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[5]CurrentPatentAssignee:CASIPHARMACEUTICALSINC-US2005/203075,2005,A1Locationinpatent:Page/Pagecolumn11;15
[6]CurrentPatentAssignee:ZHENGZHOUUNIVERSITY-CN105153259,2017,B
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[1]Ho,Abby;Kim,Yang-eon;Lee,Hyo-Sung;Cyrus,Kedra;Baek,Sun-Hee;Kim,Kyung-Bo[BioorganicandMedicinalChemistryLetters,2006,vol.16,#13,p.3383-3387]
Title: Novel role of mitochondrial manganese superoxide dismutase in STAT3 dependent pluripotency of mouse embryonic stem cells.
Journal: Scientific reports 20150101
Title: Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth.
Journal: PloS one 20150101
Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.
Journal: Bioorganic & medicinal chemistry letters 20130801
Title: Study on TRPV1-mediated mechanism for the hypersecretion of mucus in respiratory inflammation.
Journal: Molecular immunology 20130101
Title: 2-methoxyestradiol induces mitotic arrest, apoptosis, and synergistic cytotoxicity with arsenic trioxide in human urothelial carcinoma cells.
Journal: PloS one 20130101
Title: Neuronal damage and functional deficits are ameliorated by inhibition of aquaporin and HIF1α after traumatic brain injury (TBI).
Journal: Journal of the neurological sciences 20121215
Title: Sulphamoylated estradiol analogue induces antiproliferative activity and apoptosis in breast cell lines.
Journal: Cellular & molecular biology letters 20121201
Title: Low 2-methoxyestradiol levels at the first trimester of pregnancy are associated with the development of pre-eclampsia.
Journal: Prenatal diagnosis 20121101
Title: AMPK activation reduces vascular permeability and airway inflammation by regulating HIF/VEGFA pathway in a murine model of toluene diisocyanate-induced asthma.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20121001
Title: 2-methoxyestradiol in the pathophysiology of endometriosis: focus on angiogenesis and therapeutic potential.
Journal: Reproductive sciences (Thousand Oaks, Calif.) 20121001
Title: Modulation of the hypoxic response following partial bladder outlet obstruction.
Journal: The Journal of urology 20121001
Title: Potential contribution of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 to blood-brain barrier disruption and brain edema after experimental subarachnoid hemorrhage.
Journal: Journal of molecular neuroscience : MN 20120901
Title: Critical role of cyclin B1/Cdc2 up-regulation in the induction of mitotic prometaphase arrest in human breast cancer cells treated with 2-methoxyestradiol.
Journal: Biochimica et biophysica acta 20120801
Title: Sexual dimorphisms in the immune system of catechol-O-methyltransferase knockout mice.
Journal: Immunobiology 20120801
Title: 2-Methoxyestradiol induced Bax phosphorylation and apoptosis in human retinoblastoma cells via p38 MAPK activation.
Journal: Molecular carcinogenesis 20120701
Title: 2-Methoxyestradiol causes functional repression of transforming growth factor β3 signaling by ameliorating Smad and non-Smad signaling pathways in immortalized uterine fibroid cells.
Journal: Fertility and sterility 20120701
Title: Interleukin-6 counteracts therapy-induced cellular oxidative stress in multiple myeloma by up-regulating manganese superoxide dismutase.
Journal: The Biochemical journal 20120615
Title: Glycerol accumulation in edema formation following diffuse traumatic brain injury.
Journal: Neurological research 20120601
Title: Acquisition of resistance of pancreatic cancer cells to 2-methoxyestradiol is associated with the upregulation of manganese superoxide dismutase.
Journal: Molecular cancer research : MCR 20120601
Title: In vivo controlled release and prolonged antitumor effects of 2-methoxyestradiol solid lipid nanoparticles incorporated into a thermosensitive hydrogel.
Journal: Drug delivery 20120501
Title: Differentiation induction enhances bortezomib efficacy and overcomes drug resistance in multiple myeloma.
Journal: Biochemical and biophysical research communications 20120413
Title: A phase II study of 2-methoxyestradiol nanocrystal colloidal dispersion alone and in combination with sunitinib malate in patients with metastatic renal cell carcinoma progressing on sunitinib malate.
Journal: Investigational new drugs 20120401
Title: The increased expression of DEC1 gene is related to HIF-1α protein in gastric cancer cell lines.
Journal: Molecular biology reports 20120401
Title: Pharmacokinetic evaluation and antitumor activity of 2-methoxyestradiol nanosuspension.
Journal: Drug development and industrial pharmacy 20120401
Title: A simple and convenient synthesis of 2-methoxyestradiol from estrone.
Journal: Steroids 20120401
Title: Synthesis of 3'-methoxy-E-diethylstilbestrol and its analogs as tumor angiogenesis inhibitors.
Journal: Steroids 20120401
Title: Pharmacologic effects of 2-methoxyestradiol on angiotensin type 1 receptor down-regulation in rat liver epithelial and aortic smooth muscle cells.
Journal: Gender medicine 20120401
Title: Preparation and cytotoxicity of poly (DL-lactide-co-glycolide) microspheres encapsulating 2-methoxyestradiol.
Journal: Drug delivery 20120401
Title: Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome.
Journal: Molecular and cellular endocrinology 20120305
Title: ERα phenotype, estrogen level, and benzo[a]pyrene exposure modulate tumor growth and metabolism of lung adenocarcinoma cells.
Journal: Lung cancer (Amsterdam, Netherlands) 20120301
Title: Effects of 2-methoxyestradiol on proliferation, apoptosis and gene expression of cyclin B1 and c-Myc in esophageal carcinoma EC9706 cells.
Journal: Cell biochemistry and function 20120301
Title: 2-Hydroxyestradiol slows progression of experimental polycystic kidney disease.
Journal: American journal of physiology. Renal physiology 20120301
Title: Preparation and cytotoxicity of 2-methoxyestradiol-loaded solid lipid nanoparticles.
Journal: Anti-cancer drugs 20120201
Title: A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: a mass spectrometric analysis.
Journal: Electrophoresis 20120201
Title: Analysis of multiplex endogenous estrogen metabolites in human urine using ultra-fast liquid chromatography-tandem mass spectrometry: a case study for breast cancer.
Journal: Analytica chimica acta 20120120
Title: Development of GC-MS/MS method with programmable temperature vaporization large volume injection for monitoring of 17β-estradiol and 2-methoxyestradiol in plasma.
Journal: Analytica chimica acta 20120104
Title: HIF-1 is involved in high glucose-induced paracellular permeability of brain endothelial cells.
Journal: Cellular and molecular life sciences : CMLS 20120101
Title: Serum 2-methoxyestradiol, an estrogen metabolite, is positively associated with serum HDL-C in a population-based sample.
Journal: Lipids 20120101
Title: Synergistic Apoptosis-Inducing Antileukemic Effects of Arsenic Trioxide and Mucuna macrocarpa Stem Extract in Human Leukemic Cells via a Reactive Oxygen Species-Dependent Mechanism.
Journal: Evidence-based complementary and alternative medicine : eCAM 20120101
Title: Cyanide preconditioning protects brain endothelial and NT2 neuron-like cells against glucotoxicity: role of mitochondrial reactive oxygen species and HIF-1α.
Journal: Neurobiology of disease 20120101
Title: Antioxidant inhibitors potentiate the cytotoxicity of photodynamic therapy.
Journal: Photochemistry and photobiology 20120101
Title: MAP Kinases and Prostate Cancer.
Journal: Journal of signal transduction 20120101
Title: Taxol alleviates 2-methoxyestradiol-induced endothelial permeability.
Journal: Vascular pharmacology 20120101
Title: Angiogenesis in head and neck cancer: a review of the literature.
Journal: Journal of oncology 20120101
Title: Preeclampsia, hypoxia, thrombosis, and inflammation.
Journal: Journal of pregnancy 20120101
Title: Preeclampsia: multiple approaches for a multifactorial disease.
Journal: Disease models & mechanisms 20120101
Title: RhoA/ROCK-dependent moesin phosphorylation regulates AGE-induced endothelial cellular response.
Journal: Cardiovascular diabetology 20120101
Title: Activation of CD40 with platelet derived CD154 promotes reactive oxygen species dependent death of human hepatocytes during hypoxia and reoxygenation.
Journal: PloS one 20120101
Title: ELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinoma.
Journal: PloS one 20120101
Title: Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells.
Journal: International journal of nanomedicine 20120101
Title: 3,3'-Diindolylmethane exhibits antileukemic activity in vitro and in vivo through a Akt-dependent process.
Journal: PloS one 20120101
Title: Regulation of interferon pathway in 2-methoxyestradiol-treated osteosarcoma cells.
Journal: BMC cancer 20120101
Title: Bevacizumab based chemotherapy in first line treatment of HER2 negative metastatic breast cancer: results of a Moroccan observational institutional study.
Journal: BMC research notes 20120101
Title: Benzyl isothiocyanate causes FoxO1-mediated autophagic death in human breast cancer cells.
Journal: PloS one 20120101
Title: Tetrathiomolybdate sensitizes ovarian cancer cells to anticancer drugs doxorubicin, fenretinide, 5-fluorouracil and mitomycin C.
Journal: BMC cancer 20120101
Title: Molecular mechanisms of preeclampsia.
Journal: Journal of pregnancy 20120101
Title: Hypoxia-inducible factor 1 protects hypoxic astrocytes against glutamate toxicity.
Journal: ASN neuro 20120101
Title: Development and validation of an automated high-throughput system for zebrafish in vivo screenings.
Journal: PloS one 20120101
Title: A comprehensive review of hypertension in pregnancy.
Journal: Journal of pregnancy 20120101
Title: Synthetic 2-methoxyestradiol derivatives: structure-activity relationships.
Journal: Current medicinal chemistry 20120101
Title: Differential regulation of Smad3 and of the type II transforming growth factor-β receptor in mitosis: implications for signaling.
Journal: PloS one 20120101
Title: Involvement of reactive oxygen species in 2-methoxyestradiol-induced apoptosis in human neuroblastoma cells.
Journal: Cancer letters 20111227
Title: Hypoxia stimulates the production of the angiogenesis inhibitor 2-methoxyestradiol by swine granulosa cells.
Journal: Steroids 20111211
Title: A phase II study of 2-methoxyestradiol (2ME2) NanoCrystal® dispersion (NCD) in patients with taxane-refractory, metastatic castrate-resistant prostate cancer (CRPC).
Journal: Investigational new drugs 20111201
Title: Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability.
Journal: American journal of respiratory cell and molecular biology 20111201
Title: Catechol-O-methyltransferase is dispensable for vascular protection by estradiol in mouse models of atherosclerosis and neointima formation.
Journal: Endocrinology 20111201
Title: Effects of estrogen metabolite 2-methoxyestradiol on tumor suppressor protein p53 and proliferation of breast cancer cells.
Journal: Systems biology in reproductive medicine 20111201
Title: [Mechanism associated to enhancing the sensitivity of myeloma cells U266 to bortezomib by 2-methoxyestradiol].
Journal: Zhongguo shi yan xue ye xue za zhi 20111201
Title: Selenium is a modulator of circadian clock that protects mice from the toxicity of a chemotherapeutic drug via upregulation of the core clock protein, BMAL1.
Journal: Oncotarget 20111201
Title: Investigation of a new injectable thermosensitive hydrogel loading solid lipid nanoparticles.
Journal: Die Pharmazie 20111201
Title: 2-Methoxyestradiol-bis-sulfamate induces apoptosis and autophagy in a tumorigenic breast epithelial cell line.
Journal: Molecular and cellular biochemistry 20111101
Title: Environmental impact on vascular development predicted by high-throughput screening.
Journal: Environmental health perspectives 20111101
Title: Anticancer agent 2-methoxyestradiol improves survival in septic mice by reducing the production of cytokines and nitric oxide.
Journal: Shock (Augusta, Ga.) 20111101
Title: Propranolol potentiates the anti-angiogenic effects and anti-tumor efficacy of chemotherapy agents: implication in breast cancer treatment.
Journal: Oncotarget 20111001
Title: Pregnancy ameliorates the inhibitory effects of 2-methoxyestradiol on angiogenesis in primary sheep uterine endothelial cells.
Journal: Reproductive sciences (Thousand Oaks, Calif.) 20110901
Title: The effect of tamoxifen and raloxifene on estrogen metabolism and endometrial cancer risk.
Journal: The Journal of steroid biochemistry and molecular biology 20110901
Title: A prospective phase II study of 2-methoxyestradiol administered in combination with bevacizumab in patients with metastatic carcinoid tumors.
