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2140-76-3,MFCD00056054
Catalog No.:AA0037SB

2140-76-3 | 1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

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250mg
98%
in stock  
$6.00   $4.00
- +
1g
98%
in stock  
$7.00   $5.00
- +
5g
98%
in stock  
$16.00   $11.00
- +
10g
98%
in stock  
$28.00   $19.00
- +
25g
98%
in stock  
$65.00   $45.00
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100g
98%
in stock  
$222.00   $155.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0037SB
Chemical Name:
1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
CAS Number:
2140-76-3
Molecular Formula:
C10H14N2O6
Molecular Weight:
258.2280
MDL Number:
MFCD00056054
SMILES:
CO[C@@H]1[C@H](O)[C@H](O[C@H]1n1ccc(=O)[nH]c1=O)CO
Properties
Computed Properties
 
Complexity:
385  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  
XLogP3:
-1.4  

Literature

Title: Synthesis, gene-silencing activity and nuclease resistance of 3'-3'-linked double short hairpin RNA.

Journal: Bioorganic & medicinal chemistry 20101201

Title: Transfer RNA modifications and genes for modifying enzymes in Arabidopsis thaliana.

Journal: BMC plant biology 20100101

Title: Chemical synthesis of LNA-2-thiouridine and its influence on stability and selectivity of oligonucleotide binding to RNA.

Journal: Biochemistry 20091124

Title: Effect of a water molecule on the sugar puckering of uridine, 2'-deoxyuridine, and 2'-O-methyl uridine inserted in duplexes.

Journal: The journal of physical chemistry. A 20080207

Title: Suppression of immunostimulatory siRNA-driven innate immune activation by 2'-modified RNAs.

Journal: Biochemical and biophysical research communications 20070914

Title: Synthesis and in vitro anti-mycobacterial activity of 5-substituted pyrimidine nucleosides.

Journal: Bioorganic & medicinal chemistry 20051215

Title: Design and studies of novel 5-substituted alkynylpyrimidine nucleosides as potent inhibitors of mycobacteria.

Journal: Journal of medicinal chemistry 20051103

Title: A specific substrate-inhibitor, a 2'-deoxy-2'-fluorouridine-containing oligoribonucleotide, against human RNase L.

Journal: Bioorganic & medicinal chemistry 20031117

Title: 2'-O-[2-(methylthio)ethyl]-modified oligonucleotide: an analogue of 2'-O-[2-(methoxy)-ethyl]-modified oligonucleotide with improved protein binding properties and high binding affinity to target RNA.

Journal: Biochemistry 20021001

Title: Aučynaitė A, et al. Identification of a 2'-O-Methyluridine Nucleoside Hydrolase Using the Metagenomic Libraries. Molecules. 2018;23(11):2904. Published 2018 Nov 7.

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Tags:2140-76-3 Molecular Formula|2140-76-3 MDL|2140-76-3 SMILES|2140-76-3 1-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione