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95233-18-4,MFCD00889188
Catalog No.:AA0036RU

95233-18-4 | Atovaquone

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1mg
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5mg
99%
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$8.00   $6.00
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250mg
99%
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0036RU
Chemical Name:
Atovaquone
CAS Number:
95233-18-4
Molecular Formula:
C22H19ClO3
Molecular Weight:
366.8375
MDL Number:
MFCD00889188
SMILES:
Clc1ccc(cc1)[C@@H]1CC[C@H](CC1)C1=C(O)C(=O)c2c(C1=O)cccc2
NSC Number:
759582
Properties
Properties
 
BP:
542.2°C at 760 mmHg  
Form:
Solid  
MP:
216-2190C  
Solubility:
DMSO: >10mg/mL  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
595  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
5.2  

Literature

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Journal: Chemical research in toxicology 20150518

Title: Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP).

Journal: Journal of medicinal chemistry 20140327

Title: In vitro and in vivo combination of cepharanthine with anti-malarial drugs.

Journal: Malaria journal 20140101

Title: Design, synthesis and biological evaluation of WC-9 analogs as antiparasitic agents.

Journal: European journal of medicinal chemistry 20131101

Title: FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1.

Journal: Chemico-biological interactions 20130905

Title: Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria.

Journal: Journal of medicinal chemistry 20130613

Title: The antimalarial activities of methylene blue and the 1,4-naphthoquinone 3-[4-(trifluoromethyl)benzyl]-menadione are not due to inhibition of the mitochondrial electron transport chain.

Journal: Antimicrobial agents and chemotherapy 20130501

Title: On dihydroorotate dehydrogenases and their inhibitors and uses.

Journal: Journal of medicinal chemistry 20130425

Title: Quinolone-3-diarylethers: a new class of antimalarial drug.

Journal: Science translational medicine 20130320

Title: 4(1H)-Quinolones with liver stage activity against Plasmodium berghei.

Journal: Antimicrobial agents and chemotherapy 20130101

Title: A SYBR Green 1-based in vitro test of susceptibility of Ghanaian Plasmodium falciparum clinical isolates to a panel of anti-malarial drugs.

Journal: Malaria journal 20130101

Title: Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20121226

Title: New naphthoquinones and an alkaloid with in vitro activity against Toxoplasma gondii RH and EGS strains.

Journal: Experimental parasitology 20121201

Title: Efficacy and safety of atovaquone-proguanil in treating imported malaria in Japan: the second report from the research group.

Journal: Parasitology international 20120901

Title: A cluster of Plasmodium vivax malaria in an expedition group to Ethiopia: prophylactic efficacy of atovaquone/proguanil on liver stages of P. vivax.

Journal: The Journal of infection 20120901

Title: Re-emergence of Babesia conradae and effective treatment of infected dogs with atovaquone and azithromycin.

Journal: Veterinary parasitology 20120608

Title: Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials.

Journal: Journal of medicinal chemistry 20120510

Title: Characterization of Plasmodium liver stage inhibition by halofuginone.

Journal: ChemMedChem 20120501

Title: Standby emergency treatment of malaria in travelers: experience to date and new developments.

Journal: Expert review of anti-infective therapy 20120501

Title: Development of in vitro atovaquone-resistant Babesia gibsoni with a single-nucleotide polymorphism in cytb.

Journal: Veterinary parasitology 20120430

Title: Drug screen targeted at Plasmodium liver stages identifies a potent multistage antimalarial drug.

Journal: The Journal of infectious diseases 20120415

Title: Dosing rationale for fixed-dose combinations in children: shooting from the hip?

Journal: Clinical pharmacology and therapeutics 20120401

Title: Bridging strategies for drug combinations in pediatric indications.

Journal: Clinical pharmacology and therapeutics 20120401

Title: Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression.

Journal: The Journal of biological chemistry 20120323

Title: Identification, design and biological evaluation of bisaryl quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).

Journal: Journal of medicinal chemistry 20120308

Title: Identification, design and biological evaluation of heterocyclic quinolones targeting Plasmodium falciparum type II NADH:quinone oxidoreductase (PfNDH2).

Journal: Journal of medicinal chemistry 20120308

Title: Anti-malarial chemoprophylaxis following evacuation from Afghanistan.

Journal: Journal of the Royal Army Medical Corps 20120301

Title: Prolonged protection provided by a single dose of atovaquone-proguanil for the chemoprophylaxis of Plasmodium falciparum malaria in a human challenge model.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20120115

Title: Randomized, prospective, three-arm study to confirm the auditory safety and efficacy of artemether-lumefantrine in Colombian patients with uncomplicated Plasmodium falciparum malaria.

Journal: The American journal of tropical medicine and hygiene 20120101

Title: Atovaquone versus trimethoprim-sulfamethoxazole as Pneumocystis jirovecii pneumonia prophylaxis following renal transplantation.

Journal: Clinical transplantation 20120101

Title: The effects of serum lipids on the in vitro activity of lumefantrine and atovaquone against Plasmodium falciparum.

Journal: Malaria journal 20120101

Title: Therapy of uncomplicated falciparum malaria in Europe: MALTHER - a prospective observational multicentre study.

Journal: Malaria journal 20120101

Title: A longitudinal trial comparing chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria.

Journal: PloS one 20120101

Title: Atovaquone ameliorate gastrointestinal toxoplasmosis complications in a pregnancy model.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20120101

Title: [Mitochondria as targets of chemotherapy].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20120101

Title: Focused Screening and Treatment (FSAT): a PCR-based strategy to detect malaria parasite carriers and contain drug resistant P. falciparum, Pailin, Cambodia.

Journal: PloS one 20120101

Title: Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.

Journal: Chemistry & biology 20111223

Title: Synthesis, antimalarial activity, and structure-activity relationship of 7-(2-phenoxyethoxy)-4(1H)-quinolones.

Journal: Journal of medicinal chemistry 20111222

Title: Cyclodextrin/poly(anhydride) nanoparticles as drug carriers for the oral delivery of atovaquone.

Journal: Biomedical microdevices 20111201

Title: Review: Malaria chemoprophylaxis for travelers to Latin America.

Journal: The American journal of tropical medicine and hygiene 20111201

Title: Malaria therapy in HIV: drug interactions between nevirapine and quinine.

Journal: International journal of STD & AIDS 20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: [Atovaquone-proguanil treatment failure in Plasmodium falciparum].

Journal: Presse medicale (Paris, France : 1983) 20111101

Title: Pharmacokinetics of antimalarials in pregnancy: a systematic review.

Journal: Clinical pharmacokinetics 20111101

Title: Prophylactic use of antimalarials during pregnancy.

Journal: Canadian family physician Medecin de famille canadien 20111101

Title: Synthetic chromanol derivatives and their interaction with complex III in mitochondria from bovine, yeast, and Leishmania.

Journal: Chemical research in toxicology 20111017

Title: Sensitivity of Plasmodium vivax to chloroquine, mefloquine, artemisinin and atovaquone in north-western Thailand.

Journal: Wiener klinische Wochenschrift 20111001

Title: Variation among Plasmodium falciparum strains in their reliance on mitochondrial electron transport chain function.

Journal: Eukaryotic cell 20110801

Title: Synthesis and biological activities of 4-N-(anilinyl-n-[oxazolyl])-7-chloroquinolines (n=3' or 4') against Plasmodium falciparum in in vitro models.

Journal: Bioorganic & medicinal chemistry letters 20110801

Title: [Diagnosis and treatment of pneumocystis jirovecii pneumonia].