Journal: Cancer chemotherapy and pharmacology 20110801
Title: Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part II.
Journal: Archivum immunologiae et therapiae experimentalis 20110801
Title: Catechol metabolites of endogenous estrogens induce redox cycling and generate reactive oxygen species in breast epithelial cells.
Journal: Carcinogenesis 20110801
Title: Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4.
Journal: Journal of medicinal chemistry 20110714
Title: Effect of 2-hydroxyestradiol on binge intake in rats.
Journal: Physiology & behavior 20110706
Title: Synergistic interactions between peloruside A and other microtubule-stabilizing and destabilizing agents in cultured human ovarian carcinoma cells and murine T cells.
Journal: Cancer chemotherapy and pharmacology 20110701
Title: A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2).
Journal: Molecular human reproduction 20110701
Title: Role of 2-methoxyestradiol as inhibitor of arthritis and osteoporosis in a model of postmenopausal rheumatoid arthritis.
Journal: Clinical immunology (Orlando, Fla.) 20110701
Title: Hypoxia inducible factor promotes murine allergic airway inflammation and is increased in asthma and rhinitis.
Journal: Allergy 20110701
Title: 2-methoxyestradiol attenuates autophagy activation after global ischemia.
Journal: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20110701
Title: HIF-1-α and survivin involved in the anti-apoptotic effect of 2ME2 after global ischemia in rats.
Journal: Neurological research 20110701
Title: Testosterone attenuates morpho-functional alterations by 2-methoxyestradiol exposure and induces differentiation in C6 cells.
Journal: Journal of cellular physiology 20110601
Title: 2ME and 2OHE2 exhibit growth inhibitory effects and cell cycle arrest at G2/M in RL95-2 human endometrial cancer cells through activation of p53 and Chk1.
Journal: Molecular and cellular biochemistry 20110601
Title: Injectable delivery system of 2-methoxyestradiol for breast cancer therapy using biodegradable thermosensitive poly(organophosphazene) hydrogel.
Journal: Journal of drug targeting 20110501
Title: Selective inhibition of early--but not late--expressed HIF-1α is neuroprotective in rats after focal ischemic brain damage.
Journal: Brain pathology (Zurich, Switzerland) 20110501
Title: Hypoxia-inducible factor-1α (HIF-1α) and autophagy in polycystic kidney disease (PKD).
Journal: American journal of physiology. Renal physiology 20110501
Title: 2-Methoxyestradiol, an endogenous estrogen metabolite, sensitizes radioresistant MCF-7/FIR breast cancer cells through multiple mechanisms.
Journal: International journal of radiation oncology, biology, physics 20110501
Title: 2-methoxyestradiol analogue ENMD-1198 reduces breast cancer-induced osteolysis and tumor burden both in vitro and in vivo.
Journal: Molecular cancer therapeutics 20110501
Title: Hypoxia enhances platelet-derived growth factor signaling in the pulmonary vasculature by down-regulation of protein tyrosine phosphatases.
Journal: American journal of respiratory and critical care medicine 20110415
Title: A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer.
Journal: Investigational new drugs 20110401
Title: Encapsulation of 2-methoxyestradiol within multifunctional poly(amidoamine) dendrimers for targeted cancer therapy.
Journal: Biomaterials 20110401
Title: Hypoxia-induced sensitization of transient receptor potential vanilloid 1 involves activation of hypoxia-inducible factor-1 alpha and PKC.
Journal: Pain 20110401
Title: In vitro and in vivo evidence for anti-inflammatory properties of 2-methoxyestradiol.
Journal: The Journal of pharmacology and experimental therapeutics 20110301
Title: Negative regulation of the endocytic adaptor disabled-2 (Dab2) in mitosis.
Journal: The Journal of biological chemistry 20110218
Title: Hypoxia-inducible factor-1α contributes to brain edema after stroke by regulating aquaporins and glycerol distribution in brain.
Journal: Current neurovascular research 20110201
Title: 2-Methoxyestradiol inhibits the up-regulation of AQP4 and AQP1 expression after spinal cord injury.
Journal: Brain research 20110125
Title: The role of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 in blood-brain barrier disruption and brain edema after traumatic brain injury.
Journal: Journal of neurosurgery 20110101
Title: 2-Methoxyestradiol: new perspectives in colon carcinoma treatment.
Journal: Molecular and cellular endocrinology 20110101
Title: Enhancement of radiosensitivity in human glioblastoma cells by the DNA N-mustard alkylating agent BO-1051 through augmented and sustained DNA damage response.
Journal: Radiation oncology (London, England) 20110101
Title: Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia.
Journal: PloS one 20110101
Title: Compound C prevents Hypoxia-Inducible Factor-1α protein stabilization by regulating the cellular oxygen availability via interaction with Mitochondrial Complex I.
Journal: BMC research notes 20110101
Title: Organometallic iron(III)-salophene exerts cytotoxic properties in neuroblastoma cells via MAPK activation and ROS generation.
Journal: PloS one 20110101
Title: Participation of the oviductal s100 calcium binding protein G in the genomic effect of estradiol that accelerates oviductal embryo transport in mated rats.
Journal: Reproductive biology and endocrinology : RB&E 20110101
Title: Cancer therapeutic agents targeting hypoxia-inducible factor-1.
Journal: Current medicinal chemistry 20110101
Title: Mechanisms of estrogens' dose-dependent neuroprotective and neurodamaging effects in experimental models of cerebral ischemia.
Journal: International journal of molecular sciences 20110101
Title: The role of calcineurin/NFAT in SFRP2 induced angiogenesis--a rationale for breast cancer treatment with the calcineurin inhibitor tacrolimus.
Journal: PloS one 20110101
Title: Hyaluronan modulates accumulation of hypoxia-inducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model.
Journal: Arthritis research & therapy 20110101
Title: P2Y receptors as regulators of lung endothelial barrier integrity.
Journal: Journal of cardiovascular disease research 20110101
Title: Pancreatic β-cell death in response to pro-inflammatory cytokines is distinct from genuine apoptosis.
Journal: PloS one 20110101
Title: Anti-angiogenic and anti-inflammatory properties of kahweol, a coffee diterpene.
Journal: PloS one 20110101
Title: Effect of magnetic Fe3O4 nanoparticles with 2-methoxyestradiol on the cell-cycle progression and apoptosis of myelodysplastic syndrome cells.
Journal: International journal of nanomedicine 20110101
Title: Multifunctional dendrimer/combretastatin A4 inclusion complexes enable in vitro targeted cancer therapy.
Journal: International journal of nanomedicine 20110101
Title: Mitochondrial peroxiredoxin III is a potential target for cancer therapy.
Journal: International journal of molecular sciences 20110101
Title: Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma.
Journal: Sarcoma 20110101
Title: The genetics of pulmonary arterial hypertension in the post-BMPR2 era.
Journal: Pulmonary circulation 20110101
Title: In vitro effects of 2-methoxyestradiol-bis-sulphamate on reactive oxygen species and possible apoptosis induction in a breast adenocarcinoma cell line.
Journal: Cancer cell international 20110101
Title: The effect of 2-methoxyestradiol liposome on growth inhibition, angiogenesis and expression of VEGF and Ki67 in mice bearing H22 hepatocellular carcinoma.
Journal: Tumori 20110101
Title: Functional and transcriptional induction of aquaporin-1 gene by hypoxia; analysis of promoter and role of Hif-1α.
Journal: PloS one 20110101
Title: Development of pulmonary arterial hypertension in mice over-expressing S100A4/Mts1 is specific to females.
Journal: Respiratory research 20110101
Title: Lymph Node Staging with Choline PET/CT in Patients with Prostate Cancer: A Review.
Journal: ISRN oncology 20110101
Title: Therapeutic promises of 2-methoxyestradiol and its drug disposition challenges.
Journal: Molecular pharmaceutics 20101206
Title: Estrogens and development of pulmonary hypertension: interaction of estradiol metabolism and pulmonary vascular disease.
Journal: Journal of cardiovascular pharmacology 20101201
Title: Influence of estradiol analogue on cell growth, morphology and death in esophageal carcinoma cells.
Journal: Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 20101201
Title: Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance.
Journal: Journal of medicinal chemistry 20101125
Title: Synergistic therapeutic effects of 2-methoxyestradiol with either sildenafil or bosentan on amelioration of monocrotaline-induced pulmonary hypertension and vascular remodeling.
Journal: Journal of cardiovascular pharmacology 20101101
Title: Candidate genes and mechanisms for 2-methoxyestradiol-mediated vasoprotection.
Journal: Hypertension (Dallas, Tex. : 1979) 20101101
Title: Additive growth inhibition after combined treatment of 2-methoxyestradiol and conventional chemotherapeutic agents in human pancreatic cancer cells.
Journal: Anticancer research 20101101
Title: Diaryl dimers of estradiol and of estrone may be formed as major metabolites by mouse mammary glands.
Journal: Biochemical and biophysical research communications 20101022
Title: 2-Methoxyestradiol--biology and mechanism of action.
Journal: Steroids 20101001
Title: Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines.
Journal: The Journal of pharmacology and experimental therapeutics 20101001
Title: O-methylation of catechol estrogens by human placental catechol-o-methyltransferase: interindividual differences in sensitivity to heat inactivation and to inhibition by dietary polyphenols.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20101001
Title: HIF-1α inhibition ameliorates an allergic airway disease via VEGF suppression in bronchial epithelium.
Journal: European journal of immunology 20101001
Title: Resveratrol, a red wine constituent, blocks the antimitogenic effects of estradiol on human female coronary artery smooth muscle cells.
Journal: The Journal of clinical endocrinology and metabolism 20100901
Title: Dietary quercetin exacerbates the development of estrogen-induced breast tumors in female ACI rats.
Journal: Toxicology and applied pharmacology 20100901
Title: HIF-2alpha--a mediator of osteoarthritis?
Journal: Cell research 20100901
Title: Pre-eclampsia: connecting angiogenic and metabolic pathways.
Journal: Trends in endocrinology and metabolism: TEM 20100901
Title: 2-Methoxyestradiol blocks cell-cycle progression at the G2/M phase and induces apoptosis in human acute T lymphoblastic leukemia CEM cells.
Journal: Acta biochimica et biophysica Sinica 20100901
Title: Acute effects of 2-methoxyestradiol on endothelial aortic No release in male and ovariectomized female rats.
Journal: Nitric oxide : biology and chemistry 20100801
Title: 2-Methoxyoestradiol inhibits glucose transport in rodent skeletal muscle.
Journal: Experimental physiology 20100801
Title: In vitro effects of 2-methoxyestradiol-bis-sulphamate on cell growth, morphology and cell cycle dynamics in the MCF-7 breast adenocarcinoma cell line.
Journal: Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 20100801
Title: Suppression of hypoxia-inducible factor-1alpha and its downstream genes reduces acute hyperglycemia-enhanced hemorrhagic transformation in a rat model of cerebral ischemia.
Journal: Journal of neuroscience research 20100701
Title: In vitro effects of 2-methoxyestradiol-bis-sulphamate on the non-tumorigenic MCF-12A cell line.
Journal: Cell biochemistry and function 20100701
Title: Preparation and characterization of freeze-dried 2-methoxyestradiol nanoparticle powders.
Journal: Die Pharmazie 20100701
Title: 2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells.
Journal: Hormones & cancer 20100601
Title: Phenylcinnamides as novel antimitotic agents.
Journal: Journal of medicinal chemistry 20100527
Title: In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer.
Journal: Cancer research 20100515
Title: Correlation of 2-methoxyestradiol levels in cord blood and complications of prematurity.
Journal: Pediatric research 20100501
Title: ENMD-1198, a new analogue of 2-methoxyestradiol, displays both antiangiogenic and vascular-disrupting properties.
Journal: Molecular cancer therapeutics 20100501
Title: Structures of human carbonic anhydrase II/inhibitor complexes reveal a second binding site for steroidal and nonsteroidal inhibitors.
Journal: Biochemistry 20100427
Title: N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)arylamide as a new scaffold that provides rapid access to antimicrotubule agents: synthesis and evaluation of antiproliferative activity against select cancer cell lines.
Journal: Journal of medicinal chemistry 20100422
Title: Simultaneous determination of eight estrogens and their metabolites in serum using liquid chromatography with electrochemical detection.
Journal: Talanta 20100415
Title: 2-Methoxyestradiol induce the conversion of human peripheral blood memory B lymphocytes into plasma cells.
Journal: Journal of immunological methods 20100415
Title: Synthesis, antitubulin, and antiproliferative SAR of analogues of 2-methoxyestradiol-3,17-O,O-bis-sulfamate.
