Home Carboxes 215543-92-3
215543-92-3,MFCD08235144
Catalog No.:AA00383T

215543-92-3 | 2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$36.00   $25.00
- +
5mg
≥95%
in stock  
$99.00   $69.00
- +
10mg
≥95%
in stock  
$162.00   $113.00
- +
25mg
98% by HPLC
in stock  
$310.00   $217.00
- +
50mg
98% by HPLC
in stock  
$483.00   $338.00
- +
100mg
98% by HPLC
in stock  
$788.00   $552.00
- +
500mg
98% by HPLC
in stock  
$2,401.00   $1,681.00
- +
1000mg
98% by HPLC
in stock  
$3,803.00   $2,662.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00383T
Chemical Name:
2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid
CAS Number:
215543-92-3
Molecular Formula:
C17H16N2O3
Molecular Weight:
296.3205
MDL Number:
MFCD08235144
SMILES:
OC(=O)CCc1c([nH]cc1C)C=C1C(=O)Nc2c1cccc2
Properties
Computed Properties
 
Complexity:
488  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
1.8  

Literature

Title: Eosinophil cationic protein enhances cardiomyocyte differentiation of P19CL6 embryonal carcinoma cells by stimulating the FGF receptor signaling pathway.

Journal: Growth factors (Chur, Switzerland) 20121001

Title: Pravastatin-induced proangiogenic effects depend upon extracellular FGF-2.

Journal: Journal of cellular and molecular medicine 20120901

Title: Antidepressant effects of fibroblast growth factor-2 in behavioral and cellular models of depression.

Journal: Biological psychiatry 20120815

Title: Regulatory role of kit ligand-c-kit interaction and oocyte factors in steroidogenesis by rat granulosa cells.

Journal: Molecular and cellular endocrinology 20120706

Title: Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors.

Journal: Nature biotechnology 20120701

Title: Fgf-dependent glial cell bridges facilitate spinal cord regeneration in zebrafish.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120530

Title: Involvement of NCAM and FGF receptor signaling in the development of analgesic tolerance to morphine.

Journal: European journal of pharmacology 20111215

Title: Fibroblast growth factor regulates human neuroectoderm specification through ERK1/2-PARP-1 pathway.

Journal: Stem cells (Dayton, Ohio) 20111201

Title: Optimization of culture conditions to support long-term self-renewal of buffalo (Bubalus bubalis) embryonic stem cell-like cells.

Journal: Cellular reprogramming 20111201

Title: Isolation and characterization of node/notochord-like cells from mouse embryonic stem cells.

Journal: Stem cells and development 20111101

Title: Acenaphtho[1,2-b]pyrrole-based selective fibroblast growth factor receptors 1 (FGFR1) inhibitors: design, synthesis, and biological activity.

Journal: Journal of medicinal chemistry 20110609

Title: Diffusible signals, not autonomous mechanisms, determine the main proximodistal limb subdivision.

Journal: Science (New York, N.Y.) 20110527

Title: A novel glycosylation signal regulates transforming growth factor beta receptors as evidenced by endo-beta-galactosidase C expression in rodent cells.

Journal: Glycobiology 20110401

Title: Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing.

Journal: Cell death and differentiation 20110301

Title: Ginsenoside-Rg1 induces angiogenesis via non-genomic crosstalk of glucocorticoid receptor and fibroblast growth factor receptor-1.

Journal: Cardiovascular research 20110201

Title: Wnt/β-catenin dependent cell proliferation underlies segmented lateral line morphogenesis.

Journal: Developmental biology 20110115

Title: Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo.

Journal: British journal of cancer 20110104

Title: Zebrafish Ext2 is necessary for Fgf and Wnt signaling, but not for Hh signaling.

Journal: BMC developmental biology 20110101

Title: Biochemical dissection of Anosmin-1 interaction with FGFR1 and components of the extracellular matrix.