Journal: Deutsche medizinische Wochenschrift (1946) 20110701

Title: Lead optimization of aryl and aralkyl amine-based triazolopyrimidine inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with antimalarial activity in mice.

Journal: Journal of medicinal chemistry 20110609

Title: Community management of anti-malarials in Africa and iatrogenic risk.

Journal: Journal of tropical pediatrics 20110601

Title: Persistent babesiosis in a stem cell transplant recipient.

Journal: Leukemia research 20110601

Title: Diagnostic and therapeutic challenges.

Journal: Retina (Philadelphia, Pa.) 20110601

Title: Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection.

Journal: Molecular and biochemical parasitology 20110501

Title: Novel HIV-1 protease inhibitors (PIs) containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran, that are potent against multi-PI-resistant HIV-1 variants.

Journal: Antimicrobial agents and chemotherapy 20110401

Title: Babesiosis in an Egyptian boy aquired from pet dog, and a general review.

Journal: Journal of the Egyptian Society of Parasitology 20110401

Title: Azithromycin for treating uncomplicated malaria.

Journal: The Cochrane database of systematic reviews 20110216

Title: Atovaquone-proguanil use in early pregnancy and the risk of birth defects.

Journal: Archives of internal medicine 20110214

Title: SDS-coated atovaquone nanosuspensions show improved therapeutic efficacy against experimental acquired and reactivated toxoplasmosis by improving passage of gastrointestinal and blood-brain barriers.

Journal: Journal of drug targeting 20110201

Title: Plasmodium falciparum: Solanum nudum SN-1 steroid antiplasmodial activity when combined with antimalarial drugs.

Journal: Experimental parasitology 20110101

Title: [Post-malaria neurological syndrome complicating a relapse of Plasmodium falciparum malaria after atovaquone-proguanil treatment].

Journal: Medecine et maladies infectieuses 20110101

Title: Toxoplasma gondii primary infection in renal transplant recipients. Two case reports and literature review.

Journal: Transplant international : official journal of the European Society for Organ Transplantation 20110101

Title: Efficacy of atovaquone and azithromycin or imidocarb dipropionate in cats with acute cytauxzoonosis.

Journal: Journal of veterinary internal medicine 20110101

Title: A potential interaction between warfarin and atovaquone.

Journal: The Annals of pharmacotherapy 20110101

Title: Parasitostatic effect of maslinic acid. I. Growth arrest of Plasmodium falciparum intraerythrocytic stages.

Journal: Malaria journal 20110101

Title: Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis.

Journal: Malaria journal 20110101

Title: Pneumocystis carinii pneumonia prophylaxis: current therapies and recommendations.

Journal: Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses 20110101

Title: Resolution of a proteinuric nephropathy associated with Babesia gibsoni infection in a dog.

Journal: Journal of the American Animal Hospital Association 20110101

Title: Mitochondrial electron transport inhibition and viability of intraerythrocytic Plasmodium falciparum.

Journal: Antimicrobial agents and chemotherapy 20101201

Title: Antimalarial drugs: modes of action and mechanisms of parasite resistance.

Journal: Future microbiology 20101201

Title: Combination of chiroptical, absorption and fluorescence spectroscopic methods reveals multiple, hydrophobicity-driven human serum albumin binding of the antimalarial atovaquone and related hydroxynaphthoquinone compounds.

Journal: Organic & biomolecular chemistry 20101107

Title: Protoporphyrinogen IX oxidase from Plasmodium falciparum is anaerobic and is localized to the mitochondrion.

Journal: Molecular and biochemical parasitology 20101101

Title: Acute disseminated fatal toxoplasmosis after haploidentical stem cell transplantation despite atovaquone prophylaxis in a young man.

Journal: The Pediatric infectious disease journal 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections.

Journal: Bioorganic & medicinal chemistry 20101101

Title: Endochin optimization: structure-activity and structure-property relationship studies of 3-substituted 2-methyl-4(1H)-quinolones with antimalarial activity.

Journal: Journal of medicinal chemistry 20101014

Title: Computer-assisted design of pro-drugs for antimalarial atovaquone.

Journal: Chemical biology & drug design 20101001

Title: Spiroindolones, a potent compound class for the treatment of malaria.

Journal: Science (New York, N.Y.) 20100903

Title: Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.

Journal: Antimicrobial agents and chemotherapy 20100901

Title: Babesiosis in a patient on infliximab for Crohn's disease.

Journal: Inflammatory bowel diseases 20100801

Title: Does atovaquone prolong the disease-free interval of toxoplasmic retinochoroiditis?

Journal: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20100801

Title: Inhibiting Plasmodium cytochrome bc1: a complex issue.

Journal: Current opinion in chemical biology 20100801

Title: Evaluation and structure-activity relationship study of acute toxicity of naphthoquinones to Photobacterium phosphoreum, Photobacterium T3B.

Journal: Bulletin of environmental contamination and toxicology 20100801

Title: Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir.

Journal: AIDS (London, England) 20100515

Title: LC-APCI mass spectrometric method development and validation for the determination of atovaquone in human plasma.

Journal: Biomedical chromatography : BMC 20100501

Title: Letter to the editor of travel medicine and infectious disease.

Journal: Travel medicine and infectious disease 20100501

Title: Chronic malaria infections increase family inequalities and reduce parental fitness: experimental evidence from a wild bird population.

Journal: Journal of evolutionary biology 20100301

Title: Emergence of resistance to azithromycin-atovaquone in immunocompromised patients with Babesia microti infection.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20100201

Title: [Effects of combined addition of atovaquone and lithium on the in vitro cell growth of the pathogenic yeast Candida albicans].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20100201

Title: Congenital babesiosis in a four-week-old female infant.

Journal: The Pediatric infectious disease journal 20100201

Title: Probing binding determinants in center P of the cytochrome bc(1) complex using novel hydroxy-naphthoquinones.

Journal: Biochimica et biophysica acta 20100101

Title: Oral atovaquone for the treatment of severe Pneumocystis jirovecii pneumonia in a patient with glucose-6-phosphate dehydrogenase deficiency.

Journal: Scandinavian journal of infectious diseases 20100101

Title: In vitro and in vivo activities of 1-hydroxy-2-alkyl-4(1H)quinolone derivatives against Toxoplasma gondii.

Journal: Antimicrobial agents and chemotherapy 20100101

Title: Alternatives for malaria prophylaxis during the first trimester of pregnancy: our personal view.

Journal: Journal of travel medicine 20100101

Title: Rapid identification of chloroquine and atovaquone drug resistance in Plasmodium falciparum using high-resolution melt polymerase chain reaction.

Journal: Malaria journal 20100101

Title: Plasmodium chabaudi chabaudi malaria parasites can develop stable resistance to atovaquone with a mutation in the cytochrome b gene.

Journal: Malaria journal 20100101

Title: Assessment of adherence to atovaquone-proguanil prophylaxis in travelers.

Journal: Journal of travel medicine 20100101

Title: Different mutation patterns of Plasmodium falciparum among patients in Jimma University Hospital, Ethiopia.

Journal: Malaria journal 20100101

Title: Transfusion-associated babesiosis in a 7-month-old infant after bidirectional Glenn procedure.

Journal: Congenital heart disease 20100101

Title: Babesiosis in the immediate postoperative period after splenectomy for trauma.

Journal: Surgical infections 20091201

Title: Synthesis and antimalarial activity of new atovaquone derivatives.

