870483-87-7,MFCD12024701
Catalog No.:AA0036A4

870483-87-7 | Gw2580

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Purity
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1mg
98%
in stock  
$24.00   $17.00
- +
10mg
98%
in stock  
$66.00   $46.00
- +
25mg
≥99%
in stock  
$163.00   $114.00
- +
50mg
in stock  
$192.00   $134.00
- +
100mg
in stock  
$227.00   $159.00
- +
250mg
95%
in stock  
$284.00   $199.00
- +
1g
95%
in stock  
$731.00   $512.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0036A4
Chemical Name:
Gw2580
CAS Number:
870483-87-7
Molecular Formula:
C20H22N4O3
Molecular Weight:
366.4137
MDL Number:
MFCD12024701
SMILES:
COc1cc(ccc1OCc1ccc(cc1)OC)Cc1cnc(nc1N)N
Properties
Properties
 
BP:
617.5±65.0°C at 760 mmHg  
Form:
Solid  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
433  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
2.6  

Literature

Title: Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology.

Journal: Brain : a journal of neurology 20160301

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Regulation of microglial proliferation during chronic neurodegeneration.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20130206

Title: Role of cell cycle-associated proteins in microglial proliferation in the axotomized rat facial nucleus.

Journal: Glia 20120401

Title: Tyrosine kinase inhibitors ameliorate autoimmune encephalomyelitis in a mouse model of multiple sclerosis.

Journal: Journal of clinical immunology 20111201

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Comprehensive analysis of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111030

Title: Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.

Journal: European journal of medicinal chemistry 20110601

Title: Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood.

Journal: Cytokine 20101201

Title: Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.

Journal: Chemistry & biology 20101124

Title: Interleukin-34 is expressed by giant cell tumours of bone and plays a key role in RANKL-induced osteoclastogenesis.

Journal: The Journal of pathology 20100501

Title: Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy.

Journal: Blood 20100218

Title: c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis.

Journal: Arthritis research & therapy 20100101

Title: Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats.

Journal: The Journal of pharmacology and experimental therapeutics 20080701

Title: A quantitative analysis of kinase inhibitor selectivity.

Journal: Nature biotechnology 20080101

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218

Title: Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20051101

Title: Conway JG, et al. Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16078-83.

Title: Priceman SJ, et al. Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood. 2010 Feb 18;115(7):1461-71

Title: Conway JG, et al. Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats. J Pharmacol Exp Ther. 2008 Jul;326(1):41-50.

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SDS
Tags:870483-87-7 Molecular Formula|870483-87-7 MDL|870483-87-7 SMILES|870483-87-7 Gw2580
Catalog No.: AA0036A4
870483-87-7,MFCD12024701
870483-87-7 | Gw2580
Pack Size: 1mg
Purity: 98%
in stock
$24.00 $17.00
Pack Size: 10mg
Purity: 98%
in stock
$66.00 $46.00
Pack Size: 25mg
Purity: ≥99%
in stock
$163.00 $114.00
Pack Size: 50mg
Purity:
in stock
$192.00 $134.00
Pack Size: 100mg
Purity:
in stock
$227.00 $159.00
Pack Size: 250mg
Purity: 95%
in stock
$284.00 $199.00
Pack Size: 1g
Purity: 95%
in stock
$731.00 $512.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA0036A4
Chemical Name: Gw2580
CAS Number: 870483-87-7
Molecular Formula: C20H22N4O3
Molecular Weight: 366.4137
MDL Number: MFCD12024701
SMILES: COc1cc(ccc1OCc1ccc(cc1)OC)Cc1cnc(nc1N)N
Properties
BP: 617.5±65.0°C at 760 mmHg  
Form: Solid  
Storage: Keep in dry area;-20 ℃;  
Complexity: 433  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 27  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 2  
Rotatable Bond Count: 7  
XLogP3: 2.6  
Literature fold

Title: Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology.

Journal: Brain : a journal of neurology20160301

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters20130801

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal20130415

Title: Regulation of microglial proliferation during chronic neurodegeneration.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20130206

Title: Role of cell cycle-associated proteins in microglial proliferation in the axotomized rat facial nucleus.

Journal: Glia20120401

Title: Tyrosine kinase inhibitors ameliorate autoimmune encephalomyelitis in a mouse model of multiple sclerosis.

Journal: Journal of clinical immunology20111201

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology20111101

Title: Comprehensive analysis of kinase inhibitor selectivity.

Journal: Nature biotechnology20111030

Title: Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.

Journal: European journal of medicinal chemistry20110601

Title: Macrophage-colony stimulating factor and interleukin-34 induce chemokines in human whole blood.

Journal: Cytokine20101201

Title: Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.

Journal: Chemistry & biology20101124

Title: Interleukin-34 is expressed by giant cell tumours of bone and plays a key role in RANKL-induced osteoclastogenesis.

Journal: The Journal of pathology20100501

Title: Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy.

Journal: Blood20100218

Title: c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis.

Journal: Arthritis research & therapy20100101

Title: Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats.

Journal: The Journal of pharmacology and experimental therapeutics20080701

Title: A quantitative analysis of kinase inhibitor selectivity.

Journal: Nature biotechnology20080101

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America20071218

Title: Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580.

Journal: Proceedings of the National Academy of Sciences of the United States of America20051101

Title: Conway JG, et al. Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16078-83.

Title: Priceman SJ, et al. Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood. 2010 Feb 18;115(7):1461-71

Title: Conway JG, et al. Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats. J Pharmacol Exp Ther. 2008 Jul;326(1):41-50.

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