Journal: Journal of medicinal chemistry 20100408
Title: 2-methoxyestradiol-mediated anti-tumor effect increases osteoprotegerin expression in osteosarcoma cells.
Journal: Journal of cellular biochemistry 20100401
Title: An SPME-GC-MS method using an octadecyl silica fibre for the determination of the potential angiogenesis modulators 17beta-estradiol and 2-methoxyestradiol in culture media.
Journal: Analytical and bioanalytical chemistry 20100401
Title: In vitro effects of 2-methoxyestradiol on morphology, cell cycle progression, cell death and gene expression changes in the tumorigenic MCF-7 breast epithelial cell line.
Journal: The Journal of steroid biochemistry and molecular biology 20100401
Title: 2-Methoxyestradiol induces endoreduplication through the induction of mitochondrial oxidative stress and the activation of MAPK signaling pathways.
Journal: Biochemical pharmacology 20100315
Title: 2-methoxyestradiol inhibits atorvastatin-induced rounding of human vascular smooth muscle cells.
Journal: Journal of cellular physiology 20100301
Title: A non-genomic signaling pathway shut down by mating changes the estradiol-induced gene expression profile in the rat oviduct.
Journal: Reproduction (Cambridge, England) 20100301
Title: 2-methoxyestradiol inhibits Barrett's esophageal adenocarcinoma growth and differentiation through differential regulation of the beta-catenin-E-cadherin axis.
Journal: Molecular cancer therapeutics 20100301
Title: 2-methoxyestradiol induces morpho-functional changes and impairs the microtubular system in mouse neuroblastoma and rat glioma cells.
Journal: Archives italiennes de biologie 20100301
Title: Preeclampsia: 2-methoxyestradiol induces cytotrophoblast invasion and vascular development specifically under hypoxic conditions.
Journal: The American journal of pathology 20100201
Title: Nongenomic inhibition of coronary constriction by 17ß-estradiol, 2-hydroxyestradiol, and 2-methoxyestradiol.
Journal: Canadian journal of physiology and pharmacology 20100201
Title: Class III beta-tubulin expression and in vitro resistance to microtubule targeting agents.
Journal: British journal of cancer 20100119
Title: Preparation, characterization and in vivo evaluation of 2-methoxyestradiol-loaded liposomes.
Journal: International journal of pharmaceutics 20100115
Title: A human brainstem glioma xenograft model enabled for bioluminescence imaging.
Journal: Journal of neuro-oncology 20100101
Title: A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells.
Journal: The Journal of steroid biochemistry and molecular biology 20100101
Title: An efficient, practical synthesis of 2-methoxyestradiol.
Journal: Steroids 20100101
Title: Evidence for the interplay between JNK and p53-DRAM signalling pathways in the regulation of autophagy.
Journal: Autophagy 20100101
Title: New insights in synovial angiogenesis.
Journal: Joint, bone, spine : revue du rhumatisme 20100101
Title: Structure activity analysis of 2-methoxyestradiol analogues reveals targeting of microtubules as the major mechanism of antiproliferative and proapoptotic activity.
Journal: Molecular cancer therapeutics 20100101
Title: Effect of flaxseed consumption on urinary levels of estrogen metabolites in postmenopausal women.
Journal: Nutrition and cancer 20100101
Title: Triple-negative breast cancer: role of antiangiogenic agents.
Journal: Cancer journal (Sudbury, Mass.) 20100101
Title: Effects of PPAR gamma ligands on TGF-beta1-induced epithelial-mesenchymal transition in alveolar epithelial cells.
Journal: Respiratory research 20100101
Title: Novel approaches to treat experimental pulmonary arterial hypertension: a review.
Journal: Journal of biomedicine & biotechnology 20100101
Title: Expression and regulation of HIF-1alpha in macrophages under inflammatory conditions; significant reduction of VEGF by CaMKII inhibitor.
Journal: BMC musculoskeletal disorders 20100101
Title: In vivo intratumor angiogenic treatment effects during taxane-based neoadjuvant chemotherapy of ovarian cancer.
Journal: BMC cancer 20100101
Title: Granulocyte colony-stimulating factor activating HIF-1alpha acts synergistically with erythropoietin to promote tissue plasticity.
Journal: PloS one 20100101
Title: Antiangiogenic therapy and mechanisms of tumor resistance in malignant glioma.
Journal: Journal of oncology 20100101
Title: The coordinated p53 and estrogen receptor cis-regulation at an FLT1 promoter SNP is specific to genotoxic stress and estrogenic compound.
Journal: PloS one 20100101
Title: Topical application of recombinant calreticulin peptide, vasostatin 48, alleviates laser-induced choroidal neovascularization in rats.
Journal: Molecular vision 20100101
Title: The normal breast microenvironment of premenopausal women differentially influences the behavior of breast cancer cells in vitro and in vivo.
Journal: BMC medicine 20100101
Title: Estradiol suppresses tissue androgens and prostate cancer growth in castration resistant prostate cancer.
Journal: BMC cancer 20100101
Title: NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells.
Journal: Molecular cancer 20100101
Title: Comparison of estrogens and estrogen metabolites in human breast tissue and urine.
Journal: Reproductive biology and endocrinology : RB&E 20100101
Title: Dose-dependent therapeutic effects of 2-Methoxyestradiol on Monocrotaline-Induced pulmonary hypertension and vascular remodelling.
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Title: Identifying molecular effects of diet through systems biology: influence of herring diet on sterol metabolism and protein turnover in mice.
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Title: Anti-apoptotic effect of claudin-1 in tamoxifen-treated human breast cancer MCF-7 cells.
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Title: Comparison of mitotic cell death by chromosome fragmentation to premature chromosome condensation.
Journal: Molecular cytogenetics 20100101
Title: 4-oxo-N-(4-hydroxyphenyl)retinamide: two independent ways to kill cancer cells.
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Title: Superoxide dismutase is upregulated in Staphylococcus aureus following protoporphyrin-mediated photodynamic inactivation and does not directly influence the response to photodynamic treatment.
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Title: Beta-estradiol attenuates hypoxic pulmonary hypertension by stabilizing the expression of p27kip1 in rats.
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Title: Effects of a breast-health herbal formula supplement on estrogen metabolism in pre- and post-menopausal women not taking hormonal contraceptives or supplements: a randomized controlled trial.
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Title: Intra-Laboratory Pre-Validation of a Human Cell Based in vitro Angiogenesis Assay for Testing Angiogenesis Modulators.
Journal: Frontiers in pharmacology 20100101
Title: p53 gene expression and 2-methoxyestradiol treatment differentially induce nuclear factor kappa B activation in human lung cancer cells with different p53 phenotypes.
Journal: DNA and cell biology 20091201
Title: The hematopoietic-specific beta1-tubulin is naturally resistant to 2-methoxyestradiol and protects patients from drug-induced myelosuppression.
Journal: Cell cycle (Georgetown, Tex.) 20091201
Title: C2- and C4-position 17beta-estradiol metabolites and their relation to breast cancer.
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Title: Gateways to clinical trials.
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Title: Synthesis and antitumor activities of 3-modified 2-methoxyestradiol analogs.
Journal: Bioorganic & medicinal chemistry letters 20091115
Title: Synthesis, antiproliferative, and pharmacokinetic properties of 3- and 17-double-modified analogs of 2-methoxyestradiol.
Journal: Bioorganic & medicinal chemistry letters 20091101
Title: Angiogenesis in rheumatoid arthritis.
Journal: Autoimmunity 20091101
Title: An investigation on intestinal absorption of a new anticancer drug, 2-methoxyestradiol.
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Title: Synthesis of 2- and 17-substituted estrone analogs and their antiproliferative structure-activity relationships compared to 2-methoxyestradiol.
Journal: Bioorganic & medicinal chemistry 20091015
Title: Activity of 2 methoxyestradiol (Panzem NCD) in advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis: a Hoosier Oncology Group trial.
Journal: Gynecologic oncology 20091001
Title: Potential vascular actions of 2-methoxyestradiol.
Journal: Trends in endocrinology and metabolism: TEM 20091001
Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
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Title: Dioxin receptor deficiency impairs angiogenesis by a mechanism involving VEGF-A depletion in the endothelium and transforming growth factor-beta overexpression in the stroma.
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Title: 2-Methoxyestradiol-induced radiosensitization is independent of SOD but depends on inhibition of Akt and DNA-PKcs activities.
Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20090901
Title: c-Jun NH2-terminal kinase activation is essential for DRAM-dependent induction of autophagy and apoptosis in 2-methoxyestradiol-treated Ewing sarcoma cells.
Journal: Cancer research 20090901
Title: A short, economical synthesis of 2-methoxyestradiol, an anticancer agent in clinical trials.
Journal: The Journal of organic chemistry 20090821
Title: Superoxide is the major reactive oxygen species regulating autophagy.
Journal: Cell death and differentiation 20090701
Title: Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation.
Journal: Biochemical pharmacology 20090701
Title: Effects of estradiol metabolites on cAMP production and degradation.
Journal: Prilozi 20090701
Title: In vitro effects of 2-methoxyestradiol on cell numbers, morphology, cell cycle progression, and apoptosis induction in oesophageal carcinoma cells.
Journal: Cell biochemistry and function 20090601
Title: Therapeutic efficacy of 2-methoxyestradiol microcrystals encapsulated within polyelectrolyte multilayers.
Journal: Macromolecular bioscience 20090513
Title: Synapse loss regulated by matrix metalloproteinases in traumatic brain injury is associated with hypoxia inducible factor-1alpha expression.
Journal: Brain research 20090501
Title: Low dose combinations of 2-methoxyestradiol and docetaxel block prostate cancer cells in mitosis and increase apoptosis.
Journal: Cancer letters 20090408
Title: Salidroside protects cardiomyocyte against hypoxia-induced death: a HIF-1alpha-activated and VEGF-mediated pathway.
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Title: [Effects of 2-methoxyestradiol on the expression of caspase-3 and survivin in chronic myelocytic leukemia K562 cells].
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Title: [Mechanism underlying 2-methoxyestradiol inducing apoptosis of K562 cells].
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Title: Influence of 2-methoxyestradiol on MCF-7 cells: an improved differential interference contrasting technique and Bcl-2 and Bax protein expression levels.
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Title: Hypoxia-inducible factor-1alpha signaling in aquaporin upregulation after traumatic brain injury.
Journal: Neuroscience letters 20090327
Title: The novel Akt inhibitor Palomid 529 (P529) enhances the effect of radiotherapy in prostate cancer.
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Title: Involvement of FLIP in 2-methoxyestradiol-induced tumor regression in transgenic adenocarcinoma of mouse prostate model.
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Title: [Endocrine factors influencing melanoma progression].
Journal: Magyar onkologia 20090301
Title: The specific effect of 2-methoxyestradiol on lymphatic vascular endothelial cells.
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Title: Phase I trial of 2-methoxyestradiol NanoCrystal dispersion in advanced solid malignancies.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090215
Title: BCRP expression does not result in resistance to STX140 in vivo, despite the increased expression of BCRP in A2780 cells in vitro after long-term STX140 exposure.
Journal: British journal of cancer 20090210
Title: 2-Methoxyestradiol and multidrug resistance: can 2-methoxyestradiol chemosensitize resistant breast cancer cells?
Journal: Breast cancer research and treatment 20090101
Title: Mechanism of 2-methoxyestradiol-induced apoptosis and growth arrest in human breast cancer cells.
Journal: Molecular carcinogenesis 20090101
Title: Low catechol-O-methyltransferase and 2-methoxyestradiol in preeclampsia: more than a unifying hypothesis.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090101
Title: Combination of 2-methoxyestradiol (2-ME2) and eugenol for apoptosis induction synergistically in androgen independent prostate cancer cells.
Journal: The Journal of steroid biochemistry and molecular biology 20090101
Title: Mouse models for preeclampsia: disruption of redox-regulated signaling.
Journal: Reproductive biology and endocrinology : RB&E 20090101
Title: 2-methoxyestradiol as a potential cytostatic drug in gliomas?
Journal: Anti-cancer agents in medicinal chemistry 20090101
Title: A comparative study on the anti-angiogenic effects of DNA-damaging and cytoskeletal-disrupting agents.
Journal: Angiogenesis 20090101
Title: Is there any potential link among caspase-8, p-p38 MAPK and bcl-2 in clear cell renal cell carcinomas? A comparative immunohistochemical analysis with clinical connotations.
Journal: Diagnostic pathology 20090101
Title: Hypoxia. The role of hypoxia and HIF-dependent signalling events in rheumatoid arthritis.
