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Title: The cyclin-dependent kinase inhibitor flavopiridol potentiates doxorubicin efficacy in advanced sarcomas: preclinical investigations and results of a phase I dose-escalation clinical trial.
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Title: The BH3-only protein Noxa is stimulated during apoptosis of chronic lymphocytic leukemia cells triggered by M2YN, a new plant-derived extract.
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Title: Combining proteasome with cell cycle inhibitors: a dual attack potentially applicable to multiple hematopoietic malignancies.
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Title: Acute myeloid leukaemia: optimal management and recent developments.
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Title: Leukemia cutis in association With Grover's disease.
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Title: Constitutive Smad linker phosphorylation in melanoma: a mechanism of resistance to transforming growth factor-β-mediated growth inhibition.
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Title: Phase I trial of bortezomib (PS-341; NSC 681239) and alvocidib (flavopiridol; NSC 649890) in patients with recurrent or refractory B-cell neoplasms.
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Title: Phase 1 and pharmacokinetic study of bolus-infusion flavopiridol followed by cytosine arabinoside and mitoxantrone for acute leukemias.
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Title: Homology modeling, molecular dynamic simulation and docking studies of cyclin dependent kinase 1.
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Title: Flavopiridol protects against inflammation by attenuating leukocyte-endothelial interaction via inhibition of cyclin-dependent kinase 9.
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Title: The CDK9/cyclin T1 subunits of P-TEFb in mouse oocytes and preimplantation embryos: a possible role in embryonic genome activation.
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Title: CDK9 regulates AR promoter selectivity and cell growth through serine 81 phosphorylation.
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Title: Assaying pharmacodynamic endpoints with targeted therapy: flavopiridol and 17AAG induced dephosphorylation of histone H1.5 in acute myeloid leukemia.
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Title: Combination of vorinostat and flavopiridol is selectively cytotoxic to multidrug-resistant neuroblastoma cell lines with mutant TP53.
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Title: Inhibition of MCL-1 in breast cancer cells promotes cell death in vitro and in vivo.
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Title: A phase I clinical trial of FOLFIRI in combination with the pan-cyclin-dependent kinase (CDK) inhibitor flavopiridol.
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Title: A phase I study of flavopiridol in combination with gemcitabine and irinotecan in patients with metastatic cancer.
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Title: Human chorionic gonadotropin up-regulates expression of myeloid cell leukemia-1 protein in human granulosa-lutein cells: implication of corpus luteum rescue and ovarian hyperstimulation syndrome.
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Title: Dinaciclib (SCH 727965), a novel and potent cyclin-dependent kinase inhibitor.
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Title: Preclinical pharmacokinetic/pharmacodynamic models to predict synergistic effects of co-administered anti-cancer agents.
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Title: Clinical activity of sequential flavopiridol, cytosine arabinoside, and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia.
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Title: T-loop phosphorylated Cdk9 localizes to nuclear speckle domains which may serve as sites of active P-TEFb function and exchange between the Brd4 and 7SK/HEXIM1 regulatory complexes.
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Title: Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment.
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Title: Sequential flavopiridol, mitoxantrone and cytosine arabinoside for newly diagnosed poor risk acute myeloid leukemia. What to do next?
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Title: Phase I clinical and pharmacokinetic study of a novel schedule of flavopiridol in relapsed or refractory acute leukemias.
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Title: Recombinant Leishmania mexicana CRK3:CYCA has protein kinase activity in the absence of phosphorylation on the T-loop residue Thr178.
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Title: A combination of cisplatin-eluting gelatin microspheres and flavopiridol enhances anti-tumour effects in a rabbit VX2 liver tumour model.
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Title: Chemotherapeutic drugs inhibit ribosome biogenesis at various levels.
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Title: Dysoxylum binectariferum Hook.f (Meliaceae), a rich source of rohitukine.
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Title: Flavopiridol, fludarabine, and rituximab in mantle cell lymphoma and indolent B-cell lymphoproliferative disorders.
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Title: New agents in chronic lymphocytic leukemia.
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Title: The binding of flavopiridol to blood serum albumin.
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Title: Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition.
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Title: Potent inhibition of rhabdoid tumor cells by combination of flavopiridol and 4OH-tamoxifen.
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Title: Phase II study of flavopiridol in relapsed chronic lymphocytic leukemia demonstrating high response rates in genetically high-risk disease.
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Title: Phase I study of flavopiridol with oxaliplatin and fluorouracil/leucovorin in advanced solid tumors.
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Title: Misguided transcriptional elongation causes mixed lineage leukemia.
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Title: Flavopiridol reduces the impedance of neural prostheses in vivo without affecting recording quality.
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Title: SKIP interacts with c-Myc and Menin to promote HIV-1 Tat transactivation.
