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85416-75-7,MFCD03093860
Catalog No.:AA0036BU

85416-75-7 | (4R)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one

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Purity
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Price(USD)
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1mg
≥98%
in stock  
$53.00   $37.00
- +
5mg
≥98%
in stock  
$166.00   $116.00
- +
10mg
>98.0%(HPLC)
in stock  
$181.00   $127.00
- +
25mg
97%
in stock  
$366.00   $257.00
- +
100mg
97%
in stock  
$843.00   $590.00
- +
500mg
97%
in stock  
$2,427.00   $1,699.00
- +
  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA0036BU
Chemical Name:
(4R)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
CAS Number:
85416-75-7
Molecular Formula:
C16H21NO3
Molecular Weight:
275.3428
MDL Number:
MFCD03093860
SMILES:
COc1ccc(cc1OC1CCCC1)[C@@H]1CNC(=O)C1
Properties
Properties
 
BP:
472.7°C at 760 mmHg  
Form:
Solid  
MP:
132-134°C  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
341  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
2.2  

Literature

Title: Dual β2-adrenoceptor agonists-PDE4 inhibitors for the treatment of asthma and COPD.

Journal: Bioorganic & medicinal chemistry letters 20120215

Title: SAR of a series of 5,6-dihydro-(9H)-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-alpha]pyridines as potent inhibitors of human eosinophil phosphodiesterase.

Journal: Journal of medicinal chemistry 20070125

Title: Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1.

Journal: Bioorganic & medicinal chemistry letters 20060701

Title: Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity.

Journal: Structure (London, England : 1993) 20030701

Title: Crystal structure of 5-t-butoxycarbonyl-1-benzoyl-2-pyrrolidinone, an intermediate in the synthesis of (-)-rolipram.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20020701

Title: Novel selective PDE4 inhibitors. 3. In vivo antiinflammatory activity of a new series of N-substituted cis-tetra- and cis-hexahydrophthalazinones.

Journal: Journal of medicinal chemistry 20020606

Title: Novel selective PDE4 inhibitors. 2. Synthesis and structure-activity relationships of 4-aryl-substituted cis-tetra- and cis-hexahydrophthalazinones.

Journal: Journal of medicinal chemistry 20010802

Title: Guo C, et al. Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. Immunity. 2016 Oct 18;45(4):944.

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Tags:85416-75-7 Molecular Formula|85416-75-7 MDL|85416-75-7 SMILES|85416-75-7 (4R)-4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one