Journal: Arthritis research & therapy 20090101
Title: 2-Methoxyestradiol mediated signaling network in pancreatic cancer.
Journal: Frontiers in bioscience (Landmark edition) 20090101
Title: Disease modifying and antiangiogenic activity of 2-methoxyestradiol in a murine model of rheumatoid arthritis.
Journal: BMC musculoskeletal disorders 20090101
Title: MYC prevents apoptosis and enhances endoreduplication induced by paclitaxel.
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Title: Cytotoxic effects of 2-methoxyestradiol in the hepatocellular carcinoma cell line HepG2.
Journal: Pharmacology 20090101
Title: 2-methoxyestradiol attenuates bleomycin-induced pulmonary hypertension and fibrosis in estrogen-deficient rats.
Journal: Vascular pharmacology 20090101
Title: [Effect of low-dose 2-methoxyestradiol on the expressions of two isoforms of PRDM1 gene in myeloma].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20090101
Title: Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice.
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Title: Multi-modality therapeutics with potent anti-tumor effects: photochemical internalization enhances delivery of the fusion toxin scFvMEL/rGel.
Journal: PloS one 20090101
Title: Antiproliferative effects of 2-methoxyestradiol alone and in combination with chemotherapeutic agents on human endometrial cancer cells.
Journal: European journal of gynaecological oncology 20090101
Title: Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment.
Journal: PloS one 20090101
Title: Catechol-o-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptor signaling in leiomyoma cells.
Journal: PloS one 20090101
Title: Quercetin induces oxidative stress and potentiates the apoptotic action of 2-methoxyestradiol in human hepatoma cells.
Journal: Nutrition and cancer 20090101
Title: Mating changes the subcellular distribution and the functionality of estrogen receptors in the rat oviduct.
Journal: Reproductive biology and endocrinology : RB&E 20090101
Title: Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway.
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Title: Targeted delivery of albumin bound paclitaxel in the treatment of advanced breast cancer.
Journal: OncoTargets and therapy 20090101
Title: 2-Methoxyestradiol attenuates hypertension and coronary vascular remodeling in spontaneously hypertensive rats.
Journal: Maturitas 20081220
Title: Hypoxia-inducible factor 1alpha mediates anoikis resistance via suppression of alpha5 integrin.
Journal: Cancer research 20081215
Title: Glucocorticoid protects hepatoma cells against metabolic stress-induced cell death.
Journal: International journal of oncology 20081201
Title: Bevacizumab in the treatment of HER2-negative breast cancer.
Journal: Biologics : targets & therapy 20081201
Title: The in vivo properties of STX243: a potent angiogenesis inhibitor in breast cancer.
Journal: British journal of cancer 20081104
Title: Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib.
Journal: Leukemia research 20081101
Title: Inhibition of rat aortic smooth muscle contraction by 2-methoxyestradiol.
Journal: American journal of physiology. Heart and circulatory physiology 20081101
Title: An angiogenesis inhibitor, 2-methoxyestradiol, involutes rat collagen-induced arthritis and suppresses gene expression of synovial vascular endothelial growth factor and basic fibroblast growth factor.
Journal: The Journal of rheumatology 20081101
Title: 2-Methoxyestradiol (2-ME) reduces the airway inflammation and remodeling in an experimental mouse model.
Journal: Clinical immunology (Orlando, Fla.) 20081101
Title: 2-methoxyestradiol mediates apoptosis through caspase-dependent and independent mechanisms in ovarian cancer cells but not in normal counterparts.
Journal: Reproductive sciences (Thousand Oaks, Calif.) 20081101
Title: Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Journal: Journal of medicinal chemistry 20081009
Title: Hydrogels for potential colon drug release by thiol-ene conjugate addition of a new inulin derivative.
Journal: Macromolecular bioscience 20081008
Title: 2-Methoxyestradiol inhibits hepatocellular carcinoma cell growth by inhibiting Cdc25 and inducing cell cycle arrest and apoptosis.
Journal: Cancer chemotherapy and pharmacology 20081001
Title: 2-Methoxyestradiol reverses doxorubicin resistance in human breast tumor xenograft.
Journal: Cancer chemotherapy and pharmacology 20081001
Title: Class I beta-tubulin mutations in 2-methoxyestradiol-resistant acute lymphoblastic leukemia cells: implications for drug-target interactions.
Journal: Molecular cancer therapeutics 20081001
Title: Mechanisms of 2-methoxyestradiol-induced apoptosis and G2/M cell-cycle arrest of nasopharyngeal carcinoma cells.
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Title: Expression and cyclic variations of catechol-O-methyl transferase in human endometrial stroma.
Journal: Fertility and sterility 20080901
Title: Anti-microtubule activity of tubeimoside I and its colchicine binding site of tubulin.
Journal: Cancer chemotherapy and pharmacology 20080901
Title: Effect of formulation parameters on 2-methoxyestradiol release from injectable cylindrical poly(DL-lactide-co-glycolide) implants.
Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080901
Title: HIF-1alpha inhibition ameliorates neonatal brain injury in a rat pup hypoxic-ischemic model.
Journal: Neurobiology of disease 20080901
Title: Ixabepilone: a new chemotherapeutic option for refractory metastatic breast cancer.
Journal: Biologics : targets & therapy 20080901
Title: 2-methoxyestradiol-induced cell death in osteosarcoma cells is preceded by cell cycle arrest.
Journal: Journal of cellular biochemistry 20080801
Title: In vitro and in vivo effects of 2-methoxyestradiol, either alone or combined with albendazole, against Echinococcus metacestodes.
Journal: Experimental parasitology 20080801
Title: Syntheses and biological activities of novel 2-methoxyestradiol analogs, 2-fluoroethoxyestradiol and 2-fluoropropanoxyestradiol, and a radiosynthesis of 2-[(18)F]fluoroethoxyestradiol for positron emission tomography.
Journal: Nuclear medicine and biology 20080701
Title: Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia.
Journal: Nature 20080619
Title: Targeting human 8-oxoguanine DNA glycosylase to mitochondria protects cells from 2-methoxyestradiol-induced-mitochondria-dependent apoptosis.
Journal: Oncogene 20080612
Title: Hypoxia in human trophoblasts stimulates the expression and secretion of connective tissue growth factor.
Journal: Endocrinology 20080601
Title: Estradiol and the estradiol metabolite, 2-hydroxyestradiol, activate AMP-activated protein kinase in C2C12 myotubes.
Journal: Obesity (Silver Spring, Md.) 20080601
Title: Significant antitumor activity in vivo following treatment with the microtubule agent ENMD-1198.
Journal: Molecular cancer therapeutics 20080601
Title: Regulation of catechol O-methyltransferase expression in granulosa cells: a potential role for follicular arrest in polycystic ovary syndrome.
Journal: Fertility and sterility 20080501
Title: An estrogen metabolite, 2-methoxyestradiol, disrupts cardiac microtubules and unmasks muscarinic inhibition of calcium current.
Journal: The Journal of pharmacology and experimental therapeutics 20080501
Title: Potentiation of 2-methoxyestradiol-induced cytotoxicity by blocking endothelin A receptor in prostate cancer cells.
Journal: The Prostate 20080501
Title: Modulation of adjuvant arthritis in the rat by 2-methoxyestradiol: an effect independent of an anti-angiogenic action.
Journal: International immunopharmacology 20080501
Title: Ovarian P450 aromatase activity in the catfish Heteropneustes fossilis: seasonal changes and effects of catecholestrogens.
Journal: General and comparative endocrinology 20080501
Title: Preferential induction of cytochrome P450 1A1 over cytochrome P450 1B1 in human breast epithelial cells following exposure to quercetin.
Journal: The Journal of steroid biochemistry and molecular biology 20080501
Title: Comparative effects of chemotherapeutic agents on the growth and survival of human adrenal carcinoma cells in culture.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20080501
Title: The effect of 2-methoxyestradiol, a HIF-1 alpha inhibitor, in global cerebral ischemia in rats.
Journal: Neurological research 20080401
Title: Involvement of peroxiredoxin IV in the 16alpha-hydroxyestrone-induced proliferation of human MCF-7 breast cancer cells.
Journal: Cell biology international 20080401
Title: Phytoestrogens and breast cancer prevention: possible mechanisms of action.
Journal: Environmental health perspectives 20080401
Title: Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents.
Journal: Journal of medicinal chemistry 20080313
Title: Judah Folkman, a pioneer in the study of angiogenesis.
Journal: Angiogenesis 20080301
Title: Statins impair antitumor effects of rituximab by inducing conformational changes of CD20.
Journal: PLoS medicine 20080301
Title: 2-Methoxyestradiol modulates beta-catenin in prostate cancer cells: a possible mediator of 2-methoxyestradiol-induced inhibition of cell growth.
Journal: International journal of cancer 20080201
Title: Is mitochondrial generation of reactive oxygen species a trigger for autophagy?
Journal: Autophagy 20080201
Title: Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs. Part III.
Journal: Steroids 20080201
Title: Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs--Part II.
Journal: Steroids 20080201
Title: 2-methoxyestradiol inhibits hypoxia-inducible factor-1{alpha} and suppresses growth of lesions in a mouse model of endometriosis.
Journal: The American journal of pathology 20080201
Title: Downregulation of c-Myc determines sensitivity to 2-methoxyestradiol-induced apoptosis in human acute myeloid leukemia.
Journal: Experimental hematology 20080201
Title: Influence of hormones and hormone metabolites on the growth of Schwann cells derived from embryonic stem cells and on tumor cell lines expressing variable levels of neurofibromin.
Journal: Developmental dynamics : an official publication of the American Association of Anatomists 20080201
Title: New aspects of regulatory signaling pathways and novel therapies in pancreatic cancer.
Journal: Current molecular medicine 20080201
Title: STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080115
Title: Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells.
Journal: Cell death and differentiation 20080101
Title: Biodegradable and pH-sensitive hydrogels for potential colon-specific drug delivery: characterization and in vitro release studies.
Journal: Biomacromolecules 20080101
Title: The environmental toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin disrupts morphogenesis of the rat pre-implantation embryo.
Journal: BMC developmental biology 20080101
Title: Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk.
Journal: BMC cancer 20080101
Title: 2-Ethoxyestradiol is antimitogenic and attenuates monocrotaline-induced pulmonary hypertension and vascular remodeling.
Journal: Vascular pharmacology 20080101
Title: Growth inhibition and induction of apoptosis by 2-methoxyestradiol in rat osteosarcoma and malignant fibrous histiocytoma cell lines.
Journal: In vivo (Athens, Greece) 20080101
Title: A new micronized formulation of 2-methoxyestradiol-bis-sulfamate (STX140) is therapeutically potent against breast cancer.
Journal: Anticancer research 20080101
Title: In vitro effects of 2-methoxyestradiol on MCF-12A and MCF-7 cell growth, morphology and mitotic spindle formation.
Journal: Cell biochemistry and function 20080101
Title: Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice.
Journal: BMC cancer 20080101
Title: In vitro studies on the modification of low-dose hyper-radiosensitivity in prostate cancer cells by incubation with genistein and estradiol.
Journal: Radiation oncology (London, England) 20080101
Title: Iodine alters gene expression in the MCF7 breast cancer cell line: evidence for an anti-estrogen effect of iodine.
Journal: International journal of medical sciences 20080101
Title: ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo.
Journal: BMC cancer 20080101
Title: New steroidal aromatase inhibitors: suppression of estrogen-dependent breast cancer cell proliferation and induction of cell death.
Journal: BMC cell biology 20080101
Title: Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee joints.
Journal: Arthritis research & therapy 20080101
Title: Vascular involvement in rheumatic diseases: 'vascular rheumatology'.
Journal: Arthritis research & therapy 20080101
Title: Antitumor efficacy of combination of interferon-gamma-inducible protein 10 gene with gemcitabine, a study in murine model.
Journal: Journal of experimental & clinical cancer research : CR 20080101
Title: Prognostic significance of Hypoxia-Inducible Factor 1 alpha(HIF-1 alpha) expression in serous ovarian cancer: an immunohistochemical study.
Journal: BMC cancer 20080101
Title: Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate.
Journal: BMC genomics 20080101
Title: HIF-1 alpha inhibition ameliorates neonatal brain damage after hypoxic-ischemic injury.
Journal: Acta neurochirurgica. Supplement 20080101
Title: Strategies for prostate cancer prevention: Review of the literature.
Journal: Indian journal of urology : IJU : journal of the Urological Society of India 20080101
Title: Synthesis and in vivo antitumor evaluation of 2-methoxyestradiol 3-phosphate, 17-phosphate, and 3,17-diphosphate.