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Title: CDK9 directs H2B monoubiquitination and controls replication-dependent histone mRNA 3'-end processing.
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Title: The effect of the cyclin-dependent kinase inhibitor flavopiridol on anaplastic large cell lymphoma cells and relationship with NPM-ALK kinase expression and activity.
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Title: Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia.
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Title: The effect of breast cancer resistance protein and P-glycoprotein on the brain penetration of flavopiridol, imatinib mesylate (Gleevec), prazosin, and 2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic acid (PF-407288) in mice.
Journal: Drug metabolism and disposition: the biological fate of chemicals20090501
Title: Camptothecin releases P-TEFb from the inactive 7SK snRNP complex.
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Title: Transforming growth factor-{beta}-inducible phosphorylation of Smad3.
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Title: Clinical response and pharmacokinetics from a phase 1 study of an active dosing schedule of flavopiridol in relapsed chronic lymphocytic leukemia.
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Title: Noxa upregulation is associated with apoptosis of chronic lymphocytic leukemia cells induced by hyperforin but not flavopiridol.
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Title: Role of the HIV-1 positive elongation factor P-TEFb and inhibitors thereof.
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Title: Retinoblastoma tumor suppressor gene expression determines the response to sequential flavopiridol and doxorubicin treatment in small-cell lung carcinoma.
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Title: A novel liposomal formulation of flavopiridol.
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Title: Circulating tumor cells in HER-2 positive metastatic breast cancer patients treated with trastuzumab and chemotherapy.
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Title: A phase II study of flavopiridol (Alvocidib) in combination with docetaxel in refractory, metastatic pancreatic cancer.
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Title: Flavopiridol in chronic lymphocytic leukemia: a concise review.
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Title: Development and validation of a highly sensitive liquid chromatography/mass spectrometry method for simultaneous quantification of lenalidomide and flavopiridol in human plasma.
Journal: Therapeutic drug monitoring20081001
Title: Combinatorial antileukemic disruption of oxidative homeostasis and mitochondrial stability by the redox reactive thalidomide 2-(2,4-difluoro-phenyl)-4,5,6,7-tetrafluoro-1H-isoindole-1,3(2H)-dione (CPS49) and flavopiridol.
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Title: Flavopiridol potentiates the cytotoxic effects of radiation in radioresistant tumor cells in which p53 is mutated or Bcl-2 is overexpressed.
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Title: Novel agents in chronic lymphocytic leukemia: efficacy and tolerability of new therapies.
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Title: The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation.
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Title: Development and validation of a sensitive liquid chromatography/mass spectrometry method for quantitation of flavopiridol in plasma enables accurate estimation of pharmacokinetic parameters with a clinically active dosing schedule.
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Title: Flavopiridol-induced iNOS downregulation during apoptosis of chronic lymphocytic leukemia cells is caspase-dependent.
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Title: Delayed combinatorial treatment with flavopiridol and minocycline provides longer term protection for neuronal soma but not dendrites following global ischemia.
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Title: Flavopiridol suppresses tumor necrosis factor-induced activation of activator protein-1, c-Jun N-terminal kinase, p38 mitogen-activated protein kinase (MAPK), p44/p42 MAPK, and Akt, inhibits expression of antiapoptotic gene products, and enhances apoptosis through cytochrome c release and caspase activation in human myeloid cells.
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Title: Phase I study of flavopiridol in combination with Paclitaxel and Carboplatin in patients with non-small-cell lung cancer.
Journal: Clinical lung cancer20080501
Title: Flavopiridol displays preclinical activity in acute lymphoblastic leukemia.
Journal: Pediatric blood & cancer20080401
Title: The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner.
Journal: Cancer research20080401
Title: Flavopiridol causes early mitochondrial damage in chronic lymphocytic leukemia cells with impaired oxygen consumption and mobilization of intracellular calcium.
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Title: Successful treatment of animal models of rheumatoid arthritis with small-molecule cyclin-dependent kinase inhibitors.
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Title: Transcription-dependent gene looping of the HIV-1 provirus is dictated by recognition of pre-mRNA processing signals.
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Title: Rhabdoid tumor growth is inhibited by flavopiridol.
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Title: The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression.
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Title: Lack of association between common polymorphisms in UGT1A9 and gene expression and activity.
Journal: Drug metabolism and disposition: the biological fate of chemicals20071201
Title: Extrinsic pathway- and cathepsin-dependent induction of mitochondrial dysfunction are essential for synergistic flavopiridol and vorinostat lethality in breast cancer cells.
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Title: Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury.
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Title: Flavopiridol in the treatment of chronic lymphocytic leukemia.
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Title: [Therapeutic effect of flavopiridol, a small molecular cyclin-dependent kinase inhibitor, in human ovarian carcinoma].
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Title: Phase I dose-finding study of weekly docetaxel followed by flavopiridol for patients with advanced solid tumors.