Journal: European journal of medicinal chemistry 20091101

Title: Effectiveness of malaria chemoprophylaxis against Plasmodium falciparum infection in UK travellers: retrospective observational data.

Journal: Travel medicine and infectious disease 20091101

Title: Mefloquine has more adverse effects than other drugs for malaria prophylaxis.

Journal: BMJ (Clinical research ed.) 20091013

Title: Drugs for preventing malaria in travellers.

Journal: The Cochrane database of systematic reviews 20091007

Title: Plasmodium relictum (lineage P-SGS1): Further observation of effects on experimentally infected passeriform birds, with remarks on treatment with Malarone.

Journal: Experimental parasitology 20091001

Title: Use of peroxisome proliferator-activated receptor gamma agonists as adjunctive treatment for Plasmodium falciparum malaria: a randomized, double-blind, placebo-controlled trial.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090915

Title: Atovaquone derivatives as potent cytotoxic and apoptosis inducing agents.

Journal: Bioorganic & medicinal chemistry letters 20090901

Title: Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials.

Journal: Bioorganic & medicinal chemistry letters 20090701

Title: Atovaquone + proguanil: new indication. For children weighing as little as 5 kg; an inconvenient form. A flavoured syrup would be better suited to infants and young children.

Journal: Prescrire international 20090601

Title: The role of apolipoprotein E in uptake of atovaquone into the brain in murine acute and reactivated toxoplasmosis.

Journal: Journal of drug targeting 20090501

Title: Importance of using highly pure internal standards for successful liquid chromatography/tandem mass spectrometric bioanalytical assays.

Journal: Rapid communications in mass spectrometry : RCM 20090501

Title: Pneumocystis jirovecii pneumonia after rituximab therapy for antibody-mediated rejection in a renal transplant recipient.

Journal: Transplant infectious disease : an official journal of the Transplantation Society 20090401

Title: Diterpene formamides from the tropical marine sponge Cymbastela hooperi and their antimalarial activity in vitro.

Journal: Journal of natural products 20090327

Title: 79-year-old man with fever, malaise, and jaundice.

Journal: Mayo Clinic proceedings 20090301

Title: Type II NADH dehydrogenase of the respiratory chain of Plasmodium falciparum and its inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20090201

Title: Evaluation of mood profiles during malaria chemoprophylaxis: a randomized, double-blind, four-arm study.

Journal: Journal of travel medicine 20090101

Title: [Mutations of drug target molecules in Pneumocystis jirovecii isolates and future investigations].

Journal: Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20090101

Title: Possible emergence of drug-resistant variants of Babesia gibsoni in clinical cases treated with atovaquone and azithromycin.

Journal: Journal of veterinary internal medicine 20090101

Title: Breakthrough cerebral toxoplasmosis in a patient receiving atovaquone prophylaxis after a hematopoietic stem cell transplantation.

Journal: Pediatric transplantation 20081201

Title: Well-tolerated chemoprophylaxis uniformly prevented Swedish soldiers from Plasmodium falciparum malaria in Liberia, 2004-2006.

Journal: Military medicine 20081201

Title: Adverse drug reactions to treatments for ocular toxoplasmosis: a retrospective chart review.

Journal: Clinical therapeutics 20081101

Title: Comparative genomics of the neglected human malaria parasite Plasmodium vivax.

Journal: Nature 20081009

Title: Splenic pneumocystosis: an atypical presentation of extrapulmonary Pneumocystis infection.

Journal: The AIDS reader 20081001

Title: Toxoplasmosis in wallabies (Macropus rufogriseus and Macropus eugenii): blindness, treatment with atovaquone, and isolation of Toxoplasma gondii.

Journal: The Journal of parasitology 20080801

Title: Bullous erythema multiforme after treatment with Malarone, a combination antimalarial composed of atovaquone and proguanil hydrochloride.

Journal: Tropical doctor 20080701

Title: Mutation underlying resistance of Plasmodium berghei to atovaquone in the quinone binding domain 2 (Qo(2)) of the cytochrome b gene.

Journal: Parasitology international 20080601

Title: Atovaquone-proguanil resistance in imported falciparum malaria in a young child.

Journal: The Pediatric infectious disease journal 20080601

Title: Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials.

Journal: Journal of medicinal chemistry 20080508

Title: A drug-selected Plasmodium falciparum lacking the need for conventional electron transport.

Journal: Molecular and biochemical parasitology 20080501

Title: Acridinediones: selective and potent inhibitors of the malaria parasite mitochondrial bc1 complex.

Journal: Molecular pharmacology 20080501

Title: Failure of atovaquone/proguanil to prevent Plasmodium ovale malaria in traveler returning from Cameroon.

Journal: Travel medicine and infectious disease 20080501

Title: Artemether + lumefantrine: new drug. An alternative to atovaquone + proguanil.

Journal: Prescrire international 20080401

Title: Atovaquone-statine 'double-drugs' with high antiplasmodial activity.

Journal: ChemMedChem 20080301

Title: [Tolerance and efficacy of atovaquone-proguanil for the treatment of paediatric imported Plasmodium falciparum malaria in France: clinical practice in a university hospital in Paris].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20080301

Title: [Babesiosis in an immunocompromised German patient].

Journal: Medizinische Klinik (Munich, Germany : 1983) 20080215

Title: Plasmodium falciparum malaria and atovaquone-proguanil treatment failure.

Journal: Emerging infectious diseases 20080201

Title: Complications of coinfection with Babesia and Lyme disease after splenectomy.

Journal: Journal of the American Board of Family Medicine : JABFM 20080101

Title: In vitro atovaquone/proguanil susceptibility and characterization of the cytochrome b gene of Plasmodium falciparum from different endemic regions of Thailand.

Journal: Malaria journal 20080101

Title: Ototoxicity of artemether/lumefantrine in the treatment of falciparum malaria: a randomized trial.

Journal: Malaria journal 20080101

Title: Fever of unknown origin (FUO) due to babesiosis in a immunocompetent host.

Journal: Heart & lung : the journal of critical care 20080101

Title: Trends in antimalarial prescriptions in Australia 2002 to 2005.

Journal: Journal of travel medicine 20080101

Title: Mutations in the Plasmodium falciparum cytochrome b gene are associated with delayed parasite recrudescence in malaria patients treated with atovaquone-proguanil.

Journal: Malaria journal 20080101

Title: HIV: treating Pneumocystis pneumonia (PCP).

Journal: BMJ clinical evidence 20080101

Title: Treatment of refractory Babesia microti infection with atovaquone-proguanil in an HIV-infected patient: case report.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20071215

Title: Inadequate chemoprophylaxis and the risk of malaria.

Journal: Australian family physician 20071201

Title: Malaria chemoprophylaxis: what do the travelers choose, and how does pretravel consultation influence their final decision.

Journal: The American journal of tropical medicine and hygiene 20071201

Title: Selective ambulatory management of Plasmodium falciparum malaria in paediatric refugees.

Journal: Archives of disease in childhood 20071101

Title: A systematic review and meta-analysis of the effectiveness and safety of atovaquone proguanil (Malarone) for chemoprophylaxis against malaria.

Journal: The Journal of antimicrobial chemotherapy 20071101

Title: Babesia gibsoni: detection during experimental infections and after combined atovaquone and azithromycin therapy.

Journal: Experimental parasitology 20071001

Title: Modeling the molecular basis of atovaquone resistance in parasites and pathogenic fungi.