Journal: Journal of medicinal chemistry 20071227
Title: The therapeutic potential of a series of orally bioavailable anti-angiogenic microtubule disruptors as therapy for hormone-independent prostate and breast cancers.
Journal: British journal of cancer 20071217
Title: Synthesis and structure-activity relationships of 16-modified analogs of 2-methoxyestradiol.
Journal: Bioorganic & medicinal chemistry 20071215
Title: Enhanced radiation-induced cytotoxic effect by 2-ME in glioma cells is mediated by induction of cell cycle arrest and DNA damage via activation of ATM pathways.
Journal: Brain research 20071214
Title: 2-Methoxyestradiol attenuates phosphatidylinositol 3-kinase/Akt pathway-mediated metastasis of gastric cancer.
Journal: International journal of cancer 20071201
Title: Catechol-o-methyltransferase and methoxyestradiols participate in the intraoviductal nongenomic pathway through which estradiol accelerates egg transport in cycling rats.
Journal: Biology of reproduction 20071201
Title: 2-Methoxyestradiol reduces monocyte adhesion to aortic endothelial cells in ovariectomized rats.
Journal: Endocrine journal 20071201
Title: Hypoxia-inducible factor 1alpha is involved in the prostaglandin metabolism of osteoarthritic cartilage through up-regulation of microsomal prostaglandin E synthase 1 in articular chondrocytes.
Journal: Arthritis and rheumatism 20071201
Title: From the bench to the bedside: emerging new treatments in multiple myeloma.
Journal: Best practice & research. Clinical haematology 20071201
Title: SEPT9_V1 protein expression is associated with human cancer cell resistance to microtubule-disrupting agents.
Journal: Cancer biology & therapy 20071201
Title: Transcription factors Xbp-1, Blimp-1, and BSAP are involved in the regulation of plasmacytic differentiation induced by 2-methoxyestradiol in myeloma cell lines.
Journal: International journal of hematology 20071201
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20071201
Title: 2-Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo.
Journal: Cancer research 20071101
Title: Molecular consequences of SOD2 expression in epigenetically silenced pancreatic carcinoma cell lines.
Journal: British journal of cancer 20071022
Title: Novel therapy with 2-methoxyestradiol for the treatment of relapsed and plateau phase multiple myeloma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20071015
Title: 3,17-disubstituted 2-alkylestra-1,3,5(10)-trien-3-ol derivatives: synthesis, in vitro and in vivo anticancer activity.
Journal: Journal of medicinal chemistry 20070906
Title: Coordination of upregulated XBP-1 and downregulated c-myc during myeloma cell differentiation induced by 2-methoxyestradiol.
Journal: Leukemia research 20070901
Title: The endogenous estradiol metabolite 2-methoxyestradiol reduces atherosclerotic lesion formation in female apolipoprotein E-deficient mice.
Journal: Endocrinology 20070901
Title: Multiple effects of 2ME2 and D609 on the cortical expression of HIF-1alpha and apoptotic genes in a middle cerebral artery occlusion-induced focal ischemia rat model.
Journal: Journal of neurochemistry 20070901
Title: Antineoplastic activity of 2-methoxyestradiol in human pancreatic and gastric cancer cells with different multidrug-resistant phenotypes.
Journal: Journal of gastroenterology and hepatology 20070901
Title: HPLC for stress-free screening of potential prostate cancer marker catechol estrogens in urine using a diamond-electrode electrochemical and a fluorescence detector.
Journal: Journal of separation science 20070901
Title: 2-Methoxyestradiol: a potential treatment for multiple proliferative disorders.
Journal: Endocrinology 20070901
Title: Radiosensitization and modulation of p44/42 mitogen-activated protein kinase by 2-Methoxyestradiol in prostate cancer models.
Journal: Cancer research 20070901
Title: Docetaxel monotherapy as second-line treatment for pretreated advanced non-small cell lung cancer patients.
Journal: The Korean journal of internal medicine 20070901
Title: 2-methoxyestradiol induces apoptosis and cell cycle arrest in human chondrosarcoma cells.
Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20070801
Title: Angiogenesis inhibition as a therapeutic approach for inflammatory synovitis.
Journal: Nature clinical practice. Rheumatology 20070801
Title: 2-[methyl-(11)C]methoxyestradiol: synthesis, evaluation and pharmacokinetics for in vivo studies on angiogenesis.
Journal: Nuclear medicine and biology 20070801
Title: Porcine follicular fluids: comparison of solid-phase extraction and matrix solid-phase dispersion for the GC-MS determination of hormones during follicular growth.
Journal: Journal of pharmaceutical and biomedical analysis 20070727
Title: Characterization of in vitro and in vivo metabolic pathways of the investigational anticancer agent, 2-methoxyestradiol.
Journal: Journal of pharmaceutical sciences 20070701
Title: Requirement of reactive oxygen species generation in apoptosis of leukemia cells induced by 2-methoxyestradiol.
Journal: Acta pharmacologica Sinica 20070701
Title: Antiangiogenesis in swine ovarian follicle: a potential role for 2-methoxyestradiol.
Journal: Steroids 20070701
Title: 2-Methoxyestradiol--a unique blend of activities generating a new class of anti-tumour/anti-inflammatory agents.
Journal: Drug discovery today 20070701
Title: Resistance of fibrogenic responses to glucocorticoid and 2-methoxyestradiol in bleomycin-induced lung fibrosis in mice.
Journal: Canadian journal of physiology and pharmacology 20070701
Title: Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine.
Journal: Cancer letters 20070608
Title: HIF-1alpha induced-VEGF overexpression in bone marrow stem cells protects cardiomyocytes against ischemia.
Journal: Journal of molecular and cellular cardiology 20070601
Title: In vivo inhibition of angiogenesis by sulphamoylated derivatives of 2-methoxyoestradiol.
Journal: British journal of cancer 20070507
Title: Effects of 2-methoxyestradiol on endometrial carcinoma xenografts.
Journal: Journal of cancer research and clinical oncology 20070501
Title: Integrated molecular profiling of SOD2 expression in multiple myeloma.
Journal: Blood 20070501
Title: 2-methoxyestradiol induces spindle aberrations, chromosome congression failure, and nondisjunction in mouse oocytes.
Journal: Biology of reproduction 20070501
Title: Increased expression of cyclin B1 sensitizes prostate cancer cells to apoptosis induced by chemotherapy.
Journal: Molecular cancer therapeutics 20070501
Title: [Regulation of c-myc expression by Blimp-1 during the differentiation of myeloma cells].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20070501
Title: Mechanism of 2-methoxyestradiol-induced apoptosis in myelodysplastic syndrome MUTZ-1 cell line.
Journal: Zhongguo shi yan xue ye xue za zhi 20070401
Title: Endoreduplication of human smooth muscle cells induced by 2-methoxyestradiol: a role for cyclin-dependent kinase 2.
Journal: American journal of physiology. Heart and circulatory physiology 20070301
Title: 2-methoxyestradiol induces mammary gland differentiation through amphiregulin-epithelial growth factor receptor-mediated signaling: molecular distinctions from the mammary gland of pregnant mice.
Journal: Endocrinology 20070301
Title: Ovarian cancer risk and polymorphisms involved in estrogen catabolism.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070301
Title: [Alterations of telomerase activity and apoptosis induced by 2-methoxyestradiol in human myelodysplastic syndrome cell line MUTZ-1].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20070301
Title: Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer.
Journal: Investigational new drugs 20070201
Title: Involvement of microtubules, p38, and Rho kinases pathway in 2-methoxyestradiol-induced lung vascular barrier dysfunction.
Journal: American journal of physiology. Lung cellular and molecular physiology 20070201
Title: Urinary phytoestrogen excretion of rats bearing methylnitrosourea-induced mammary carcinoma in response to treatment with 2-methoxyestradiol.
Journal: The Journal of steroid biochemistry and molecular biology 20070201
Title: Influence of 2-methoxyestradiol on cell morphology and cdc2 kinase activity in WHCO3 esophageal carcinoma cells.
Journal: Biomedical research (Tokyo, Japan) 20070201
Title: 2-methoxyestradiol inhibits the anaphase-promoting complex and protein translation in human breast cancer cells.
Journal: Cancer research 20070115
Title: Double-stranded RNA-dependent protein kinase is involved in 2-methoxyestradiol-mediated cell death of osteosarcoma cells.
Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20070101
Title: Antiproliferative effect of polyphenols and sterols of virgin argan oil on human prostate cancer cell lines.
Journal: Cancer detection and prevention 20070101
Title: Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection: a hypothesis.
Journal: Breast cancer research : BCR 20070101
Title: 2-Methoxyestradiol and 2-ethoxyestradiol retard the progression of renal disease in aged, obese, diabetic ZSF1 rats.
Journal: Journal of cardiovascular pharmacology 20070101
Title: Enhanced NF kappa B and AP-1 transcriptional activity associated with antiestrogen resistant breast cancer.
Journal: BMC cancer 20070101
Title: In vitro effects of 2-methoxyestradiol on cell morphology and Cdc2 kinase activity in SNO oesophageal carcinoma cells.
Journal: Cell biochemistry and function 20070101
Title: INGN 201: Ad-p53, Ad5CMV-p53, adenoviral p53, p53 gene therapy--introgen, RPR/INGN 201.
Journal: Drugs in R&D 20070101
Title: Reduced tumor growth in vivo and increased c-Abl activity in PC3 prostate cancer cells overexpressing the Shb adapter protein.
Journal: BMC cancer 20070101
Title: Comparison of 2-methoxyestradiol and methotrexate effects on non-Hodgkin's B-cell lymphoma.
Journal: Current eye research 20070101
Title: Estrogenic or antiestrogenic therapies for multiple myeloma?
Journal: Molecular cancer 20070101
Title: Breast tumour angiogenesis.
Journal: Breast cancer research : BCR 20070101
Title: The roles of beta-tubulin mutations and isotype expression in acquired drug resistance.
Journal: Cancer informatics 20070101
Title: Signaling mechanisms of endogenous angiogenesis inhibitors derived from type IV collagen.
Journal: Gene regulation and systems biology 20070101
Title: Bevacizumab: the evidence for its clinical potential in the treatment of nonsmall cell lung cancer.
Journal: Core evidence 20070101
Title: Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model.
Journal: Cancer research 20061215
Title: 2-Methoxyestradiol mediates the protective effects of estradiol in monocrotaline-induced pulmonary hypertension.
Journal: Vascular pharmacology 20061201
Title: 2-methoxyestradiol reduces cerebral vasospasm after 48 hours of experimental subarachnoid hemorrhage in rats.
Journal: Experimental neurology 20061201
Title: Estrogen metabolite 2-methoxyestradiol induces apoptosis and inhibits cell proliferation and collagen production in rat and human leiomyoma cells: a potential medicinal treatment for uterine fibroids.
Journal: Journal of the Society for Gynecologic Investigation 20061201
Title: 2-Methoxyestradiol inhibits superoxide anion generation while it enhances superoxide dismutase activity in swine granulosa cells.
Journal: Annals of the New York Academy of Sciences 20061201
Title: Antiangiogenic effect of oral 2-methoxyestradiol on choroidal neovascularization in mice.
Journal: Experimental eye research 20061101
Title: 2-methoxyestradiol, an endogenous mammalian metabolite, radiosensitizes colon carcinoma cells through c-Jun NH2-terminal kinase activation.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20061101
Title: 2-methoxyestradiol inhibits differentiation and is cytotoxic to osteoclasts.
Journal: Journal of cellular biochemistry 20061001
Title: Tocopherols and saponins derived from Argania spinosa exert, an antiproliferative effect on human prostate cancer.
Journal: Cancer investigation 20061001
Title: Plasma protein binding of the investigational anticancer agent 2-methoxyestradiol.
Journal: Anti-cancer drugs 20060901
Title: Hypoxia-inducible factor-1 in human breast and prostate cancer.
Journal: Endocrine-related cancer 20060901
Title: Estrogens, enzyme variants, and breast cancer: a risk model.
Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20060901
Title: 2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules.
Journal: Molecular cancer therapeutics 20060901
Title: 2-Methoxyestradiol, an estradiol metabolite, inhibits neointima formation and smooth muscle cell growth via double blockade of the cell cycle.
Journal: Circulation research 20060804
Title: Does 2-methoxyestradiol represent the new and improved hormone replacement therapy for atherosclerosis?
Journal: Circulation research 20060804
Title: Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels.
Journal: The American journal of pathology 20060801
Title: HIF-1 and tumour radiosensitivity.
