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Title: Valproic acid disrupts the oscillatory expression of core circadian rhythm transcription factors.
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Title: The Myxobacterial Metabolite Soraphen A Inhibits HIV-1 by Reducing Virus Production and Altering Virion Composition.
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Title: Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models.
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Title: Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Tox(ukn) and STOP-Tox(ukk) tests.
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Title: Bromodomain inhibitor OTX015 (MK-8628) combined with targeted agents shows strong in vivo antitumor activity in lymphoma.
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Title: Histone Deacetylase Inhibitors Prolong Cardiac Repolarization through Transcriptional Mechanisms.
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Title: Chemosensitivity enhancement toward arsenic trioxide by inhibition of histone deacetylase in NB4 cell line.
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Title: Inhibition of Histone Deacetylase 6 Reveals a Potent Immunosuppressant Effect in Models of Transplantation.
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Title: An appraisal of cinnamyl sulfonamide hydroxamate derivatives (HDAC inhibitors) for anti-cancer, anti-angiogenic and anti-metastatic activities in human cancer cells.
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Title: The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases.
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Title: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma.
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Title: Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling.
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Title: Carbonic anhydrase IX induction defines a heterogeneous cancer cell response to hypoxia and mediates stem cell-like properties and sensitivity to HDAC inhibition.
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Title: In vitro and in vivo evaluation of novel cinnamyl sulfonamide hydroxamate derivative against colon adenocarcinoma.
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Title: Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases.
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Title: Warfarin is an effective modifier of multiple UDP-glucuronosyltransferase enzymes: evaluation of its potential to alter the pharmacokinetics of zidovudine.
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Title: A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors.
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Title: HDAC8 and STAT3 repress BMF gene activity in colon cancer cells.
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Title: Chemosensitization of rhabdomyosarcoma cells by the histone deacetylase inhibitor SAHA.
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Title: Prenatal alcohol exposure causes the over-expression of DHAND and EHAND by increasing histone H3K14 acetylation in C57 BL/6 mice.
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Title: Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory.
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Title: Class I to III histone deacetylases differentially regulate inflammation-induced matrix metalloproteinase 9 expression in primary amnion cells.
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Title: Therapeutic targeting of c-Myc in T-cell acute lymphoblastic leukemia, T-ALL.
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Title: Yin Yang 1 is a repressor of glutamate transporter EAAT2, and it mediates manganese-induced decrease of EAAT2 expression in astrocytes.
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Title: Synthesis, antimalarial properties, and SAR studies of alkoxyurea-based HDAC inhibitors.
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Title: Histone deacetylase inhibitor valproic acid promotes the differentiation of human induced pluripotent stem cells into hepatocyte-like cells.
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Title: Inhibition of monomethylarsonous acid (MMA(III))-induced cell malignant transformation through restoring dysregulated histone acetylation.
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Title: Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors.
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Title: Comparing histone deacetylase inhibitor responses in genetically engineered mouse lung cancer models and a window of opportunity trial in patients with lung cancer.
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Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.
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Title: Basic nuclear processes affected by histone acetyltransferases and histone deacetylase inhibitors.
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Title: A genomic approach to predict synergistic combinations for breast cancer treatment.
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Title: Expression and Regulation of the Endogenous Retrovirus 3 in Hodgkin's Lymphoma Cells.
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Title: SAHA enhances synaptic function and plasticity in vitro but has limited brain availability in vivo and does not impact cognition.
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Title: Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination.
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Title: Resveratrol sensitizes acute myelogenous leukemia cells to histone deacetylase inhibitors through reactive oxygen species-mediated activation of the extrinsic apoptotic pathway.
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Title: The structural requirements of histone deacetylase inhibitors: suberoylanilide hydroxamic acid analogs modified at the C6 position.
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Title: Histone deacetylase inhibitor (HDACi) suberoylanilide hydroxamic acid (SAHA)-mediated correction of α1-antitrypsin deficiency.
Journal: The Journal of biological chemistry 20121102
Title: Enhancing the anticancer effect of the histone deacetylase inhibitor by activating transglutaminase.
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Title: Histone deacetylase inhibitors preserve function in aging axons.
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Title: Phase I trial of induction histone deacetylase and proteasome inhibition followed by surgery in non-small-cell lung cancer.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20121101
Title: Activation of lytic cycle of Epstein-Barr virus by suberoylanilide hydroxamic acid leads to apoptosis and tumor growth suppression of nasopharyngeal carcinoma.
Journal: International journal of cancer 20121015
Title: Induced production of mycotoxins in an endophytic fungus from the medicinal plant Datura stramonium L.
Journal: Bioorganic & medicinal chemistry letters 20121015
Title: Phase I and pharmacokinetic study of the oral histone deacetylase inhibitor vorinostat in Japanese patients with relapsed or refractory cutaneous T-cell lymphoma.
Journal: The Journal of dermatology 20121001
Title: Vorinostat with sustained exposure and high solubility in poly(ethylene glycol)-b-poly(DL-lactic acid) micelle nanocarriers: characterization and effects on pharmacokinetics in rat serum and urine.
Journal: Journal of pharmaceutical sciences 20121001
Title: Curbing autophagy and histone deacetylases to kill cancer cells.
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Title: Amide-based derivatives of β-alanine hydroxamic acid as histone deacetylase inhibitors: attenuation of potency through resonance effects.
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Title: Epigenetic modifications and p21-cyclin B1 nexus in anticancer effect of histone deacetylase inhibitors in combination with silibinin on non-small cell lung cancer cells.
Journal: Epigenetics 20121001
Title: Phase I trial of vorinostat combined with bortezomib for the treatment of relapsing and/or refractory multiple myeloma.
Journal: Clinical lymphoma, myeloma & leukemia 20121001
Title: Use of reprogrammed cells to identify therapy for respiratory papillomatosis.
Journal: The New England journal of medicine 20120927
Title: Chemoprevention of mouse lung and colon tumors by suberoylanilide hydroxamic acid and atorvastatin.
Journal: International journal of cancer 20120915
Title: Efficacy and safety of suberoylanilide hydroxamic acid (Vorinostat) in the treatment of canine corneal fibrosis.
Journal: Veterinary ophthalmology 20120901
Title: Early prediction of response to Vorinostat in an orthotopic rat glioma model.
Journal: NMR in biomedicine 20120901
Title: Secondary Epstein-Barr virus associated lymphoproliferative disorder developing in a patient with angioimmunoblastic T cell lymphoma on vorinostat.
Journal: American journal of hematology 20120901
Title: Suberoylanilide hydroxamic acid (SAHA) inhibits EGF-induced cell transformation via reduction of cyclin D1 mRNA stability.
Journal: Toxicology and applied pharmacology 20120901
Title: Co-treatment with vorinostat synergistically enhances activity of Aurora kinase inhibitor against human breast cancer cells.
Journal: Breast cancer research and treatment 20120901
Title: HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
Journal: Nature neuroscience 20120901
Title: Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells.
Journal: Cell cycle (Georgetown, Tex.) 20120901
Title: Emerging biological insights and novel treatment strategies in multiple myeloma.
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Title: SAHA, an HDAC inhibitor, synergizes with tacrolimus to prevent murine cardiac allograft rejection.
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Title: Creating a 'pro-survival' phenotype through epigenetic modulation.
Journal: Surgery 20120901
Title: The [(Cp)M(CO)(3)] (M=Re, (99m)Tc) building block for imaging agents and bioinorganic probes: perspectives and limitations.
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Title: [Synergistic effect of histone deacetylase inhibitor suberoylanilide hydroxamic acid with imatinib on K562 cells].
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Title: Cancer research: Open ambition.
Journal: Nature 20120809
Title: A novel histone deacetylase inhibitor, CG200745, potentiates anticancer effect of docetaxel in prostate cancer via decreasing Mcl-1 and Bcl-XL.
Journal: Investigational new drugs 20120801
Title: Vorinostat combined with bexarotene for treatment of cutaneous T-cell lymphoma: in vitro and phase I clinical evidence supporting augmentation of retinoic acid receptor/retinoid X receptor activation by histone deacetylase inhibition.
Journal: Leukemia & lymphoma 20120801
Title: Identification of an acetylation-dependant Ku70/FLIP complex that regulates FLIP expression and HDAC inhibitor-induced apoptosis.
Journal: Cell death and differentiation 20120801
Title: HDAC6 as a target for antileukemic drugs in acute myeloid leukemia.
Journal: Leukemia research 20120801
Title: Inhibition of histone deacetylation potentiates the evolution of acquired temozolomide resistance linked to MGMT upregulation in glioblastoma xenografts.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120801
Title: Cancer network disruption by a single molecule inhibitor targeting both histone deacetylase activity and phosphatidylinositol 3-kinase signaling.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120801
Title: LBH589 enhances T cell activation in vivo and accelerates graft-versus-host disease in mice.
Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20120801
Title: Suberoylanilide hydroxamic acid as a radiosensitizer through modulation of RAD51 protein and inhibition of homology-directed repair in multiple myeloma.
Journal: Molecular cancer research : MCR 20120801
Title: Design, synthesis, modeling, biological evaluation and photoaffinity labeling studies of novel series of photoreactive benzamide probes for histone deacetylase 2.
Journal: Bioorganic & medicinal chemistry letters 20120801
Title: HDAC inhibitors synergize antiproliferative effect of sorafenib in renal cell carcinoma cells.
Journal: Anticancer research 20120801
Title: REST is a novel prognostic factor and therapeutic target for medulloblastoma.
Journal: Molecular cancer therapeutics 20120801
Title: [Novel therapeutic approach for the treatment of post-traumatic stress disorder (PTSD): facilitating fear extinction].
Journal: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20120801
Title: Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy.
Journal: Nature 20120726
Title: Scientists investigate routing latent HIV from its reservoirs to achieve a cure.
Journal: JAMA 20120725
Title: HIV: Shock and kill.
Journal: Nature 20120725
Title: Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid.
Journal: Circulation 20120724
Title: Relationship between chromatin structure and sensitivity to molecularly targeted auger electron radiation therapy.
Journal: International journal of radiation oncology, biology, physics 20120715
Title: Synthesis and biological evaluation of N-aryl salicylamides with a hydroxamic acid moiety at 5-position as novel HDAC-EGFR dual inhibitors.
Journal: Bioorganic & medicinal chemistry 20120715
Title: Histone deacetylase inhibitors induce mitochondrial elongation.
Journal: Journal of cellular physiology 20120701
Title: SAHA inhibits the growth of colon tumors by decreasing histone deacetylase and the expression of cyclin D1 and survivin.
Journal: Pathology oncology research : POR 20120701
Title: Vorinostat enhances protein stability of p27 and p21 through negative regulation of Skp2 and Cks1 in human breast cancer cells.
Journal: Oncology reports 20120701
Title: Antimalarial activity of the anticancer histone deacetylase inhibitor SB939.
Journal: Antimicrobial agents and chemotherapy 20120701
Title: Selenium-containing histone deacetylase inhibitors for melanoma management.
Journal: Cancer biology & therapy 20120701
Title: The future of therapy for relapsed/refractory multiple myeloma: emerging agents and novel treatment strategies.
Journal: Seminars in hematology 20120701
Title: Synergistic killing of glioblastoma stem-like cells by bortezomib and HDAC inhibitors.
Journal: Anticancer research 20120701
Title: Phase II trial of vorinostat with idarubicin and cytarabine for patients with newly diagnosed acute myelogenous leukemia or myelodysplastic syndrome.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20120620
Title: Growth stimulating effect on queen bee larvae of histone deacetylase inhibitors.
Journal: Journal of agricultural and food chemistry 20120620
Title: Myc represses miR-15a/miR-16-1 expression through recruitment of HDAC3 in mantle cell and other non-Hodgkin B-cell lymphomas.
Journal: Oncogene 20120614
Title: Substrates for efficient fluorometric screening employing the NAD-dependent sirtuin 5 lysine deacylase (KDAC) enzyme.
Journal: Journal of medicinal chemistry 20120614
Title: Synergistic inhibition of hepatocellular carcinoma growth by cotargeting chromatin modifying enzymes and poly (ADP-ribose) polymerases.
Journal: Hepatology (Baltimore, Md.) 20120601
Title: Histone deacetylase inhibitors are unable to synergize with ABT-737 in killing primary chronic lymphocytic leukaemia cells in vitro.
Journal: Leukemia 20120601
Title: Repression of PDGF-R-α after cellular injury involves TNF-α, formation of a c-Fos-YY1 complex, and negative regulation by HDAC.
Journal: American journal of physiology. Cell physiology 20120601
Title: Combined diazepam and HDAC inhibitor treatment protects against seizures and neuronal damage caused by soman exposure.
Journal: Neurotoxicology 20120601
Title: Histone deacetylase inhibition restores cisplatin sensitivity of Hodgkin's lymphoma cells.
Journal: Leukemia research 20120601
Title: Tumor vasculature targeting following co-delivery of heparin-taurocholate conjugate and suberoylanilide hydroxamic acid using cationic nanolipoplex.
Journal: Biomaterials 20120601
Title: Combination of HDAC and topoisomerase inhibitors in small cell lung cancer.
Journal: Cancer biology & therapy 20120601
Title: Combined effect of histone deacetylase inhibitor suberoylanilide hydroxamic acid and anti-CD20 monoclonal antibody rituximab on mantle cell lymphoma cells apoptosis.
Journal: Leukemia research 20120601
Title: A unique histone deacetylase inhibitor alters microRNA expression and signal transduction in chemoresistant ovarian cancer cells.
Journal: Cancer biology & therapy 20120601
Title: Efficacy of class I and II vs class III histone deacetylase inhibitors in neuroblastoma.
Journal: Journal of pediatric surgery 20120601
Title: Epigenetic reprogramming reverses the relapse-specific gene expression signature and restores chemosensitivity in childhood B-lymphoblastic leukemia.
Journal: Blood 20120531
Title: Novel molecular targeted therapies for refractory thyroid cancer.
Journal: Head & neck 20120501
Title: Synergistic cytotoxicity of the DNA alkylating agent busulfan, nucleoside analogs and suberoylanilide hydroxamic acid in lymphoma cell lines.
Journal: Leukemia & lymphoma 20120501
Title: Phase II trial of vorinostat and gemtuzumab ozogamicin as induction and post-remission therapy in older adults with previously untreated acute myeloid leukemia.
Journal: Haematologica 20120501
Title: Vorinostat/SAHA-induced apoptosis in malignant mesothelioma is FLIP/caspase 8-dependent and HR23B-independent.
Journal: European journal of cancer (Oxford, England : 1990) 20120501
Title: Acute sensitization of colon cancer cells to inflammatory cytokines by prophase arrest.
Journal: Biochemical pharmacology 20120501
Title: An epigenetic approach to pancreatic cancer treatment: the prospective role of histone deacetylase inhibitors.
Journal: Current cancer drug targets 20120501
Title: Synergistic effects of suberoylanilide hydroxamic acid combined with cisplatin causing cell cycle arrest independent apoptosis in platinum-resistant ovarian cancer cells.
Journal: International journal of oncology 20120501
Title: Vorinostat, a histone deacetylase inhibitor, facilitates fear extinction and enhances expression of the hippocampal NR2B-containing NMDA receptor gene.
Journal: Journal of psychiatric research 20120501
Title: Sorafenib and HDAC inhibitors synergize to kill CNS tumor cells.
Journal: Cancer biology & therapy 20120501
Title: Suberoylanilide hydroxamic acid enhances odontoblast differentiation.
Journal: Journal of dental research 20120501
Title: Decitabine and vorinostat cooperate to sensitize colon carcinoma cells to Fas ligand-induced apoptosis in vitro and tumor suppression in vivo.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20120501
Title: Molecular pathways: old drugs define new pathways: non-histone acetylation at the crossroads of the DNA damage response and autophagy.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120501
Title: Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo.
Journal: Journal of medicinal chemistry 20120426
Title: Efficacy of vorinostat in a murine model of polycythemia vera.
Journal: Blood 20120419
Title: MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors.
Journal: Cell cycle (Georgetown, Tex.) 20120415
Title: Discovery and extensive in vitro evaluations of NK-HDAC-1: a chiral histone deacetylase inhibitor as a promising lead.
Journal: Journal of medicinal chemistry 20120412
Title: Preclinical evaluation of combined antineoplastic effect of DLC1 tumor suppressor protein and suberoylanilide hydroxamic acid on prostate cancer cells.
Journal: Biochemical and biophysical research communications 20120406
Title: Itch/AIP4-independent proteasomal degradation of cFLIP induced by the histone deacetylase inhibitor SAHA sensitizes breast tumour cells to TRAIL.
Journal: Investigational new drugs 20120401
Title: Suberoylanilide hydroxamic acid (SAHA) combined with bortezomib inhibits renal cancer growth by enhancing histone acetylation and protein ubiquitination synergistically.
Journal: BJU international 20120401
Title: Phase I-II study of vorinostat plus paclitaxel and bevacizumab in metastatic breast cancer: evidence for vorinostat-induced tubulin acetylation and Hsp90 inhibition in vivo.
Journal: Breast cancer research and treatment 20120401
Title: Histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits anti-inflammatory activities through induction of mitochondrial damage and apoptosis in activated lymphocytes.
Journal: International immunopharmacology 20120401
Title: Vorinostat: a potent agent to prevent and treat laser-induced corneal haze.
Journal: Journal of refractive surgery (Thorofare, N.J. : 1995) 20120401
Title: CD1d induction in solid tumor cells by histone deacetylase inhibitors through inhibition of HDAC1/2 and activation of Sp1.
Journal: Epigenetics 20120401
Title: Novel therapeutics in multiple myeloma.
Journal: Hematology (Amsterdam, Netherlands) 20120401
Title: A case of Sweet's syndrome due to 5-Azacytidine and vorinostat in a patient with NK/T cell lymphoma.
Journal: Cutaneous and ocular toxicology 20120301
Title: A randomized phase II study of two doses of vorinostat in combination with 5-FU/LV in patients with refractory colorectal cancer.
Journal: Cancer chemotherapy and pharmacology 20120301
Title: New generation small-molecule inhibitors in myeloproliferative neoplasms.
Journal: Current opinion in hematology 20120301
Title: HDAC inhibitors for the treatment of cutaneous T-cell lymphomas.
Journal: Future medicinal chemistry 20120301
Title: Requirement of p38 MAPK for a cell-death pathway triggered by vorinostat in MDA-MB-231 human breast cancer cells.
Journal: Cancer letters 20120227
Title: Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors.
Journal: Journal of medicinal chemistry 20120223
Title: Defining the mechanism of action and enzymatic selectivity of psammaplin A against its epigenetic targets.
Journal: Journal of medicinal chemistry 20120223
Title: Preclinical activity of the rational combination of selumetinib (AZD6244) in combination with vorinostat in KRAS-mutant colorectal cancer models.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120215
Title: Studies using an in vitro model show evidence of involvement of epithelial-mesenchymal transition of human endometrial epithelial cells in human embryo implantation.
Journal: The Journal of biological chemistry 20120210
Title: Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy.
Journal: Oncogene 20120202
Title: Proteomic study identified HSP 70 kDa protein 1A as a possible therapeutic target, in combination with histone deacetylase inhibitors, for lymphoid neoplasms.
Journal: Journal of proteomics 20120202
Title: Histone deacetylase inhibitors enhance the anticancer activity of nutlin-3 and induce p53 hyperacetylation and downregulation of MDM2 and MDM4 gene expression.
Journal: Investigational new drugs 20120201
Title: Phase I study of vorinostat (suberoylanilide hydroxamic acid, NSC 701852) in combination with docetaxel in patients with advanced and relapsed solid malignancies.
Journal: Investigational new drugs 20120201
Title: A phase 2 study of vorinostat for treatment of relapsed or refractory Hodgkin lymphoma: Southwest Oncology Group Study S0517.
Journal: Leukemia & lymphoma 20120201
Title: SAHA/TRAIL combination induces detachment and anoikis of MDA-MB231 and MCF-7 breast cancer cells.
Journal: Biochimie 20120201
Title: Combination therapy of conditionally replicating adenovirus and histone deacetylase inhibitors.
Journal: International journal of molecular medicine 20120201
Title: Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: a north central cancer treatment group study.
Journal: Neuro-oncology 20120201
Title: Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression.
Journal: Journal of leukocyte biology 20120201
Title: Role for Class I histone deacetylases in multidrug resistance.