Journal: Trends in parasitology 20071001

Title: Fluorine-containing aryloxyethyl thiocyanate derivatives are potent inhibitors of Trypanosoma cruzi and Toxoplasma gondii proliferation.

Journal: Bioorganic & medicinal chemistry letters 20070915

Title: Drug-resistant malaria - an insight.

Journal: The FEBS journal 20070901

Title: Clinical efficacy of antiparasite treatments against intestinal helminths and haematic protozoa in Gallotia caesaris (lizards).

Journal: Experimental parasitology 20070801

Title: Parallel evolution of adaptive mutations in Plasmodium falciparum mitochondrial DNA during atovaquone-proguanil treatment.

Journal: Molecular biology and evolution 20070801

Title: A non-radiolabeled heme-GSH interaction test for the screening of antimalarial compounds.

Journal: Experimental parasitology 20070701

Title: First case of human babesiosis in Germany - Clinical presentation and molecular characterisation of the pathogen.

Journal: International journal of medical microbiology : IJMM 20070601

Title: Growth inhibition of Toxoplasma gondii and Plasmodium falciparum by nanomolar concentrations of 1-hydroxy-2-dodecyl-4(1H)quinolone, a high-affinity inhibitor of alternative (type II) NADH dehydrogenases.

Journal: Antimicrobial agents and chemotherapy 20070401

Title: Prevention and treatment of congenital toxoplasmosis.

Journal: Expert review of anti-infective therapy 20070401

Title: Efficacy of atovaquone-proguanil for treatment of acute multidrug-resistant Plasmodium falciparum malaria in Thailand.

Journal: The American journal of tropical medicine and hygiene 20070401

Title: Cerebral malaria in spite of peripheral parasite clearance in a patient treated with atovaquone/proguanil.

Journal: Parasitology research 20070301

Title: In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models.

Journal: Experimental parasitology 20070301

Title: Analyses of cytochrome b mutations in Plasmodium falciparum isolates in Thai-Myanmar border.

Journal: Travel medicine and infectious disease 20070301

Title: Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum.

Journal: Nature 20070301

Title: Molecular characterisation of Babesia gibsoni infection from a pit-bull terrier pup recently imported into South Africa.

Journal: Journal of the South African Veterinary Association 20070301

Title: Motor neuron disease recovery associated with IV ceftriaxone and anti-Babesia therapy.

Journal: Acta neurologica Scandinavica 20070201

Title: Atovaquone and azithromycin treatment for babesiosis in an infant.

Journal: The Pediatric infectious disease journal 20070201

Title: Atovaquone-proguanil: report from the CDC expert meeting on malaria chemoprophylaxis (II).

Journal: The American journal of tropical medicine and hygiene 20070201

Title: [New drugs against parasitic diseases].

Journal: La Revue du praticien 20070131

Title: The traveling farm wife.

Journal: The American journal of medicine 20070101

Title: The safety and tolerance of atovaquone/proguanil for the long-term prophylaxis of plasmodium falciparum malaria in non-immune travelers and expatriates [corrected].

Journal: Journal of travel medicine 20070101

Title: A man with tropical travel history, fever, and pulmonary infiltrates.

Journal: Comprehensive therapy 20070101

Title: Synergistic interaction between atovaquone and retinol in Plasmodium falciparum in vitro.

Journal: Wiener klinische Wochenschrift 20070101

Title: Synergistic interaction between monodesbutyl-benflumetol and retinol in Plasmodium falciparum.

Journal: Wiener klinische Wochenschrift 20070101

Title: Relapsing vivax malaria after 6 months of daily atovaquone/proguanil in Afghanistan: the case for expanded use of primaquine as a causal prophylactic.

Journal: Journal of travel medicine 20070101

Title: Outpatient treatment of malaria in recently arrived African migrants.

Journal: The Medical journal of Australia 20061201

Title: A randomised, double-blind, placebo-controlled trial of atovaquone-proguanil vs. sulphadoxine-pyrimethamine in the treatment of malarial anaemia in Zambian children.

Journal: Tropical medicine & international health : TM & IH 20061101

Title: Prevalence of Plasmodium falciparum cytochrome b gene mutations in isolates imported from Africa, and implications for atovaquone resistance.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20061001

Title: Babesiosis masquerading as recurrent immune thrombocytopenic purpura in a splenectomized patient.

Journal: Annals of hematology 20061001

Title: Plasmodium falciparum malaria associated with mefloquine failure in Gambia.

Journal: Pharmacotherapy 20061001

Title: Efficacy and safety of atovaquone-proguanil compared with mefloquine in the treatment of nonimmune patients with uncomplicated P. falciparum malaria in Japan.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20061001

Title: Clinical atovaquone-proguanil resistance of Plasmodium falciparum associated with cytochrome b codon 268 mutations.

Journal: Microbes and infection 20060901

Title: Randomized, double-blind, placebo-controlled study of Malarone for malaria prophylaxis in non-immune Colombian soldiers.

Journal: The American journal of tropical medicine and hygiene 20060901

Title: Examination of the impact of a range of Pluronic surfactants on the in-vitro solubilisation behaviour and oral bioavailability of lipidic formulations of atovaquone.

Journal: The Journal of pharmacy and pharmacology 20060601

Title: Folic acid treatment of Zambian children with moderate to severe malaria anemia.

Journal: The American journal of tropical medicine and hygiene 20060601

Title: Reactivation of toxoplasma retinochoroiditis under atovaquone therapy in an immunocompetent patient.

Journal: Ocular immunology and inflammation 20060601

Title: Pneumocystis pneumonia in people with HIV.

Journal: Clinical evidence 20060601

Title: Pharmacokinetics of dihydroartemisinin following oral artesunate treatment of pregnant women with acute uncomplicated falciparum malaria.

Journal: European journal of clinical pharmacology 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Drug-induced death of the asexual blood stages of Plasmodium falciparum occurs without typical signs of apoptosis.

Journal: Microbes and infection 20060501

Title: Molecular basis of Toxoplasma gondii atovaquone resistance modeled in Saccharomyces cerevisiae.

Journal: Molecular and biochemical parasitology 20060401

Title: Short report: cloning of the Babesia gibsoni cytochrome B gene and isolation of three single nucleotide polymorphisms from parasites present after atovaquone treatment.

Journal: The American journal of tropical medicine and hygiene 20060401

Title: [Malaria: a medical and economic problem].

Journal: Presse medicale (Paris, France : 1983) 20060401

Title: Multiple synergistic interactions between atovaquone and antifolates against Plasmodium falciparum in vitro: a rational basis for combination therapy.

Journal: Acta tropica 20060301

Title: Apparent absence of atovaquone/proguanil resistance in 477 Plasmodium falciparum isolates from untreated French travellers.

Journal: The Journal of antimicrobial chemotherapy 20060101

Title: Detection of atovaquone-proguanil resistance conferring mutations in Plasmodium falciparum cytochrome b gene in Luanda, Angola.

Journal: Malaria journal 20060101

Title: Atovaquone plus cholestyramine in patients coinfected with Babesia microti and Borrelia burgdorferi refractory to other treatment.

Journal: Advances in therapy 20060101

Title: Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa.

Journal: Malaria journal 20060101

Title: Tertian malaria (Plasmodium vivax and Plasmodium ovale) in two travelers despite atovaquone-proguanil prophylaxis.

Journal: Journal of travel medicine 20060101

Title: Molecular surveillance of mutations in the cytochrome b gene of Plasmodium falciparum in Gabon and Ethiopia.

Journal: Malaria journal 20060101

Title: Pharmacodynamic interaction between atovaquone and other antimalarial compounds against Plasmodium falciparum in vitro.

Journal: Wiener klinische Wochenschrift 20060101

Title: Atovaquone/proguanil for the prophylaxis and treatment of malaria.

Journal: Expert review of anti-infective therapy 20051201

Title: Malaria: prevention in travellers.

Journal: Clinical evidence 20051201

Title: Plasmodium falciparum: interaction of shikimate analogues with antimalarial drugs.

Journal: Experimental parasitology 20051101

Title: [Ineffective change of antimalaria prophylaxis to Artemisia vulgaris in a group travelling to West Africa].

Journal: Ugeskrift for laeger 20051024

Title: Atovaquone-proguanil for treating uncomplicated malaria.

Journal: The Cochrane database of systematic reviews 20051019

Title: [Malaria chemoprophylaxis].

Journal: Ugeskrift for laeger 20051017

Title: [Malaria prophylaxis for long-term travellers and expatriates].

Journal: Ugeskrift for laeger 20051017

Title: The pharmacokinetics and pharmacodynamics of atovaquone and proguanil for the treatment of uncomplicated falciparum malaria in third-trimester pregnant women.

Journal: European journal of clinical pharmacology 20050901

Title: A randomized comparison of artesunate-atovaquone-proguanil versus quinine in treatment for uncomplicated falciparum malaria during pregnancy.

Journal: The Journal of infectious diseases 20050901

Title: Simulation of fasting gastric conditions and its importance for the in vivo dissolution of lipophilic compounds.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20050801

Title: Ubiquinone synthesis in mitochondrial and microsomal subcellular fractions of Pneumocystis spp.: differential sensitivities to atovaquone.

Journal: Eukaryotic cell 20050801

Title: Short report: no evidence of cardiotoxicity of atovaquone-proguanil alone or in combination with artesunate.

Journal: The American journal of tropical medicine and hygiene 20050801

Title: Effectiveness of antimalarial drugs.

Journal: The New England journal of medicine 20050728

Title: Uncovering the molecular mode of action of the antimalarial drug atovaquone using a bacterial system.

Journal: The Journal of biological chemistry 20050722

Title: Occult Plasmodium vivax infection diagnosed by a polymerase chain reaction-based detection system: a case report.

Journal: The American journal of tropical medicine and hygiene 20050701

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: Efficacy of atovaquone and sulfadiazine in the treatment of mice infected with Toxoplasma gondii strains isolated in Brazil.

Journal: Parasite (Paris, France) 20050601

Title: Pneumocystis pneumonia in people with HIV.

Journal: Clinical evidence 20050601

Title: Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations.

Journal: Journal of medicinal chemistry 20050505

Title: Cytochrome b mutations that modify the ubiquinol-binding pocket of the cytochrome bc1 complex and confer anti-malarial drug resistance in Saccharomyces cerevisiae.

Journal: The Journal of biological chemistry 20050429

Title: UDP-glucuronosyltransferases and clinical drug-drug interactions.

Journal: Pharmacology & therapeutics 20050401

Title: Emergence of atovaquone-proguanil resistance during treatment of Plasmodium falciparum malaria acquired by a non-immune north American traveller to west Africa.

Journal: The American journal of tropical medicine and hygiene 20050401

Title: Multiple cytochrome B mutations may cause atovaquone resistance.

Journal: The Journal of infectious diseases 20050301

Title: Pharmacodynamic interactions of amodiaquine and its major metabolite desethylamodiaquine with artemisinin, quinine and atovaquone in Plasmodium falciparum in vitro.

Journal: Acta tropica 20050301

Title: A randomized open label clinical trial to compare the efficacy and safety of intravenous quinine followed by oral malarone vs. intravenous quinine followed by oral quinine in the treatment of severe malaria.

Journal: Journal of tropical pediatrics 20050201

Title: A malaria outbreak following a British military deployment to Sierra Leone.

Journal: The Journal of infection 20050201

Title: In vitro recrudescence of Plasmodium falciparum parasites suppressed to dormant state by atovaquone alone and in combination with proguanil.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20050101

Title: Comparison of atovaquone and azithromycin with trimethoprim-sulfamethoxazole for the prevention of serious bacterial infections in children with HIV infection.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050101

Title: Stage conversion of Toxoplasma gondii RH parasites in mice by treatment with atovaquone and pyrrolidine dithiocarbamate.

Journal: Microbes and infection 20050101

Title: Simultaneous quantitation of the highly lipophilic atovaquone and hydrophilic strong basic proguanil and its metabolites using a new mixed-mode SPE approach and steep-gradient LC.

Journal: Journal of chromatographic science 20050101

Title: Malaria prophylaxis for aircrew: safety of atovaquone/proguanil in healthy volunteers under aircraft cabin pressure conditions.

Journal: Journal of travel medicine 20050101

Title: Acute hepatitis and atovaquone/proguanil.

Journal: Journal of travel medicine 20050101

Title: 2-Phenyl-beta-lapachone can affect mitochondrial function by redox cycling mediated oxidation.

Journal: Archives of biochemistry and biophysics 20041215

Title: Malaria: prevention in travellers.

Journal: Clinical evidence 20041201

Title: Screening for mutations related to atovaquone/proguanil resistance in treatment failures and other imported isolates of Plasmodium falciparum in Europe.

Journal: The Journal of infectious diseases 20041101

Title: [New aspects of epidemiology and treatment of Pneumocystis carinii infection].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20041101

Title: Efficacy of atovaquone against Babesia gibsoni in vivo and in vitro.

Journal: Veterinary parasitology 20040920

Title: Quinine-resistant severe falciparum malaria effectively treated with atovaquone and proguanil hydrochloride combination therapy.

Journal: Internal medicine (Tokyo, Japan) 20040701

Title: [Malaria: prophylaxis, treatment, stand-by medication. A single mosquito bite suffices].

Journal: MMW Fortschritte der Medizin 20040617

Title: Atovaquone-proguanil versus chloroquine-proguanil for malaria prophylaxis in nonimmune pediatric travelers: results of an international, randomized, open-label study.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040615

Title: Combined effect of atovaquone and pyrrolidine dithiocarbamate in the treatment of acute murine toxoplasmosis.

Journal: Chemotherapy 20040601

Title: Pneumocystis carinii pneumonia treatment in people infected with HIV.

Journal: Clinical evidence 20040601

Title: Malaria: prevention in travellers.

Journal: Clinical evidence 20040601

Title: Failure of low-dose atovaquone prophylaxis against Pneumocystis jiroveci infection in transplant recipients.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040415

Title: Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain.

Journal: Protein science : a publication of the Protein Society 20040401

Title: NADH-ubiquinone oxidoreductase activity in the kinetoplasts of the plant trypanosomatid Phytomonas serpens.

Journal: Parasitology research 20040301

Title: Short communication: Prevalence of mutations associated with resistance to atovaquone and to the antifolate effect of proguanil in Plasmodium falciparum isolates from northern Ghana.

Journal: Tropical medicine & international health : TM & IH 20040301

Title: A malaria outbreak following a British military deployment to Sierra Leone.

Journal: The Journal of infection 20040201

Title: CV8, a new combination of dihydroartemisinin, piperaquine, trimethoprim and primaquine, compared with atovaquone-proguanil against falciparum malaria in Vietnam.

Journal: Tropical medicine & international health : TM & IH 20040201

Title: Molecular basis for atovaquone resistance in Pneumocystis jirovecii modeled in the cytochrome bc(1) complex of Saccharomyces cerevisiae.