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Title: Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cells.
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Title: Novel agents and strategies for treatment of p53-defective chronic lymphocytic leukemia.
Journal: Best practice & research. Clinical haematology20070901
Title: Flavopiridol synergizes TRAIL cytotoxicity by downregulation of FLIPL.
Journal: Cancer chemotherapy and pharmacology20070801
Title: UGT1A1*28 genotype affects the in-vitro glucuronidation of thyroxine in human livers.
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Title: Sequential flavopiridol, cytosine arabinoside, and mitoxantrone: a phase II trial in adults with poor-risk acute myelogenous leukemia.
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Title: In vitro cytotoxicity of nelarabine, clofarabine and flavopiridol in paediatric acute lymphoblastic leukaemia.
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Title: Mechanism and functional role of XIAP and Mcl-1 down-regulation in flavopiridol/vorinostat antileukemic interactions.
Journal: Molecular cancer therapeutics20070201
Title: Timed-sequential chemotherapy as induction and/or consolidation regimen for younger adults with acute myelogenous leukemia.
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Title: Flavopiridol administered using a pharmacologically derived schedule is associated with marked clinical efficacy in refractory, genetically high-risk chronic lymphocytic leukemia.
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Title: Design, synthesis, and antiproliferative and CDK2-cyclin a inhibitory activity of novel flavopiridol analogues.
Journal: Bioorganic & medicinal chemistry20070115
Title: Inhibition of HIV-1 replication by P-TEFb inhibitors DRB, seliciclib and flavopiridol correlates with release of free P-TEFb from the large, inactive form of the complex.
Journal: Retrovirology20070101
Title: Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site.
Journal: Bioorganic & medicinal chemistry20061201
Title: Transcriptional profiling identifies cyclin D1 as a critical downstream effector of mutant epidermal growth factor receptor signaling.
Journal: Cancer research20061201
Title: A sequential blockade strategy for the design of combination therapies to overcome oncogene addiction in chronic myelogenous leukemia.
Journal: Cancer research20061115
Title: Induction of apoptosis and down regulation of cell cycle proteins in mantle cell lymphoma by flavopiridol treatment.
Journal: Leukemia research20061101
Title: Antisense inhibition of cyclin D1 expression is equivalent to flavopiridol for radiosensitization of zebrafish embryos.
Journal: International journal of radiation oncology, biology, physics20061001
Title: Sequential combinations of flavopiridol and docetaxel inhibit prostate tumors, induce apoptosis, and decrease angiogenesis in the Ggamma/T-15 transgenic mouse model of prostate cancer.
Journal: The Prostate20061001
Title: Efficacy of sequential treatment of HCT116 colon cancer monolayers and xenografts with docetaxel, flavopiridol, and 5-fluorouracil.
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Title: Combined depletion of cell cycle and transcriptional cyclin-dependent kinase activities induces apoptosis in cancer cells.
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Title: Pharmacological induction of Hsp70 protects apoptosis-prone cells from doxorubicin: comparison with caspase-inhibitor- and cycle-arrest-mediated cytoprotection.
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Title: Flavopiridol induces cellular FLICE-inhibitory protein degradation by the proteasome and promotes TRAIL-induced early signaling and apoptosis in breast tumor cells.
Journal: Cancer research20060901
Title: The cyclin-dependent kinase inhibitor flavopiridol sensitizes human hepatocellular carcinoma cells to TRAIL-induced apoptosis.
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Title: Improvement of esophageal adenocarcinoma cell and xenograft responses to radiation by targeting cyclin-dependent kinases.
Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology20060801
Title: Alvocidib (Flavopiridol) suppresses tumor growth in SCID mice with human esophageal cancer xenografts without inducing apoptosis.
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Title: MicroRNAs in leukemia.
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Title: A phase I study of flavopiridol and docetaxel.
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Title: Cyclin dependent kinase inhibitors prevent apoptosis of postmitotic mouse motoneurons.
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Title: Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells.
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Title: Sequential combination of flavopiridol and docetaxel reduces the levels of X-linked inhibitor of apoptosis and AKT proteins and stimulates apoptosis in human LNCaP prostate cancer cells.
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Title: Flavopiridol in patients with relapsed or refractory multiple myeloma: a phase 2 trial with clinical and pharmacodynamic end-points.
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Title: Flavopiridol and histone deacetylase inhibitors promote mitochondrial injury and cell death in human leukemia cells that overexpress Bcl-2.
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Title: Radiation sensitivity of GL261 murine glioma model and enhanced radiation response by flavopiridol.
Journal: Cell cycle (Georgetown, Tex.)20060101
Title: Dual action of the inhibitors of cyclin-dependent kinases: targeting of the cell-cycle progression and activation of wild-type p53 protein.
Journal: Expert opinion on investigational drugs20060101
Title: Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy.
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Title: A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets.
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Title: Effects of PRIMA-1 on wild-type L1210 cells expressing mutant p53 and drug-resistant L1210 cells lacking expression of p53: necrosis vs. apoptosis.
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Title: Potential use of pharmacological cyclin-dependent kinase inhibitors as anti-HIV therapeutics.
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Title: Phase I clinical and pharmacokinetic study of flavopiridol in children with refractory solid tumors: a Children's Oncology Group Study.
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Title: Indirubin-3'-monoxime, a derivative of a Chinese antileukemia medicine, inhibits P-TEFb function and HIV-1 replication.
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Title: Phase I and pharmacokinetic study of flavopiridol followed by 1-beta-D-arabinofuranosylcytosine and mitoxantrone in relapsed and refractory adult acute leukemias.
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Title: Flavopiridol administered as a 24-hour continuous infusion in chronic lymphocytic leukemia lacks clinical activity.
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Title: Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death.
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Title: Phase 1 trial of flavopiridol combined with cisplatin or carboplatin in patients with advanced malignancies with the assessment of pharmacokinetic and pharmacodynamic end points.
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Title: A phase II evaluation of flavopiridol as second-line chemotherapy of endometrial carcinoma: a Gynecologic Oncology Group study.
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Title: A study of cytotoxic synergy of UCN-01 and flavopiridol in syngeneic pair of cell lines.
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Title: A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia.
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Title: Accumulation of hypoxia-inducible factor-1alpha is limited by transcription-dependent depletion.
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Title: A phase II study of flavopiridol in patients with advanced renal cell carcinoma: results of Southwest Oncology Group Trial 0109.
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Title: Flavopiridol downregulates hypoxia-mediated hypoxia-inducible factor-1alpha expression in human glioma cells by a proteasome-independent pathway: implications for in vivo therapy.
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Title: Induction of apoptosis by flavopiridol unrelated to cell cycle arrest in germ cell tumour derived cell lines.
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Title: Chronic lymphocytic leukemia: a niche for flavopiridol?
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Title: Treatment of relapsed chronic lymphocytic leukemia by 72-hour continuous infusion or 1-hour bolus infusion of flavopiridol: results from Cancer and Leukemia Group B study 19805.
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Title: A phase I clinical trial of the sequential combination of irinotecan followed by flavopiridol.
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Title: Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity.
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Title: Sequence dependent potentiation of gemcitabine by flavopiridol in human breast cancer cells.
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Title: Combination therapy for adult T-cell leukemia-xenografted mice: flavopiridol and anti-CD25 monoclonal antibody.
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Title: Inhibition of multiple pathways accounts for the antiapoptotic effects of flavopiridol on potassium withdrawal-induced apoptosis in neurons.
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Title: Flavopiridol, an inhibitor of cyclin-dependent kinases, induces growth inhibition and apoptosis in bladder cancer cells in vitro and in vivo.
Journal: Anticancer research20050101
Title: Induction of apoptosis by flavopiridol in human neuroblastoma cells is enhanced under hypoxia and associated with N-myc proto-oncogene down-regulation.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20041215
Title: Cyclooxygenase-2 activity contributes to neuronal expression of cyclin D1 after anoxia/ischemia in vitro and in vivo.
Journal: Brain research. Molecular brain research20041206
Title: Flavopiridol, an inhibitor of transcription: implications, problems and solutions.
Journal: Cell cycle (Georgetown, Tex.)20041201
Title: E2F4 deficiency promotes drug-induced apoptosis.
Journal: Cancer biology & therapy20041201
Title: The small-molecule Bcl-2 inhibitor HA14-1 interacts synergistically with flavopiridol to induce mitochondrial injury and apoptosis in human myeloma cells through a free radical-dependent and Jun NH2-terminal kinase-dependent mechanism.
Journal: Molecular cancer therapeutics20041201
Title: Molecular models of cyclin-dependent kinase 1 complexed with inhibitors.
Journal: Biochemical and biophysical research communications20041112
Title: Potent antileukemic interactions between flavopiridol and TRAIL/Apo2L involve flavopiridol-mediated XIAP downregulation.
Journal: Leukemia20041101
Title: Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol.
Journal: Molecular pharmacology20041001
Title: Phase II trial of flavopiridol, a cyclin dependent kinase inhibitor, in untreated metastatic malignant melanoma.
Journal: Investigational new drugs20040801
Title: Local cyclin-dependent kinase inhibition by flavopiridol inhibits coronary artery smooth muscle cell proliferation and migration: Implications for the applicability on drug-eluting stents to prevent neointima formation following vascular injury.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20040801
Title: Phase I trial of the cyclin-dependent kinase inhibitor flavopiridol in combination with docetaxel in patients with metastatic breast cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20040801
Title: Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms.