Journal: British journal of cancer 20060703
Title: SAR studies of 2-methoxyestradiol and development of its analogs as probes of anti-tumor mechanisms.
Journal: Bioorganic & medicinal chemistry letters 20060701
Title: Flavonoid-induced glutathione depletion: potential implications for cancer treatment.
Journal: Free radical biology & medicine 20060701
Title: A very low toxic agent induces apoptosis and reduces growth of human hepatocellular carcinoma cells.
Journal: Journal of gastroenterology and hepatology 20060701
Title: Relative effects of estradiol-17beta (E2), catecholestrogens and clomiphene citrate on in vitro oocyte maturation in the catfish Heteropneustes fossilis (Bloch) and E2 inhibition of 2-hydroxyestradiol-induced maturation.
Journal: General and comparative endocrinology 20060601
Title: Sulfotransferase (SULT) 1A1 polymorphic variants *1, *2, and *3 are associated with altered enzymatic activity, cellular phenotype, and protein degradation.
Journal: Molecular pharmacology 20060601
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Effect of 2-methoxyestradiol, buthionine sulfoximine and hydrogen peroxide on the viability of renal carcinoma cell lines (ACHN and ACVB).
Journal: Biological & pharmaceutical bulletin 20060501
Title: Crosstalk between extrinsic and intrinsic cell death pathways in pancreatic cancer: synergistic action of estrogen metabolite and ligands of death receptor family.
Journal: Cancer research 20060415
Title: [2-Methoxyestradiol -- a new compound for cancer treatment].
Journal: Deutsche medizinische Wochenschrift (1946) 20060413
Title: Distinct tumor stage-specific inhibitory effects of 2-methoxyestradiol in a breast cancer mouse model associated with Id-1 expression.
Journal: Cancer research 20060401
Title: Physiologic levels of 2-methoxyestradiol interfere with nongenomic signaling of 17beta-estradiol in human breast cancer cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060401
Title: [Effect of 2-methoxyestradiol on differentiation of primary myeloma cells].
Journal: Zhongguo shi yan xue ye xue za zhi 20060401
Title: Modulation of cell-cycle regulatory signaling network by 2-methoxyestradiol in prostate cancer cells is mediated through multiple signal transduction pathways.
Journal: Biochemistry 20060321
Title: Regulation of cardiotrophin-1 expression in mouse embryonic stem cells by HIF-1alpha and intracellular reactive oxygen species.
Journal: Journal of cell science 20060315
Title: Analysis of fifteen estrogen metabolites using packed column supercritical fluid chromatography-mass spectrometry.
Journal: Analytical chemistry 20060301
Title: p38 Mitogen-activated protein kinases is required for counteraction of 2-methoxyestradiol to estradiol-stimulated cell proliferation and induction of apoptosis in ovarian carcinoma cells via phosphorylation Bcl-2.
Journal: Apoptosis : an international journal on programmed cell death 20060301
Title: Different effects of estradiol and various antiestrogens on TNF-alpha-induced changes of biochemical markers for growth and invasion of human breast cancer cells.
Journal: Life sciences 20060223
Title: 2-methoxyestradiol induces cell cycle arrest and mitotic cell apoptosis in human vascular smooth muscle cells.
Journal: Hypertension (Dallas, Tex. : 1979) 20060201
Title: 2-Methoxyestradiol inhibits prostate tumor development in transgenic adenocarcinoma of mouse prostate: role of tumor necrosis factor-alpha-stimulated gene 6.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060201
Title: 14-3-3sigma, a p53 regulator, suppresses tumor growth of nasopharyngeal carcinoma.
Journal: Molecular cancer therapeutics 20060201
Title: Preliminary investigation of 2-methoxyestradiol inducing differentiation of myeloma cell line CZ-1.
Journal: Zhongguo shi yan xue ye xue za zhi 20060201
Title: 2-methoxyestradiol induces apoptosis in cultured human anaplastic thyroid carcinoma cells.
Journal: Thyroid : official journal of the American Thyroid Association 20060201
Title: 2-Methoxyestradiol and paclitaxel have similar effects on the cell cycle and induction of apoptosis in prostate cancer cells.
Journal: Cancer letters 20060108
Title: Phase I clinical trial of oral 2-methoxyestradiol, an antiangiogenic and apoptotic agent, in patients with solid tumors.
Journal: Cancer biology & therapy 20060101
Title: The role of 17beta-hydroxysteroid dehydrogenases in modulating the activity of 2-methoxyestradiol in breast cancer cells.
Journal: Cancer research 20060101
Title: Growth of a human mammary tumor cell line is blocked by galangin, a naturally occurring bioflavonoid, and is accompanied by down-regulation of cyclins D3, E, and A.
Journal: Breast cancer research : BCR 20060101
Title: Encapsulation of submicrometer-sized 2-methoxyestradiol crystals into polymer multilayer capsules for biological applications.
Journal: Molecular pharmaceutics 20060101
Title: Laulimalide and synthetic laulimalide analogues are synergistic with paclitaxel and 2-methoxyestradiol.
Journal: Molecular pharmaceutics 20060101
Title: The Association of the COMT V158M Polymorphism with Endometrial/Ovarian Cancer in HNPCC Families Adhering to the Amsterdam Criteria.
Journal: Hereditary cancer in clinical practice 20060101
Title: Mitogenic estrogen metabolites alter the expression of 17beta-estradiol-regulated proteins including heat shock proteins in human MCF-7 breast cancer cells.
Journal: Molecules and cells 20051231
Title: Anti-angiogenic therapy and chemotherapy affect 99mTc sestamibi and 99mTc-HL91 accumulation differently in tumour xenografts.
Journal: Nuclear medicine communications 20051201
Title: Effective transscleral delivery of two retinal anti-angiogenic molecules: carboxyamido-triazole (CAI) and 2-methoxyestradiol (2ME2).
Journal: Retina (Philadelphia, Pa.) 20051201
Title: Inhibition of MDA-MB-231 cell cycle progression and cell proliferation by C-2-substituted oestradiol mono- and bis-3-O-sulphamates.
Journal: International journal of cancer 20051020
Title: beta-Tubulin mutations are associated with resistance to 2-methoxyestradiol in MDA-MB-435 cancer cells.
Journal: Cancer research 20051015
Title: Estrogen effects on tubulin expression and taxane mediated cytotoxicity in prostate cancer cells.
Journal: The Prostate 20051001
Title: Estradiol metabolites attenuate monocrotaline-induced pulmonary hypertension in rats.
Journal: Journal of cardiovascular pharmacology 20051001
Title: Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function.
Journal: Cancer research 20051001
Title: [Molecular mechanism of myeloma cell line differentiation induced by 2-methoxyestradiol].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20051001
Title: A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach.
Journal: Journal of medicinal chemistry 20050922
Title: Resistance to paclitaxel is proportional to cellular total antioxidant capacity.
Journal: Cancer research 20050915
Title: A phase II multicenter, randomized, double-blind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050915
Title: 2-Methoxyestradiol at low dose induces differentiation of myeloma cells.
Journal: Leukemia research 20050901
Title: [Effect of 2-methoxyestradiol on human cervical cancer cells HeLaS3 and xenografts].
Journal: Zhonghua fu chan ke za zhi 20050901
Title: Effects of hormone deprivation and 2-methoxyestradiol combination therapy on hormone-dependent prostate cancer in vivo.
Journal: Neoplasia (New York, N.Y.) 20050901
Title: The potential and suitability of 2-methoxyestradiol in cancer therapy.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050815
Title: A-ring-substituted estrogen-3-O-sulfamates: potent multitargeted anticancer agents.
Journal: Journal of medicinal chemistry 20050811
Title: Perspectives for combination therapy to overcome drug-resistant multiple myeloma.
Journal: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20050801
Title: Trigeminal pain transmission requires reactive oxygen species production.
Journal: Brain research 20050719
Title: Thymidine phosphorylase suppresses apoptosis induced by microtubule-interfering agents.
Journal: Biochemical pharmacology 20050701
Title: Estradiol metabolites attenuate renal and cardiovascular injury induced by chronic nitric oxide synthase inhibition.
Journal: Journal of cardiovascular pharmacology 20050701
Title: Selective insensitivity of ZR-75-1 human breast cancer cells to 2-methoxyestradiol: evidence for type II 17beta-hydroxysteroid dehydrogenase as the underlying cause.
Journal: Cancer research 20050701
Title: ZD6474--clinical experience to date.
Journal: British journal of cancer 20050601
Title: Bax/Bcl-2 expression levels of 2-methoxyestradiol-exposed esophageal cancer cells.
Journal: Biomedical research (Tokyo, Japan) 20050601
Title: 2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process.
Journal: Oncogene 20050526
Title: Colchicine and 2-methoxyestradiol Inhibit Human Angiogenesis.
Journal: The Journal of surgical research 20050501
Title: 2-Methoxyestradiol-induced apoptosis in prostate cancer cells requires Smad7.
Journal: The Journal of biological chemistry 20050415
Title: Monocrotaline pyrrole-induced endothelial cell megalocytosis involves a Golgi blockade mechanism.
Journal: American journal of physiology. Cell physiology 20050401
Title: NADPH-dependent metabolism of 17beta-estradiol and estrone to polar and nonpolar metabolites by human tissues and cytochrome P450 isoforms.
Journal: Steroids 20050401
Title: [Effect of 2-methoxyestradiol on proliferation and apoptosis of myeloma cell lines].
Journal: Zhongguo shi yan xue ye xue za zhi 20050401
Title: Targeted therapy in multiple myeloma.
Journal: Cancer control : journal of the Moffitt Cancer Center 20050401
Title: Influence of prostaglandin A2 and 2-methoxyestradiol on Bax and Bcl-2 expression levels in cervical carcinoma cells.
Journal: Biomedical research (Tokyo, Japan) 20050401
Title: [Effect of 2-methoxyestradiol on cell differentiation of myeloma cell line CZ-1].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20050401
Title: [Investigation of the effect of 2-methoxyestradiol and arsenic trioxide on the apoptosis-associated gene expression profile of myeloma cells].
Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20050401
Title: Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicity.
Journal: Oncogene 20050310
Title: 2-methoxyestradiol is an estrogen receptor agonist that supports tumor growth in murine xenograft models of breast cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050301
Title: Micromolar concentrations of 2-methoxyestradiol kill glioma cells by an apoptotic mechanism, without destroying their microtubule cytoskeleton.
Journal: Journal of neuro-oncology 20050301
Title: Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells.
Journal: Journal of molecular endocrinology 20050201
Title: Synergism between the anticancer actions of 2-methoxyestradiol and microtubule-disrupting agents in human breast cancer.
Journal: Cancer research 20050115
Title: Cytochromes 1A1/1B1- and catechol-O-methyltransferase-derived metabolites mediate estradiol-induced antimitogenesis in human cardiac fibroblast.
Journal: The Journal of clinical endocrinology and metabolism 20050101
Title: Determination of 2-methoxyestradiol in human plasma, using liquid chromatography/tandem mass spectrometry.
Journal: Rapid communications in mass spectrometry : RCM 20050101
Title: Antiproliferative activity and toxicity of 2-methoxyestradiol in cervical cancer xenograft mice.
Journal: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20050101
Title: Short incubation with 2-methoxyestradiol kills malignant glioma cells independent of death receptor 5 upregulation.
Journal: Clinical neuropathology 20050101
Title: Genetic polymorphisms in human SULT1A1 and UGT1A1 genes associate with breast tumor characteristics: a case-series study.
Journal: Breast cancer research : BCR 20050101
Title: Possible protective effects of alpha-tocopherol on enhanced induction of reactive oxygen species by 2-methoxyestradiol in tumors.
Journal: Advances in experimental medicine and biology 20050101
Title: Effects of dioxin on metabolism of estrogens in waste incinerator workers.
Journal: Archives of environmental & occupational health 20050101
Title: 2-methoxyestradiol inhibits hypoxia-inducible factor 1alpha, tumor growth, and angiogenesis and augments paclitaxel efficacy in head and neck squamous cell carcinoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041215
Title: In vitro and in vivo antitumor effect of 2-methoxyestradiol on human melanoma.
Journal: International journal of cancer 20041210
Title: 2-Methoxyestradiol induces cell cycle arrest and apoptosis of nasopharyngeal carcinoma cells.
Journal: Acta pharmacologica Sinica 20041101
Title: Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, Akt, Bid, cytochrome and caspase pathway.
Journal: Free radical biology & medicine 20041015
Title: Effects of altering the electronics of 2-methoxyestradiol on cell proliferation, on cytotoxicity in human cancer cell cultures, and on tubulin polymerization.