Journal: The Journal of biological chemistry 20040123

Title: Malarone treatment failure not associated with previously described mutations in the cytochrome b gene.

Journal: Malaria journal 20040101

Title: Efficacy of combined atovaquone and azithromycin for therapy of chronic Babesia gibsoni (Asian genotype) infections in dogs.

Journal: Journal of veterinary internal medicine 20040101

Title: Atovaquone-proguanil (malarone): an effective treatment for uncomplicated Plasmodium falciparum malaria in travelers from Denmark.

Journal: Journal of travel medicine 20040101

Title: Atovaquone and proguanil versus amodiaquine for the treatment of Plasmodium falciparum malaria in African infants and young children.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031201

Title: Military aviators, special operations forces, and causal malaria prophylaxis.

Journal: Military medicine 20031201

Title: HIV: prevention of opportunistic infections.

Journal: Clinical evidence 20031201

Title: Malaria: prevention in travellers.

Journal: Clinical evidence 20031201

Title: Diagnosis and treatment of malaria in children.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031115

Title: New antimalarial drugs.

Journal: Angewandte Chemie (International ed. in English) 20031110

Title: The pharmacokinetics of atovaquone and proguanil in pregnant women with acute falciparum malaria.

Journal: European journal of clinical pharmacology 20031001

Title: Atovaquone-proguanil for prophylaxis and treatment of malaria.

Journal: The Annals of pharmacotherapy 20030901

Title: Atovaquone-proguanil for recrudescent Plasmodium falciparum in Vietnam.

Journal: Annals of tropical medicine and parasitology 20030901

Title: Malaria and children: the risks, precautions, and the nurse's role.

Journal: Professional nurse (London, England) 20030901

Title: Molecular basis for atovaquone binding to the cytochrome bc1 complex.

Journal: The Journal of biological chemistry 20030815

Title: Genetic confirmation of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to East Africa.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030801

Title: Reinstituting trimethoprim--sulfamethoxazole in patients receiving atovaquone for Pneumocystis carinii pneumonia prophylaxis.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20030801

Title: Molecular epidemiology of malaria in Cameroon. XVII. Baseline monitoring of atovaquone-resistant Plasmodium falciparum by in vitro drug assays and cytochrome b gene sequence analysis.

Journal: The American journal of tropical medicine and hygiene 20030801

Title: Stevens-Johnson syndrome associated with Malarone antimalarial prophylaxis.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030701

Title: The impact of Malarone and primaquine on psychomotor performance.

Journal: Aviation, space, and environmental medicine 20030701

Title: HIV: opportunistic infections.

Journal: Clinical evidence 20030601

Title: Atovaquone/proguanil: the need for family protection.

Journal: Journal of travel medicine 20030501

Title: The safety of atovaquone/proguanil in long-term malaria prophylaxis of nonimmune adults.

Journal: Journal of travel medicine 20030501

Title: Post-marketing surveillance: adverse events during long-term use of atovaquone/proguanil for travelers to malaria-endemic countries.

Journal: Journal of travel medicine 20030501

Title: Toxicity related to chloroquine treatment of resistant vivax malaria.

Journal: The Annals of pharmacotherapy 20030401

Title: The new drug combinations: their place in the treatment of uncomplicated Plasmodium falciparum malaria.

Journal: Fundamental & clinical pharmacology 20030401

Title: Problems in prescribing malaria chemoprophylaxis for travelers.

Journal: Fundamental & clinical pharmacology 20030401

Title: Therapeutic evaluation of free and nanocapsule-encapsulated atovaquone in the treatment of murine visceral leishmaniasis.

Journal: Annals of tropical medicine and parasitology 20030401

Title: Evidence of Plasmodium falciparum malaria resistant to atovaquone and proguanil hydrochloride: case reports.

Journal: BMJ (Clinical research ed.) 20030322

Title: [Three newly registered drugs in the Netherlands for the treatment and chemoprophylaxis of malaria: atovaquone-proguanil, artemether-lumefantrine and artemotil].

Journal: Nederlands tijdschrift voor geneeskunde 20030215

Title: Atovaquone-loaded nanocapsules: influence of the nature of the polymer on their in vitro characteristics.

Journal: International journal of pharmaceutics 20030102

Title: Persistence of atovaquone in human sera following treatment: inhibition of Plasmodium falciparum development in vivo and in vitro.

Journal: The American journal of tropical medicine and hygiene 20030101

Title: Atovaquone/proguanil: a review of its use for the prophylaxis of Plasmodium falciparum malaria.

Journal: Drugs 20030101

Title: Different mutation patterns of atovaquone resistance to Plasmodium falciparum in vitro and in vivo: rapid detection of codon 268 polymorphisms in the cytochrome b as potential in vivo resistance marker.

Journal: Malaria journal 20030101

Title: The efficacy of chemoprophylaxis against malaria with chloroquine plus proguanil, mefloquine, and atovaquone plus proguanil in travelers from Denmark.

Journal: Journal of travel medicine 20030101

Title: Current status and replies to frequently posed questions on atovaquone plus proguanil (Malarone) for the prevention of malaria.

Journal: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20030101

Title: Detection of atovaquone and Malarone resistance conferring mutations in Plasmodium falciparum cytochrome b gene (cytb).

Journal: Molecular and cellular probes 20030101

Title: Plasmodium falciparum outwits Malarone, protector of travellers.

Journal: Bulletin of the World Health Organization 20030101

Title: Plasmodium vivax malaria in spite of atovaquone/proguanil (malarone) prophylaxis.

Journal: Journal of travel medicine 20030101

Title: Atovaquone/proguanil resistance in Africa: a case report.

Journal: Scandinavian journal of infectious diseases 20030101

Title: Pharmacodynamic interactions among atovaquone, proguanil and cycloguanil against Plasmodium falciparum in vitro.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20030101

Title: Artesunate-atovaquone-proguanil rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: a preliminary report.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20030101

Title: Treatment of uncomplicated multidrug-resistant falciparum malaria with artesunate-atovaquone-proguanil.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021215

Title: Efficacy of atovaquone combined with clindamycin against murine infection with a cystogenic (Me49) strain of Toxoplasma gondii.

Journal: The Journal of antimicrobial chemotherapy 20021201

Title: Efficacy of atovaquone/proguanil for malaria prophylaxis in children and its effect on the immunogenicity of live oral typhoid and cholera vaccines.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021115

Title: Atovaquone/proguanil therapy for Plasmodium falciparum and Plasmodium vivax malaria in Indonesians who lack clinical immunity.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021101

Title: Randomized, placebo-controlled trial of atovaquone/proguanil for the prevention of Plasmodium falciparum or Plasmodium vivax malaria among migrants to Papua, Indonesia.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021001

Title: [Preventive vaccination for travel. Every dog has it, but only every 10th grandmother].

Journal: MMW Fortschritte der Medizin 20020919

Title: [Blackwater fever].

Journal: Presse medicale (Paris, France : 1983) 20020907

Title: Atovaquone plus chloroguanide versus mefloquine for malaria prophylaxis: a focus on neuropsychiatric adverse events.

Journal: Clinical pharmacology and therapeutics 20020901

Title: [Value of malarone in therapy of malaria tropica].

Journal: Medizinische Klinik (Munich, Germany : 1983) 20020815

Title: Babesiosis in humans: a treatment review.

Journal: Expert opinion on pharmacotherapy 20020801

Title: Atovaquone/proguanil for plasmodium falciparum malaria.

