Home Amines 944396-07-0
944396-07-0,MFCD18251596
Catalog No.:AA0036M4

944396-07-0 | 5-(2,6-Dimorpholinopyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$22.00   $15.00
- +
5mg
98%
in stock  
$36.00   $25.00
- +
10mg
98%
in stock  
$47.00   $33.00
- +
50mg
≥95%
in stock  
$202.00   $141.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0036M4
Chemical Name:
5-(2,6-Dimorpholinopyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine
CAS Number:
944396-07-0
Molecular Formula:
C18H21F3N6O2
Molecular Weight:
410.3935
MDL Number:
MFCD18251596
SMILES:
Nc1ncc(c(c1)C(F)(F)F)c1cc(nc(n1)N1CCOCC1)N1CCOCC1
Properties
Properties
 
Form:
Solid  
MP:
143-147°C  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
530  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
1.5  

Downstream Synthesis Route
10244-24-3    944401-57-4   
4-(trifluoromethyl)-5-(2,6-dimorpholinopyrimidin-4-yl)pyridin-2-amine 

[1]Patent:WO2007/84786,2007,A1.Locationinpatent:Page/Pagecolumn139-140;164

[2]JournalofMedicinalChemistry,2016,vol.59,p.7268-7274

[3]Patent:WO2012/109423,2012,A1.Locationinpatent:Page/Pagecolumn29

944401-56-3    1370351-45-3   
4-(trifluoromethyl)-5-(2,6-dimorpholinopyrimidin-4-yl)pyridin-2-amine 

[1]Patent:WO2012/44727,2012,A2.Locationinpatent:Page/Pagecolumn66-67

[2]Patent:CN105461714,2016,A.Locationinpatent:Paragraph0242;0243;0253;0254;0255

[3]Patent:CN105541792,2016,A.Locationinpatent:Paragraph0235;0236;0237

CASUnavailable 
  1370351-47-5    944396-07-0 

[1]CurrentPatentAssignee:Novartis(w/oSandoz);NOVARTISAG-WO2012/44727,2012,A2Locationinpatent:Page/Pagecolumn73-74

[1]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-WO2014/64058,2014,A1Locationinpatent:Page/Pagecolumn28;29

Literature

Title: Burger MT, et al. Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer. ACS Med Chem Lett. 2011 Aug 26;2(10):774-9.

Title: Zheng Y, et al. Novel phosphatidylinositol 3-kinase inhibitor NVP-BKM120 induces apoptosis in myeloma cells and shows synergistic anti-myeloma activity. J Mol Med (Berl). 2012 Jun;90(6):695-706.

Title: Ni J, et al. Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases. Nat Med. 2016 Jul;22(7):723-6.

Title: Liu H, et al. Identifying and Targeting Sporadic Oncogenic Genetic Aberrations in Mouse Models of Triple Negative Breast Cancer. Cancer Discov. 2018 Mar;8(3):354-369.

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SDS
Tags:944396-07-0 Molecular Formula|944396-07-0 MDL|944396-07-0 SMILES|944396-07-0 5-(2,6-Dimorpholinopyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine