal: Case reports in oncology20120101

Title: Drugs in traffic: the road to approval.

Journal: Nature medicine20111206

Title: TMPRSS2-ERG status in circulating tumor cells as a predictive biomarker of sensitivity in castration-resistant prostate cancer patients treated with abiraterone acetate.

Journal: European urology20111101

Title: Circulating tumour cells as surrogate biomarkers in castration-resistant prostate cancer trials.

Journal: European urology20111101

Title: Clinical implications of the 5α-androstanedione pathway for castration-resistant prostate cancer.

Journal: Future oncology (London, England)20111101

Title: Abiraterone acetate: in metastatic castration-resistant prostate cancer.

Journal: Drugs20111022

Title: Flushing oral oncology drugs down the toilet.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20111020

Title: Abiraterone acetate for prostate cancer: a new era of hormonal therapies.

Journal: Asian journal of andrology20110901

Title: Phase II study of abiraterone acetate in chemotherapy-naive metastatic castration-resistant prostate cancer displaying bone flare discordant with serologic response.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20110715

Title: [The trend toward development of novel agents based on the mechanism of prostate cancer progression].

Journal: Nihon rinsho. Japanese journal of clinical medicine20110601

Title: CYP17 inhibitors for prostate cancer therapy.

Journal: The Journal of steroid biochemistry and molecular biology20110501

Title: Roflumilast, indacaterol maleate, and abiraterone acetate.

Journal: Journal of the American Pharmacists Association : JAPhA20110101

Title: Abiraterone acetate.

Journal: Drugs in R&D20101101

Title: CYP17 inhibition as a hormonal strategy for prostate cancer.

Journal: Nature clinical practice. Urology20081101

Title: Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge.

Journal: Bioorganic & medicinal chemistry20080815

Title: Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure.

Journal: Bioorganic & medicinal chemistry20080215

Title: Hormonal impact of the 17alpha-hydroxylase/C(17,20)-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer.

Journal: British journal of cancer20040614

Title: Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer.

Journal: Journal of medicinal chemistry19950623

Title: Stein MN, et al. Androgen synthesis inhibitors in the treatment of castration-resistant prostate cancer. Asian J Androl. 2014 May-Jun;16(3):387-400.

Title: Richards J, et al. Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100. Cancer Res. 2012 May 1;72(9):2176-82.

Title: Li R, et al. Abiraterone inhibits 3β-hydroxysteroid dehydrogenase: a rationale for increasing drug exposure in castration-resistant prostate cancer. Clin Cancer Res. 2012 Jul 1;18(13):3571-9.

Title: Lee GT, et al. Intracrine androgen biosynthesis in renal cell carcinoma. Br J Cancer. 2017 Mar 28;116(7):937-943.

Title: A O'Donnell, et al. Hormonal impact of the 17α-hydroxylase/C17,20-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer. British Journal of Cancervolume 90, pages2317–2325 (2004)

Building Blocks More >
1109-15-5
1109-15-5
Tris(pentafluorophenyl)borane
AA003639 | MFCD00269813
89380-70-1
89380-70-1
4-Hydroxynicotinaldehyde
AA00366N | MFCD10697542
86520-96-9
86520-96-9
1-Ethynylisoquinoline
AA00369O | MFCD16659652
83734-43-4
83734-43-4
2-Hydroxyquinoline-5-carboxylic acid
AA0036CU | MFCD11557267
784150-41-0
784150-41-0
6-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
AA0036G8 | MFCD08276174
736989-98-3
736989-98-3
3-(3-Hydroxypropyl)phenylboronic acid
AA0036J1 | MFCD04115650
6946-22-1
6946-22-1
3-Aminophthalic acid, HCl
AA0036ML | MFCD00150282
681-68-5
681-68-5
Allyl 2,2,3,3-tetrafluoropropyl ether
AA0036Q0 | MFCD02093319
64741-27-1
64741-27-1
2,6-Bis(diphenylphosphino)pyridine
AA0036T9 | MFCD04039760
63069-49-8
63069-49-8
2-Amino-5-fluorobenzamide
AA0036WG | MFCD03428522
Submit
© 2017 AA BLOCKS, INC. All rights reserved.