Journal: Blood20040715
Title: Flavopiridol increases therapeutic ratio of radiotherapy by preferentially enhancing tumor radioresponse.
Journal: International journal of radiation oncology, biology, physics20040715
Title: Transcriptional signature of flavopiridol-induced tumor cell death.
Journal: Molecular cancer therapeutics20040701
Title: Gene profiling and the cyclin-dependent kinase inhibitor flavopiridol: what's in a name?
Journal: Molecular cancer therapeutics20040701
Title: Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20040615
Title: Neutropenic enterocolitis (typhilitis) associated with docetaxel therapy in a patient with non-small-cell lung cancer: case report and review of literature.
Journal: Lung cancer (Amsterdam, Netherlands)20040601
Title: Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b. Comparison with ligand binding to pCDK2-cyclin A complex.
Journal: European journal of biochemistry20040601
Title: Flavopiridol: pleiotropic biological effects enhance its anti-cancer activity.
Journal: Anti-cancer drugs20040601
Title: Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells.
Journal: Cancer research20040515
Title: Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor.
Journal: Cancer research20040515
Title: Growth inhibition and induction of apoptosis by flavopiridol in rat lung adenocarcinoma, osteosarcoma and malignant fibrous histiocytoma cell lines.
Journal: Oncology reports20040501
Title: Enhancement of radiation effects by combined docetaxel and flavopiridol treatment in lung cancer cells.
Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology20040501
Title: Flavopiridol enhances human tumor cell radiosensitivity and prolongs expression of gammaH2AX foci.
Journal: Molecular cancer therapeutics20040401
Title: Combining flavopiridol with various signal transduction inhibitors.
Journal: Oncology reports20040301
Title: Evidence of a functional role for p21WAF1/CIP1 down-regulation in synergistic antileukemic interactions between the histone deacetylase inhibitor sodium butyrate and flavopiridol.
Journal: Molecular pharmacology20040301
Title: Abrogation of p21 expression by flavopiridol enhances depsipeptide-mediated apoptosis in malignant pleural mesothelioma cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20040301
Title: Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9.
Journal: The Journal of biological chemistry20040206
Title: Inhibition of cell cycle pathway by flavopiridol promotes survival of cerebellar granule cells after an excitotoxic treatment.
Journal: The Journal of pharmacology and experimental therapeutics20040201
Title: Flavopiridol: where do we stand in chronic lymphocytic leukemia?
Journal: Leukemia20040201
Title: Flavopiridol inhibits the growth of GL261 gliomas in vivo: implications for malignant glioma therapy.
Journal: Cell cycle (Georgetown, Tex.)20040201
Title: A Phase II trial of flavopiridol (NSC #649890) in patients with previously untreated metastatic androgen-independent prostate cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20040201
Title: Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes.
Journal: Molecular cell20040116
Title: A novel approach to develop anti-HIV drugs: adapting non-nucleoside anticancer chemotherapeutics.
Journal: Antiviral research20040101
Title: Cell-cycle targeted therapies.
Journal: The Lancet. Oncology20040101
Title: Flavopiridol as a radio-sensitizer for esophageal cancer cell lines.
Journal: Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus20040101
Title: Gemcitabine-induced apoptosis in a drug-resistant mouse leukemia L1210 cell line that does not express p53.
Journal: Advances in enzyme regulation20040101
Title: In vitro cell growth pharmacodynamic studies: a new nonparametric approach to determining the relative importance of drug concentration and treatment time.
Journal: Cancer chemotherapy and pharmacology20031201
Title: Flavopiridol downregulates the expression of both the inducible NO synthase and p27(kip1) in malignant cells from B-cell chronic lymphocytic leukemia.
Journal: Leukemia20031201
Title: The cyclin-dependent kinase inhibitor flavopiridol potentiates gamma-irradiation-induced apoptosis in colon and gastric cancer cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20031201
Title: The role of hepatic Mrp2 in the interaction of flavopiridol and bilirubin: impact on therapy.
Journal: International journal of clinical pharmacology and therapeutics20031201
Title: The inducible NO synthase is downregulated during apoptosis of malignant cells from B-cell chronic lymphocytic leukemia induced by flavopiridol and polyphenols.
Journal: Annals of the New York Academy of Sciences20031201
Title: Inhibition of CDKs: a strategy for preventing kainic acid-induced apoptosis in neurons.
Journal: Annals of the New York Academy of Sciences20031201
Title: Acquired cellular resistance to flavopiridol in a human colon carcinoma cell line involves up-regulation of the telomerase catalytic subunit and telomere elongation. Sensitivity of resistant cells to combination treatment with a telomerase inhibitor.
Journal: Molecular pharmacology20031101
Title: Flavopiridol-induced apoptosis during S phase requires E2F-1 and inhibition of cyclin A-dependent kinase activity.
