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Home Amines 953769-46-5
953769-46-5,MFCD28142668
Catalog No.:AA003662

953769-46-5 | 4-[[2-[[(1R,2R)-2-Hydroxycyclohexyl]amino]-6-benzothiazolyl]oxy]-N-methyl-2-pyridinecarboxamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$13.00   $9.00
- +
2mg
98%
in stock  
$16.00   $11.00
- +
5mg
98%
in stock  
$27.00   $19.00
- +
10mg
98%
in stock  
$39.00   $28.00
- +
100mg
98%
in stock  
$184.00   $129.00
- +
250mg
98%
in stock  
$347.00   $243.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003662
Chemical Name:
4-[[2-[[(1R,2R)-2-Hydroxycyclohexyl]amino]-6-benzothiazolyl]oxy]-N-methyl-2-pyridinecarboxamide
CAS Number:
953769-46-5
Molecular Formula:
C20H22N4O3S
Molecular Weight:
398.4787
MDL Number:
MFCD28142668
SMILES:
CNC(=O)c1nccc(c1)Oc1ccc2c(c1)sc(n2)N[C@@H]1CCCC[C@H]1O
Properties
Properties
 
Form:
Solid  
Storage:
Light sensitive;Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
540  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
3.4  

Downstream Synthesis Route

[1]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-US2008/45528,2008,A1Locationinpatent:Page/Pagecolumn107

[1]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2018/69892,2018,A1Locationinpatent:Page/Pagecolumn14

[1]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2018/69892,2018,A1Locationinpatent:Page/Pagecolumn14

[1]CurrentPatentAssignee:UNIVERSITYOFMASSACHUSETTS-US2021/113659,2021,A1Locationinpatent:Paragraph0017;0077;0106

Literature

Title: Phenotypic and metabolic investigation of a CSF-1R kinase receptor inhibitor (BLZ945) and its pharmacologically active metabolite.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20150201

Title: CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8(+) T cells.

Journal: Oncoimmunology 20131201

Title: Investigation of correlation among safety biomarkers in serum, histopathological examination, and toxicogenomics.

Journal: International journal of toxicology 20110501

Title: Pyonteck SM, et al. CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nat Med. 2013 Oct;19(10):1264-72.

Title: Strachan DC, et al. CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells. Oncoimmunology. 2013 Dec 1;2(12):e26968.

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SDS
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Tags:953769-46-5 Molecular Formula|953769-46-5 MDL|953769-46-5 SMILES|953769-46-5 4-[[2-[[(1R,2R)-2-Hydroxycyclohexyl]amino]-6-benzothiazolyl]oxy]-N-methyl-2-pyridinecarboxamide