Journal: Experimental cell research 20120201
Title: Suberoylanilide hydroxamic acid affects γH2AX expression in osteosarcoma, atypical teratoid rhabdoid tumor and normal tissue cell lines after irradiation.
Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20120201
Title: Anti-inflammatory properties of histone deacetylase inhibitors: a mechanistic study.
Journal: The journal of trauma and acute care surgery 20120201
Title: Histone deacetylase inhibitors induce growth arrest and differentiation in uveal melanoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120115
Title: Synthesis and biochemical analysis of 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-octanediamides as inhibitors of human histone deacetylases.
Journal: Bioorganic & medicinal chemistry 20120115
Title: Preclinical evaluation of dual PI3K-mTOR inhibitors and histone deacetylase inhibitors in head and neck squamous cell carcinoma.
Journal: British journal of cancer 20120103
Title: Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, protects dopaminergic neurons from neurotoxin-induced damage.
Journal: British journal of pharmacology 20120101
Title: Mutations in epigenetic modifiers in myeloid malignancies and the prospect of novel epigenetic-targeted therapy.
Journal: Advances in hematology 20120101
Title: The Role of mTOR Inhibitors for the Treatment of B-Cell Lymphomas.
Journal: Advances in hematology 20120101
Title: miRNAs and Melanoma: How Are They Connected?
Journal: Dermatology research and practice 20120101
Title: Phase I trial of vorinostat combined with bevacizumab and CPT-11 in recurrent glioblastoma.
Journal: Neuro-oncology 20120101
Title: NBM-HD-1: A Novel Histone Deacetylase Inhibitor with Anticancer Activity.
Journal: Evidence-based complementary and alternative medicine : eCAM 20120101
Title: HDAC inhibitors in HIV.
Journal: Immunology and cell biology 20120101
Title: HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications.
Journal: Immunology and cell biology 20120101
Title: Novel therapies in phase II and III trials for malignant pleural mesothelioma.
Journal: Journal of the National Comprehensive Cancer Network : JNCCN 20120101
Title: Emerging therapies in hematopoietic stem cell transplantation.
Journal: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20120101
Title: A searchable cross-platform gene expression database reveals connections between drug treatments and disease.
Journal: BMC genomics 20120101
Title: Linear Discriminant Functions in Connection with the micro-RNA Diagnosis of Colon Cancer.
Journal: Cancer informatics 20120101
Title: Modularity in protein complex and drug interactions reveals new polypharmacological properties.
Journal: PloS one 20120101
Title: Mitochondrial apoptosis and FAK signaling disruption by a novel histone deacetylase inhibitor, HTPB, in antitumor and antimetastatic mouse models.
Journal: PloS one 20120101
Title: A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer.
Journal: Oncotarget 20120101
Title: ELR510444 inhibits tumor growth and angiogenesis by abrogating HIF activity and disrupting microtubules in renal cell carcinoma.
Journal: PloS one 20120101
Title: Class I histone deacetylase inhibitor entinostat suppresses regulatory T cells and enhances immunotherapies in renal and prostate cancer models.
Journal: PloS one 20120101
Title: Emerging pharmacotherapies for adult patients with acute lymphoblastic leukemia.
Journal: Clinical Medicine Insights. Oncology 20120101
Title: Histone deacetylase inhibitors globally enhance h3/h4 tail acetylation without affecting h3 lysine 56 acetylation.
Journal: Scientific reports 20120101
Title: Induction of sodium/iodide symporter (NIS) expression and radioiodine uptake in non-thyroid cancer cells.
Journal: PloS one 20120101
Title: Comparative gene expression profiling of P. falciparum malaria parasites exposed to three different histone deacetylase inhibitors.
Journal: PloS one 20120101
Title: Blocking autophagy prevents bortezomib-induced NF-κB activation by reducing I-κBα degradation in lymphoma cells.
Journal: PloS one 20120101
Title: AIDS-Related Non-Hodgkin's Lymphoma in the Era of Highly Active Antiretroviral Therapy.
Journal: Advances in hematology 20120101
Title: Clinical efficacy of vorinostat in a patient with leiomyosarcoma.
Journal: Clinical Medicine Insights. Oncology 20120101
Title: Conference highlights of the 5th international workshop on HIV persistence during therapy, 6-9 December 2011, St. Maartin, West Indies.
Journal: AIDS research and therapy 20120101
Title: Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors.
Journal: Clinical epigenetics 20120101
Title: Management of cutaneous T cell lymphoma: new and emerging targets and treatment options.
Journal: Cancer management and research 20120101
Title: In vivo efficacy of the histone deacetylase inhibitor suberoylanilide hydroxamic acid in combination with radiotherapy in a malignant rhabdoid tumor mouse model.
Journal: Radiation oncology (London, England) 20120101
Title: Triple-negative breast cancer: an update on neoadjuvant clinical trials.
Journal: International journal of breast cancer 20120101
Title: Regulation of immune responses by histone deacetylase inhibitors.
Journal: ISRN hematology 20120101
Title: Genes are often sheltered from the global histone hyperacetylation induced by HDAC inhibitors.
Journal: PloS one 20120101
Title: Optimizing molecular-targeted therapies in ovarian cancer: the renewed surge of interest in ovarian cancer biomarkers and cell signaling pathways.
Journal: Journal of oncology 20120101
Title: Tumor-specific histone signature and DNA methylation in multiple myeloma and leukemia cells.
Journal: Neoplasma 20120101
Title: Genistein cooperates with the histone deacetylase inhibitor vorinostat to induce cell death in prostate cancer cells.
Journal: BMC cancer 20120101
Title: Novel Insights into the Interplay between Apoptosis and Autophagy.
Journal: International journal of cell biology 20120101
Title: Combination of the deacetylase inhibitor panobinostat and the multi-kinase inhibitor sorafenib for the treatment of metastatic hepatocellular carcinoma - review of the underlying molecular mechanisms and first case report.
Journal: Journal of Cancer 20120101
Title: Biodegradable thermosensitive hydrogel for SAHA and DDP delivery: therapeutic effects on oral squamous cell carcinoma xenografts.
Journal: PloS one 20120101
Title: Novel therapies in glioblastoma.
Journal: Neurology research international 20120101
Title: Current trends in targeted therapies for glioblastoma multiforme.
Journal: Neurology research international 20120101
Title: Novel therapies for aggressive B-cell lymphoma.
Journal: Advances in hematology 20120101
Title: Relapsed and/or Refractory Mantle Cell Lymphoma: What Role for Temsirolimus?
Journal: Clinical Medicine Insights. Oncology 20120101
Title: Histone deacetylase inhibitors in cell pluripotency, differentiation, and reprogramming.
Journal: Stem cells international 20120101
Title: Arsenic induces functional re-expression of estrogen receptor α by demethylation of DNA in estrogen receptor-negative human breast cancer.
Journal: PloS one 20120101
Title: Vorinostat approved in Japan for treatment of cutaneous T-cell lymphomas: status and prospects.
Journal: OncoTargets and therapy 20120101
Title: Activating Death Receptor DR5 as a Therapeutic Strategy for Rhabdomyosarcoma.
Journal: ISRN oncology 20120101
Title: Molecular pathogenesis and targeted therapeutics in Ewing sarcoma/primitive neuroectodermal tumours.
Journal: Clinical sarcoma research 20120101
Title: Histone deacetylase inhibitors enhance expression of NKG2D ligands in Ewing sarcoma and sensitize for natural killer cell-mediated cytolysis.
Journal: Clinical sarcoma research 20120101
Title: Divergent genomic and epigenomic landscapes of lung cancer subtypes underscore the selection of different oncogenic pathways during tumor development.
Journal: PloS one 20120101
Title: The histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates human astrocyte neurotoxicity induced by interferon-γ.
Journal: Journal of neuroinflammation 20120101
Title: Epigenetics modifications and therapeutic prospects in human thyroid cancer.
Journal: Frontiers in endocrinology 20120101
Title: Acute myeloid leukemia: focus on novel therapeutic strategies.
Journal: Clinical Medicine Insights. Oncology 20120101
Title: Analyzing gene expression profile in K562 cells exposed to sodium valproate using microarray combined with the connectivity map database.
Journal: Journal of biomedicine & biotechnology 20120101
Title: Valproic acid downregulates the expression of MGMT and sensitizes temozolomide-resistant glioma cells.
Journal: Journal of biomedicine & biotechnology 20120101
Title: Targeted therapies in sarcomas: challenging the challenge.
Journal: Sarcoma 20120101
Title: Adult T-cell leukemia/lymphoma: a retroviral malady.
Journal: Indian journal of dermatology 20120101
Title: QT interval prolongation and torsades de pointes in a patient undergoing treatment with vorinostat: a case report and review of the literature.
Journal: Cardiology journal 20120101
Title: The effect of vorinostat on the development of resistance to doxorubicin in neuroblastoma.
Journal: PloS one 20120101
Title: A novel class of anti-HIV agents with multiple copies of enfuvirtide enhances inhibition of viral replication and cellular transmission in vitro.
Journal: PloS one 20120101
Title: Valproic acid decreases urothelial cancer cell proliferation and induces thrombospondin-1 expression.
Journal: BMC urology 20120101
Title: Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell lines.
Journal: PloS one 20120101
Title: Radiosensitization by the histone deacetylase inhibitor vorinostat under hypoxia and with capecitabine in experimental colorectal carcinoma.
Journal: Radiation oncology (London, England) 20120101
Title: [Multikinase inhibitor sorafenib and HDAC inhibitor suberoylanilide hydroxamic acid suppress confluent resistance of cancer cells to recombinant protein izTRAIL].
Journal: Biofizika 20120101
Title: Mechanisms of resistance to histone deacetylase inhibitors.
Journal: Advances in cancer research 20120101
Title: Benzothiazole-containing hydroxamic acids as histone deacetylase inhibitors and antitumor agents.
Journal: Bioorganic & medicinal chemistry letters 20111215
Title: Histone deacetylase inhibitors: emerging mechanisms of resistance.
Journal: Molecular pharmaceutics 20111205
Title: Inhibitors of histone deacetylases in class I and class II suppress human osteoclasts in vitro.
Journal: Journal of cellular physiology 20111201
Title: Grand rounds at the National Institutes of Health: HDAC inhibitors as radiation modifiers, from bench to clinic.
Journal: Journal of cellular and molecular medicine 20111201
Title: SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis.
Journal: Cell death and differentiation 20111201
Title: Efficacy and safety of the third-generation chloroethylnitrosourea fotemustine for the treatment of chemorefractory T-cell lymphomas.
Journal: European journal of haematology 20111201
Title: Antitumor activity of a novel histone deacetylase inhibitor (S)-HDAC42 in oral squamous cell carcinoma.
Journal: Oral oncology 20111201
Title: MiR-129-5p is required for histone deacetylase inhibitor-induced cell death in thyroid cancer cells.
Journal: Endocrine-related cancer 20111201
Title: Identification of selective class II histone deacetylase inhibitors using a novel dual-parameter binding assay based on fluorescence anisotropy and lifetime.
Journal: Journal of biomolecular screening 20111201
Title: A new target for personalized medicine.
Journal: EMBO reports 20111201
Title: Diagnostic and prognostic markers in differentiated thyroid cancer.
Journal: Current genomics 20111201
Title: miR-200a regulates Nrf2 activation by targeting Keap1 mRNA in breast cancer cells.
Journal: The Journal of biological chemistry 20111125
Title: Reversible molecular pathology of skeletal muscle in spinal muscular atrophy.
Journal: Human molecular genetics 20111115
Title: Enhanced suppression of tumor growth by concomitant treatment of human lung cancer cells with suberoylanilide hydroxamic acid and arsenic trioxide.
Journal: Toxicology and applied pharmacology 20111115
Title: 4-N-Hydroxy-4-[1-(sulfonyl)piperidin-4-yl]-butyramides as HDAC inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20111115
Title: Determination of HS270, a new histone deacetylase inhibitor, in rat plasma by LC-MS/MS--application to a preclinical pharmacokinetic study.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111115
Title: Largazole and analogues with modified metal-binding motifs targeting histone deacetylases: synthesis and biological evaluation.
Journal: Journal of medicinal chemistry 20111110
Title: Design, synthesis and biological evaluation of hydroxamic acid derivatives as potential high density lipoprotein (HDL) receptor CLA-1 up-regulating agents.
Journal: Molecules (Basel, Switzerland) 20111102
Title: Addition of a histone deacetylase inhibitor redirects tamoxifen-treated breast cancer cells into apoptosis, which is opposed by the induction of autophagy.
Journal: Breast cancer research and treatment 20111101
Title: STAT6 activation in ulcerative colitis: a new target for prevention of IL-13-induced colon epithelial cell dysfunction.
Journal: Inflammatory bowel diseases 20111101
Title: A 5-aza-2'-deoxycytidine/valproate combination induces cytotoxic T-cell response against mesothelioma.
Journal: The European respiratory journal 20111101
Title: Vorinostat modulates cell cycle regulatory proteins in glioma cells and human glioma slice cultures.
Journal: Journal of neuro-oncology 20111101
Title: Impact of UDP-gluconoryltransferase 2B17 genotype on vorinostat metabolism and clinical outcomes in Asian women with breast cancer.
Journal: Pharmacogenetics and genomics 20111101
Title: A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat.
Journal: Acta neuropathologica 20111101
Title: HDAC inhibitor SAHA normalizes the levels of VLCFAs in human skin fibroblasts from X-ALD patients and downregulates the expression of proinflammatory cytokines in Abcd1/2-silenced mouse astrocytes.
Journal: Journal of lipid research 20111101
Title: Mechanism of action of proteasome inhibitors and deacetylase inhibitors and the biological basis of synergy in multiple myeloma.
Journal: Molecular cancer therapeutics 20111101
Title: Unexpected high levels of vorinostat when combined with vinorelbine in patients with advanced cancer.
Journal: Current clinical pharmacology 20111101
Title: Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activities.
Journal: Journal of natural products 20111028
Title: p53-independent epigenetic repression of the p21(WAF1) gene in T-cell acute lymphoblastic leukemia.
Journal: The Journal of biological chemistry 20111028
Title: The use of molecular profiling for diagnosis and research in non-Hodgkin's lymphoma.
Journal: Hematology reports 20111028
Title: The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity.
Journal: Bioorganic & medicinal chemistry letters 20111015
Title: Trilysinoyl oleylamide-based cationic liposomes for systemic co-delivery of siRNA and an anticancer drug.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20111010
Title: Synergistic induction of apoptosis in brain cancer cells by targeted codelivery of siRNA and anticancer drugs.
Journal: Molecular pharmaceutics 20111003
Title: A phase I pharmacokinetic study of pulse-dose vorinostat with flavopiridol in solid tumors.
Journal: Investigational new drugs 20111001
Title: Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy.
Journal: Cancer 20111001
Title: Vorinostat, SAHA, represses telomerase activity via epigenetic regulation of telomerase reverse transcriptase in non-small cell lung cancer cells.
Journal: Journal of cellular biochemistry 20111001
Title: Rescue of the mutant CFTR chloride channel by pharmacological correctors and low temperature analyzed by gene expression profiling.
Journal: American journal of physiology. Cell physiology 20111001
Title: Pharmacological characterization of histone deacetylase inhibitor and tumor cell-growth inhibition properties of new benzofuranone compounds.
Journal: Current cancer drug targets 20111001
Title: MCF10A and MDA-MB-231 human breast basal epithelial cell co-culture in silicon micro-arrays.
Journal: Biomaterials 20111001
Title: SAHA Capture Compound--a novel tool for the profiling of histone deacetylases and the identification of additional vorinostat binders.
Journal: Proteomics 20111001
Title: Analysis of apoptosis regulatory genes altered by histone deacetylase inhibitors in chronic lymphocytic leukemia cells.
Journal: Epigenetics 20111001
Title: Prevention of mouse lung tumors by combinations of chemopreventive agents using concurrent and sequential administration.
Journal: Anticancer research 20111001
Title: Vitamin D deficiency in a man with multiple myeloma.
Journal: North American journal of medical sciences 20111001
Title: Disruption of IkappaB kinase (IKK)-mediated RelA serine 536 phosphorylation sensitizes human multiple myeloma cells to histone deacetylase (HDAC) inhibitors.
Journal: The Journal of biological chemistry 20110930
Title: Discovery, synthesis, and biological evaluation of novel SMN protein modulators.
Journal: Journal of medicinal chemistry 20110922
Title: Chemotherapy and targeted therapies for unresectable malignant mesothelioma.
Journal: Lung cancer (Amsterdam, Netherlands) 20110901
Title: Vorinostat induced cellular stress disrupts the p38 mitogen activated protein kinase and extracellular signal regulated kinase pathways leading to apoptosis in Waldenström macroglobulinemia cells.
Journal: Leukemia & lymphoma 20110901
Title: HDAC inhibitor vorinostat enhances the antitumor effect of gefitinib in squamous cell carcinoma of head and neck by modulating ErbB receptor expression and reverting EMT.
Journal: Journal of cellular physiology 20110901
Title: HDAC inhibitors potentiate the apoptotic effect of enzastaurin in lymphoma cells.
Journal: Apoptosis : an international journal on programmed cell death 20110901
Title: Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor.
Journal: Cancer chemotherapy and pharmacology 20110901
Title: Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors.
Journal: European journal of medicinal chemistry 20110901
Title: Application of the histone deacetylase inhibitors for the treatment of endometriosis: histone modifications as pathogenesis and novel therapeutic target.
Journal: Human reproduction (Oxford, England) 20110901
Title: Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo.
Journal: Molecular cancer therapeutics 20110901
Title: Proteomic analysis identifies differentially expressed proteins after HDAC vorinostat and EGFR inhibitor gefitinib treatments in Hep-2 cancer cells.
Journal: Proteomics 20110901
Title: Targeting Waldenstrom macroglobulinemia with histone deacetylase inhibitors.
Journal: Leukemia & lymphoma 20110901
Title: Identification of citrullinated histone H3 as a potential serum protein biomarker in a lethal model of lipopolysaccharide-induced shock.
Journal: Surgery 20110901
Title: Discovery of a tetrahydroisoquinoline-based hydroxamic acid derivative (ZYJ-34c) as histone deacetylase inhibitor with potent oral antitumor activities.
Journal: Journal of medicinal chemistry 20110811
Title: In vivo PET imaging of histone deacetylases by 18F-suberoylanilide hydroxamic acid (18F-SAHA).
Journal: Journal of medicinal chemistry 20110811
Title: Antitumor effects of (S)-HDAC42, a phenylbutyrate-derived histone deacetylase inhibitor, in multiple myeloma cells.
Journal: Cancer chemotherapy and pharmacology 20110801
Title: Cytotoxicity and genotoxicity of capecitabine in head and neck cancer and normal cells.
Journal: Molecular biology reports 20110801
Title: Effects and mechanisms of the combination of suberoylanilide hydroxamic acid and bortezomib on the anticancer property of gemcitabine in pancreatic cancer.
Journal: Pancreas 20110801
Title: Histone deacetylase inhibitors induce thymidine phosphorylase expression in cultured breast cancer cell lines.
Journal: Oncology reports 20110801
Title: Structure-based optimization of click-based histone deacetylase inhibitors.
Journal: European journal of medicinal chemistry 20110801
Title: Histone deacetylase inhibitors sensitize human non-small cell lung cancer cells to ionizing radiation through acetyl p53-mediated c-myc down-regulation.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20110801
Title: Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors.
Journal: Neuro-oncology 20110801
Title: Romidepsin: a novel histone deacetylase inhibitor for cancer.
Journal: Expert opinion on investigational drugs 20110801
Title: Design, synthesis and biological evaluation of tyrosine-based hydroxamic acid analogs as novel histone deacetylases (HDACs) inhibitors.
Journal: Bioorganic & medicinal chemistry 20110801
Title: [Histone deacetylase inhibitors in the treatment of hematological malignancies].
Journal: Bulletin du cancer 20110801
Title: [Development of novel agents for multiple myeloma; now and the future].
Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology 20110801
Title: [Present status and perspective of targeted therapy for B-cell lymphoma].
Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology 20110801
Title: Subcutaneous panniculitis-like T-cell lymphoma: a clinical and pathologic study of 14 korean patients.
Journal: Annals of dermatology 20110801
Title: Epigenetic treatment of neurological disease.
Journal: Epigenomics 20110801
Title: Epigenetic regulation of prostate cancer.
Journal: Clinical epigenetics 20110801
Title: Epigenetic abnormalities in myeloproliferative neoplasms: a target for novel therapeutic strategies.
Journal: Clinical epigenetics 20110801
Title: Targeting Huntington's disease through histone deacetylases.
Journal: Clinical epigenetics 20110801
Title: Epigenetic approaches in stem cell transplantation.
Journal: Clinical epigenetics 20110801
Title: Cooperation of the HDAC inhibitor vorinostat and radiation in metastatic neuroblastoma: efficacy and underlying mechanisms.
Journal: Cancer letters 20110728
Title: Vaccination with epigenetically treated mesothelioma cells induces immunisation and blocks tumour growth.
Journal: Vaccine 20110726
Title: A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold.
Journal: Bioorganic & medicinal chemistry letters 20110715
Title: Design, synthesis, docking, and biological evaluation of novel diazide-containing isoxazole- and pyrazole-based histone deacetylase probes.
Journal: Journal of medicinal chemistry 20110714
Title: Discovery of (2E)-3-{2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile.
Journal: Journal of medicinal chemistry 20110714
Title: Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.
Journal: Journal of medicinal chemistry 20110714
Title: Combination of vorinostat and adenovirus-TRAIL exhibits a synergistic antitumor effect by increasing transduction and transcription of TRAIL in lung cancer cells.
Journal: Cancer gene therapy 20110701
Title: Physical association of HDAC1 and HDAC2 with p63 mediates transcriptional repression and tumor maintenance in squamous cell carcinoma.
Journal: Cancer research 20110701
Title: The synthesis and evaluation of N1-(4-(2-[18F]-fluoroethyl)phenyl)-N8-hydroxyoctanediamide ([18F]-FESAHA), a PET radiotracer designed for the delineation of histone deacetylase expression in cancer.
Journal: Nuclear medicine and biology 20110701
Title: [Epigenetic therapy in myelodysplastic syndromes].
Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology 20110701
Title: Efficient organic monoliths prepared by γ-radiation induced polymerization in the evaluation of histone deacetylase inhibitors by capillary(nano)-high performance liquid chromatography and ion trap mass spectrometry.
Journal: Journal of chromatography. A 20110624
Title: Epigenetic profiling of the antitumor natural product psammaplin A and its analogues.
Journal: Bioorganic & medicinal chemistry 20110615
Title: Modulation of the activity of histone acetyltransferases by long chain alkylidenemalonates (LoCAMs).
Journal: Bioorganic & medicinal chemistry 20110615
Title: Vorinostat-induced apoptosis in mantle cell lymphoma is mediated by acetylation of proapoptotic BH3-only gene promoters.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110615
Title: A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer.
Journal: British journal of cancer 20110607
Title: Enhancer of Zeste 2 (EZH2) is up-regulated in malignant gliomas and in glioma stem-like cells.
Journal: Neuropathology and applied neurobiology 20110601
Title: Leukemia cutis in association With Grover's disease.
Journal: The American Journal of dermatopathology 20110601
Title: Histone deacetylase inhibition attenuates diabetes-associated kidney growth: potential role for epigenetic modification of the epidermal growth factor receptor.
Journal: Kidney international 20110601
Title: Suberoylanilide hydroxamic acid, a potent histone deacetylase inhibitor; its X-ray crystal structure and solid state and solution studies of its Zn(II), Ni(II), Cu(II) and Fe(III) complexes.
Journal: Journal of inorganic biochemistry 20110601
Title: Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels.
Journal: Cancer research 20110601
Title: Metabolism as a key to histone deacetylase inhibition.
Journal: Critical reviews in biochemistry and molecular biology 20110601
Title: HDAC1 inhibition by maspin abrogates epigenetic silencing of glutathione S-transferase pi in prostate carcinoma cells.
Journal: Molecular cancer research : MCR 20110601
Title: Myeloproliferative neoplasms: from JAK2 mutations discovery to JAK2 inhibitor therapies.
Journal: Oncotarget 20110601
Title: Clinical development of panobinostat in classical Hodgkin's lymphoma.
Journal: Expert review of hematology 20110601
Title: SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability.
Journal: PLoS genetics 20110601
Title: Deciphering the molecular events necessary for synergistic tumor cell apoptosis mediated by the histone deacetylase inhibitor vorinostat and the BH3 mimetic ABT-737.
Journal: Cancer research 20110515
Title: HDAC inhibitors potentiate the activity of the BCR/ABL kinase inhibitor KW-2449 in imatinib-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110515
Title: Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia.
Journal: The Journal of biological chemistry 20110506
Title: Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts.
Journal: Bone 20110501
Title: Discovery of histone deacetylase 8 selective inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20110501
Title: Long-term administration of the histone deacetylase inhibitor vorinostat attenuates renal injury in experimental diabetes through an endothelial nitric oxide synthase-dependent mechanism.
Journal: The American journal of pathology 20110501
Title: Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors.
Journal: Journal of medicinal chemistry 20110428
Title: Development of tetrahydroisoquinoline-based hydroxamic acid derivatives: potent histone deacetylase inhibitors with marked in vitro and in vivo antitumor activities.
Journal: Journal of medicinal chemistry 20110428
Title: Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20110415
Title: Vorinostat increases expression of functional norepinephrine transporter in neuroblastoma in vitro and in vivo model systems.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110415
Title: Oxime amides as a novel zinc binding group in histone deacetylase inhibitors: synthesis, biological activity, and computational evaluation.
Journal: Journal of medicinal chemistry 20110414
Title: The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy.
Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20110401
Title: Decitabine-induced apoptosis is derived by Puma and Noxa induction in chronic myeloid leukemia cell line as well as in PBL and is potentiated by SAHA.
Journal: Molecular and cellular biochemistry 20110401
Title: The histone deacetylase inhibitors vorinostat and romidepsin downmodulate IL-10 expression in cutaneous T-cell lymphoma cells.
Journal: British journal of pharmacology 20110401
Title: Loss of RUNX3 expression by histone deacetylation is associated with biliary tract carcinogenesis.
Journal: Cancer science 20110401
Title: KRAS-mutated non-small cell lung cancer cells are responsive to either co-treatment with erlotinib or gefitinib and histone deacetylase inhibitors or single treatment with lapatinib.
Journal: Oncology reports 20110401
Title: Differentiation of NUT midline carcinoma by epigenomic reprogramming.
Journal: Cancer research 20110401
Title: The efficacy of vorinostat in combination with interferon alpha and extracorporeal photopheresis in late stage mycosis fungoides and Sezary syndrome.
Journal: Journal of drugs in dermatology : JDD 20110401
Title: Phase II study of vorinostat for treatment of relapsed or refractory indolent non-Hodgkin's lymphoma and mantle cell lymphoma.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110320
Title: Phase I study of decitabine in combination with vorinostat in patients with advanced solid tumors and non-Hodgkin's lymphomas.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110315
Title: Potentiation of apoptosis by histone deacetylase inhibitors and doxorubicin combination: cytoplasmic cathepsin B as a mediator of apoptosis in multiple myeloma.
Journal: British journal of cancer 20110315
Title: Pretreatment with anti-oxidants sensitizes oxidatively stressed human cancer cells to growth inhibitory effect of suberoylanilide hydroxamic acid (SAHA).
Journal: Cancer chemotherapy and pharmacology 20110301
Title: The emerging role of histone deacetylase inhibitors in treating T-cell lymphomas.
Journal: Current hematologic malignancy reports 20110301
Title: Thioredoxin-binding protein-2 (TBP-2/VDUP1/TXNIP) regulates T-cell sensitivity to glucocorticoid during HTLV-I-induced transformation.
Journal: Leukemia 20110301
Title: HDAC inhibitors downregulate MRP2 expression in multidrug resistant cancer cells: implication for chemosensitization.
Journal: International journal of oncology 20110301
Title: 1,25-dihydroxyvitamin D3 and a superagonistic analog in combination with paclitaxel or suberoylanilide hydroxamic acid have potent antiproliferative effects on anaplastic thyroid cancer.
Journal: The Journal of steroid biochemistry and molecular biology 20110301
Title: Phase I clinical, pharmacokinetic and pharmacodynamic study of SB939, an oral histone deacetylase (HDAC) inhibitor, in patients with advanced solid tumours.
Journal: British journal of cancer 20110301
Title: New drug therapies in peripheral T-cell lymphoma.
Journal: Expert review of anticancer therapy 20110301
Title: Epigenetics in cancer: what's the future?
Journal: Oncology (Williston Park, N.Y.) 20110301
Title: [Design, synthesis, and biological activities of histone deacetylase inhibitors with diketo ester as zinc binding group].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20110301
Title: Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis.
Journal: The Journal of biological chemistry 20110225
Title: Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2.
Journal: Biochemical pharmacology 20110215
Title: Histone deacetylase inhibitors as a tool to up-regulate new fungal biosynthetic products: isolation of EGM-556, a cyclodepsipeptide, from Microascus sp.
Journal: Organic letters 20110204
Title: Vorinostat in acute myeloid leukemia and myelodysplastic syndromes.
Journal: Expert opinion on investigational drugs 20110201
Title: Rational therapeutic combinations with histone deacetylase inhibitors for the treatment of cancer.
Journal: Future oncology (London, England) 20110201
Title: Efficacy of adenovirally expressed soluble TRAIL in human glioma organotypic slice culture and glioma xenografts.
Journal: Cell death & disease 20110201
Title: Therapeutic advances in cutaneous T-cell lymphoma.
Journal: Skin therapy letter 20110201
Title: Epigenetic status of Gdnf in the ventral striatum determines susceptibility and adaptation to daily stressful events.
Journal: Neuron 20110127
Title: Coumarin-suberoylanilide hydroxamic acid as a fluorescent probe for determining binding affinities and off-rates of histone deacetylase inhibitors.
Journal: Analytical biochemistry 20110115
Title: Acetylation of EGF receptor contributes to tumor cell resistance to histone deacetylase inhibitors.
Journal: Biochemical and biophysical research communications 20110107
Title: Synthetic lethality: general principles, utility and detection using genetic screens in human cells.
Journal: FEBS letters 20110103
Title: Identification of genes associated with chemosensitivity to SAHA/taxane combination treatment in taxane-resistant breast cancer cells.
Journal: Breast cancer research and treatment 20110101
Title: Histone deacetylase inhibitors stimulate histone H3 lysine 4 methylation in part via transcriptional repression of histone H3 lysine 4 demethylases.
Journal: Molecular pharmacology 20110101
Title: Identification of clinically used drugs that activate pregnane X receptors.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110101
Title: The Role of Allogeneic Stem Cell Transplantation in Relapsed/Refractory Hodgkin's Lymphoma Patients.
Journal: Advances in hematology 20110101
Title: Rationale for possible targeting of histone deacetylase signaling in cancer diseases with a special reference to pancreatic cancer.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Epigenetic modulation of gene expression of human leukemia cell lines - induction of cell death and senescence.
Journal: Neoplasma 20110101
Title: Roles and targets of class I and IIa histone deacetylases in cardiac hypertrophy.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Histone deacetylase inhibitors: the epigenetic therapeutics that repress hypoxia-inducible factors.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Histone deacetylase inhibitors in the treatment of hematological malignancies and solid tumors.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Manipulating protein acetylation in breast cancer: a promising approach in combination with hormonal therapies?
Journal: Journal of biomedicine & biotechnology 20110101
Title: Psorinum therapy in treating stomach, gall bladder, pancreatic, and liver cancers: a prospective clinical study.
Journal: Evidence-based complementary and alternative medicine : eCAM 20110101
Title: Regulating the regulators: the post-translational code of class I HDAC1 and HDAC2.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Identification of four potential epigenetic modulators from the NCI structural diversity library using a cell-based assay.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Effect of small interfering RNA 3'-end overhangs on chemosensitivity to thymidylate synthase inhibitors.
Journal: Silence 20110101
Title: HDAC activity is required for efficient core promoter function at the mouse mammary tumor virus promoter.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Finding a cure for HIV: will it ever be achievable?
Journal: Journal of the International AIDS Society 20110101
Title: Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks.
Journal: Genome integrity 20110101
Title: The role of HDACs inhibitors in childhood and adolescence acute leukemias.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Role of HDAC3 on p53 expression and apoptosis in T cells of patients with multiple sclerosis.
Journal: PloS one 20110101
Title: Inhibition of histone deacetylases 1 and 6 enhances cytarabine-induced apoptosis in pediatric acute myeloid leukemia cells.
Journal: PloS one 20110101
Title: C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo.
Journal: Cell death & disease 20110101
Title: Histone deacetylase inhibitors: molecular mechanisms of action and clinical trials as anti-cancer drugs.
Journal: American journal of translational research 20110101
Title: Heterogeneity in the kinetics of nuclear proteins and trajectories of substructures associated with heterochromatin.
Journal: Epigenetics & chromatin 20110101
Title: Histone deacetylase inhibitors for purging HIV-1 from the latent reservoir.
Journal: Molecular medicine (Cambridge, Mass.) 20110101
Title: HDAC inhibition decreases the expression of EGFR in colorectal cancer cells.
Journal: PloS one 20110101
Title: Romidepsin: evidence for its potential use to manage previously treated cutaneous T cell lymphoma.
Journal: Core evidence 20110101
Title: Gastrointestinal toxicity of vorinostat: reanalysis of phase 1 study results with emphasis on dose-volume effects of pelvic radiotherapy.
Journal: Radiation oncology (London, England) 20110101
Title: Identification of common differentially expressed genes in urinary bladder cancer.
Journal: PloS one 20110101
Title: Apoptotic sphingolipid ceramide in cancer therapy.
Journal: Journal of lipids 20110101
Title: p53 hypersensitivity is the predominant mechanism of the unique responsiveness of testicular germ cell tumor (TGCT) cells to cisplatin.
Journal: PloS one 20110101
Title: Antitumor effect of suberoylanilide hydroxamic acid and topotecan in renal cancer cells.
Journal: Oncology research 20110101
Title: Critical appraisal of nilotinib in frontline treatment of chronic myeloid leukemia.
Journal: Cancer management and research 20110101
Title: Selectivity of Inhibition of N-Succinyl-l,l-Diaminopimelic Acid Desuccinylase in Bacteria: The product of dapE-gene Is Not the Target of l-Captopril Antimicrobial Activity.
Journal: Bioinorganic chemistry and applications 20110101
Title: Histone deacetylase inhibitors SAHA and sodium butyrate block G1-to-S cell cycle progression in neurosphere formation by adult subventricular cells.
Journal: BMC neuroscience 20110101
Title: Histone deacetylase turnover and recovery in sulforaphane-treated colon cancer cells: competing actions of 14-3-3 and Pin1 in HDAC3/SMRT corepressor complex dissociation/reassembly.
Journal: Molecular cancer 20110101
Title: Interpreting clinical assays for histone deacetylase inhibitors.
Journal: Cancer management and research 20110101
Title: Autophagic and apoptotic effects of HDAC inhibitors on cancer cells.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Myelodysplastic syndrome and histone deacetylase inhibitors: 'to be or not to be acetylated'?
Journal: Journal of biomedicine & biotechnology 20110101
Title: Emerging role of carfilzomib in treatment of relapsed and refractory lymphoid neoplasms and multiple myeloma.
Journal: Core evidence 20110101
Title: Epigenetic changes in cancer.
Journal: F1000 biology reports 20110101
Title: Vorinostat induces reactive oxygen species and DNA damage in acute myeloid leukemia cells.
Journal: PloS one 20110101
Title: Promising molecular targeted therapies in breast cancer.
Journal: Indian journal of pharmacology 20110101
Title: Epigenetic predictor of age.
Journal: PloS one 20110101
Title: Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors.
Journal: Journal of biomedicine & biotechnology 20110101
Title: A pharmacogenomic method for individualized prediction of drug sensitivity.
Journal: Molecular systems biology 20110101
Title: Synergistic activity of ixabepilone plus other anticancer agents: preclinical and clinical evidence.
Journal: Therapeutic advances in medical oncology 20110101
Title: Synergistic interactions between HDAC and sirtuin inhibitors in human leukemia cells.
Journal: PloS one 20110101
Title: The effect of the histone deacetylase inhibitor M344 on BRCA1 expression in breast and ovarian cancer cells.
Journal: Cancer cell international 20110101
Title: Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90.
Journal: Molecular cancer 20110101
Title: The biology of HDAC in cancer: the nuclear and epigenetic components.
Journal: Handbook of experimental pharmacology 20110101
Title: Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells.
Journal: PloS one 20110101
Title: Latency profiles of full length HIV-1 molecular clone variants with a subtype specific promoter.
Journal: Retrovirology 20110101
Title: The mechanism of action of the histone deacetylase inhibitor vorinostat involves interaction with the insulin-like growth factor signaling pathway.
Journal: PloS one 20110101
Title: Gene expression signature analysis identifies vorinostat as a candidate therapy for gastric cancer.
Journal: PloS one 20110101
Title: Combination of suberoylanilide hydroxamic acid with heavy ion therapy shows promising effects in infantile sarcoma cell lines.
Journal: Radiation oncology (London, England) 20110101
Title: Targeting HDACs: a promising therapy for Alzheimer's disease.
Journal: Oxidative medicine and cellular longevity 20110101
Title: Systematic in-vitro evaluation of the NCI/NIH Developmental Therapeutics Program Approved Oncology Drug Set for the identification of a candidate drug repertoire for MLL-rearranged leukemia.
Journal: OncoTargets and therapy 20110101
Title: Generation of reactive oxygen species during apoptosis induced by DNA-damaging agents and/or histone deacetylase inhibitors.
Journal: Oxidative medicine and cellular longevity 20110101
Title: Promoting illiteracy in epigenetics: an emerging therapeutic strategy.
Journal: Current chemical genomics 20110101
Title: GSTP1 DNA methylation and expression status is indicative of 5-aza-2'-deoxycytidine efficacy in human prostate cancer cells.
Journal: PloS one 20110101
Title: Expression and reactivation of HIV in a chemokine induced model of HIV latency in primary resting CD4+ T cells.
Journal: Retrovirology 20110101
Title: Expression pattern of class I histone deacetylases in vulvar intraepithelial neoplasia and vulvar cancer: a tissue microarray study.
Journal: BMC cancer 20110101
Title: A mechanism for synergy with combined mTOR and PI3 kinase inhibitors.
Journal: PloS one 20110101
Title: Potential non-oncological applications of histone deacetylase inhibitors.
Journal: American journal of translational research 20110101
Title: The microenvironment in breast cancer progression: biology and implications for treatment.
Journal: Breast cancer research : BCR 20110101
Title: Epigenetics in breast cancer: what's new?
Journal: Breast cancer research : BCR 20110101
Title: Secretome Analysis of Skeletal Myogenesis Using SILAC and Shotgun Proteomics.
Journal: International journal of proteomics 20110101
Title: A Systematic Review and Meta-Analysis of Front-line Anthracycline-Based Chemotherapy Regimens for Peripheral T-Cell Lymphoma.
Journal: ISRN hematology 20110101
Title: Metastatic bladder cancer: a review of current management.
Journal: ISRN urology 20110101
Title: Concurrent HDAC and mTORC1 inhibition attenuate androgen receptor and hypoxia signaling associated with alterations in microRNA expression.
Journal: PloS one 20110101
Title: New insights into the androgen-targeted therapies and epigenetic therapies in prostate cancer.
Journal: Prostate cancer 20110101
Title: SAHA decreases HDAC 2 and 4 levels in vivo and improves molecular phenotypes in the R6/2 mouse model of Huntington's disease.
Journal: PloS one 20110101
Title: Differentiation of breast cancer stem cells by knockdown of CD44: promising differentiation therapy.
Journal: Journal of translational medicine 20110101
Title: Epigenetics in prostate cancer.
Journal: Prostate cancer 20110101
Title: Molecular mechanisms of bortezomib resistant adenocarcinoma cells.
Journal: PloS one 20110101
Title: Dietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cells.
Journal: Clinical epigenetics 20110101
Title: Romidepsin in the treatment of cutaneous T-cell lymphoma.
Journal: Journal of blood medicine 20110101
Title: An update on the management of peripheral T-cell lymphoma and emerging treatment options.
Journal: Journal of blood medicine 20110101
Title: Autophagy: friend or foe in breast cancer development, progression, and treatment.
Journal: International journal of breast cancer 20110101
Title: The role of aryl hydrocarbon receptor and crosstalk with estrogen receptor in response of breast cancer cells to the novel antitumor agents benzothiazoles and aminoflavone.
Journal: International journal of breast cancer 20110101
Title: In silico modification of suberoylanilide hydroxamic acid (SAHA) as potential inhibitor for class II histone deacetylase (HDAC).
Journal: BMC bioinformatics 20110101
Title: Suffocating cancer: hypoxia-associated epimutations as targets for cancer therapy.
Journal: Clinical epigenetics 20110101
Title: Cell death signaling and anticancer therapy.
Journal: Frontiers in oncology 20110101
Title: Investigational approaches for mesothelioma.
Journal: Frontiers in oncology 20110101
Title: Ocular manifestations and pathology of adult T-cell leukemia/lymphoma associated with human T-lymphotropic virus type 1.
Journal: Rare tumors 20101231
Title: Sequential treatment of CD34+ cells from patients with primary myelofibrosis with chromatin-modifying agents eliminate JAK2V617F-positive NOD/SCID marrow repopulating cells.
Journal: Blood 20101223
Title: Novel chimeric histone deacetylase inhibitors: a series of lapatinib hybrides as potent inhibitors of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and histone deacetylase activity.
Journal: Journal of medicinal chemistry 20101223
Title: Discovery of 2-(6-{[(6-fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a class I selective orally active histone deacetylase inhibitor.
Journal: Journal of medicinal chemistry 20101223
Title: Discovery of 1H-benzo[d][1,2,3]triazol-1-yl 3,4,5-trimethoxybenzoate as a potential antiproliferative agent by inhibiting histone deacetylase.
Journal: Bioorganic & medicinal chemistry 20101215
Title: Novel herbal flavonoids promote apoptosis but differentially induce cell cycle arrest in human colon cancer cell.
Journal: Investigational new drugs 20101201
Title: Heritable and non-genetic factors as variables of pharmacologic phenotypes in lymphoblastoid cell lines.
Journal: The pharmacogenomics journal 20101201
Title: Identification of genes related to a synergistic effect of taxane and suberoylanilide hydroxamic acid combination treatment in gastric cancer cells.
Journal: Journal of cancer research and clinical oncology 20101201
Title: Histone deacetylase (HDAC) 1 and 2 expression and chemotherapy in gastric cancer.
Journal: Annals of surgical oncology 20101201
Title: Autophagy and tumorigenesis.
Journal: Seminars in immunopathology 20101201
Title: A novel xenograft model of cutaneous T-cell lymphoma.
Journal: Experimental dermatology 20101201
Title: Inhibition of class IIb histone deacetylase significantly improves cloning efficiency in mice.
Journal: Biology of reproduction 20101201
Title: Suberoylanilide hydroxamic acid partly reverses resistance to paclitaxel in human ovarian cancer cell lines.
Journal: Gynecologic oncology 20101201
Title: Inhibitors selective for HDAC6 in enzymes and cells.
Journal: Bioorganic & medicinal chemistry letters 20101201
Title: Crucial function of histone deacetylase 1 for differentiation of teratomas in mice and humans.
Journal: The EMBO journal 20101201
Title: The DAC system and associations with multiple myeloma.
Journal: Investigational new drugs 20101201
Title: Deactylase inhibition in myeloproliferative neoplasms.
Journal: Investigational new drugs 20101201
Title: Histone deacetylase inhibitors in Hodgkin lymphoma.
Journal: Investigational new drugs 20101201
Title: Targeting histone deacetyalses in the treatment of B- and T-cell malignancies.
Journal: Investigational new drugs 20101201
Title: The DAC system and associations with acute leukemias and myelodysplastic syndromes.
Journal: Investigational new drugs 20101201
Title: The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss.
Journal: Molecular cancer therapeutics 20101201
Title: Combination of vorinostat and flavopiridol is selectively cytotoxic to multidrug-resistant neuroblastoma cell lines with mutant TP53.
Journal: Molecular cancer therapeutics 20101201
Title: Histone deacetylase inhibitors: potential targets responsible for their anti-cancer effect.
Journal: Investigational new drugs 20101201
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20101201
Title: Selenium-containing analogs of SAHA induce cytotoxicity in lung cancer cells.
Journal: Bioorganic & medicinal chemistry letters 20101115
Title: Design and synthesis of novel pyrimidine hydroxamic acid inhibitors of histone deacetylases.
Journal: Bioorganic & medicinal chemistry letters 20101115
Title: Poikilodermatous mycosis fungoides.
Journal: Dermatology online journal 20101115
Title: Schwann cell autophagy induced by SAHA, 17-AAG, or clonazepam can reduce bortezomib-induced peripheral neuropathy.
Journal: British journal of cancer 20101109
Title: Impact of histone deacetylase inhibitors SAHA and MS-275 on DNA repair pathways in human mesenchymal stem cells.
Journal: Journal of cellular physiology 20101101
Title: Inhibition of radiation-induced DNA repair and prosurvival pathways contributes to vorinostat-mediated radiosensitization of pancreatic cancer cells.
Journal: Pancreas 20101101
Title: Efficacy of MK-0457 and in combination with vorinostat against Philadelphia chromosome positive acute lymphoblastic leukemia cells.
Journal: Annals of hematology 20101101
Title: HDAC inhibitors with different gene regulation activities depend on the mitochondrial pathway for the sensitization of leukemic T cells to TRAIL-induced apoptosis.
Journal: Cancer letters 20101101
Title: In vitro and in vivo histone deacetylase inhibitor therapy with vorinostat and paclitaxel in ovarian cancer models: does timing matter?
Journal: Gynecologic oncology 20101101
Title: The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces growth inhibition and enhances taxol-induced cell death in breast cancer.
Journal: Cancer chemotherapy and pharmacology 20101101
Title: A histone deacetylase-dependent screen in yeast.
Journal: Bioorganic & medicinal chemistry 20101101
Title: Induction of a less aggressive phenotype in human colon carcinoma HCT116 cells by chronic exposure to HDAC inhibitor SAHA.
Journal: Oncology reports 20101101
Title: Synergistic killing effect between vorinostat and target of CD146 in malignant cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20101101
Title: Autophagy potentiates the anti-cancer effects of the histone deacetylase inhibitors in hepatocellular carcinoma.
Journal: Autophagy 20101101
Title: Identification of fetal hemoglobin-inducing agents using the human leukemia KU812 cell line.
Journal: Experimental biology and medicine (Maywood, N.J.) 20101101
Title: Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase.
Journal: British journal of cancer 20101101
Title: Combination of sapacitabine and HDAC inhibitors stimulates cell death in AML and other tumour types.
Journal: British journal of cancer 20101026
Title: Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition.
Journal: Blood 20101021
Title: Overcoming resistance to histone deacetylase inhibitors in human leukemia with the redox modulating compound β-phenylethyl isothiocyanate.
Journal: Blood 20101014
Title: Adenovirus 5 E1A enhances histone deacetylase inhibitors-induced apoptosis through Egr-1-mediated Bim upregulation.
Journal: Oncogene 20101014
Title: Phase I study of vorinostat in patients with advanced solid tumors and hepatic dysfunction: a National Cancer Institute Organ Dysfunction Working Group study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20101010
Title: Autophagy inhibition enhances vorinostat-induced apoptosis via ubiquitinated protein accumulation.
Journal: Journal of cellular and molecular medicine 20101001
Title: Histone deacetylase inhibitors synergistically potentiate death receptor 4-mediated apoptotic cell death of human T-cell acute lymphoblastic leukemia cells.
Journal: Apoptosis : an international journal on programmed cell death 20101001
Title: Protection of dopaminergic cells from MPP+-mediated toxicity by histone deacetylase inhibition.
Journal: Brain research 20101001
Title: Regulation of apoptosis-associated genes by histone deacetylase inhibitors: implications in cancer therapy.
Journal: Anti-cancer drugs 20101001
Title: The NF (Nuclear factor)-κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells.
Journal: British journal of haematology 20101001
Title: Multigene expression-based predictors for sensitivity to Vorinostat and Velcade in non-small cell lung cancer.
Journal: Molecular cancer therapeutics 20101001
Title: The combination of a histone deacetylase inhibitor with the BH3-mimetic GX15-070 has synergistic antileukemia activity by activating both apoptosis and autophagy.
Journal: Autophagy 20101001
Title: A pharmacogenetic study of vorinostat glucuronidation.
Journal: Pharmacogenetics and genomics 20101001
Title: Solubilization of vorinostat by cyclodextrins.
Journal: Journal of clinical pharmacy and therapeutics 20101001
Title: Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes.
Journal: Aging 20101001
Title: HDAC pharmacological inhibition promotes cell death through the eIF2α kinases PKR and GCN2.
Journal: Aging 20101001
Title: Histone deacetylase inhibitors prevent activation of tumour-reactive NK cells and T cells but do not interfere with their cytolytic effector functions.
Journal: Cancer letters 20100928
Title: Vorinostat enhances the cytotoxic effects of the topoisomerase I inhibitor SN38 in glioblastoma cell lines.
Journal: Journal of neuro-oncology 20100901
Title: Identification of type-specific anticancer histone deacetylase inhibitors: road to success.
Journal: Cancer chemotherapy and pharmacology 20100901
Title: Actions of the anti-cancer drug suberoylanilide hydroxamic acid (SAHA) on human breast cancer cytoarchitecture in silicon microstructures.
Journal: Biomaterials 20100901
Title: Treatment with histone deacetylase inhibitor attenuates MAP kinase mediated liver injury in a lethal model of septic shock.
Journal: The Journal of surgical research 20100901
Title: Combination of suberoylanilide hydroxamic acid and ritonavir is effective against renal cancer cells.
Journal: Urology 20100901
Title: Design and synthesis of novel isoxazole-based HDAC inhibitors.
Journal: European journal of medicinal chemistry 20100901
Title: Enhancement of radiation response in osteosarcoma and rhabdomyosarcoma cell lines by histone deacetylase inhibition.
Journal: International journal of radiation oncology, biology, physics 20100901
Title: Investigational histone deacetylase inhibitors for non-Hodgkin lymphomas.
Journal: Expert opinion on investigational drugs 20100901
Title: Histone deacetylase inhibitors in lymphoma.
Journal: Current opinion in oncology 20100901
Title: Drug-induced regulation of target expression.
Journal: PLoS computational biology 20100901
Title: [Development of HDAC inhibitors].
Journal: Gan to kagaku ryoho. Cancer & chemotherapy 20100901
Title: Non-peptide macrocyclic histone deacetylase inhibitors derived from tricyclic ketolide skeleton.
Journal: Journal of medicinal chemistry 20100826
Title: Histone deacetylase inhibition as a mechanism for the therapeutic effect of statins (3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors) in follicular lymphoma.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100820
Title: Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20100817
Title: A novel Ca2+/calmodulin antagonist HBC inhibits angiogenesis and down-regulates hypoxia-inducible factor.
Journal: The Journal of biological chemistry 20100813
Title: A structure-activity relationship study of the antimalarial and antileishmanial activities of nonpeptide macrocyclic histone deacetylase inhibitors.
Journal: ChemMedChem 20100802
Title: Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant.
Journal: The Journal of clinical investigation 20100802
Title: The histone deacetylase inhibitor vorinostat induces calreticulin exposure in childhood brain tumour cells in vitro.
Journal: Cancer chemotherapy and pharmacology 20100801
Title: Histone deacetylase inhibitors MS-275 and SAHA induced growth arrest and suppressed lipopolysaccharide-stimulated NF-kappaB p65 nuclear accumulation in human rheumatoid arthritis synovial fibroblastic E11 cells.
Journal: Rheumatology (Oxford, England) 20100801
Title: The combination of a histone deacetylase inhibitor with the Bcl-2 homology domain-3 mimetic GX15-070 has synergistic antileukemia activity by activating both apoptosis and autophagy.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100801
Title: Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells.
Journal: Autophagy 20100801
Title: Surviving lethal septic shock without fluid resuscitation in a rodent model.
Journal: Surgery 20100801
Title: Anticancer effects of the MHY218 novel hydroxamic acid-derived histone deacetylase inhibitor in human ovarian cancer cells.
Journal: International journal of oncology 20100801
Title: Pediatric phase I trial and pharmacokinetic study of vorinostat: a Children's Oncology Group phase I consortium report.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100801
Title: Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway.
Journal: Cancer research 20100801
Title: Validation of a novel statistical model for assessing the synergy of combined-agent cancer chemoprevention.
Journal: Cancer prevention research (Philadelphia, Pa.) 20100801
Title: Serine proteases in histone deacetylase inhibitor-induced apoptosis.
Journal: Molecular cancer therapeutics 20100801
Title: Sorafenib activates CD95 and promotes autophagy and cell death via Src family kinases in gastrointestinal tumor cells.
Journal: Molecular cancer therapeutics 20100801
Title: An experimental study of rabbit conjunctival epithelial toxicity using co-treatment with mitomycin-C and a histone deacetylase inhibitor.
Journal: Archives of pharmacal research 20100801
Title: A phase I, pharmacokinetic, and pharmacodynamic study of two schedules of vorinostat in combination with 5-fluorouracil and leucovorin in patients with refractory solid tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100715
Title: The functional significance of microRNA-145 in prostate cancer.
Journal: British journal of cancer 20100713
Title: The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis, down-regulates the CXCR4 chemokine receptor and impairs migration of chronic lymphocytic leukemia cells.
Journal: Haematologica 20100701
Title: The histone deacetylase inhibitor suberoylanilide hydroxamic acid reduces cardiac arrhythmias in dystrophic mice.
Journal: Cardiovascular research 20100701
Title: A phase I study of vorinostat in combination with idarubicin in relapsed or refractory leukaemia.
Journal: British journal of haematology 20100701
Title: Targeted treatment and new agents in peripheral T-cell lymphoma.
Journal: International journal of hematology 20100701
Title: Design, synthesis and anticancer activity of piperazine hydroxamates and their histone deacetylase (HDAC) inhibitory activity.
Journal: Bioorganic & medicinal chemistry letters 20100701
Title: A phase I study of the safety and pharmacokinetics of the histone deacetylase inhibitor belinostat administered in combination with carboplatin and/or paclitaxel in patients with solid tumours.
Journal: British journal of cancer 20100629
Title: Suberoylanilide hydroxamic acid limits migration and invasion of glioma cells in two and three dimensional culture.
Journal: Cancer letters 20100628
Title: Probing the probes: fitness factors for small molecule tools.
Journal: Chemistry & biology 20100625
Title: Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues.
Journal: Journal of medicinal chemistry 20100624
Title: Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function .
Journal: Biochemistry 20100622
Title: New aryldithiolethione derivatives as potent histone deacetylase inhibitors.
Journal: Bioorganic & medicinal chemistry 20100615
Title: The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo.
Journal: Blood 20100603
Title: Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS.
Journal: Journal of leukocyte biology 20100601
Title: Anti-melanoma effects of vorinostat in combination with polyphenolic antioxidant (-)-epigallocatechin-3-gallate (EGCG).
Journal: Pharmaceutical research 20100601
Title: Histone deacetylase inhibitor enhances sensitivity of non-small-cell lung cancer cells to 5-FU/S-1 via down-regulation of thymidylate synthase expression and up-regulation of p21(waf1/cip1) expression.
Journal: Cancer science 20100601
Title: Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity.
Journal: Bioorganic & medicinal chemistry letters 20100601
Title: Vitamin D receptor agonist/histone deacetylase inhibitor molecular hybrids.
Journal: Bioorganic & medicinal chemistry 20100601
Title: Inhibition of histone deacetylase in cancer cells slows down replication forks, activates dormant origins, and induces DNA damage.
Journal: Cancer research 20100601
Title: Suberoylanilide hydroxamic acid blocks self-renewal and homotypic aggregation of inflammatory breast cancer spheroids.
Journal: Cancer 20100601
Title: Turning off the switch in medulloblastoma: the inhibitory acetylation of an oncogene.
Journal: Cell cycle (Georgetown, Tex.) 20100601
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20100601
Title: Exciting new targets in lung cancer therapy: ALK, IGF-1R, HDAC, and Hh.
Journal: Current treatment options in oncology 20100601
Title: Targeting histone deacetylases: development of vorinostat for the treatment of cancer.
Journal: Epigenomics 20100601
Title: AR-42, a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit.
Journal: Blood 20100527
Title: Suberoylanilide hydroxamic acid induces viral lytic cycle in Epstein-Barr virus-positive epithelial malignancies and mediates enhanced cell death.
Journal: International journal of cancer 20100515
Title: Exploration of the HDAC2 foot pocket: Synthesis and SAR of substituted N-(2-aminophenyl)benzamides.
Journal: Bioorganic & medicinal chemistry letters 20100515
Title: Synthesis and anticancer evaluation of alpha-lipoic acid derivatives.
Journal: Bioorganic & medicinal chemistry letters 20100515
Title: Histone deacetylase inhibitors: Are they here to stay?
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100515
Title: Vorinostat: A novel therapy for the treatment of cutaneous T-cell lymphoma.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100515
Title: Valproic acid stimulates clusterin expression in human astrocytes: Implications for Alzheimer's disease.
Journal: Neuroscience letters 20100514
Title: Vorinostat, a histone deacetylase inhibitor, combined with pelvic palliative radiotherapy for gastrointestinal carcinoma: the Pelvic Radiation and Vorinostat (PRAVO) phase 1 study.
Journal: The Lancet. Oncology 20100501
Title: Combined proteasome and histone deacetylase inhibition attenuates epithelial-mesenchymal transition through E-cadherin in esophageal cancer cells.
Journal: The Journal of thoracic and cardiovascular surgery 20100501
Title: [Vorinostat in the treatment of cutaneous T-cell lymphomas. Treatment with histone deacetylases inhibitors].
Journal: Pharmazie in unserer Zeit 20100501
Title: SAHA and curcumin combinations co-enhance histone acetylation in human cancer cells but operate antagonistically in exerting cytotoxic effects.
Journal: Journal of Asian natural products research 20100501
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20100501
Title: Diagnosis and management of mycosis fungoides.
Journal: Oncology (Williston Park, N.Y.) 20100501
Title: [Three different drug interaction mathematical models used to evaluate the cytotoxicity of SAHA and arsenic trioxide in combination].
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100501
Title: Modified cap group suberoylanilide hydroxamic acid histone deacetylase inhibitor derivatives reveal improved selective antileukemic activity.
Journal: Journal of medicinal chemistry 20100422
Title: SAHA ameliorates the SMA phenotype in two mouse models for spinal muscular atrophy.
Journal: Human molecular genetics 20100415
Title: Histone deacetylase inhibitors and 15-deoxy-Delta12,14-prostaglandin J2 synergistically induce apoptosis.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100415
Title: Synthesis of N-hydroxycinnamides capped with a naturally occurring moiety as inhibitors of histone deacetylase.
Journal: ChemMedChem 20100406
Title: Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells.
Journal: Breast cancer research and treatment 20100401
Title: Resveratrol enhances p53 acetylation and apoptosis in prostate cancer by inhibiting MTA1/NuRD complex.
Journal: International journal of cancer 20100401
Title: A phase I/II trial of vorinostat in combination with 5-fluorouracil in patients with metastatic colorectal cancer who previously failed 5-FU-based chemotherapy.
Journal: Cancer chemotherapy and pharmacology 20100401
Title: Vorinostat interferes with the signaling transduction pathway of T-cell receptor and synergizes with phosphoinositide-3 kinase inhibitors in cutaneous T-cell lymphoma.
Journal: Haematologica 20100401
Title: Antifibrotic activity of an inhibitor of histone deacetylases in DOCA-salt hypertensive rats.
Journal: British journal of pharmacology 20100401
Title: Synergistic antineoplastic effect of DLC1 tumor suppressor protein and histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), on prostate and liver cancer cells: perspectives for therapeutics.
Journal: International journal of oncology 20100401
Title: The role of histone deacetylase inhibitors in the treatment of patients with cutaneous T-cell lymphoma.
Journal: Clinical lymphoma, myeloma & leukemia 20100401
Title: Vorinostat plus bortezomib for the treatment of relapsed/refractory multiple myeloma: a case series illustrating utility in clinical practice.