Journal: Cancer research20031101
Title: Biliary excretion of flavopiridol and its glucuronides in the isolated perfused rat liver: role of multidrug resistance protein 2 (Mrp2).
Journal: Life sciences20031017
Title: Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-kappaB-dependent process.
Journal: Oncogene20031016
Title: Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis.
Journal: Neuropharmacology20031001
Title: Novel functional polymorphisms in the UGT1A7 and UGT1A9 glucuronidating enzymes in Caucasian and African-American subjects and their impact on the metabolism of 7-ethyl-10-hydroxycamptothecin and flavopiridol anticancer drugs.
Journal: The Journal of pharmacology and experimental therapeutics20031001
Title: Clinical pharmacology of flavopiridol following a 72-hour continuous infusion.
Journal: The Annals of pharmacotherapy20031001
Title: Flavopiridol potently induces small cell lung cancer apoptosis during S phase in a manner that involves early mitochondrial dysfunction.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20031001
Title: Quantitative analysis of breast cancer resistance protein and cellular resistance to flavopiridol in acute leukemia patients.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20030815
Title: Phase II study of flavopiridol in patients with advanced colorectal cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20030801
Title: Cyclin-dependent kinase inhibitors.
Journal: Current opinion in pharmacology20030801
Title: A computational model of binding thermodynamics: the design of cyclin-dependent kinase 2 inhibitors.
Journal: Journal of medicinal chemistry20030717
Title: Novel direct and indirect cyclin-dependent kinase modulators for the prevention and treatment of human neoplasms.
Journal: Cancer chemotherapy and pharmacology20030701
Title: Epidermal growth factor receptor expression is a candidate target of the synergistic combination of trastuzumab and flavopiridol in breast cancer.
Journal: Cancer research20030701
Title: Flavopiridol, a cyclin-dependent kinase inhibitor, enhances radiosensitivity of ovarian carcinoma cells.
Journal: Cancer research20030615
Title: Commentary: effect of flavonoids on normal and leukemic cells.
Journal: Leukemia research20030601
Title: Flavonoid effects on normal and leukemic cells.
Journal: Leukemia research20030601
Title: The effect of flavopiridol on the growth of p16+ and p16- melanoma cell lines.
Journal: Melanoma research20030601
Title: Flavopiridol enhances the effect of docetaxel in vitro and in vivo in human gastric cancer cells.
Journal: Molecular cancer therapeutics20030601
Title: Flavopiridol in untreated or relapsed mantle-cell lymphoma: results of a phase II study of the National Cancer Institute of Canada Clinical Trials Group.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20030501
Title: Enhancement of depsipeptide-mediated apoptosis of lung or esophageal cancer cells by flavopiridol: activation of the mitochondria-dependent death-signaling pathway.
Journal: The Journal of thoracic and cardiovascular surgery20030501
Title: The lethal effects of pharmacological cyclin-dependent kinase inhibitors in human leukemia cells proceed through a phosphatidylinositol 3-kinase/Akt-dependent process.
Journal: Cancer research20030415
Title: Amelioration of nephropathy in mice expressing HIV-1 genes by the cyclin-dependent kinase inhibitor flavopiridol.
Journal: The Journal of antimicrobial chemotherapy20030401
Title: Cyclin-dependent kinase activity is required for apoptotic death but not inclusion formation in cortical neurons after proteasomal inhibition.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20030215
Title: Rapid induction of apoptosis by combination of flavopiridol and tumor necrosis factor (TNF)-alpha or TNF-related apoptosis-inducing ligand in human cancer cell lines.
Journal: Cancer research20030201
Title: Clinical pharmacology and pharmacogenetics of flavopiridol 1-h i.v. infusion in patients with refractory neoplasms.
Journal: Anti-cancer drugs20030201
Title: Flavopiridol-related proinflammatory syndrome is associated with induction of interleukin-6.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20030201
Title: Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway.
Journal: Molecular cancer therapeutics20030201
Title: Flavopiridol induces apoptosis in B-cell chronic lymphocytic leukaemia cells through a p38 and ERK MAP kinase-dependent mechanism.
Journal: Leukemia & lymphoma20030201
Title: Flavopiridol, a cyclin dependent kinase (CDK) inhibitor, induces apoptosis by regulating Bcl-x in oral cancer cells.
Journal: Oral oncology20030101
Title: Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis.
Journal: Cancer research20030101
Title: Suppression of survivin phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis.
Journal: Cancer research20030101
Title: Flavopiridol-induced apoptosis is mediated through up-regulation of E2F1 and repression of Mcl-1.
Journal: Molecular cancer therapeutics20030101
Title: Protein kinase C-dependent activation of the tumor necrosis factor receptor-mediated extrinsic cell death pathway underlies enhanced apoptosis in human myeloid leukemia cells exposed to bryostatin 1 and flavopiridol.
Journal: Molecular cancer therapeutics20030101
Title: Timed sequential therapy of acute leukemia with flavopiridol: in vitro model for a phase I clinical trial.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20030101
Title: Cyclin-dependent kinase modulators studied at the NCI: pre-clinical and clinical studies.
Journal: Current medicinal chemistry. Anti-cancer agents20030101
Title: Leukemic and non-leukemic lymphocytes from patients with Li Fraumeni syndrome demonstrate loss of p53 function, Bcl-2 family dysregulation and intrinsic resistance to conventional chemotherapeutic drugs but not flavopiridol.
Journal: Cell cycle (Georgetown, Tex.)20030101
Title: Flavopiridol induces mitochondrial-mediated apoptosis in murine glioma GL261 cells via release of cytochrome c and apoptosis inducing factor.
Journal: Cell cycle (Georgetown, Tex.)20030101
Title: Irinotecan in metastatic colorectal cancer: dose intensification and combination with new agents, including biological response modifiers.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20030101
Title: c-Myc oncoprotein: cell cycle-related events and new therapeutic challenges in cancer and cardiovascular diseases.
Journal: Cell cycle (Georgetown, Tex.)20030101
Title: Phase I clinical and pharmacokinetic trial of the cyclin-dependent kinase inhibitor flavopiridol.
Journal: Cancer chemotherapy and pharmacology20021201
Title: The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20021101
Title: Zebrafish: a preclinical model for drug screening.
Journal: Assay and drug development technologies20021101
Title: Phase I clinical and pharmacokinetic study of flavopiridol administered as a daily 1-hour infusion in patients with advanced neoplasms.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20021001
Title: Cyclin-dependent kinases as new targets for the prevention and treatment of cancer.
Journal: Hematology/oncology clinics of North America20021001
Title: A high-performance liquid chromatography method using ultraviolet detection for the quantitation of flavopiridol from human plasma.
Journal: Biomedical chromatography : BMC20020901
Title: Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20020901
Title: Clinical trials referral resource. Flavopiridol.
Journal: Oncology (Williston Park, N.Y.)20020901
Title: Hematologic malignancies: new developments and future treatments.
Journal: Seminars in oncology20020801
Title: Drg1, a novel target for modulating sensitivity to CPT-11 in colon cancer cells.
Journal: Cancer research20020715
Title: Synergistic induction of mitochondrial damage and apoptosis in human leukemia cells by flavopiridol and the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA).
Journal: Leukemia20020701
Title: Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling pathways.
Journal: Molecular cancer therapeutics20020701
Title: Flavopiridol inhibits vascular endothelial growth factor production induced by hypoxia or picolinic acid in human neuroblastoma.
Journal: International journal of cancer20020610
Title: Synergistic induction of apoptosis in human myeloid leukemia cells by phorbol 12-myristate 13-acetate and flavopiridol proceeds via activation of both the intrinsic and tumor necrosis factor-mediated extrinsic cell death pathways.
Journal: Molecular pharmacology20020601
Title: Review of flavopiridol, a cyclin-dependent kinase inhibitor, as breast cancer therapy.
Journal: Seminars in oncology20020601
Title: Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate-mediated excitotoxicity.
Journal: The Journal of pharmacology and experimental therapeutics20020501
Title: Flavopiridol, a novel cyclin-dependent kinase inhibitor, in clinical development.
Journal: The Annals of pharmacotherapy20020501
Title: Evidence for CRK3 participation in the cell division cycle of Trypanosoma cruzi.
Journal: Molecular and biochemical parasitology20020501
Title: In vitro characterization of hepatic flavopiridol metabolism using human liver microsomes and recombinant UGT enzymes.
Journal: Pharmaceutical research20020501
Title: Structural basis for inhibition of cyclin-dependent kinase 9 by flavopiridol.
Journal: Biochemical and biophysical research communications20020426
Title: Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics.
Journal: Journal of medicinal chemistry20020425
Title: Rate-limiting effects of Cyclin D1 in transformation by ErbB2 predicts synergy between herceptin and flavopiridol.
Journal: Cancer research20020415
Title: Phase I study of the cyclin-dependent kinase inhibitor flavopiridol in combination with paclitaxel in patients with advanced solid tumors.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20020415
Title: Seventy-two hour continuous infusion flavopiridol in relapsed and refractory mantle cell lymphoma.
Journal: Leukemia & lymphoma20020401
Title: Selective sensitization of transformed cells to flavopiridol-induced apoptosis following recruitment to S-phase.
Journal: Cancer research20020315
Title: Growth inhibition and apoptosis of myeloma cells by the CDK inhibitor flavopiridol.
Journal: Leukemia research20020301
Title: Prevalent loss of mitotic spindle checkpoint in adult T-cell leukemia confers resistance to microtubule inhibitors.
Journal: The Journal of biological chemistry20020215
Title: Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the rat.
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism20020201
Title: The cyclin-dependent kinase inhibitor flavopiridol disrupts sodium butyrate-induced p21WAF1/CIP1 expression and maturation while reciprocally potentiating apoptosis in human leukemia cells.
Journal: Molecular cancer therapeutics20020201
Title: The cell cycle as a target for cancer therapy: basic and clinical findings with the small molecule inhibitors flavopiridol and UCN-01.
Journal: The oncologist20020101
Title: Loss of the Bcl-2 phosphorylation loop domain is required to protect human myeloid leukemia cells from flavopiridol-mediated mitochondrial damage and apoptosis.
Journal: Cancer biology & therapy20020101
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Journal: Bulletin du cancer20020101
Title: CDK inhibitors: cell cycle arrest versus apoptosis.
Journal: Cell cycle (Georgetown, Tex.)20020101
Title: Flavopiridol inversely affects p21(WAF1/CIP1) and p53 and protects p21-sensitive cells from paclitaxel.
Journal: Cancer biology & therapy20020101
Title: Role reversal for anticancer agents.
Journal: Cancer biology & therapy20020101
Title: Suppression of HIV-1 expression by inhibitors of cyclin-dependent kinases promotes differentiation of infected podocytes.
Journal: Journal of the American Society of Nephrology : JASN20011201
Title: Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20011201
Title: Characterization of a human colorectal carcinoma cell line with acquired resistance to flavopiridol.
Journal: Molecular pharmacology20011101
Title: Microtubule-targeting drugs induce bcl-2 phosphorylation and association with Pin1.
Journal: Neoplasia (New York, N.Y.)20011101
Title: Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo.
Journal: The Journal of biological chemistry20010824
Title: Flavopiridol increases sensitization to gemcitabine in human gastrointestinal cancer cell lines and correlates with down-regulation of ribonucleotide reductase M2 subunit.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20010801
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Journal: Current opinion in investigational drugs (London, England : 2000)20010801
Title: The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathway.
Journal: Cell death and differentiation20010701
Title: Flavopiridol circumvents Bcl-2 family mediated inhibition of apoptosis and drug resistance in B-cell chronic lymphocytic leukaemia.
Journal: British journal of haematology20010701
Title: A phase II trial of the cyclin-dependent kinase inhibitor flavopiridol in patients with previously untreated stage IV non-small cell lung cancer.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20010601
Title: Treatment with inhibitors of caspases, that are substrates of drug transporters, selectively permits chemotherapy-induced apoptosis in multidrug-resistant cells but protects normal cells.
Journal: Leukemia20010601
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Journal: Critical reviews in oncology/hematology20010501
Title: Characterization of autoantibodies against uridine-diphosphate glucuronosyltransferase in patients with inflammatory liver diseases.
Journal: Hepatology (Baltimore, Md.)20010501
Title: Effect of P-glycoprotein on flavopiridol sensitivity.
Journal: British journal of cancer20010501
Title: The CRK3 protein kinase is essential for cell cycle progression of Leishmania mexicana.
Journal: Molecular and biochemical parasitology20010406
Title: In vitro glucuronidation of the cyclin-dependent kinase inhibitor flavopiridol by rat and human liver microsomes: involvement of UDP-glucuronosyltransferases 1A1 and 1A9.
Journal: Drug metabolism and disposition: the biological fate of chemicals20010401
Title: Phase II study of the cyclin-dependent kinase inhibitor flavopiridol administered to patients with advanced gastric carcinoma.
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Title: [CDK inhibitors for therapy of cancer].
Journal: Nihon rinsho. Japanese journal of clinical medicine20010401
Title: Selective sensitization of retinoblastoma protein-deficient sarcoma cells to doxorubicin by flavopiridol-mediated inhibition of cyclin-dependent kinase 2 kinase activity.
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Title: The cyclin-dependent kinase inhibitor (CDKI) flavopiridol disrupts phorbol 12-myristate 13-acetate-induced differentiation and CDKI expression while enhancing apoptosis in human myeloid leukemia cells.
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Title: Characterization of the Trypanosoma cruzi Cdc2p-related protein kinase 1 and identification of three novel associating cyclins.
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Title: The cyclin-dependent kinase (CDK) inhibitor flavopiridol inhibits glycogen phosphorylase.
Journal: Archives of biochemistry and biophysics20010215
Title: Possible mechanisms of diarrheal side effects associated with the use of a novel chemotherapeutic agent, flavopiridol.
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Title: Strategies to circumvent SV40 oncoprotein expression in malignant pleural mesotheliomas.
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Title: Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?
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Title: Overexpression of the ATP-binding cassette half-transporter, ABCG2 (Mxr/BCrp/ABCP1), in flavopiridol-resistant human breast cancer cells.
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Title: Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies.
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