Journal: Journal of medicinal chemistry 20041007
Title: Effects of 2-methoxyestradiol on proliferation, apoptosis and PET-tracer uptake in human prostate cancer cell aggregates.
Journal: Nuclear medicine and biology 20041001
Title: The new cancer blockers.
Journal: The Johns Hopkins medical letter health after 50 20041001
Title: Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol.
Journal: Biochemical and biophysical research communications 20040924
Title: Tumor suppressor ARF inhibits HER-2/neu-mediated oncogenic growth.
Journal: Oncogene 20040916
Title: 2-Methoxyestradiol inhibits proliferation of normal and neoplastic glial cells, and induces cell death, in vitro.
Journal: Cancer letters 20040915
Title: Mass spectrometric measurement of differential reactivity of cysteine to localize protein-ligand binding sites. Application to tubulin-binding drugs.
Journal: Analytical biochemistry 20040915
Title: In vitro model of mammary estrogen metabolism: structural and kinetic differences between catechol estrogens 2- and 4-hydroxyestradiol.
Journal: Chemical research in toxicology 20040901
Title: Examination of a modified cell cycle synchronization method and bovine nuclear transfer using synchronized early G1 phase fibroblast cells.
Journal: Theriogenology 20040801
Title: Catecholamines block the antimitogenic effect of estradiol on human coronary artery smooth muscle cells.
Journal: The Journal of clinical endocrinology and metabolism 20040801
Title: 2-methoxyestradiol enhances p53 protein transduction therapy-associated inhibition of the proliferation of oral cancer cells through the suppression of NFkappaB activity.
Journal: Acta medica Okayama 20040801
Title: Effects of estrogens and metabolites on endometrial carcinogenesis in young adult mice initiated with N-ethyl-N'-nitro-N-nitrosoguanidine.
Journal: Cancer letters 20040728
Title: Chemotherapy of breast cancer-additive anticancerogenic effects by 2-methoxyestradiol?
Journal: Life sciences 20040723
Title: Determination of the antiangiogenesis agent 2-methoxyestradiol in human plasma by liquid chromatography with ultraviolet detection.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040705
Title: Gastrointestinally distributed UDP-glucuronosyltransferase 1A10, which metabolizes estrogens and nonsteroidal anti-inflammatory drugs, depends upon phosphorylation.
Journal: The Journal of biological chemistry 20040702
Title: Improved survival of mice bearing liver metastases of colon cancer cells treated with a combination of radioimmunotherapy and antiangiogenic therapy.
Journal: European journal of nuclear medicine and molecular imaging 20040701
Title: New drugs for treatment of multiple myeloma.
Journal: The Lancet. Oncology 20040701
Title: 2-Alkylsulfanyl estrogen derivatives: synthesis of a novel class of multi-targeted anti-tumour agents.
Journal: Bioorganic & medicinal chemistry letters 20040621
Title: 2-hydroxyestradiol is a prodrug of 2-methoxyestradiol.
Journal: The Journal of pharmacology and experimental therapeutics 20040601
Title: Suppressive effects of 17beta-estradiol on hepatic fibrosis in CCl4-induced rat model.
Journal: World journal of gastroenterology 20040501
Title: Differential regulation of estrogen receptor subtypes alpha and beta in human aortic smooth muscle cells by oligonucleotides and estradiol.
Journal: The Journal of clinical endocrinology and metabolism 20040501
Title: Mitochondrial superoxide dismutase: a promising target for new anticancer therapies.
Journal: Current medicinal chemistry 20040501
Title: 2-MeOE2bisMATE induces caspase-dependent apoptosis in CAL51 breast cancer cells and overcomes resistance to TRAIL via cooperative activation of caspases.
Journal: Apoptosis : an international journal on programmed cell death 20040501
Title: Blockade of ubiquitin-conjugating enzyme CDC34 enhances anti-myeloma activity of Bortezomib/Proteasome inhibitor PS-341.
Journal: Oncogene 20040429
Title: Inhibition of in vitro angiogenesis by 2-methoxy- and 2-ethyl-estrogen sulfamates.
Journal: International journal of cancer 20040420
Title: Antitumour and antiangiogenic effects of IDN 5390, a novel C-seco taxane, in a paclitaxel-resistant human ovarian tumour xenograft.
Journal: British journal of cancer 20040405
Title: A gas chromatography/mass spectrometry assay to measure estradiol, catecholestradiols, and methoxyestradiols in plasma.
Journal: Steroids 20040401
Title: Intrinsic oxidative stress in cancer cells: a biochemical basis for therapeutic selectivity.
Journal: Cancer chemotherapy and pharmacology 20040301
Title: 2-Methoxyestardiol and bortezomib/proteasome-inhibitor overcome dexamethasone-resistance in multiple myeloma cells by modulating Heat Shock Protein-27.
Journal: Apoptosis : an international journal on programmed cell death 20040301
Title: Concentration-dependent mitogenic and antiproliferative actions of 2-methoxyestradiol in estrogen receptor-positive human breast cancer cells.
Journal: The Journal of steroid biochemistry and molecular biology 20040301
Title: Pulsed estrogen exposure selectively modulates tissue response: a hypothesis.
Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20040301
Title: Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents.
Journal: British journal of cancer 20040223
Title: Estrogens and anti-estrogens: key mediators of prostate carcinogenesis and new therapeutic candidates.
Journal: Journal of cellular biochemistry 20040215
Title: A comparative study on the effects of 2,3,7,8,-tetrachlorodibenzo-p-dioxin polychlorinated biphenyl126 and estrogen in human bronchial epithelial cells.
Journal: Toxicology and applied pharmacology 20040215
Title: 2-methoxyestradiol induces caspase-independent, mitochondria-centered apoptosis in DS-sarcoma cells.
Journal: International journal of cancer 20040210
Title: A simple quantitative method for evaluation of angiogenesis activity.
Journal: Assay and drug development technologies 20040201
Title: Prevention of mammary carcinogenesis by short-term estrogen and progestin treatments.
Journal: Breast cancer research : BCR 20040101
Title: The molecular mechanism of sensitization to Fas-mediated apoptosis by 2-methoxyestradiol in PC3 prostate cancer cells.
Journal: Molecular carcinogenesis 20040101
Title: The extracellular matrix, p53 and estrogen compete to regulate cell-surface Fas/Apo-1 suicide receptor expression in proliferating embryonic cerebral cortical precursors, and reciprocally, Fas-ligand modifies estrogen control of cell-cycle proteins.
Journal: BMC neuroscience 20040101
Title: Cytotoxic effects of B lymphocytes mediated by reactive oxygen species.
Journal: Current pharmaceutical design 20040101
Title: Recent translational research: antiangiogenic therapy for breast cancer - where do we stand?
Journal: Breast cancer research : BCR 20040101
Title: [Report of the National Oncology Research and Developement Consortium, 2003].
Journal: Magyar onkologia 20040101
Title: Induction of apoptosis and G2/M arrest by 2-methoxyestradiol in human cervical cancer HeLaS3 cells.
Journal: Anticancer research 20040101
Title: Cytochrome P450 1A2 (CYP1A2) activity, mammographic density, and oxidative stress: a cross-sectional study.
Journal: Breast cancer research : BCR 20040101
Title: Is the combination with 2-methoxyestradiol able to reduce the dosages of chemotherapeutices in the treatment of human ovarian cancer? Preliminary in vitro investigations.
Journal: European journal of gynaecological oncology 20040101
Title: Use of a monoclonal antibody specific for activated endothelial cells to quantitate angiogenesis in vivo in zebrafish after drug treatment.
Journal: Angiogenesis 20040101
Title: Induction of apoptosis or necrosis in human endometrial carcinoma cells by 2-methoxyestradiol.
Journal: Anticancer research 20040101
Title: Methoxyestradiols mediate the antimitogenic effects of 17beta-estradiol: direct evidence from catechol-O-methyltransferase-knockout mice.
Journal: Circulation 20031216
Title: Exposure of bovine oocytes to the endogenous metabolite 2-methoxyestradiol during in vitro maturation inhibits early embryonic development.
Journal: Biology of reproduction 20031201
Title: Pharmacogenetics of estrogen metabolism and transport in relation to cancer.
Journal: Current drug metabolism 20031201
Title: Mechanism of action of 2-methoxyestradiol: new developments.
Journal: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20031201
Title: TNFalpha potentiates 2-methoxyestradiol-induced mitochondrial death pathway.
Journal: Annals of the New York Academy of Sciences 20031201
Title: Inhibitory action of ICI-182,780, an estrogen receptor antagonist, on BK(Ca) channel activity in cultured endothelial cells of human coronary artery.
Journal: Biochemical pharmacology 20031115
Title: Neuroprotective and neurotoxic effects of estrogens.
Journal: Brain research 20031114
Title: The nonsteroidal effects of diethylstilbestrol: the rationale for androgen deprivation therapy without estrogen deprivation in the treatment of prostate cancer.
Journal: The Journal of urology 20031101
Title: 2-methoxyestradiol strongly inhibits human uterine sarcomatous cell growth.
Journal: Gynecologic oncology 20031101
Title: New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent.
Journal: Current opinion in oncology 20031101
Title: [Estrogen-dependent neoplasia - what is the significance of estradiol metabolites].
Journal: Zentralblatt fur Gynakologie 20031101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20031101
Title: Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism.
Journal: The Journal of biological chemistry 20030926
Title: Superoxide-dependent and -independent mitochondrial signaling during apoptosis in multiple myeloma cells.
Journal: Oncogene 20030918
Title: Catecholamines block the antimitogenic effect of estradiol on human glomerular mesangial cells.
Journal: Hypertension (Dallas, Tex. : 1979) 20030901
Title: 2-Methoxyestradiol exhibits a biphasic effect on VEGF-A in tumor cells and upregulation is mediated through ER-alpha: a possible signaling pathway associated with the impact of 2-ME2 on proliferative cells.
Journal: Neoplasia (New York, N.Y.) 20030901
Title: In vitro effects of 2-methoxyestradiol on canine tumour cells.
Journal: Veterinary and comparative oncology 20030901
Title: Mechanisms of cell death and survival in multiple myeloma (MM): Therapeutic implications.
Journal: Apoptosis : an international journal on programmed cell death 20030801
Title: Effects of several dioxin-like compounds on estrogen metabolism in the malignant MCF-7 and nontumorigenic MCF-10A human mammary epithelial cell lines.
Journal: Toxicology and applied pharmacology 20030801
Title: The effects of 2-methoxy oestrogens and their sulphamoylated derivatives in conjunction with TNF-alpha on endothelial and fibroblast cell growth, morphology and apoptosis.
Journal: The Journal of steroid biochemistry and molecular biology 20030801
Title: Comparison of ex vivo inhibitory effect between 2-hydroxyestradiol and its 17-sulfate on rat hepatic microsomal lipid peroxidation.
Journal: Lipids 20030801
Title: Carboxymethyl benzylamide dextran inhibits angiogenesis and growth of VEGF-overexpressing human epidermoid carcinoma xenograft in nude mice.
Journal: British journal of cancer 20030707
Title: 2-methoxyestradiol alters cell motility, migration, and adhesion.
Journal: Blood 20030701
Title: Methylation of 2-hydroxyestradiol in isolated organs.
Journal: Hypertension (Dallas, Tex. : 1979) 20030701
Title: Effect of antivascular endothelial growth factor treatment on the intratumoral uptake of CPT-11.
Journal: British journal of cancer 20030616
Title: Methoxyestrogens exert feedback inhibition on cytochrome P450 1A1 and 1B1.
Journal: Cancer research 20030615
Title: Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis.
Journal: Carcinogenesis 20030601
Title: Structure/function analyses of human sex hormone-binding globulin: effects of zinc on steroid-binding specificity.
Journal: The Journal of steroid biochemistry and molecular biology 20030601
Title: Free radical stress in chronic lymphocytic leukemia cells and its role in cellular sensitivity to ROS-generating anticancer agents.
Journal: Blood 20030515
Title: Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays.
Journal: Blood 20030501
Title: 2-Methoxyestradiol induces apoptosis in Ewing sarcoma cells through mitochondrial hydrogen peroxide production.
Journal: Oncogene 20030501
Title: Synthesis and evaluation of a novel nonsteroidal-specific endothelial cell proliferation inhibitor.
Journal: Journal of medicinal chemistry 20030410
Title: Novel 2-methoxyestradiol analogues with antitumor activity.
Journal: Cancer research 20030401
Title: Cell cycle block and apoptosis induction in a human melanoma cell line following treatment with 2-methoxyoestradiol: therapeutic implications?
Journal: Melanoma research 20030401
Title: 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF.