Journal: The Pediatric infectious disease journal 20020801

Title: [New strategies in therapy to roll back malaria].

Journal: Deutsche medizinische Wochenschrift (1946) 20020726

Title: Characterisation of atovaquone resistance in Leishmania infantum promastigotes.

Journal: International journal for parasitology 20020701

Title: Determination of atovaquone in tablets by differential pulse polarography.

Journal: Die Pharmazie 20020701

Title: Zoonotic babesiosis.

Journal: International journal of medical microbiology : IJMM 20020601

Title: Randomized phase II trial of atovaquone with pyrimethamine or sulfadiazine for treatment of toxoplasmic encephalitis in patients with acquired immunodeficiency syndrome: ACTG 237/ANRS 039 Study. AIDS Clinical Trials Group 237/Agence Nationale de Recherche sur le SIDA, Essai 039.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020501

Title: Tolerability of antimalaria drugs.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020501

Title: Genetic analysis of tachyzoite to bradyzoite differentiation mutants in Toxoplasma gondii reveals a hierarchy of gene induction.

Journal: Molecular microbiology 20020501

Title: Prophylaxis for human immunodeficiency virus-related Pneumocystis carinii pneumonia: using simulation modeling to inform clinical guidelines.

Journal: Archives of internal medicine 20020422

Title: Time-dependent pharmacokinetics and drug metabolism of atovaquone plus proguanil (Malarone) when taken as chemoprophylaxis.

Journal: European journal of clinical pharmacology 20020401

Title: Inhibition by atovaquone of CYP2C9-mediated sulphamethoxazole hydroxylamine formation.

Journal: European journal of clinical pharmacology 20020401

Title: [Malarone: a new antimalarial for malaria chemoprevention].

Journal: Medecine tropicale : revue du Corps de sante colonial 20020101

Title: Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria.

Journal: Malaria journal 20020101

Title: [Mechanism of action of antimalarials. Value of combined atovaquone/proguanil].

Journal: Medecine tropicale : revue du Corps de sante colonial 20020101

Title: [Clinical studies using the combination atovaquone-proguanil as malaria prophylaxis in non-immune adult and child travelers].

Journal: Medecine tropicale : revue du Corps de sante colonial 20020101

Title: [Experience with the combination atovaquone-proguanil in the treatment of uncomplicated Plasmodium falciparum malaria--report of 112 cases].

Journal: Medecine tropicale : revue du Corps de sante colonial 20020101

Title: [What is the value of the combination atovaquone-proguanil for the clinician?].

Journal: Medecine tropicale : revue du Corps de sante colonial 20020101

Title: Randomized, parallel placebo-controlled trial of primaquine for malaria prophylaxis in Papua, Indonesia.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20011215

Title: Time of treatment influences the appearance of drug-resistant parasites in Plasmodium falciparum infections.

Journal: Parasitology 20011201

Title: Current drugs for antimalarial chemoprophylaxis: a review of efficacy and safety.

Journal: Journal of travel medicine 20011201

Title: New insights into transmission, diagnosis, and drug treatment of Pneumocystis carinii pneumonia.

Journal: JAMA 20011121

Title: Atovaquone-proguanil versus mefloquine for malaria prophylaxis in nonimmune travelers: results from a randomized, double-blind study.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20011001

Title: What's new: newly approved drugs for children.

Journal: Pediatrics in review 20011001

Title: [symbol: see text] Atovaquone + proguanil for malaria prophylaxis.

Journal: Drug and therapeutics bulletin 20011001

Title: Malaria remains a military medical problem.

Journal: Journal of the Royal Army Medical Corps 20011001

Title: Are cytochrome b gene mutations the only cause of atovaquone resistance in Pneumocystis?

Journal: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20011001

Title: [Guidelines for Prevention of Pneumocystis carinii Pneumonitis in Children and Adolescents with Cancer].

Journal: Klinische Padiatrie 20010901

Title: Pneumocystis carinii pneumonia prophylaxis with atovaquone in trimethoprim-sulfamethoxazole-intolerant orthotopic liver transplant patients: a preliminary study.

Journal: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20010801

Title: Plasmodium falciparum: the effects of atovaquone resistance on respiration.

Journal: Experimental parasitology 20010801

Title: Malaria chemoprophylaxis in the age of drug resistance. I. Currently recommended drug regimens.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010715

Title: Automated solid-phase extraction method for the determination of atovaquone in capillary blood applied onto sampling paper by rapid high-performance liquid chromatography.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010715

Title: [Expanded arsenal for prevention and therapy. What is the value of the new malaria drugs? (interview by Waltraut Paukstadt)].

Journal: MMW Fortschritte der Medizin 20010705

Title: Atovaquone nanosuspensions show excellent therapeutic effect in a new murine model of reactivated toxoplasmosis.

Journal: Antimicrobial agents and chemotherapy 20010601

Title: A political analysis of corporate drug donations: the example of Malarone in Kenya.

Journal: Health policy and planning 20010601

Title: Microbial drug resistance and the roles of the new antibiotics.

Journal: Cleveland Clinic journal of medicine 20010601

Title: [Malaria--chemoprophylaxis 2001].

Journal: Therapeutische Umschau. Revue therapeutique 20010601

Title: The effect of atovaquone on etoposide pharmacokinetics in children with acute lymphoblastic leukemia.

Journal: Cancer chemotherapy and pharmacology 20010601

Title: Efficacy of atovaquone-proguanil?

Journal: Lancet (London, England) 20010421

Title: Atovaquone and proguani hydrochloride compared with chloroquine or pyrimethamine/sulfodaxine for treatment of acute Plasmodium falciparum malaria in Peru.

Journal: The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20010401

Title: The treatment of babesiosis.

Journal: The New England journal of medicine 20010308

Title: The treatment of babesiosis.

Journal: The New England journal of medicine 20010308

Title: Pneumocystis carinii cytochrome b mutations are associated with atovaquone exposure in patients with AIDS.

Journal: The Journal of infectious diseases 20010301

Title: Biorelevant dissolution testing to predict the plasma profile of lipophilic drugs after oral administration.

Journal: Pharmaceutical research 20010301

Title: Quantifying and documenting prior beliefs in clinical trials.

Journal: Statistics in medicine 20010227

Title: In vitro quantitative analysis of (3)H-uracil incorporation by Sarcocytis neurona to determine efficacy of anti-protozoal agents.

Journal: Veterinary parasitology 20010226

Title: Structure-activity relationships of novel anti-malarial agents. Part 2: cinnamic acid derivatives.

Journal: Bioorganic & medicinal chemistry letters 20010212

Title: Mode of action and mechanisms of resistance for antimalarial drugs.

Journal: Pharmacology & therapeutics 20010201

Title: Atovaquone suspension for treatment of Pneumocystis carinii pneumonia in HIV-infected patients.

Journal: AIDS (London, England) 20010126

Title: Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20010101

Title: Causal prophylactic efficacy of atovaquone-proguanil (Malarone) in a human challenge model.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20010101

Title: The interaction of atovaquone with the P. carinii cytochrome bc1 complex.

Journal: The Journal of eukaryotic microbiology 20010101

Title: Pneumocystis carinii synthesizes four ubiquinone homologs: inhibition by atovaquone and bupravaquone but not by stigmatellin.

Journal: The Journal of eukaryotic microbiology 20010101

Title: Atovaquone-proguanil versus chloroquine-proguanil for malaria prophylaxis in non-immune travellers: a randomised, double-blind study. Malarone International Study Team.