Journal: Clinical lymphoma, myeloma & leukemia 20100401
Title: Emerging role of epigenetic therapies in cutaneous T-cell lymphomas.
Journal: Expert review of hematology 20100401
Title: The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice.
Journal: Blood 20100325
Title: SelSA, selenium analogs of SAHA as potent histone deacetylase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20100315
Title: Discovery of 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide (CUDc-101) as a potent multi-acting HDAC, EGFR, and HER2 inhibitor for the treatment of cancer.
Journal: Journal of medicinal chemistry 20100311
Title: Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short alkyl groups on the phenyl ring.
Journal: Journal of medicinal chemistry 20100311
Title: Amphiregulin promotes resistance to gefitinib in nonsmall cell lung cancer cells by regulating Ku70 acetylation.
Journal: Molecular therapy : the journal of the American Society of Gene Therapy 20100301
Title: Vorinostat enhances the antimyeloma effects of melphalan and bortezomib.
Journal: European journal of haematology 20100301
Title: Chronic cocaine-induced H3 acetylation and transcriptional activation of CaMKIIalpha in the nucleus accumbens is critical for motivation for drug reinforcement.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100301
Title: Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100301
Title: The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition.
Journal: Cellular and molecular life sciences : CMLS 20100301
Title: Screening for therapeutic targets of vorinostat by SILAC-based proteomic analysis in human breast cancer cells.
Journal: Proteomics 20100301
Title: Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy.
Journal: Leukemia 20100301
Title: Chemical phylogenetics of histone deacetylases.
Journal: Nature chemical biology 20100301
Title: Design, synthesis and preliminary activity assay of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as novel Histone deacetylases (HDACs) inhibitors.
Journal: Bioorganic & medicinal chemistry 20100301
Title: SB939, a novel potent and orally active histone deacetylase inhibitor with high tumor exposure and efficacy in mouse models of colorectal cancer.
Journal: Molecular cancer therapeutics 20100301
Title: Current and emerging treatment strategies for cutaneous T-cell lymphoma.
Journal: Drugs 20100212
Title: Synthesis and biological evaluation of triazol-4-ylphenyl-bearing histone deacetylase inhibitors as anticancer agents.
Journal: Journal of medicinal chemistry 20100211
Title: Vorinostat increases carboplatin and paclitaxel activity in non-small-cell lung cancer cells.
Journal: International journal of cancer 20100201
Title: Inhibitors of histone deacetylases suppress cisplatin-induced p53 activation and apoptosis in renal tubular cells.
Journal: American journal of physiology. Renal physiology 20100201
Title: Induction of thyroid gene expression and radioiodine uptake in thyroid cancer cells by targeting major signaling pathways.
Journal: The Journal of clinical endocrinology and metabolism 20100201
Title: Histone deacetylase inhibitors in malignant pleural mesothelioma: preclinical rationale and clinical trials.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20100201
Title: Suberoylanilide hydroxyamic acid modification of chromatin architecture affects DNA break formation and repair.
Journal: International journal of radiation oncology, biology, physics 20100201
Title: HDAC inhibitors in cancer care.
Journal: Oncology (Williston Park, N.Y.) 20100201
Title: Will DNA methylation inhibitors work in solid tumors? A review of the clinical experience with azacitidine and decitabine in solid tumors.
Journal: Epigenomics 20100201
Title: Deacetylase inhibitors dissociate the histone-targeting ING2 subunit from the Sin3 complex.
Journal: Chemistry & biology 20100129
Title: Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors.
Journal: Journal of medicinal chemistry 20100128
Title: Fluoroalkene modification of mercaptoacetamide-based histone deacetylase inhibitors.
Journal: Bioorganic & medicinal chemistry 20100115
Title: Histone deacetylase inhibitors induce thyroid cancer-specific apoptosis through proteasome-dependent inhibition of TRAIL degradation.
Journal: Oncogene 20100107
Title: Potential efficacy of the oral histone deacetylase inhibitor vorinostat in a phase I trial in follicular and mantle cell lymphoma.
Journal: Cancer science 20100101
Title: Suberoylanilide hydroxamic acid (SAHA) potentiates paclitaxel-induced apoptosis in ovarian cancer cell lines.
Journal: Gynecologic oncology 20100101
Title: Nonclinical safety assessment of the histone deacetylase inhibitor vorinostat.
Journal: International journal of toxicology 20100101
Title: Suberoylanilide hydroxamic acid (SAHA) at subtoxic concentrations increases the adhesivity of human leukemic cells to fibronectin.
Journal: Journal of cellular biochemistry 20100101
Title: Antimalarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group.
Journal: Bioorganic & medicinal chemistry 20100101
Title: Carboplatin and Paclitaxel in combination with either vorinostat or placebo for first-line therapy of advanced non-small-cell lung cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100101
Title: HDAC inhibition radiosensitizes human normal tissue cells and reduces DNA Double-Strand Break repair capacity.
Journal: Oncology reports 20100101
Title: Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis.
Journal: Nature chemical biology 20100101
Title: Vorinostat enhances the activity of temsirolimus in renal cell carcinoma through suppression of survivin levels.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100101
Title: Histone deacetylase inhibitor therapy in epithelial ovarian cancer.
Journal: Journal of oncology 20100101
Title: The saving switch.
Journal: Nature medicine 20100101
Title: Activation of the unfolded protein response contributes toward the antitumor activity of vorinostat.
Journal: Neoplasia (New York, N.Y.) 20100101
Title: Two new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse model.
Journal: PloS one 20100101
Title: Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents.
Journal: Journal of hematology & oncology 20100101
Title: EBV-positive Hodgkin lymphoma is associated with suppression of p21cip1/waf1 and a worse prognosis.
Journal: Molecular cancer 20100101
Title: PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells.
Journal: International journal of cell biology 20100101
Title: Linking ER Stress to Autophagy: Potential Implications for Cancer Therapy.
Journal: International journal of cell biology 20100101
Title: Preclinical studies of chemotherapy using histone deacetylase inhibitors in endometrial cancer.
Journal: Obstetrics and gynecology international 20100101
Title: BRCA1 as a Therapeutic Target in Sporadic Epithelial Ovarian Cancer.
Journal: Journal of oncology 20100101
Title: Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection.
Journal: PloS one 20100101
Title: Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo.
Journal: Molecular cancer 20100101
Title: Response to hydralazine-valproate in a patient with mycosis fungoides.
Journal: Case reports in medicine 20100101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20100101
Title: Antiangiogenic therapy and mechanisms of tumor resistance in malignant glioma.
Journal: Journal of oncology 20100101
Title: Novel agents and regimens for acute myeloid leukemia: 2009 ASH annual meeting highlights.
Journal: Journal of hematology & oncology 20100101
Title: Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice.
Journal: BMC molecular biology 20100101
Title: Updates in non-small cell lung cancer--insights from the 2009 45th annual meeting of the American Society of Clinical Oncology.
Journal: Journal of hematology & oncology 20100101
Title: Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamides.
Journal: Marine drugs 20100101
Title: Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.
Journal: PloS one 20100101
Title: The novel deacetylase inhibitor AR-42 demonstrates pre-clinical activity in B-cell malignancies in vitro and in vivo.
Journal: PloS one 20100101
Title: Epigenetics of human cutaneous melanoma: setting the stage for new therapeutic strategies.
Journal: Journal of translational medicine 20100101
Title: Bryostatin modulates latent HIV-1 infection via PKC and AMPK signaling but inhibits acute infection in a receptor independent manner.
Journal: PloS one 20100101
Title: Downregulation of homologous recombination DNA repair genes by HDAC inhibition in prostate cancer is mediated through the E2F1 transcription factor.
Journal: PloS one 20100101
Title: An update on the safety and efficacy of decitabine in the treatment of myelodysplastic syndromes.
Journal: OncoTargets and therapy 20100101
Title: Histone deacetylase 3 depletion in osteo/chondroprogenitor cells decreases bone density and increases marrow fat.
Journal: PloS one 20100101
Title: Molecular and therapeutic potential and toxicity of valproic acid.
Journal: Journal of biomedicine & biotechnology 20100101
Title: Activating Transcription Factor 3 regulates in part the enhanced tumour cell cytotoxicity of the histone deacetylase inhibitor M344 and cisplatin in combination.
Journal: Cancer cell international 20100101
Title: Suberoylanilide hydroxamic acid induces apoptosis and sub-G1 arrest of 320 HSR colon cancer cells.
Journal: Journal of biomedical science 20100101
Title: Epigenetic approaches in the treatment of myelodysplastic syndromes: clinical utility of azacitidine.
Journal: OncoTargets and therapy 20100101
Title: A novel histone deacetylase inhibitor exhibits antitumor activity via apoptosis induction, F-actin disruption and gene acetylation in lung cancer.
Journal: PloS one 20100101
Title: Maximum growth and survival of estrogen receptor-alpha positive breast cancer cells requires the Sin3A transcriptional repressor.
Journal: Molecular cancer 20100101
Title: Oral systemic therapy: Not all 'win-win'.
Journal: Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology 20100101
Title: Safety and efficacy of azacitidine in myelodysplastic syndromes.
Journal: Drug design, development and therapy 20100101
Title: Dietary, metabolic, and potentially environmental modulation of the lysine acetylation machinery.
Journal: International journal of cell biology 20100101
Title: Targeted therapy in lymphoma.
Journal: Journal of hematology & oncology 20100101
Title: Proteasome inhibition and its therapeutic potential in multiple myeloma.
Journal: Biologics : targets & therapy 20100101
Title: Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.
Journal: PloS one 20100101
Title: Proteomic profile of differentially expressed plasma proteins from dystrophic mice and following suberoylanilide hydroxamic acid treatment.
Journal: Proteomics. Clinical applications 20100101
Title: Temsirolimus in the treatment of relapsed and/or refractory mantle cell lymphoma.
Journal: Cancer management and research 20100101
Title: An update in management of noncutaneous T-cell lymphomas.
Journal: Advances in hematology 20100101
Title: CoFactor: Folate Requirement for Optimization of 5-Fluouracil Activity in Anticancer Chemotherapy.
Journal: Journal of oncology 20100101
Title: Peripheral T-cell lymphoma: review and updates of current management strategies.
Journal: Advances in hematology 20100101
Title: Relapsed multiple myeloma.
Journal: Hematology. American Society of Hematology. Education Program 20100101
Title: Enhancement of vaccinia virus based oncolysis with histone deacetylase inhibitors.
Journal: PloS one 20100101
Title: New treatments for myelodysplastic syndromes.
Journal: Mediterranean journal of hematology and infectious diseases 20100101
Title: Synergistic induction of apoptosis in HeLa cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitor SAHA.
Journal: Molecular medicine reports 20100101
Title: A putrescine-anthracene conjugate: a paradigm for selective drug delivery.
Journal: The Biochemical journal 20091215
Title: Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862): trial results and interleukin-6 analysis: a study by the Department of Defense Prostate Cancer Clinical Trial Consortium and University of Chicago Phase 2 Consortium.
Journal: Cancer 20091201
Title: HTS and hit finding in academia--from chemical genomics to drug discovery.
Journal: Drug discovery today 20091201
Title: Design and synthesis of novel histone deacetylase inhibitor derived from nuclear localization signal peptide.
Journal: Bioorganic & medicinal chemistry letters 20091201
Title: MicroRNAs that respond to histone deacetylase inhibitor SAHA and p53 in HCT116 human colon carcinoma cells.
Journal: International journal of oncology 20091201
Title: Molecular targets in malignant pleural mesothelioma treatment.
Journal: Current drug targets 20091201
Title: Emerging treatment combinations: integrating therapy into clinical practice.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20091201
Title: New patented histone deacetylase inhibitors.
Journal: Expert opinion on therapeutic patents 20091201
Title: Evaluation of the long-term tolerability and clinical benefit of vorinostat in patients with advanced cutaneous T-cell lymphoma.
Journal: Clinical lymphoma & myeloma 20091201
Title: Induction of E-cadherin in lung cancer and interaction with growth suppression by histone deacetylase inhibition.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20091201
Title: New treatment strategy enhances outcome for lung cancer.
Journal: Cancer biology & therapy 20091201
Title: A single supratherapeutic dose of vorinostat does not prolong the QTc interval in patients with advanced cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20091115
Title: Hydroxamates: relationships between structure and plasma stability.
Journal: Journal of medicinal chemistry 20091112
Title: Histone deacetylase inhibitors in cancer therapy.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091110
Title: Enhancement of cisplatin cytotoxicity by SAHA involves endoplasmic reticulum stress-mediated apoptosis in oral squamous cell carcinoma cells.
Journal: Cancer chemotherapy and pharmacology 20091101
Title: Protective effect of suberoylanilide hydroxamic acid against LPS-induced septic shock in rodents.
Journal: Shock (Augusta, Ga.) 20091101
Title: Response of an adult patient with pineoblastoma to vorinostat and retinoic acid.
Journal: Journal of neuro-oncology 20091101
Title: Histone deacetylase inhibitors induce apoptosis, histone hyperacetylation and up-regulation of gene transcription in Schistosoma mansoni.
Journal: Molecular and biochemical parasitology 20091101
Title: Design, synthesis and preliminary biological evaluation of N-hydroxy-4-(3-phenylpropanamido)benzamide (HPPB) derivatives as novel histone deacetylase inhibitors.
Journal: European journal of medicinal chemistry 20091101
Title: Pathway targets to explore in the treatment of small cell and large cell lung cancers.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20091101
Title: Regulation of EP receptors in non-small cell lung cancer by epigenetic modifications.
Journal: European journal of cancer (Oxford, England : 1990) 20091101
Title: Synergistic antitumor effect between vorinostat and topotecan in small cell lung cancer cells is mediated by generation of reactive oxygen species and DNA damage-induced apoptosis.
Journal: Molecular cancer therapeutics 20091101
Title: Identification of LIV1, a putative zinc transporter gene responsible for HDACi-induced apoptosis, using a functional gene screen approach.
Journal: Molecular cancer therapeutics 20091101
Title: Leukonychia related to vorinostat.
Journal: Archives of dermatology 20091101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20091101
Title: Cell cycle regulatory effects of retinoic Acid and forskolin are mediated by the cyclin C gene.
Journal: Journal of molecular biology 20091023
Title: Suberoylanilide hydroxamic acid promotes cardiomyocyte differentiation of rat mesenchymal stem cells.
Journal: Experimental cell research 20091015
Title: Hydroxamic acids as a novel family of serine racemase inhibitors: mechanistic analysis reveals different modes of interaction with the pyridoxal-5'-phosphate cofactor.
Journal: Journal of medicinal chemistry 20091008
Title: Phase I trial of vorinostat and doxorubicin in solid tumours: histone deacetylase 2 expression as a predictive marker.
Journal: British journal of cancer 20091006
Title: Abrogation of mitogen-activated protein kinase and Akt signaling by vandetanib synergistically potentiates histone deacetylase inhibitor-induced apoptosis in human glioma cells.
Journal: The Journal of pharmacology and experimental therapeutics 20091001
Title: Vorinostat interferes with Wnt and NF-kappaB pathways in the M-07e cell line.
Journal: Leukemia 20091001
Title: A novel histone deacetylase inhibitor, CG0006, induces cell death through both extrinsic and intrinsic apoptotic pathways.
Journal: Anti-cancer drugs 20091001
Title: Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20091001
Title: Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20091001
Title: A phase 2 study of vorinostat in acute myeloid leukemia.
Journal: Haematologica 20091001
Title: Antidepressant actions of histone deacetylase inhibitors.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090916
Title: SAHA treatment overcomes the anti-apoptotic effects of Bcl-2 and is associated with the formation of mature PML nuclear bodies in human leukemic U937 cells.
Journal: Chemico-biological interactions 20090914
Title: Histone deacetylase inhibitors cooperate with IFN-gamma to restore caspase-8 expression and overcome TRAIL resistance in cancers with silencing of caspase-8.
Journal: Oncogene 20090903
Title: Inhibition of histone deacetylase suppresses EGF signaling pathways by destabilizing EGFR mRNA in ER-negative human breast cancer cells.
Journal: Breast cancer research and treatment 20090901
Title: Antitumor activity of suberoylanilide hydroxamic acid against human oral squamous cell carcinoma cell lines in vitro and in vivo.
Journal: Oral oncology 20090901
Title: Molecular sequelae of histone deacetylase inhibition in human retinoblastoma cell lines: clinical implications.
Journal: Investigative ophthalmology & visual science 20090901
Title: Initial testing (stage 1) of vorinostat (SAHA) by the pediatric preclinical testing program.
Journal: Pediatric blood & cancer 20090901
Title: Chemical induction of silent biosynthetic pathway transcription in Aspergillus niger.
Journal: Journal of industrial microbiology & biotechnology 20090901
Title: KLF4 suppresses HDACi induced caspase activation and the SAPK pathway by targeting p57(Kip2).
Journal: Apoptosis : an international journal on programmed cell death 20090901
Title: Cell cycle and apoptotic effects of SAHA are regulated by the cellular microenvironment in HCT116 multicellular tumour spheroids.
Journal: European journal of cancer (Oxford, England : 1990) 20090901
Title: Phase I and pharmacokinetic study of vorinostat (suberoylanilide hydroxamic acid) in Japanese patients with solid tumors.
Journal: Cancer science 20090901
Title: MLH1 protects from resistance acquisition by the histone deacetylase inhibitor trichostatin A in colon tumor cells.
Journal: International journal of oncology 20090901
Title: The histone deacetylase inhibitor suberoylanilide hydroxamic acid sensitises human hepatocellular carcinoma cells to TRAIL-induced apoptosis by TRAIL-DISC activation.
Journal: European journal of cancer (Oxford, England : 1990) 20090901
Title: Short communication: activation of latent HIV type 1 gene expression by suberoylanilide hydroxamic acid (SAHA), an HDAC inhibitor approved for use to treat cutaneous T cell lymphoma.
Journal: AIDS research and human retroviruses 20090901
Title: Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors.
Journal: Cancer research 20090901
Title: Suberoylanilide hydroxamic acid sensitizes human oral cancer cells to TRAIL-induced apoptosis through increase DR5 expression.
Journal: Molecular cancer therapeutics 20090901
Title: Vorinostat for the treatment of bullous pemphigoid in the setting of advanced, refractory cutaneous T-cell lymphoma.
Journal: Archives of dermatology 20090901
Title: The inhibitors of histone deacetylase suberoylanilide hydroxamate and trichostatin A release nitric oxide upon oxidation.
Journal: Free radical biology & medicine 20090815
Title: Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer.
Journal: Cancer research 20090815
Title: Phase I study of vorinostat in combination with bortezomib for relapsed and refractory multiple myeloma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090815
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Journal: Science (New York, N.Y.) 20090814
Title: Recent advances in the development of polyamine analogues as antitumor agents.
Journal: Journal of medicinal chemistry 20090813
Title: MeCP2 function in the basolateral amygdala in Rett syndrome.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090812
Title: Development of vorinostat: current applications and future perspectives for cancer therapy.
Journal: Cancer letters 20090808
Title: HDAC inhibitors: magic bullets, dirty drugs or just another targeted therapy.
Journal: Cancer letters 20090808
Title: Histone deacetylase inhibitors as anti-neoplastic agents.
Journal: Cancer letters 20090808
Title: Enhancing the apoptotic and therapeutic effects of HDAC inhibitors.
Journal: Cancer letters 20090808
Title: The proteasome inhibitor bortezomib interacts synergistically with the histone deacetylase inhibitor suberoylanilide hydroxamic acid to induce T-leukemia/lymphoma cells apoptosis.
Journal: Leukemia 20090801
Title: Sorafenib and vorinostat kill colon cancer cells by CD95-dependent and -independent mechanisms.
Journal: Molecular pharmacology 20090801
Title: BCL-2 family inhibitors enhance histone deacetylase inhibitor and sorafenib lethality via autophagy and overcome blockade of the extrinsic pathway to facilitate killing.
Journal: Molecular pharmacology 20090801
Title: HDAC inhibitor-based therapies and haematological malignancy.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20090801
Title: Histone modifier, the gatekeeper of good memory.
Journal: Cell research 20090801
Title: In vitro evaluation of histone deacetylase inhibitors as combination agents for colorectal cancer.
Journal: Anticancer research 20090801
Title: Histone deacetylase inhibitors suppress thymidylate synthase gene expression and synergize with the fluoropyrimidines in colon cancer cells.
Journal: International journal of cancer 20090715
Title: Molecular modifications on carboxylic acid derivatives as potent histone deacetylase inhibitors: Activity and docking studies.
Journal: Bioorganic & medicinal chemistry 20090715
Title: Clinical efficacy of vorinostat in a patient with essential thrombocytosis and subsequent myelofibrosis.
Journal: Annals of hematology 20090701
Title: Suberoylanilide hydroxamic acid: a potential epigenetic therapeutic agent for lung fibrosis?
Journal: The European respiratory journal 20090701
Title: Novel therapies for peripheral T-cell non-Hodgkin's lymphomas.
Journal: Current opinion in hematology 20090701
Title: Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer.
Journal: Cancer biology & therapy 20090701
Title: Co-treatment with heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and vorinostat: a highly active combination against human mantle cell lymphoma (MCL) cells.
Journal: Cancer biology & therapy 20090701
Title: Epigenetic modulation and attacking the hedgehog pathway: potentially synergistic therapeutic targets for pancreatic cancer.
Journal: Cancer biology & therapy 20090701
Title: Histone deacetylase inhibitors: Potential in cancer therapy.
Journal: Journal of cellular biochemistry 20090701
Title: Suberoylanilide hydroxamic acid (SAHA) changes microRNA expression profiles in A549 human non-small cell lung cancer cells.
Journal: International journal of molecular medicine 20090701
Title: A novel regimen of vorinostat with interferon gamma for refractory Sézary syndrome.
Journal: Journal of the American Academy of Dermatology 20090701
Title: Clinical roundtable monograph. Combination therapies for MDS.
Journal: Clinical advances in hematology & oncology : H&O 20090701
Title: Epigenetic modifiers: basic understanding and clinical development.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090615
Title: Clinical studies of histone deacetylase inhibitors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090615
Title: Discovery of a potent class I selective ketone histone deacetylase inhibitor with antitumor activity in vivo and optimized pharmacokinetic properties.
Journal: Journal of medicinal chemistry 20090611
Title: Pharmacokinetics and tissue distribution of Kendine 91, a novel histone deacetylase inhibitor, in mice.
Journal: Cancer chemotherapy and pharmacology 20090601
Title: An apicomplexan ankyrin-repeat histone deacetylase with relatives in photosynthetic eukaryotes.
Journal: International journal for parasitology 20090601
Title: Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in cutaneous T cell lymphoma.
Journal: European journal of haematology 20090601
Title: Suberoylanilide hydroxamic acid (SAHA) induces growth arrest and apoptosis in pituitary adenoma cells.
Journal: Endocrine 20090601
Title: Acquired vorinostat resistance shows partial cross-resistance to 'second-generation' HDAC inhibitors and correlates with loss of histone acetylation and apoptosis but not with altered HDAC and HAT activities.
Journal: Anti-cancer drugs 20090601
Title: Histone deacetylase inhibitors with a primary amide zinc binding group display antitumor activity in xenograft model.
Journal: Bioorganic & medicinal chemistry letters 20090601
Title: Isoxazole moiety in the linker region of HDAC inhibitors adjacent to the Zn-chelating group: effects on HDAC biology and antiproliferative activity.
Journal: Bioorganic & medicinal chemistry letters 20090601
Title: Radiosensitization by SAHA in experimental colorectal carcinoma models-in vivo effects and relevance of histone acetylation status.
Journal: International journal of radiation oncology, biology, physics 20090601
Title: Histone deacetylase inhibitors induce a very broad, pleiotropic anticancer drug resistance phenotype in acute myeloid leukemia cells by modulation of multiple ABC transporter genes.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090601
Title: American Association for Cancer Research 100th Annual Meeting.
Journal: The Lancet. Oncology 20090601
Title: Vorinostat enhances the radiosensitivity of a breast cancer brain metastatic cell line grown in vitro and as intracranial xenografts.
Journal: Molecular cancer therapeutics 20090601
Title: Suberoylanilide hydroxamic acid (Zolinza/vorinostat) sensitizes TRAIL-resistant breast cancer cells orthotopically implanted in BALB/c nude mice.
Journal: Molecular cancer therapeutics 20090601
Title: Exploring bis-(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20090515
Title: Synthesis, biological evaluation, and molecular docking of Ugi products containing a zinc-chelating moiety as novel inhibitors of histone deacetylases.
Journal: Journal of medicinal chemistry 20090514
Title: Design, synthesis, and biological activity of boronic acid-based histone deacetylase inhibitors.
Journal: Journal of medicinal chemistry 20090514
Title: HDAC2 negatively regulates memory formation and synaptic plasticity.
Journal: Nature 20090507
Title: Histone deacetylase inhibitors promote apoptosis and senescence in human mesenchymal stem cells.
Journal: Stem cells and development 20090501
Title: Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.
Journal: European journal of medicinal chemistry 20090501
Title: Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain.
Journal: Molecular pharmacology 20090501
Title: Modulation of thymidilate synthase and p53 expression by HDAC inhibitor vorinostat resulted in synergistic antitumor effect in combination with 5FU or raltitrexed.
Journal: Cancer biology & therapy 20090501
Title: Efficient continuous flow synthesis of hydroxamic acids and suberoylanilide hydroxamic acid preparation.
Journal: The Journal of organic chemistry 20090501
Title: A phase I, pharmacokinetic and pharmacodynamic study on vorinostat in combination with 5-fluorouracil, leucovorin, and oxaliplatin in patients with refractory colorectal cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090501
Title: Targeted therapies for renal cell carcinoma: more gains from using them again.
Journal: Current oncology (Toronto, Ont.) 20090501
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20090501
Title: Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells.
Journal: Blood 20090430
Title: Cotreatment with BCL-2 antagonist sensitizes cutaneous T-cell lymphoma to lethal action of HDAC7-Nur77-based mechanism.
Journal: Blood 20090423
Title: Design of chimeric histone deacetylase- and tyrosine kinase-inhibitors: a series of imatinib hybrides as potent inhibitors of wild-type and mutant BCR-ABL, PDGF-Rbeta, and histone deacetylases.
Journal: Journal of medicinal chemistry 20090423
Title: Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum.
Journal: Journal of medicinal chemistry 20090423
Title: Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090420
Title: Valproate, in combination with pemetrexed and cisplatin, provides additional efficacy to the treatment of malignant mesothelioma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090415
Title: Zn(II)-dependent histone deacetylase inhibitors: suberoylanilide hydroxamic acid and trichostatin A.
Journal: The international journal of biochemistry & cell biology 20090401
Title: ErbB-3 expression is associated with E-cadherin and their coexpression restores response to gefitinib in non-small-cell lung cancer (NSCLC).
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20090401
Title: Characterization of UGTs active against SAHA and association between SAHA glucuronidation activity phenotype with UGT genotype.
Journal: Cancer research 20090401
Title: Evaluation of 6-([(18)F]fluoroacetamido)-1-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain.
Journal: Nuclear medicine and biology 20090401
Title: Variations in c-Myc and p21WAF1 expression protect normal peripheral blood lymphocytes against BimEL-mediated cell death.
Journal: Cell biochemistry and function 20090401
Title: Melding a New 3-Dimensional Agarose Colony Assay with the E(max) Model to Determine the Effects of Drug Combinations on Cancer Cells.
Journal: Technology in cancer research & treatment 20090401
Title: MeCP2-mediated transcription repression in the basolateral amygdala may underlie heightened anxiety in a mouse model of Rett syndrome.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090401
Title: Vorinostat (NSC# 701852) in patients with relapsed non-small cell lung cancer: a Wisconsin Oncology Network phase II study.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20090401
Title: A kernel for open source drug discovery in tropical diseases.
Journal: PLoS neglected tropical diseases 20090401
Title: Regulation of adipocyte differentiation by histone deacetylase inhibitors.
Journal: Archives of pharmacal research 20090401
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20090401
Title: HDAC6 modulates Hsp90 chaperone activity and regulates activation of aryl hydrocarbon receptor signaling.
Journal: The Journal of biological chemistry 20090320
Title: Identification of (1H)-pyrroles as histone deacetylase inhibitors with antitumoral activity.
Journal: Oncogene 20090319
Title: Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives.
Journal: Bioorganic & medicinal chemistry 20090315
Title: Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells.
Journal: The Journal of biological chemistry 20090313
Title: Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20090301
Title: Elevated NCOR1 disrupts a network of dietary-sensing nuclear receptors in bladder cancer cells.
Journal: Carcinogenesis 20090301
Title: Preclinical studies of vorinostat (suberoylanilide hydroxamic acid) combined with cytosine arabinoside and etoposide for treatment of acute leukemias.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090301
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20090301
Title: Defining the target specificity of ABT-737 and synergistic antitumor activities in combination with histone deacetylase inhibitors.
Journal: Blood 20090226
Title: Epigenetic regulation and molecular characterization of C/EBPalpha in pancreatic cancer cells.
Journal: International journal of cancer 20090215
Title: Vorinostat and bortezomib exert synergistic antiproliferative and proapoptotic effects in colon cancer cell models.
Journal: Molecular cancer therapeutics 20090201
Title: Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid.
Journal: AIDS research and human retroviruses 20090201
Title: The anticancer effect of histone deacetylase inhibitors and combination with the cytotoxic agents in lung cancer cells: biological analyses for future clinical application.
Journal: Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 20090201
Title: High-throughput screening compatible cell-based assay for interrogating activated notch signaling.
Journal: Assay and drug development technologies 20090201
Title: Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition.
Journal: Human molecular genetics 20090115
Title: Sulfamides as novel histone deacetylase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20090115
Title: Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090115
Title: A phase I-II study of the histone deacetylase inhibitor valproic acid plus chemoimmunotherapy in patients with advanced melanoma.
Journal: British journal of cancer 20090113
Title: Lack of therapeutic effect of the histone deacetylase inhibitor vorinostat in patients with metastatic radioiodine-refractory thyroid carcinoma.
Journal: The Journal of clinical endocrinology and metabolism 20090101
Title: Structure-activity relationship studies of novel oxygen-incorporated SAHA analogues.
Journal: Archives of pharmacal research 20090101
Title: Targeting histone deacetylases in neuroblastoma.
Journal: Current pharmaceutical design 20090101
Title: Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy.
Journal: Molecular cancer 20090101
Title: Toxicity of targeted therapy in non-small-cell lung cancer management.
Journal: Clinical lung cancer 20090101
Title: Assays for histone deacetylases.
Journal: Current topics in medicinal chemistry 20090101
Title: Non-cancer uses of histone deacetylase inhibitors: effects on infectious diseases and beta-hemoglobinopathies.
Journal: Current topics in medicinal chemistry 20090101
Title: Induction of Foxp3+ regulatory T cells with histone deacetylase inhibitors.
Journal: Cellular immunology 20090101
Title: New clinical developments in histone deacetylase inhibitors for epigenetic therapy of cancer.
Journal: Journal of hematology & oncology 20090101
Title: 'Shock and kill' effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence.
Journal: Retrovirology 20090101
Title: Synergistic activation of HIV-1 expression by deacetylase inhibitors and prostratin: implications for treatment of latent infection.
Journal: PloS one 20090101
Title: Vorinostat in solid and hematologic malignancies.
Journal: Journal of hematology & oncology 20090101
Title: Cyclophosphamide chemotherapy sensitizes tumor cells to TRAIL-dependent CD8 T cell-mediated immune attack resulting in suppression of tumor growth.
Journal: PloS one 20090101
Title: Anti-leukemia activity of MS-275 histone deacetylase inhibitor implicates 4-1BBL/4-1BB immunomodulatory functions.
Journal: PloS one 20090101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20090101
Title: Aurora-A down-regulates IkappaBalpha via Akt activation and interacts with insulin-like growth factor-1 induced phosphatidylinositol 3-kinase pathway for cancer cell survival.
Journal: Molecular cancer 20090101
Title: High class I HDAC activity and expression are associated with RelA/p65 activation in pancreatic cancer in vitro and in vivo.
Journal: BMC cancer 20090101
Title: DNA microarray profiling of genes differentially regulated by the histone deacetylase inhibitors vorinostat and LBH589 in colon cancer cell lines.
Journal: BMC medical genomics 20090101
Title: Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies.
Journal: Retrovirology 20090101
Title: Managing myelodysplastic symptoms in elderly patients.
Journal: Clinical interventions in aging 20090101
Title: Targeted therapy in the treatment of malignant gliomas.
Journal: OncoTargets and therapy 20090101
Title: Lenalidomide in multiple myeloma: an evidence-based review of its role in therapy.
Journal: Core evidence 20090101
Title: Effects of a selection of histone deacetylase inhibitors on mast cell activation and airway and colonic smooth muscle contraction.
Journal: International immunopharmacology 20081220
Title: Histone deacetylase inhibitors through click chemistry.
Journal: Journal of medicinal chemistry 20081211
Title: HDAC inhibition upregulates the expression of angiostatic ADAMTS1.
Journal: FEBS letters 20081210
Title: Histone deacetylase inhibitors sensitize tumour cells for cytotoxic effects of natural killer cells.
Journal: Cancer letters 20081208
Title: Blocking TH17-polarizing cytokines by histone deacetylase inhibitors in vitro and in vivo.
Journal: Journal of leukocyte biology 20081201
Title: Drug Insight: histone deacetylase inhibitor-based therapies for cutaneous T-cell lymphomas.
Journal: Nature clinical practice. Oncology 20081201
Title: SAHA induces caspase-independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathway.
Journal: The Journal of pathology 20081201
Title: Molecular biology and targeted therapy of cutaneous T-cell lymphomas.
Journal: Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 20081201
Title: Proteomic analysis of cervical cancer cells treated with suberonylanilide hydroxamic acid.
Journal: Journal of biosciences 20081201
Title: Denileukin diftitox for the treatment of cutaneous T-cell lymphoma.
Journal: Biologics : targets & therapy 20081201
Title: Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases.
Journal: Journal of medicinal chemistry 20081127
Title: Inactivation of NF-kappaB by proteasome inhibition contributes to increased apoptosis induced by histone deacetylase inhibitors in human breast cancer cells.
Journal: Breast cancer research and treatment 20081101
Title: Sensitization of RPE cells by alphaB-crystallin siRNA to SAHA-induced stage 1 apoptosis through abolishing the association of alphaB-crystallin with HDAC1 in SC35 speckles.
Journal: Investigative ophthalmology & visual science 20081101
Title: A multiple-loop, double-cube microarray design applied to prostate cancer cell lines with variable sensitivity to histone deacetylase inhibitors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20081101
Title: A phase II trial of vorinostat (suberoylanilide hydroxamic acid) in metastatic breast cancer: a California Cancer Consortium study.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20081101
Title: Comparative molecular dynamics simulations of histone deacetylase-like protein: binding modes and free energy analysis to hydroxamic acid inhibitors.
Journal: Proteins 20081001
Title: The potential role of histone deacetylase inhibitors in the treatment of non-small-cell lung cancer.
Journal: Critical reviews in oncology/hematology 20081001
Title: Early phase II trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer.
Journal: Investigational new drugs 20081001
Title: Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA.
Journal: Blood 20081001
Title: Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells.
Journal: Blood 20081001
Title: HDAC-class II specific inhibition involves HDAC proteasome-dependent degradation mediated by RANBP2.
Journal: Biochimica et biophysica acta 20081001
Title: Regulation of autophagy by ceramide-CD95-PERK signaling.
Journal: Autophagy 20081001
Title: Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment.
Journal: Cancer biology & therapy 20081001
Title: Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation.
Journal: Cancer biology & therapy 20081001
Title: Treatment of cutaneous T-cell lymphoma: focus on vorinostat.
Journal: Journal of the American Academy of Dermatology 20081001
Title: Future directions in myelodysplastic syndrome: newer agents and the role of combination approaches.
Journal: Cancer control : journal of the Moffitt Cancer Center 20081001
Title: Histone deacetylase inhibitors: apoptotic effects and clinical implications (Review).
Journal: International journal of oncology 20081001
Title: Cotreatment with vorinostat enhances activity of MK-0457 (VX-680) against acute and chronic myelogenous leukemia cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20081001
Title: [Epigenetics in hematological disorders].
Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology 20081001
Title: Histone deacetylase inhibitors as novel anticancer therapeutics.
Journal: Current oncology (Toronto, Ont.) 20081001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20081001
Title: Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents.
Journal: Bioorganic & medicinal chemistry letters 20080915
Title: Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?
Journal: British journal of cancer 20080902
Title: Synthesis of benzamides related to anacardic acid and their histone acetyltransferase (HAT) inhibitory activities.
Journal: ChemMedChem 20080901
Title: In vitro plasma stability, permeability and solubility of mercaptoacetamide histone deacetylase inhibitors.
Journal: International journal of pharmaceutics 20080901
Title: Suberoyl bishydroxamic acid activates notch1 signaling and suppresses tumor progression in an animal model of medullary thyroid carcinoma.
Journal: Annals of surgical oncology 20080901
Title: Prognostic significance of the therapeutic targets histone deacetylase 1, 2, 6 and acetylated histone H4 in cutaneous T-cell lymphoma.
Journal: Histopathology 20080901
Title: Aurora A, Aurora B and survivin are novel targets of transcriptional regulation by histone deacetylase inhibitors in non-small cell lung cancer.
Journal: Cancer biology & therapy 20080901
Title: Recent advances in the treatment of malignant pleural mesothelioma.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20080901
Title: Vorinostat and sorafenib synergistically kill tumor cells via FLIP suppression and CD95 activation.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080901
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20080901
Title: Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor.
Journal: Journal of the American Chemical Society 20080820
Title: Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines.
Journal: Blood 20080815
Title: Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.
Journal: Journal of medicinal chemistry 20080814
Title: Vorinostat synergistically potentiates MK-0457 lethality in chronic myelogenous leukemia cells sensitive and resistant to imatinib mesylate.
Journal: Blood 20080801
Title: The role of oxidative stress in apoptosis induced by the histone deacetylase inhibitor suberoylanilide hydroxamic acid in human colon adenocarcinoma HT-29 cells.
Journal: International journal of oncology 20080801
Title: Acetylation: a novel method for modulation of the immune response following trauma/hemorrhage and inflammatory second hit in animals and humans.
Journal: Surgery 20080801
Title: Differential responsiveness of human hepatoma cells versus normal hepatocytes to TRAIL in combination with either histone deacetylase inhibitors or conventional cytostatics.
Journal: Cancer science 20080801
Title: Epigenetic silencing of AXIN2/betaTrCP and deregulation of p53-mediated control lead to wild-type beta-catenin nuclear accumulation in lung tumorigenesis.
Journal: Oncogene 20080724
Title: Experimental design and interaction analysis of combination studies of drugs with log-linear dose responses.
Journal: Statistics in medicine 20080720
Title: Trithiocarbonates as a novel class of HDAC inhibitors: SAR studies, isoenzyme selectivity, and pharmacological profiles.
Journal: Journal of medicinal chemistry 20080710
Title: Proteomic analysis identifies protein targets responsible for depsipeptide sensitivity in tumor cells.
Journal: Journal of proteome research 20080701
Title: Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase-dependent DC functions and regulates experimental graft-versus-host disease in mice.
Journal: The Journal of clinical investigation 20080701
Title: Isoform-selective histone deacetylase inhibitors.
Journal: Chemical Society reviews 20080701
Title: Histone deacetylase inhibitors and aspirin interact synergistically to induce cell death in ovarian cancer cells.
Journal: Oncology reports 20080701
Title: Evaluation of the effects of histone deacetylase inhibitors on cells from canine cancer cell lines.
Journal: American journal of veterinary research 20080701
Title: Antitumor activity of histone deacetylase inhibitors in non-small cell lung cancer cells: development of a molecular predictive model.
Journal: Molecular cancer therapeutics 20080701
Title: Histone deacetylase inhibitors: mechanism of action and therapeutic use in cancer.
Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20080701
Title: Targeted treatment and new agents in diffuse large B-cell lymphoma.
Journal: Seminars in hematology 20080701
Title: A series of potent and selective, triazolylphenyl-based histone deacetylases inhibitors with activity against pancreatic cancer cells and Plasmodium falciparum.
Journal: Journal of medicinal chemistry 20080626
Title: Induction of apoptosis in renal tubular cells by histone deacetylase inhibitors, a family of anticancer agents.
Journal: The Journal of pharmacology and experimental therapeutics 20080601
Title: Epigenetic treatment of myelodysplastic syndromes and acute myeloid leukemias.
Journal: Current medicinal chemistry 20080601
Title: Targeting autophagy: a novel anticancer strategy with therapeutic implications for imatinib resistance.
Journal: Biologics : targets & therapy 20080601
Title: The use of diversity profiling to characterize chemical modulators of the histone deacetylases.
Journal: Life sciences 20080523
Title: Structural origin of selectivity in class II-selective histone deacetylase inhibitors.
Journal: Journal of medicinal chemistry 20080522
Title: Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphoma.
Journal: Cancer research 20080515
Title: OSU-HDAC42, a histone deacetylase inhibitor, blocks prostate tumor progression in the transgenic adenocarcinoma of the mouse prostate model.
Journal: Cancer research 20080515
Title: Evaluation of the in vitro and in vivo antitumor activity of histone deacetylase inhibitors for the therapy of retinoblastoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080515
Title: Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice.
Journal: Gut 20080501
Title: A phase II study of vorinostat in the treatment of persistent or recurrent epithelial ovarian or primary peritoneal carcinoma: a Gynecologic Oncology Group study.
Journal: Gynecologic oncology 20080501
Title: Phase II trial of oral vorinostat (suberoylanilide hydroxamic acid) in relapsed diffuse large-B-cell lymphoma.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20080501
Title: Histone deacetylase inhibitor SAHA induces ERalpha degradation in breast cancer MCF-7 cells by CHIP-mediated ubiquitin pathway and inhibits survival signaling.
Journal: Biochemical pharmacology 20080501
Title: Synthesis and structure-activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group.
Journal: Bioorganic & medicinal chemistry 20080501
Title: Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases.
Journal: Bioorganic & medicinal chemistry letters 20080501
Title: Monitoring the effect of belinostat in solid tumors by H4 acetylation.
Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20080501
Title: KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo.
Journal: Molecular cancer therapeutics 20080501
Title: Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin.
Journal: Molecular cancer therapeutics 20080501
Title: Reprogramming epigenetic silencing: artificial transcription factors synergize with chromatin remodeling drugs to reactivate the tumor suppressor mammary serine protease inhibitor.
Journal: Molecular cancer therapeutics 20080501
Title: Complete clinical remission of tumor-stage mycosis fungoides after acute extensive skin necroses, granulomatous reaction, and fever under treatment with bexarotene, vorinostat, and high-dose fenofibrate.
Journal: Journal of the American Academy of Dermatology 20080501
Title: Polyaminohydroxamic acids and polyaminobenzamides as isoform selective histone deacetylase inhibitors.
Journal: Journal of medicinal chemistry 20080424
Title: Novel uracil-based 2-aminoanilide and 2-aminoanilide-like derivatives: histone deacetylase inhibition and in-cell activities.
Journal: Bioorganic & medicinal chemistry letters 20080415
Title: Proteomic analysis of liver cancer cells treated with suberonylanilide hydroxamic acid.
Journal: Cancer chemotherapy and pharmacology 20080401
Title: Response of preclinical medulloblastoma models to combination therapy with 13-cis retinoic acid and suberoylanilide hydroxamic acid (SAHA).
Journal: Journal of neuro-oncology 20080401
Title: Temsirolimus downregulates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma.
Journal: Experimental hematology 20080401
Title: Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2.
Journal: Cancer research 20080401
Title: Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of a novel histone deacetylase inhibitor, LAQ824, in human colon carcinoma cells and xenografts.
Journal: Neoplasia (New York, N.Y.) 20080401
Title: MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo.
Journal: Molecular cancer therapeutics 20080401
Title: HDAC inhibitor reduces cytokine storm and facilitates induction of chimerism that reverses lupus in anti-CD3 conditioning regimen.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20080325
Title: Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts.
Journal: Bioorganic & medicinal chemistry 20080315
Title: Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.
Journal: Bioorganic & medicinal chemistry letters 20080315
Title: Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode.
Journal: Journal of medicinal chemistry 20080313
Title: Vorinostat and bortezomib significantly inhibit WT1 gene expression in MO7-e and P39 cell lines.
Journal: Leukemia 20080301
Title: Combined effects of sulindac and suberoylanilide hydroxamic acid on apoptosis induction in human lung cancer cells.
Journal: Molecular pharmacology 20080301
Title: Histone deacetylase inhibitor treatment downregulates VLA-4 adhesion in hematopoietic stem cells and acute myeloid leukemia blast cells.
Journal: Haematologica 20080301
Title: Phase I trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) in patients with advanced multiple myeloma.
Journal: Leukemia & lymphoma 20080301
Title: Co-treatment of suberoylanilide hydroxamic acid and mitomycin-C induces the apoptosis of rabbit tenon's capsule fibroblast and improves the outcome of glaucoma filtration surgery.
Journal: Current eye research 20080301
Title: Histone deacetylase inhibitors in lymphoma and solid malignancies.
Journal: Expert review of anticancer therapy 20080301
Title: Effects of histone deacetylase inhibitor SAHA on effector and FOXP3+regulatory T cells in rhesus macaques.
Journal: Transplantation proceedings 20080301
Title: Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes.
Journal: Journal of the American Chemical Society 20080220
Title: Simultaneous determination of decitabine and vorinostat (Suberoylanalide hydroxamic acid, SAHA) by liquid chromatography tandem mass spectrometry for clinical studies.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080215
Title: Histone deacetylase inhibitors induce growth arrest and apoptosis of HTLV-1-infected T-cells via blockade of signaling by nuclear factor kappaB.
Journal: Leukemia research 20080201
Title: Phase II trial of the histone deacetylase inhibitor vorinostat (Zolinza, suberoylanilide hydroxamic acid, SAHA) in patients with recurrent and/or metastatic head and neck cancer.
Journal: Investigational new drugs 20080201
Title: Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes.
Journal: Blood 20080201
Title: Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in mantle cell lymphoma.
Journal: European journal of haematology 20080201
Title: Assessment of female and male fertility in Sprague-Dawley rats administered vorinostat, a histone deacetylase inhibitor.
Journal: Birth defects research. Part B, Developmental and reproductive toxicology 20080201
Title: Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors.
Journal: The Biochemical journal 20080115
Title: Autophagy induced by suberoylanilide hydroxamic acid in Hela S3 cells involves inhibition of protein kinase B and up-regulation of Beclin 1.
Journal: The international journal of biochemistry & cell biology 20080101
Title: Amino acid derivatives as histone deacetylase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20080101
Title: Histone deacetylase inhibitors induce in human hepatoma HepG2 cells acetylation of p53 and histones in correlation with apoptotic effects.
Journal: International journal of oncology 20080101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20080101
Title: EWS/FLI mediates transcriptional repression via NKX2.2 during oncogenic transformation in Ewing's sarcoma.
Journal: PloS one 20080101
Title: A simple and robust method for connecting small-molecule drugs using gene-expression signatures.
Journal: BMC bioinformatics 20080101
Title: Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells.
Journal: Molecular cancer 20080101
Title: Phenylhexyl isothiocyanate has dual function as histone deacetylase inhibitor and hypomethylating agent and can inhibit myeloma cell growth by targeting critical pathways.
Journal: Journal of hematology & oncology 20080101
Title: Suberoylanilide hydroxamic acid (SAHA) induces apoptosis or autophagy-associated cell death in chondrosarcoma cell lines.
Journal: Anticancer research 20080101
Title: Prostate 25-hydroxyvitamin D-1alpha-hydroxylase is up-regulated by suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor.
Journal: Anticancer research 20080101
Title: FDG-PET/CT for the evaluation of response to therapy of cutaneous T-cell lymphoma to vorinostat (suberoylanilide hydroxamic acid, SAHA) in a phase II trial.
Journal: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20080101
Title: Differential effects of class I isoform histone deacetylase depletion and enzymatic inhibition by belinostat or valproic acid in HeLa cells.
Journal: Molecular cancer 20080101
Title: Gateways to clinical trials. July-August 2008.
Journal: Methods and findings in experimental and clinical pharmacology 20080101
Title: Targeting histone deacetylase activity in rheumatoid arthritis and asthma as prototypes of inflammatory disease: should we keep our HATs on?
Journal: Arthritis research & therapy 20080101
Title: Ovarian cancer plasticity and epigenomics in the acquisition of a stem-like phenotype.
Journal: Journal of ovarian research 20080101
Title: Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer.
Journal: BMC cancer 20080101
Title: A Single Institution's Experience with Bevacizumab in Combination with Cytotoxic Chemotherapy in Progressive Malignant Glioma.
Journal: Clinical medicine. Oncology 20080101
Title: Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment.
Journal: Journal of medicinal chemistry 20071227
Title: Mechanisms of resistance to histone deacetylase inhibitors and their therapeutic implications.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20071215
Title: Histone deacetylase inhibitors decrease Toll-like receptor-mediated activation of proinflammatory gene expression by impairing transcription factor recruitment.
Journal: Immunology 20071201
Title: Combined effects of histone deacetylase inhibitor and rituximab on non-Hodgkin's B-lymphoma cells apoptosis.
Journal: Experimental hematology 20071201
Title: Epigenetic regulation of chemosensitivity to 5-fluorouracil and cisplatin by zebularine in oral squamous cell carcinoma.
Journal: International journal of oncology 20071201
Title: Anti-estrogenic actions of histone deacetylase inhibitors in MCF-7 breast cancer cells.
Journal: Endocrine-related cancer 20071201
Title: Histone deacetylase inhibitors promote the tumoricidal effect of HAMLET.
Journal: Cancer research 20071201
Title: Epigenetic regulation as a new target for breast cancer therapy.
Journal: Cancer investigation 20071201
Title: Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells.
Journal: Molecular cancer therapeutics 20071201
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20071201
Title: Update on the treatment of cutaneous T-cell lymphoma (CTCL): Focus on vorinostat.
Journal: Biologics : targets & therapy 20071201
Title: Targeted therapies in the management of metastatic bladder cancer.
Journal: Biologics : targets & therapy 20071201
Title: R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies.
Journal: British journal of cancer 20071119
Title: Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence.
Journal: Bioorganic & medicinal chemistry letters 20071115
Title: Antiproliferative activities of a library of hybrids between indanones and HDAC inhibitor SAHA and MS-275 analogues.
Journal: Bioorganic & medicinal chemistry letters 20071115
Title: Modification of cap group in delta-lactam-based histone deacetylase (HDAC) inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20071115
Title: The first biologically active synthetic analogues of FK228, the depsipeptide histone deacetylase inhibitor.
Journal: Journal of medicinal chemistry 20071115
Title: Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli.
Journal: Neuron 20071108
Title: Histone deacetylase inhibitors induce cell death and enhance the apoptosis-inducing activity of TRAIL in Ewing's sarcoma cells.
Journal: Journal of cancer research and clinical oncology 20071101
Title: Histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis through both mitochondrial and Fas (Cd95) signaling in head and neck squamous carcinoma cells.
Journal: Molecular cancer therapeutics 20071101
Title: Synergistic activity of the histone deacetylase inhibitor suberoylanilide hydroxamic acid and the bisphosphonate zoledronic acid against prostate cancer cells in vitro.
Journal: Molecular cancer therapeutics 20071101
Title: Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cells.
Journal: Blood 20071001
Title: Efficacy of a novel histone deacetylase inhibitor in murine models of hepatocellular carcinoma.
Journal: Hepatology (Baltimore, Md.) 20071001
Title: Comment on developmental toxicity evaluation on Vorinostat and relationship with HDAC inhibition.
Journal: Birth defects research. Part B, Developmental and reproductive toxicology 20071001
Title: Histone deacetylase inhibitor-induced glycodelin enhances the initial step of implantation.
Journal: Human reproduction (Oxford, England) 20071001
Title: Epigenetic alterations and cancer: new targets for therapy.
Journal: IDrugs : the investigational drugs journal 20071001
Title: FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma.
Journal: The oncologist 20071001
Title: Histone deacetylase inhibitors.
Journal: Oncology (Williston Park, N.Y.) 20071001
Title: 2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide substructures as a novel series of rationally designed histone deacetylase inhibitors.
Journal: Journal of medicinal chemistry 20070906
Title: HDAC inhibitors: clinical update and mechanism-based potential.
Journal: Biochemical pharmacology 20070901
Title: Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20070901
Title: Trithiocarbonates: exploration of a new head group for HDAC inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20070901
Title: Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera.
Journal: Bioorganic & medicinal chemistry letters 20070901
Title: The histone deacetylase inhibitors suberoylanilide hydroxamic (Vorinostat) and valproic acid induce irreversible and MDR1-independent resistance in human colon cancer cells.
Journal: International journal of oncology 20070901
Title: Histone deacetylase inhibitors selectively suppress expression of HDAC7.
Journal: Molecular cancer therapeutics 20070901
Title: Vorinostat in cutaneous T-cell lymphoma.
Journal: Drugs of today (Barcelona, Spain : 1998) 20070901
Title: Design of novel histone deacetylase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20070815
Title: Hydroxamic acid analogue histone deacetylase inhibitors attenuate estrogen receptor-alpha levels and transcriptional activity: a result of hyperacetylation and inhibition of chaperone function of heat shock protein 90.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070815
Title: Histone deacetylase inhibitors: molecular mechanisms of action.
Journal: Oncogene 20070813
Title: Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (Vorinostat, SAHA) profoundly inhibits the growth of human pancreatic cancer cells.
Journal: International journal of cancer 20070801
Title: Novel role of HDAC inhibitors in AML1/ETO AML cells: activation of apoptosis and phagocytosis through induction of annexin A1.
Journal: Cell death and differentiation 20070801
Title: Phase IIb multicenter trial of vorinostat in patients with persistent, progressive, or treatment refractory cutaneous T-cell lymphoma.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070720
Title: Aminosuberoyl hydroxamic acids (ASHAs): a potent new class of HDAC inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20070715
Title: Synergistic interactions between vorinostat and sorafenib in chronic myelogenous leukemia cells involve Mcl-1 and p21CIP1 down-regulation.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070715
Title: Continuous intracranial administration of suberoylanilide hydroxamic acid (SAHA) inhibits tumor growth in an orthotopic glioma model.
Journal: Journal of neuro-oncology 20070701
Title: SAHA induces apoptosis in hepatoma cells and synergistically interacts with the proteasome inhibitor Bortezomib.
Journal: Apoptosis : an international journal on programmed cell death 20070701
Title: Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance.
Journal: Blood 20070701
Title: Vorinostat: a new oral histone deacetylase inhibitor approved for cutaneous T-cell lymphoma.
Journal: Expert opinion on investigational drugs 20070701
Title: A brief primer on treatments of cutaneous T cell lymphoma, newly approved or late in development.
Journal: Journal of drugs in dermatology : JDD 20070701
Title: Enhancement of cisplatin induced apoptosis by suberoylanilide hydroxamic acid in human oral squamous cell carcinoma cell lines.
Journal: Biochemical pharmacology 20070615
Title: Phase I and pharmacokinetic study of vorinostat, a histone deacetylase inhibitor, in combination with carboplatin and paclitaxel for advanced solid malignancies.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070615
Title: Histone deacetylase inhibitors--turning epigenic mechanisms of gene regulation into tools of therapeutic intervention in malignant and other diseases.
Journal: Applied microbiology and biotechnology 20070601
Title: Combined treatment with Ad-hTRAIL and DTIC or SAHA is associated with increased mitochondrial-mediated apoptosis in human melanoma cell lines.
Journal: The journal of gene medicine 20070601
Title: Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest.
Journal: International journal of oncology 20070601
Title: Histone deacetylase as therapeutic target in a rodent model of hemorrhagic shock: effect of different resuscitation strategies on lung and liver.
Journal: Surgery 20070601
Title: Scriptaid and suberoylanilide hydroxamic acid are histone deacetylase inhibitors with potent anti-Toxoplasma gondii activity in vitro.
Journal: The Journal of parasitology 20070601
Title: Bispyridinium dienes: histone deacetylase inhibitors with selective activities.
Journal: Journal of medicinal chemistry 20070517
Title: Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20070515
Title: Epigenetic combination therapy as a tumor-selective treatment approach for hepatocellular carcinoma.
Journal: Cancer 20070515
Title: Discovery of epigenetically silenced genes in acute myeloid leukemias.
Journal: Leukemia 20070501
Title: Drug-induced inactivation or gene silencing of class I histone deacetylases suppresses ovarian cancer cell growth: implications for therapy.
Journal: Cancer biology & therapy 20070501
Title: Chemosensitization of oral squamous cell carcinoma cells to cisplatin by histone deacetylase inhibitor, suberoylanilide hydroxamic acid.
Journal: International journal of oncology 20070501
Title: In vitro phase I cytochrome P450 metabolism, permeability and pharmacokinetics of SB639, a novel histone deacetylase inhibitor in preclinical species.
Journal: Biological & pharmaceutical bulletin 20070501
Title: Structural requirements of HDAC inhibitors: SAHA analogs functionalized adjacent to the hydroxamic acid.
Journal: Bioorganic & medicinal chemistry letters 20070415
Title: Vorinostat for treatment of cutaneous manifestations of advanced primary cutaneous T-cell lymphoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070415
Title: Histone deacetylase inhibitors suppress natural killer cell cytolytic activity.
Journal: FEBS letters 20070403
Title: Contribution of reactivated RUNX3 to inhibition of gastric cancer cell growth following suberoylanilide hydroxamic acid (vorinostat) treatment.
Journal: Biochemical pharmacology 20070401
Title: Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents.
Journal: British journal of pharmacology 20070401
Title: Combined effects of retinoic acid and histone deacetylase inhibitors on human neuroblastoma SH-SY5Y cells.
Journal: Molecular cancer therapeutics 20070401
Title: Targeted therapy and the T315I mutation in Philadelphia-positive leukemias.
Journal: Haematologica 20070401
Title: [Histone deacetylase inhibitor SAHA induces inactivation of MAPK signaling and apoptosis in HL-60 cells].
Journal: Zhongguo shi yan xue ye xue za zhi 20070401
Title: Disposition of vorinostat, a novel histone deacetylase inhibitor and anticancer agent, in preclinical species.
Journal: Drug metabolism letters 20070401
Title: Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20070328
Title: Vorinostat (Zolinza) for cutaneous T-Cell lymphoma.
Journal: The Medical letter on drugs and therapeutics 20070312
Title: In vitro and in vivo histone deacetylase inhibitor therapy with suberoylanilide hydroxamic acid (SAHA) and paclitaxel in ovarian cancer.
Journal: Gynecologic oncology 20070301
Title: Discovery of uracil-based histone deacetylase inhibitors able to reduce acquired antifungal resistance and trailing growth in Candida albicans.
Journal: Bioorganic & medicinal chemistry letters 20070301
Title: Discovery and development of SAHA as an anticancer agent.
Journal: Oncogene 20070226
Title: Synthesis and biological evaluation of the suberoylanilide hydroxamic acid (SAHA) beta-glucuronide and beta-galactoside for application in selective prodrug chemotherapy.
Journal: Bioorganic & medicinal chemistry letters 20070215
Title: Histone deacetylase inhibitors stimulate cell migration in human endometrial adenocarcinoma cells through up-regulation of glycodelin.
Journal: Endocrinology 20070201
Title: Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma.
Journal: Leukemia 20070201
Title: Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor: effects on gene expression and growth of glioma cells in vitro and in vivo.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070201
Title: Assessment of developmental toxicity of vorinostat, a histone deacetylase inhibitor, in Sprague-Dawley rats and Dutch Belted rabbits.
Journal: Birth defects research. Part B, Developmental and reproductive toxicology 20070201
Title: Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions.
Journal: Molecular cancer therapeutics 20070201
Title: Systemic monotherapy vs combination therapy for CTCL: rationale and future strategies.
Journal: Oncology (Williston Park, N.Y.) 20070201
Title: Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20070115
Title: Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20070115
Title: Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL).
Journal: Blood 20070101
Title: Apoptosis, proliferation and differentiation patterns are influenced by Zebularine and SAHA in pancreatic cancer models.
Journal: Scandinavian journal of gastroenterology 20070101
Title: The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces growth inhibition and enhances gemcitabine-induced cell death in pancreatic cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070101
Title: HDAC inhibitors overcome first hurdle.
Journal: Nature biotechnology 20070101
Title: Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug.
Journal: Nature biotechnology 20070101
Title: Suberoylanilide hydroxamic acid (vorinostat) represses androgen receptor expression and acts synergistically with an androgen receptor antagonist to inhibit prostate cancer cell proliferation.
Journal: Molecular cancer therapeutics 20070101
Title: Vorinostat.
Journal: Nature reviews. Drug discovery 20070101
Title: c-Myc overexpression sensitizes Bim-mediated Bax activation for apoptosis induced by histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through regulating Bcl-2/Bcl-xL expression.
Journal: The international journal of biochemistry & cell biology 20070101
Title: New skin cancer drug.
Journal: FDA consumer 20070101
Title: Modulating autophagy for therapeutic benefit.
Journal: Autophagy 20070101
Title: HDAC inhibitors induce apoptosis in glucocorticoid-resistant acute lymphatic leukemia cells despite a switch from the extrinsic to the intrinsic death pathway.
Journal: The international journal of biochemistry & cell biology 20070101
Title: Protein kinase C-alpha antagonizes apoptosis induction by histone deacetylase inhibitors in multidrug resistant leukaemia cells.
Journal: The international journal of biochemistry & cell biology 20070101
Title: The histone deacetylase inhibitor belinostat (PXD101) suppresses bladder cancer cell growth in vitro and in vivo.
Journal: Journal of translational medicine 20070101
Title: Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain.
Journal: Molecular pharmacology 20061201
Title: A study to determine the effects of food and multiple dosing on the pharmacokinetics of vorinostat given orally to patients with advanced cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20061201
Title: Histone deacetylase inhibitor enhances 5-fluorouracil cytotoxicity by down-regulating thymidylate synthase in human cancer cells.
Journal: Molecular cancer therapeutics 20061201
Title: Treatment of cutaneous T-cell lymphoma/mycosis fungoides.
Journal: Dermatology nursing 20061201
Title: Stability studies of vorinostat and its two metabolites in human plasma, serum and urine.
Journal: Journal of pharmaceutical and biomedical analysis 20061116
Title: Vorinostat approved for rare lymphoma.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20061115
Title: Histone deacetylase inhibitors induce cell death in supratentorial primitive neuroectodermal tumor cells.
Journal: Oncology reports 20061101
Title: Suberoylanilide hydroxamic acid induces Akt-mediated phosphorylation of p300, which promotes acetylation and transcriptional activation of RelA/p65.
Journal: The Journal of biological chemistry 20061020
Title: Epigenetic cancer therapy makes headway.
Journal: Journal of the National Cancer Institute 20061018
Title: Synthesis of rigid trichostatin A analogs as HDAC inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20061015
Title: Synthesis and biological properties of novel, uracil-containing histone deacetylase inhibitors.
Journal: Journal of medicinal chemistry 20061005
Title: PML-RARalpha and AML1-ETO translocations are rarely associated with methylation of the RARbeta2 promoter.
Journal: Annals of hematology 20061001
Title: Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia.
Journal: Nature chemical biology 20061001
Title: Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20061001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20061001
Title: Exploring alternative Zn-binding groups in the design of HDAC inhibitors: squaric acid, N-hydroxyurea, and oxazoline analogues of SAHA.
Journal: Bioorganic & medicinal chemistry letters 20060915
Title: Adenomatous polyposis coli determines sensitivity to histone deacetylase inhibitor-induced apoptosis in colon cancer cells.
Journal: Cancer research 20060915
Title: Antitumor activity of suberoylanilide hydroxamic acid against thyroid cancer cell lines in vitro and in vivo.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060915
Title: Suberoylanilide hydroxamic acid is effective in preclinical studies of medulloblastoma.
Journal: Journal of neuro-oncology 20060901
Title: Antitumor effects of a novel phenylbutyrate-based histone deacetylase inhibitor, (S)-HDAC-42, in prostate cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060901
Title: A liquid chromatography-electrospray ionization tandem mass spectrometric assay for quantitation of the histone deacetylase inhibitor, vorinostat (suberoylanilide hydroxamicacid, SAHA), and its metabolites in human serum.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060818
Title: The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, overcomes resistance of human breast cancer cells to Apo2L/TRAIL.
Journal: International journal of cancer 20060815
Title: Antileukemia activity of the combination of an anthracycline with a histone deacetylase inhibitor.
Journal: Blood 20060815
Title: The benzamide M344, a novel histone deacetylase inhibitor, significantly increases SMN2 RNA/protein levels in spinal muscular atrophy cells.
Journal: Human genetics 20060801
Title: Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci.
Journal: Molecular cancer therapeutics 20060801
Title: SAHA-sensitized prostate cancer cells to TNFalpha-related apoptosis-inducing ligand (TRAIL): mechanisms leading to synergistic apoptosis.
Journal: International journal of cancer 20060701
Title: Reduction of graft-versus-host disease by histone deacetylase inhibitor suberonylanilide hydroxamic acid is associated with modulation of inflammatory cytokine milieu and involves inhibition of STAT1.
Journal: Experimental hematology 20060601
Title: Carbonyl- and sulfur-containing analogs of suberoylanilide hydroxamic acid: Potent inhibition of histone deacetylases.
Journal: Bioorganic & medicinal chemistry 20060515
Title: Histone deacetylase inhibitors suppress the inducibility of nuclear factor-kappaB by tumor necrosis factor-alpha receptor-1 down-regulation.
Journal: Cancer research 20060515
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Histone hyperacetylation is associated with amelioration of experimental colitis in mice.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20060415
Title: Apoptosis signal-regulating kinase 1 is a direct target of E2F1 and contributes to histone deacetylase inhibitor-induced apoptosis through positive feedback regulation of E2F1 apoptotic activity.
Journal: The Journal of biological chemistry 20060414
Title: Loss of interleukin-2-dependency in HTLV-I-infected T cells on gene silencing of thioredoxin-binding protein-2.
Journal: Oncogene 20060406
Title: M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells.
Journal: Gynecologic oncology 20060401
Title: Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells.
Journal: Cancer research 20060401
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20060401
Title: Histone deacetylase inhibitors sit at crossroads of diet, aging, cancer.
Journal: Journal of the National Cancer Institute 20060315
Title: Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation.
Journal: The Journal of biological chemistry 20060303
Title: Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells.
Journal: International journal of oncology 20060301
Title: Human endometrial cytodifferentiation by histone deacetylase inhibitors.
Journal: Human cell 20060201
Title: Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides.
Journal: Journal of medicinal chemistry 20060126
Title: 5-Aza-2'-deoxycytidine (decitabine) can relieve p21WAF1 repression in human acute myeloid leukemia by a mechanism involving release of histone deacetylase 1 (HDAC1) without requiring p21WAF1 promoter demethylation.
Journal: Leukemia research 20060101
Title: SAHA, a HDAC inhibitor, has profound anti-growth activity against non-small cell lung cancer cells.
Journal: Oncology reports 20060101
Title: Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignancies.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060101
Title: Histone deacetylase inhibitors reduce VEGF production and induce growth suppression and apoptosis in human mantle cell lymphoma.
Journal: European journal of haematology 20060101
Title: Potential role of histone deacetylase inhibitors in mesothelioma: clinical experience with suberoylanilide hydroxamic acid.
Journal: Clinical lung cancer 20060101
Title: Comparative evaluation of the treatment efficacy of suberoylanilide hydroxamic acid (SAHA) and paclitaxel in ovarian cancer cell lines and primary ovarian cancer cells from patients.
Journal: BMC cancer 20060101
Title: Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio.
Journal: BMC cancer 20060101
Title: Histone deacetylase inhibitors in cancer therapy.
Journal: Cancer investigation 20060101
Title: Molecule of the month. Vorinostat.
Journal: Drug news & perspectives 20060101
Title: Antitumor activity of SK-7041, a novel histone deacetylase inhibitor, in human lung and breast cancer cells.
Journal: Anticancer research 20060101
Title: Histone deacetylase inhibitors induce differentiation of human endometrial adenocarcinoma cells through up-regulation of glycodelin.
Journal: Endocrinology 20051201
Title: Crystal structure of a bacterial class 2 histone deacetylase homologue.
Journal: Journal of molecular biology 20051118
Title: Exploring the connection unit in the HDAC inhibitor pharmacophore model: novel uracil-based hydroxamates.
Journal: Bioorganic & medicinal chemistry letters 20051101
Title: Suberoylanilide hydroxamic acid enhances gap junctional intercellular communication via acetylation of histone containing connexin 43 gene locus.
Journal: Cancer research 20051101
Title: Selective induction of apoptosis by histone deacetylase inhibitor SAHA in cutaneous T-cell lymphoma cells: relevance to mechanism of therapeutic action.
Journal: The Journal of investigative dermatology 20051101
Title: Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors.
Journal: Leukemia 20051001
Title: Histone deacetylase inhibitors suppress the induction of c-Jun and its target genes including COX-2.
Journal: The Journal of biological chemistry 20050923
Title: Synergistic interactions between MEK1/2 and histone deacetylase inhibitors in BCR/ABL+ human leukemia cells.
Journal: Leukemia 20050901
Title: Induction of polyploidy by histone deacetylase inhibitor: a pathway for antitumor effects.
Journal: Cancer research 20050901
Title: Activity of suberoylanilide hydroxamic Acid against human breast cancer cells with amplification of her-2.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050901
Title: Early clinical data and potential clinical utility of novel histone deacetylase inhibitors in prostate cancer.
Journal: Clinical prostate cancer 20050901
Title: It's about time: scheduling alters effect of histone deacetylase inhibitors on camptothecin-treated cells.
Journal: Cancer research 20050801
Title: Histone deacetylase inhibitors induced caspase-independent apoptosis in human pancreatic adenocarcinoma cell lines.
Journal: Molecular cancer therapeutics 20050801
Title: Synergistic apoptosis induction by proteasome and histone deacetylase inhibitors is dependent on protein synthesis.
Journal: Apoptosis : an international journal on programmed cell death 20050801
Title: Suberoylanilide hydroxamic acid combined with gemcitabine enhances apoptosis in non-small cell lung cancer.
Journal: Surgery 20050801
Title: A new simple and high-yield synthesis of suberoylanilide hydroxamic acid and its inhibitory effect alone or in combination with retinoids on proliferation of human prostate cancer cells.
Journal: Journal of medicinal chemistry 20050728
Title: Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent.
Journal: Bioorganic & medicinal chemistry 20050701
Title: Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and human erythroleukemia cell lines.
Journal: Anti-cancer drugs 20050701
Title: Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation.
Journal: Molecular and cellular biology 20050701
Title: Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma.
Journal: Neoplasia (New York, N.Y.) 20050701
Title: Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050610
Title: The histone-deacetylase inhibitor SAHA potentiates proapoptotic effects of 5-fluorouracil and irinotecan in hepatoma cells.
Journal: Journal of cancer research and clinical oncology 20050601
Title: Novel histone deacetylase inhibitors in the treatment of thyroid cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050515
Title: Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.
Journal: Journal of medicinal chemistry 20050505
Title: The role of histone acetylation in SMN gene expression.
Journal: Human molecular genetics 20050501
Title: Modulation of radiation response by histone deacetylase inhibition.
Journal: International journal of radiation oncology, biology, physics 20050501
Title: Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo.
Journal: Journal of neurochemistry 20050501
Title: Cotreatment with suberanoylanilide hydroxamic acid and 17-allylamino 17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl+ Cells sensitive and resistant to STI571 (imatinib mesylate) in association with down-regulation of Bcr-Abl, abrogation of signal transducer and activator of transcription 5 activity, and Bax conformational change.
Journal: Molecular pharmacology 20050401
Title: Histone deacetylase inhibitors in programmed cell death and cancer therapy.
Journal: Cell cycle (Georgetown, Tex.) 20050401
Title: Coadministration of histone deacetylase inhibitors and perifosine synergistically induces apoptosis in human leukemia cells through Akt and ERK1/2 inactivation and the generation of ceramide and reactive oxygen species.
Journal: Cancer research 20050315
Title: [Histone deacetylase inhibitors as a new generation of anti-cancer agents].
Journal: Postepy higieny i medycyny doswiadczalnej (Online) 20050311
Title: Effects of suberoylanilide hydroxamic acid and trichostatin A on induction of cytochrome P450 enzymes and benzo[a]pyrene DNA adduct formation in human cells.
Journal: Bioorganic & medicinal chemistry letters 20050301
Title: Histone deacetylase inhibitors interact synergistically with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in carcinoma cell lines.
Journal: Investigational new drugs 20050301
Title: 4-Hydroxybenzoyl derivative from the aqueous extract of the hydroid Campanularia sp.
Journal: Journal of natural products 20050301
Title: Drug insight: Histone deacetylase inhibitors--development of the new targeted anticancer agent suberoylanilide hydroxamic acid.
Journal: Nature clinical practice. Oncology 20050301
Title: Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates.
Journal: Journal of medicinal chemistry 20050224
Title: Identification of a potent non-hydroxamate histone deacetylase inhibitor by mechanism-based drug design.
Journal: Bioorganic & medicinal chemistry letters 20050117
Title: The histone deacetylase inhibitor suberoylanilide hydroxamic acid down-regulates expression levels of Bcr-abl, c-Myc and HDAC3 in chronic myeloid leukemia cell lines.
Journal: International journal of molecular medicine 20050101
Title: Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines.
Journal: Experimental hematology 20050101
Title: High turbulence liquid chromatography online extraction and tandem mass spectrometry for the simultaneous determination of suberoylanilide hydroxamic acid and its two metabolites in human serum.
Journal: Rapid communications in mass spectrometry : RCM 20050101
Title: The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells.
Journal: Cancer research 20041201
Title: Histone deacetylase inhibitors up-regulate the expression of tight junction proteins.
Journal: Molecular cancer research : MCR 20041201
Title: Proteasome inhibition sensitizes non-small cell lung cancer to histone deacetylase inhibitor-induced apoptosis through the generation of reactive oxygen species.
Journal: The Journal of thoracic and cardiovascular surgery 20041101
Title: Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol.
Journal: Molecular pharmacology 20041001
Title: Targeting CREB-binding protein (CBP) loss of function as a therapeutic strategy in neurological disorders.
Journal: Biochemical pharmacology 20040915
Title: Modulation of renal disease in MRL/lpr mice by suberoylanilide hydroxamic acid.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20040915
Title: Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors.
Journal: Apoptosis : an international journal on programmed cell death 20040901
Title: Combined histone deacetylase and NF-kappaB inhibition sensitizes non-small cell lung cancer to cell death.
Journal: Surgery 20040801
Title: Restoration of transforming growth factor-beta signaling through receptor RI induction by histone deacetylase activity inhibition in breast cancer cells.
Journal: The Journal of biological chemistry 20040730
Title: Requirement of histone deacetylase activity for signaling by STAT1.
Journal: The Journal of biological chemistry 20040716
Title: Suberanilohydroxamic Acid. Aton Pharma.
Journal: IDrugs : the investigational drugs journal 20040701
Title: Thiol-based SAHA analogues as potent histone deacetylase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20040621
Title: On the function of the 14 A long internal cavity of histone deacetylase-like protein: implications for the design of histone deacetylase inhibitors.
Journal: Journal of medicinal chemistry 20040617
Title: Role of oxidative enzymatic treatments on enzymatic hydrolysis of softwood.
Journal: Biotechnology and bioengineering 20040605
Title: Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors.
Journal: Radiation research 20040601
Title: Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040601
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20040601
Title: Sequence-specific potentiation of topoisomerase II inhibitors by the histone deacetylase inhibitor suberoylanilide hydroxamic acid.
Journal: Journal of cellular biochemistry 20040515
Title: The mechanism of the anti-tumor activity of the histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA).
Journal: Cell cycle (Georgetown, Tex.) 20040501
Title: [Therapeutic targets in polyglutamine diseases].
Journal: Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 20040501
Title: Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines.
Journal: International journal of oncology 20040401
Title: 3-(4-Aroyl-1-methyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 3. Discovery of novel lead compounds through structure-based drug design and docking studies.
Journal: Journal of medicinal chemistry 20040311
Title: Silent advances.
Journal: Environmental health perspectives 20040301
Title: 3-(4-Aroyl-1-methyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamides as a new class of synthetic histone deacetylase inhibitors. 2. Effect of pyrrole-C2 and/or -C4 substitutions on biological activity.
Journal: Journal of medicinal chemistry 20040226
Title: QSAR studies of PC-3 cell line inhibition activity of TSA and SAHA-like hydroxamic acids.
Journal: Bioorganic & medicinal chemistry letters 20040209
Title: Histone deacetylase inhibitors have a profound antigrowth activity in endometrial cancer cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040201
Title: Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group.
Journal: Bioorganic & medicinal chemistry letters 20040119
Title: (2-amino-phenyl)-amides of omega-substituted alkanoic acids as new histone deacetylase inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20040105
Title: Novel histone deacetylase inhibitors: design, synthesis, enzyme inhibition, and binding mode study of SAHA-based non-hydroxamates.
Journal: Bioorganic & medicinal chemistry letters 20031215
Title: Coadministration of the heat shock protein 90 antagonist 17-allylamino- 17-demethoxygeldanamycin with suberoylanilide hydroxamic acid or sodium butyrate synergistically induces apoptosis in human leukemia cells.
Journal: Cancer research 20031201
Title: Simultaneous activation of the intrinsic and extrinsic pathways by histone deacetylase (HDAC) inhibitors and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induces mitochondrial damage and apoptosis in human leukemia cells.
Journal: Molecular cancer therapeutics 20031201
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20031201
Title: The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to STI571.
Journal: Blood 20031115
Title: Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA.
Journal: Cancer research 20031101
Title: N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824).
Journal: Journal of medicinal chemistry 20031009
Title: Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20030901
Title: Phosphorus-based SAHA analogues as histone deacetylase inhibitors.
Journal: Organic letters 20030821
Title: Novel mechanisms of apoptosis induced by histone deacetylase inhibitors.
Journal: Cancer research 20030801
Title: Indole amide hydroxamic acids as potent inhibitors of histone deacetylases.
Journal: Bioorganic & medicinal chemistry letters 20030602
Title: Molecular sequelae of histone deacetylase inhibition in human malignant B cells.
Journal: Blood 20030515
Title: Susceptibility of multidrug resistance tumor cells to apoptosis induction by histone deacetylase inhibitors.
Journal: International journal of cancer 20030501
Title: Histone deacetylase inhibitors promote STI571-mediated apoptosis in STI571-sensitive and -resistant Bcr/Abl+ human myeloid leukemia cells.
Journal: Cancer research 20030501
Title: Cotreatment with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) enhances imatinib-induced apoptosis of Bcr-Abl-positive human acute leukemia cells.
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Title: Role of caspases, Bid, and p53 in the apoptotic response triggered by histone deacetylase inhibitors trichostatin-A (TSA) and suberoylanilide hydroxamic acid (SAHA).
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Title: Induction of fetal hemoglobin expression by the histone deacetylase inhibitor apicidin.
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Title: Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse.
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Title: Chemopreventive efficacy of suberoylanilide hydroxamic acid (SAHA) against 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in female A/J mice.
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Title: Trifluoromethyl ketones as inhibitors of histone deacetylase.
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Title: One-step SFE-plus-C(18) selective extraction of low-polarity compounds, with lipid removal, from smoked fish and bovine milk.
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Title: Structure-activity relationships on phenylalanine-containing inhibitors of histone deacetylase: in vitro enzyme inhibition, induction of differentiation, and inhibition of proliferation in Friend leukemic cells.
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Title: The histone deacetylase inhibitor sodium butyrate interacts synergistically with phorbol myristate acetate (PMA) to induce mitochondrial damage and apoptosis in human myeloid leukemia cells through a tumor necrosis factor-alpha-mediated process.
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Title: Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA).
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Title: Suberoylanilide hydroxamic acid (SAHA), a histone deacetylase inhibitor, suppresses the growth of carcinogen-induced mammary tumors.
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Title: The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces differentiation of human breast cancer cells.
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Title: Histone deacetylase inhibitors induce caspase-dependent apoptosis and downregulation of daxx in acute promyelocytic leukaemia with t(15;17).
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Title: The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species.
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Title: Inhibitors of histone deacetylase are potentially effective anticancer agents.
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Title: Mechanisms of suberoylanilide hydroxamic acid inhibition of mammary cell growth.
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