Journal: Cancer cell 20030401
Title: Novel therapies in multiple myeloma.
Journal: International journal of hematology 20030401
Title: Short synthesis of 2-methoxyestradiol and 2-hydroxyestradiol.
Journal: Steroids 20030401
Title: Metabolism of [6,7-3H, 35S] estradiol 17-sulfate in rats.
Journal: Steroids 20030401
Title: IDN 5390: an oral taxane candidate for protracted treatment schedules.
Journal: British journal of cancer 20030324
Title: Identification of a novel Bcl-xL phosphorylation site regulating the sensitivity of taxol- or 2-methoxyestradiol-induced apoptosis.
Journal: FEBS letters 20030313
Title: Medical hypothesis: hyperhomocysteinemia is a risk factor for estrogen-induced hormonal cancer.
Journal: International journal of oncology 20030301
Title: Dose-response effects of 2-methoxyestradiol on estrogen target tissues in the ovariectomized rat.
Journal: Endocrinology 20030301
Title: In vitro effects of catecholamines and catecholestrogens on brain tyrosine hydroxylase activity and kinetics in the female catfish Heteropneustes fossilis.
Journal: Journal of neuroendocrinology 20030301
Title: Angiogenesis inhibition with TNP-470, 2-methoxyestradiol, and paclitaxel in experimental pancreatic carcinoma.
Journal: Pancreas 20030301
Title: CYP450- and COMT-derived estradiol metabolites inhibit activity of human coronary artery SMCs.
Journal: Hypertension (Dallas, Tex. : 1979) 20030301
Title: 2-Methoxyestradiol interferes with NF kappa B transcriptional activity in primitive neuroectodermal brain tumors: implications for management.
Journal: Carcinogenesis 20030201
Title: 2-Methoxyestradiol, a promising anticancer agent.
Journal: Pharmacotherapy 20030201
Title: Effect of tamoxifen and 2-methoxyestradiol alone and in combination on human breast cancer cell proliferation.
Journal: The Journal of steroid biochemistry and molecular biology 20030201
Title: Growth inhibition of multi-drug-resistant breast cancer cells by 2-methoxyoestradiol-bis-sulphamate and 2-ethyloestradiol-bis-sulphamate.
Journal: The Journal of steroid biochemistry and molecular biology 20030201
Title: The effects of 2-substituted oestrogen sulphamates on the growth of prostate and ovarian cancer cells.
Journal: The Journal of steroid biochemistry and molecular biology 20030201
Title: Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate.
Journal: The Journal of steroid biochemistry and molecular biology 20030201
Title: 2-methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway.
Journal: Cancer research 20030115
Title: The effect of endogenous estradiol metabolites on the proliferation of human breast cancer cells.
Journal: Life sciences 20030110
Title: Antitumor effects of photodynamic therapy are potentiated by 2-methoxyestradiol. A superoxide dismutase inhibitor.
Journal: The Journal of biological chemistry 20030103
Title: Novel therapies for multiple myeloma.
Journal: British journal of haematology 20030101
Title: Effect of 2-methoxyestradiol on the growth of methyl-nitroso-urea (MNU)-induced rat mammary carcinoma.
Journal: The Journal of steroid biochemistry and molecular biology 20030101
Title: INGN 201: Ad-p53, Ad5CMV-p53, Adenoviral p53, INGN 101, p53 gene therapy--Introgen, RPR/INGN 201.
Journal: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20030101
Title: Opposite regulation of XIAP and Smac/DIABLO in the rat endometrium in response to 17beta-estradiol at estrus.
Journal: Reproductive biology and endocrinology : RB&E 20030101
Title: 2-Methoxyestradiol induces p53-associated apoptosis of colorectal cancer cells.
Journal: Cancer letters 20021210
Title: A new, practical synthesis of 2-methoxyestradiols.
Journal: Steroids 20021201
Title: Synthesis and antimitotic activity of novel 2-methoxyestradiol analogs.
Journal: Steroids 20021201
Title: Promising preclinical activity of 2-methoxyestradiol in multiple myeloma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20021201
Title: Introgen obtains key patent obtained for p53-targeted chemotherapy.
Journal: Expert review of anticancer therapy 20021201
Title: Regulation of the activation of nuclear factor kappaB by mitochondrial respiratory function: evidence for the reactive oxygen species-dependent and -independent pathways.
Journal: Antioxidants & redox signaling 20021201
Title: Crystal structure of human sex hormone-binding globulin in complex with 2-methoxyestradiol reveals the molecular basis for high affinity interactions with C-2 derivatives of estradiol.
Journal: The Journal of biological chemistry 20021122
Title: Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells.
Journal: FEBS letters 20021106
Title: Evidence for genomic and nongenomic actions of estrogen in growth plate regulation in female and male rats at the onset of sexual maturation.
Journal: The Journal of endocrinology 20021101
Title: The effect of exchanging various substituents at the 2-position of 2-methoxyestradiol on cytotoxicity in human cancer cell cultures and inhibition of tubulin polymerization.
Journal: Journal of medicinal chemistry 20021010
Title: Estradiol metabolism and malignant disease.
Journal: Maturitas 20020930
Title: 2-Methoxyestradiol enhances reactive oxygen species formation and increases the efficacy of oxygen radical generating tumor treatment.
Journal: European journal of medical research 20020930
Title: 2-Methoxyestradiol overcomes drug resistance in multiple myeloma cells.
Journal: Blood 20020915
Title: Novel therapies for multiple myeloma.
Journal: Blood reviews 20020901
Title: Evidence that 2-methoxyestradiol suppresses proliferation and accelerates apoptosis in normal rat growth plate chondrocytes.
Journal: Journal of cancer research and clinical oncology 20020901
Title: 2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta.
Journal: Cancer research 20020701
Title: Tumour microvessel density as predictor of chemotherapy response in breast cancer patients.
Journal: British journal of cancer 20020617
Title: 2-Methoxyestradiol induces mitochondria dependent apoptotic signaling in pancreatic cancer cells.
Journal: Oncogene 20020613
Title: Introduction of a novel proliferation assay for pharmacological studies allowing the combination of BrdU detection and phenotyping.
Journal: Journal of immunological methods 20020601
Title: 2-Methoxyestradiol and analogs as novel antiproliferative agents: analysis of three-dimensional quantitative structure-activity relationships for DNA synthesis inhibition and estrogen receptor binding.
Journal: Molecular pharmacology 20020501
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: A radical approach to cancer.
Journal: Medical science monitor : international medical journal of experimental and clinical research 20020401
Title: Catecholamines block 2-hydroxyestradiol-induced antimitogenesis in mesangial cells.
Journal: Hypertension (Dallas, Tex. : 1979) 20020401
Title: Methoxyestradiols mediate estradiol-induced antimitogenesis in human aortic SMCs.
Journal: Hypertension (Dallas, Tex. : 1979) 20020401
Title: Cytotoxicity of estradiol, equilin, equilenin, and their derivatives on Chinese hamster V79 cells.
Journal: Drug and chemical toxicology 20020201
Title: 2-methoxyestradiol induces interferon gene expression and apoptosis in osteosarcoma cells.
Journal: Bone 20020201
Title: Role of methoxyestradiols in the growth inhibitory effects of estradiol on human glomerular mesangial cells.
Journal: Hypertension (Dallas, Tex. : 1979) 20020201
Title: Safety and pharmacokinetics of intravitreal 2-methoxyestradiol implants in normal rabbit and pharmacodynamics in a rat model of choroidal neovascularization.
Journal: Experimental eye research 20020201
Title: Dual effect of 2-methoxyestradiol on cell cycle events in human osteosarcoma 143B cells.
Journal: Acta biochimica Polonica 20020101
Title: Reduction of post injury neointima formation due to 17beta-estradiol and phytoestrogen treatment is not influenced by the pure synthetic estrogen receptor antagonist ICI 182,780 in vitro.
Journal: BMC cardiovascular disorders 20020101
Title: Mitochondrial defects in cancer.
Journal: Molecular cancer 20020101
Title: Identification of small molecule binding sites within proteins using phage display technology.
Journal: Combinatorial chemistry & high throughput screening 20011101
Title: Catecholamines abrogate antimitogenic effects of 2-hydroxyestradiol on human aortic vascular smooth muscle cells.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20011101
Title: Estradiol, in the CNS, targets several physiologically relevant membrane-associated proteins.
Journal: Brain research. Brain research reviews 20011101
Title: Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms.
Journal: Cancer research 20010915
Title: Anti-angiogenic therapy and radioimmunotherapy in colon cancer xenografts.
Journal: European journal of nuclear medicine 20010901
Title: 2-methoxyestradiol does not inhibit superoxide dismutase.
Journal: Archives of biochemistry and biophysics 20010815
Title: 2-Methoxyestradiol induces G2/M arrest and apoptosis in prostate cancer.
Journal: Biochemical and biophysical research communications 20010803
Title: 2-Methoxyestradiol, an endogenous estradiol metabolite, differentially inhibits granulosa and endothelial cell mitosis: a potential follicular antiangiogenic regulator.
Journal: Biology of reproduction 20010801
Title: 2-Methoxyestradiol-induced caspase-3 activation and apoptosis occurs through G(2)/M arrest dependent and independent pathways in gastric carcinoma cells.
Journal: Cancer 20010801
Title: Inhibition of large-conductance calcium-activated potassium channel by 2-methoxyestradiol in cultured vascular endothelial (HUV-EC-C) cells.
Journal: The Journal of membrane biology 20010801
Title: Structure-effect relationship in the induction of mitotic phase-specific abnormality of centrosome integrity and multipolar spindles by steroidal estrogens and their derivatives in cultured mammalian cells.
Journal: The Journal of steroid biochemistry and molecular biology 20010801
Title: 2-Methoxymethylestradiol: a new 2-methoxy estrogen analog that exhibits antiproliferative activity and alters tubulin dynamics.
Journal: The Journal of steroid biochemistry and molecular biology 20010801
Title: The physiological estrogen metabolite 2-methoxyestradiol reduces tumor growth and induces apoptosis in human solid tumors.
Journal: Journal of cancer research and clinical oncology 20010701
Title: 2-methoxyestradiol blocks cell-cycle progression at G(2)/M phase and inhibits growth of human prostate cancer cells.
Journal: Molecular carcinogenesis 20010701
Title: Aromatase regulation and breast cancer.
Journal: Clinical endocrinology 20010501
Title: The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors.
Journal: Cancer research 20010415
Title: Estradiol metabolites inhibit endothelin synthesis by an estrogen receptor-independent mechanism.
Journal: Hypertension (Dallas, Tex. : 1979) 20010201
Title: Effects of estradiol and its metabolites on glomerular endothelial nitric oxide synthesis and mesangial cell growth.
Journal: Hypertension (Dallas, Tex. : 1979) 20010201
Title: Increased 2-methoxyestradiol production in human coronary versus aortic vascular cells.
Journal: Hypertension (Dallas, Tex. : 1979) 20010201
Title: Opposite effects of microtubule-stabilizing and microtubule-destabilizing drugs on biogenesis of mitochondria in mammalian cells.
Journal: Journal of cell science 20010101
Title: Angiogenesis in the pathogenesis of inflammatory joint and lung diseases.
Journal: Arthritis research 20010101
Title: Therapeutic angiogenesis inhibitors in the treatment of cancer.
Journal: Advances in internal medicine 20010101
Title: An ex vivo angiogenesis assay utilizing commercial porcine carotid artery: modification of the rat aortic ring assay.
Journal: Angiogenesis 20010101
Title: Inhibition of superoxide dismutase by 2-methoxyoestradiol analogues and oestrogen derivatives: structure-activity relationships.
Journal: Anti-cancer drug design 20010101
Title: Comparison of 2-methoxyestradiol-induced, docetaxel-induced, and paclitaxel-induced apoptosis in hepatoma cells and its correlation with reactive oxygen species.
Journal: Cancer 20000901
Title: Inhibition of deoxyglucose uptake in MCF-7 breast cancer cells by 2-methoxyestrone and 2-methoxyestrone-3-O-sulfamate.
Journal: Molecular and cellular endocrinology 20000225
Title: 12-O-tetradecanoylphorbol-13-acetate upregulates the Ah receptor and differentially alters CYP1B1 and CYP1A1 expression in MCF-7 breast cancer cells.
Journal: Journal of cellular biochemistry 19980901
Title: [Metabolism of 2-hydroxyestradiol-(17 beta) and 2-methoxyestradiol-(17 beta)in human and rat tissues].
Journal: Hoppe-Seyler's Zeitschrift fur physiologische Chemie 19610530
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