Journal: Lancet (London, England) 20001202

Title: Atovaquone and azithromycin for the treatment of babesiosis.

Journal: The New England journal of medicine 20001116

Title: Evaluation of the efficacy of atovaquone alone or in combination with azithromycin against acute murine toxoplasmosis.

Journal: Veterinary research communications 20000401

Title: Effects of atovaquone and diospyrin-based drugs on the cellular ATP of Pneumocystis carinii f. sp. carinii.

Journal: Antimicrobial agents and chemotherapy 20000301

Title: Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid.

Journal: Chemico-biological interactions 20000103

Title: Effects of atovaquone and diospyrin-based drugs on ubiquinone biosynthesis in Pneumocystis carinii organisms.

Journal: Antimicrobial agents and chemotherapy 20000101

Title: Synergistic effect of clindamycin and atovaquone in acute murine toxoplasmosis.

Journal: Antimicrobial agents and chemotherapy 19990901

Title: Atovaquone suspension compared with aerosolized pentamidine for prevention of Pneumocystis carinii pneumonia in human immunodeficiency virus-infected subjects intolerant of trimethoprim or sulfonamides.

Journal: The Journal of infectious diseases 19990801

Title: Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites.

Journal: Molecular microbiology 19990801

Title: A mechanism for the synergistic antimalarial action of atovaquone and proguanil.

Journal: Antimicrobial agents and chemotherapy 19990601

Title: Use of ketolides in combination with other drugs to treat experimental toxoplasmosis.

Journal: The Journal of antimicrobial chemotherapy 19981101

Title: Effects of aerosolized synthetic surfactant, atovaquone, and the combination of these on murine Pneumocystis carinii pneumonia.

Journal: The Journal of infectious diseases 19980401

Title: Chronic infection with Toxoplasma gondii does not prevent acute disease or colonization of the brain with tissue cysts following reinfection with different strains of the parasite.

Journal: The Journal of parasitology 19970601

Title: Activity of trovafloxacin in combination with other drugs for treatment of acute murine toxoplasmosis.

Journal: Antimicrobial agents and chemotherapy 19970501

Title: Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite.

Journal: The Journal of biological chemistry 19970214

Title: Clinically used antimicrobial drugs against experimental pneumocystosis, singly and in combination: analysis of drug interactions and efficacies.

Journal: Antimicrobial agents and chemotherapy 19970201

Title: Immunodeficient and immunosuppressed mice as models to test anti-Pneumocystis carinii drugs.

Journal: Antimicrobial agents and chemotherapy 19970201

Title: Treatment with interleukin 12 in combination with atovaquone or clindamycin significantly increases survival of mice with acute toxoplasmosis.

Journal: Antimicrobial agents and chemotherapy 19970101

Title: Efficacy of lasalocid against murine Pneumocystis carinii pneumonitis.

Journal: Antimicrobial agents and chemotherapy 19970101

Title: In vitro and in vivo effects of rifabutin alone or combined with atovaquone against Toxoplasma gondii.

Journal: Antimicrobial agents and chemotherapy 19960901

Title: In-vitro activity of macrolides alone and in combination with artemisin, atovaquone, dapsone, minocycline or pyrimethamine against Cryptosporidium parvum.

Journal: The Journal of antimicrobial chemotherapy 19960901

Title: Use of rifabutin in combination with atovaquone, clindamycin, pyrimethamine, or sulfadiazine for treatment of toxoplasmic encephalitis in mice.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 19960501

Title: Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand.

Journal: The American journal of tropical medicine and hygiene 19960101

Title: Influence of antimicrobial agents on replication and stage conversion of Toxoplasma gondii.

Journal: Current topics in microbiology and immunology 19960101

Title: Evaluation of the activities of rifabutin combined with atovaquone or low-dose of cotrimoxazole for prevention of pneumocystosis and toxoplasmosis in a dual infection rat model.

Journal: The Journal of eukaryotic microbiology 19960101

Title: Nonionic block copolymers potentiate activities of drugs for treatment of infections with Toxoplasma gondii.

Journal: Antimicrobial agents and chemotherapy 19951201

Title: New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.

Journal: Journal of medicinal chemistry 19951124

Title: Acute severe autonomic insufficiency during pentamidine therapy.

Journal: Southern medical journal 19951001

Title: Antipneumocystis activity of 17C91, a prodrug of atovaquone.

Journal: Antimicrobial agents and chemotherapy 19951001

Title: Interactions of atovaquone with other antimalarial drugs against Plasmodium falciparum in vitro.

Journal: Experimental parasitology 19950501

Title: Effect of atovaquone and atovaquone drug combinations on prophylaxis of Pneumocystis carinii pneumonia in SCID mice.

Journal: Antimicrobial agents and chemotherapy 19950401

Title: Effects of atovaquone and other inhibitors on Pneumocystis carinii dihydroorotate dehydrogenase.

Journal: Antimicrobial agents and chemotherapy 19950201

Title: In vitro model to assess effect of antimicrobial agents on Encephalitozoon cuniculi.

Journal: Antimicrobial agents and chemotherapy 19941001

Title: Relative potency of 10 drugs with anti-Pneumocystis carinii activity in an animal model.

Journal: The Journal of infectious diseases 19941001

Title: Rifabutin is active in murine models of toxoplasmosis.

Journal: Antimicrobial agents and chemotherapy 19940301

Title: Mutants of Toxoplasma gondii resistant to atovaquone (566C80) or decoquinate.

Journal: The Journal of parasitology 19930801

Title: Comparison of atovaquone (566C80) with trimethoprim-sulfamethoxazole to treat Pneumocystis carinii pneumonia in patients with AIDS.

Journal: The New England journal of medicine 19930527

Title: Structural features of Plasmodium cytochrome b that may underlie susceptibility to 8-aminoquinolines and hydroxynaphthoquinones.

Journal: Molecular and biochemical parasitology 19930301

Title: The activity of atovaquone (566C80) in murine toxoplasmosis is markedly augmented when used in combination with pyrimethamine or sulfadiazine.

Journal: The Journal of infectious diseases 19930201

Title: In vitro and in vivo activities of the hydroxynaphthoquinone 566C80 against the cyst form of Toxoplasma gondii.

Journal: Antimicrobial agents and chemotherapy 19920201

Title: Evaluation of the effect of drugs on the cyst form of Toxoplasma gondii.

Journal: The Journal of infectious diseases 19910701

Title: Remarkable in vitro and in vivo activities of the hydroxynaphthoquinone 566C80 against tachyzoites and tissue cysts of Toxoplasma gondii.

Journal: Antimicrobial agents and chemotherapy 19910201

Title: 566C80, an antimalarial hydroxynaphthoquinone with broad spectrum: experimental activity against opportunistic parasitic infections of AIDS patients.

Journal: The Journal of protozoology 19910101

Title: Efficacy of a hydroxynaphthoquinone, 566C80, in experimental Pneumocystis carinii pneumonitis.

Journal: Antimicrobial agents and chemotherapy 19900201

Title: Nilsen A, et al. Quinolone-3-diarylethers: a new class of antimalarial drug.Sci Transl Med. 2013 Mar 20;5(177):177ra37.

Title: Schöler N, et al. Atovaquone nanosuspensions show excellent therapeutic effect in a new murine model of reactivated toxoplasmosis.Antimicrob Agents Chemother. 2001 Jun;45(6):1771-9.

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Tags:95233-18-4 Molecular Formula|95233-18-4 MDL|95233-18-4 SMILES|95233-18-4 Atovaquone