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26172-55-4,MFCD00792550
Catalog No.:AA003820

26172-55-4 | 5-Chloro-2-methyl-4-isothiazolin-3-one, tech grade, >14% in water. CMI/MI >2.0

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1g
ActiveIngredient>14%CMI/MI2.5-4.0
in stock  
$24.00   $17.00
- +
5g
ActiveIngredient>14%CMI/MI2.5-4.0
in stock  
$51.00   $36.00
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10g
ActiveIngredient>14%CMI/MI2.5-4.0
in stock  
$88.00   $62.00
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25g
ActiveIngredient>14%CMI/MI2.5-4.0
in stock  
$151.00   $106.00
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100g
68%
in stock  
$427.00   $299.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003820
Chemical Name:
5-Chloro-2-methyl-4-isothiazolin-3-one, tech grade, >14% in water. CMI/MI >2.0
CAS Number:
26172-55-4
Molecular Formula:
C4H4ClNOS
Molecular Weight:
149.5987
MDL Number:
MFCD00792550
SMILES:
Cn1sc(cc1=O)Cl
Properties
Computed Properties
 
Complexity:
156  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
8  
Hydrogen Bond Acceptor Count:
2  
XLogP3:
0.9  

Literature

Title: Determination of Protein Haptenation by Chemical Sensitizers Within the Complexity of the Human Skin Proteome.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20180401

Title: SENS-IS, a 3D reconstituted epidermis based model for quantifying chemical sensitization potency: Reproducibility and predictivity results from an inter-laboratory study.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20160401

Title: Chemical allergens stimulate human epidermal keratinocytes to produce lymphangiogenic vascular endothelial growth factor.

Journal: Toxicology and applied pharmacology 20150301

Title: Multicenter study of preservative sensitivity in patients with suspected cosmetic contact dermatitis in Korea.

Journal: The Journal of dermatology 20120801

Title: B cell increases and ex vivo IL-2 production as secondary endpoints for the detection of sensitizers in non-radioisotopic local lymph node assay using flow cytometry.

Journal: Toxicology letters 20120325

Title: Effects of 5-chloro-2-methyl-4-isothiazolin-3-one and other candidate biodiesel biocides on rat alveolar macrophages and NR8383 cells.

Journal: Archives of toxicology 20111101

Title: Non-fragrance allergens in specific cosmetic products.

Journal: Contact dermatitis 20111101

Title: Patch testing in children with hand eczema. A 5-year multicentre study in Spain.

Journal: Contact dermatitis 20111001

Title: [Current contact allergens].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20111001

Title: Can exposure limitations for well-known contact allergens be simplified? An analysis of dose-response patch test data.

Journal: Contact dermatitis 20110601

Title: Danger from the workplace: allergic contact dermatitis from the first exposure to isothiazolinones.

Journal: Contact dermatitis 20110601

Title: The intra- and inter-laboratory reproducibility and predictivity of the KeratinoSens assay to predict skin sensitizers in vitro: results of a ring-study in five laboratories.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20110401

Title: [Sensitization to methylchloroisothiazolinone-methylisothiazolinone after a burn caused by massive accidental occupational exposure].

Journal: Actas dermo-sifiliograficas 20110401

Title: Contact sensitization to methylisothiazolinone in Finland--a multicentre study.

Journal: Contact dermatitis 20110101

Title: Susceptibility of Mycobacterium immunogenum and Pseudomonas fluorescens to formaldehyde and non-formaldehyde biocides in semi-synthetic metalworking fluids.

Journal: International journal of molecular sciences 20110101

Title: Analysis of isothiazolinone biocides in paper for food packaging by ultra-high-performance liquid chromatography-tandem mass spectrometry.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20101201

Title: Prediction of the contact sensitizing potential of chemicals using analysis of gene expression changes in human THP-1 monocytes.

Journal: Toxicology letters 20101110

Title: A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells.

Journal: Cutaneous and ocular toxicology 20100901

Title: Prevalence and cause of methylisothiazolinone contact allergy.

Journal: Contact dermatitis 20100901

Title: Methylisothiazolinone, an emerging allergen in cosmetics?

Journal: Contact dermatitis 20100801

Title: Methylchloroisothiazolinone / methylisothiazolinone and moist wipe dermatitis.

Journal: Dermatology online journal 20100515

Title: Consumer exposure to biocides--identification of relevant sources and evaluation of possible health effects.

Journal: Environmental health : a global access science source 20100101

Title: Concomitant contact allergy to methylchloroisothiazolinone/methylisothiazolinone and formaldehyde-releasing preservatives.

Journal: Contact dermatitis 20100101

Title: Identifying the optimal patch test concentration for methylchloroisothiazolinone and methylisothiazolinone.

Journal: Contact dermatitis 20090501

Title: Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals.

Journal: Contact dermatitis 20090401

Title: Mechanistic assessment of peptide reactivity assay to predict skin allergens with Kathon CG isothiazolinones.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090401

Title: Role of intracellular calcium and S-glutathionylation in cell death induced by a mixture of isothiazolinones in HL60 cells.

Journal: Biochimica et biophysica acta 20090301

Title: Methyl gallate.

Journal: Acta crystallographica. Section E, Structure reports online 20090201

Title: Shampoos.

Journal: Dermatitis : contact, atopic, occupational, drug 20090101

Title: Alkalization of wall paint prevents airborne contact dermatitis in patients with sensitization to isothiazolinones.

Journal: Contact dermatitis 20080801

Title: Suitability of macrophage inflammatory protein-1beta production by THP-1 cells in differentiating skin sensitizers from irritant chemicals.

Journal: Contact dermatitis 20080401

Title: Airborne allergic contact dermatitis to methylchloroisothiazolinone/methylisothiazolinone in ironing water.

Journal: Contact dermatitis 20080301

Title: Cross-reactivity between methylchloroisothiazolinone/methylisothiazolinone, methylisothiazolinone, and other isothiazolinones in workers at a plant producing binders for paints and glues.

Journal: Contact dermatitis 20080101

Title: Different regulation of T helper 1- and T helper 2-promoting cytokine signalling factors in human dendritic cells after exposure to protein versus contact allergens.

Journal: Immunology 20080101

Title: Quantitative relationships between patch test reactivity and use test reactivity: an overview.

Journal: Cutaneous and ocular toxicology 20080101

Title: Analysis of isothiazolinones in environmental waters by gas chromatography-mass spectrometry.

Journal: Journal of chromatography. A 20070914

Title: 'Dermatologically tested' baby toilet tissues: a cause of allergic contact dermatitis in adults.

Journal: Contact dermatitis 20070801

Title: Iron dependent degradation of an isothiazolone biocide (5-chloro-2-methyl-4-isothiazolin-3-one).

Journal: Biofouling 20070101

Title: Preservatives sensitivity in Israel: a 10-year overview (1995-2004).

Journal: Contact dermatitis 20061001

Title: An evaluation of dose/unit area and time as key factors influencing the elicitation capacity of methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) in MCI/MI-allergic patients.

Journal: Contact dermatitis 20060901

Title: Contact dermatitis from methylisothiazolinone in a paint factory.

Journal: Contact dermatitis 20060601

Title: GSH depletion, protein S-glutathionylation and mitochondrial transmembrane potential hyperpolarization are early events in initiation of cell death induced by a mixture of isothiazolinones in HL60 cells.

Journal: Biochimica et biophysica acta 20060201

Title: Patch testing with patients' own cosmetics and toiletries--results of the IVDK*, 1998-2002.

Journal: Contact dermatitis 20051001

Title: Occupational contact dermatitis to 1,2-benzisothiazolin-3-one and 5-chloro-2-methylisothiazolin-3-one/2-methylisothiazolin-3-one in paint manufacturers.

Journal: Contact dermatitis 20050801

Title: Oxidative stress in mouse skin following application of contact allergenic 5-chloro-2-methyl-4-isothiazolin-3-one and oxazolone.

Journal: Contact dermatitis 20050301

Title: From experiment to theory: molecular orbital parameters to interpret the skin sensitization potential of 5-chloro-2-methylisothiazol-3-one and 2-methylisothiazol-3-one.

Journal: Chemical research in toxicology 20050201

Title: Effect of glutathione on the covalent binding of the 13C-labeled skin sensitizer 5-chloro-2-methylisothiazol-3-one to human serum albumin: identification of adducts by nuclear magnetic resonance, matrix-assisted laser desorption/ionization mass spectrometry, and nanoelectrospray tandem mass spectrometry.

Journal: Chemical research in toxicology 20040901

Title: Covalent binding of the 13C-labeled skin sensitizers 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI) to a model peptide and glutathione.

Journal: Bioorganic & medicinal chemistry letters 20040119

Title: Contact sensitization to 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one in children.

Journal: Contact dermatitis 20031001

Title: Co-existing sensitivity to metronidazole and isothiazolinone.

Journal: Clinical and experimental dermatology 20030901

Title: Involvement of oxidative stress in apoptosis induced by a mixture of isothiazolinones in normal human keratinocytes.

Journal: The Journal of investigative dermatology 20030801

Title: Studies of chemical selectivity of hapten, reactivity, and skin sensitization potency. 3. Synthesis and studies on the reactivity toward model nucleophiles of the 13C-labeled skin sensitizers, 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI).

Journal: Chemical research in toxicology 20030501

Title: Coupling of contact sensitizers to thiol groups is a key event for the activation of monocytes and monocyte-derived dendritic cells.

Journal: The Journal of investigative dermatology 20030201

Title: Audit of Finn Chamber patch test preparation.

Journal: Contact dermatitis 20021201

Title: Elucidating changes in surface marker expression of dendritic cells following chemical allergen treatment.

Journal: Toxicology and applied pharmacology 20020801

Title: Monitoring levels of preservative sensitivity in Europe. A 10-year overview (1991-2000).

Journal: Contact dermatitis 20020401

Title: In vitro induction of apoptosis vs. necrosis by widely used preservatives: 2-phenoxyethanol, a mixture of isothiazolinones, imidazolidinyl urea and 1,2-pentanediol.

Journal: Biochemical pharmacology 20020201

Title: Occupational allergic contact dermatitis from methylchloroisothiazolinone and methylisothiazolinone (MCI/MI) in a silicone-emulsion lock lubricant.

Journal: Contact dermatitis 20010401

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Tags:26172-55-4 Molecular Formula|26172-55-4 MDL|26172-55-4 SMILES|26172-55-4 5-Chloro-2-methyl-4-isothiazolin-3-one, tech grade, >14% in water. CMI/MI >2.0