Journal: Journal of neurochemistry 20101201

Title: Three inhibitors of FGF receptor, ERK, and GSK3 establishes germline-competent embryonic stem cells of C57BL/6N mouse strain with high efficiency and stability.

Journal: Genesis (New York, N.Y. : 2000) 20100501

Title: Reduced expression of fibroblast growth factor receptor 2IIIb in hepatocellular carcinoma induces a more aggressive growth.

Journal: The American journal of pathology 20100301

Title: Heparan sulfation-dependent fibroblast growth factor signaling maintains embryonic stem cells primed for differentiation in a heterogeneous state.

Journal: Stem cells (Dayton, Ohio) 20100201

Title: Dynamic expression of axon guidance cues required for optic tract development is controlled by fibroblast growth factor signaling.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100113

Title: Basic fibroblast growth factor promotes the generation of microtubule-associated protein 2-positive cells from microglia.

Journal: Biochemical and biophysical research communications 20091218

Title: Comparative expression profiling reveals an essential role for raldh2 in epimorphic regeneration.

Journal: The Journal of biological chemistry 20091127

Title: Agonists of fibroblast growth factor receptor induce neurite outgrowth and survival of cerebellar granule neurons.

Journal: Developmental neurobiology 20091101

Title: Xenopus Rnd1 and Rnd3 GTP-binding proteins are expressed under the control of segmentation clock and required for somite formation.

Journal: Developmental dynamics : an official publication of the American Association of Anatomists 20091101

Title: Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo.

Journal: Development (Cambridge, England) 20091001

Title: FGF2 is crucial for the development of bovine luteal endothelial networks in vitro.

Journal: Reproduction (Cambridge, England) 20090901

Title: FGF-activated calcium channels control neural gene expression in Xenopus.

Journal: Biochimica et biophysica acta 20090601

Title: FGF8 signaling regulates growth of midbrain dopaminergic axons by inducing semaphorin 3F.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090401

Title: Synthesis of 1-(2,6-dichlorophenyl)-3-methylene-1,3-dihydro-indol-2-one derivatives and in vitro anticancer evaluation against SW620 colon cancer cell line.

Journal: European journal of medicinal chemistry 20090301

Title: Sequential RARbeta and alpha signalling in vivo can induce adult forebrain neural progenitor cells to differentiate into neurons through Shh and FGF signalling pathways.

Journal: Developmental biology 20090215

Title: Growth factors involved in aqueous humour-induced lens cell proliferation.

Journal: Growth factors (Chur, Switzerland) 20090201

Title: Mitogen-activated protein kinase-signaling stimulates Müller glia to proliferate in acutely damaged chicken retina.

Journal: Glia 20090115

Title: Fibroblast growth factor receptor 1 is a key regulator of early adipogenic events in human preadipocytes.

Journal: American journal of physiology. Endocrinology and metabolism 20090101

Title: FGF4 and retinoic acid direct differentiation of hESCs into PDX1-expressing foregut endoderm in a time- and concentration-dependent manner.

Journal: PloS one 20090101

Title: Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis.

Journal: PloS one 20090101

Title: Enhancer detection and developmental expression of zebrafish sprouty1, a member of the fgf8 synexpression group.

Journal: Developmental dynamics : an official publication of the American Association of Anatomists 20080901

Title: Expression and regulation of HTRA1 during chick and early mouse development.

Journal: Developmental dynamics : an official publication of the American Association of Anatomists 20080701

Title: Retina development in zebrafish requires the heparan sulfate proteoglycan agrin.

Journal: Developmental neurobiology 20080601

Title: Fibroblast growth factor controls the timing of Scl, Lmo2, and Runx1 expression during embryonic blood development.

Journal: Blood 20080201

Title: Fibroblast growth factor-derived peptides: functional agonists of the fibroblast growth factor receptor.

Journal: Journal of neurochemistry 20080201

Title: Negative feedback for endothelial apoptosis: a potential physiological role for fibroblast growth factor.

Journal: Journal of vascular research 20080101

Title: Midkine-b regulates cell specification at the neural plate border in zebrafish.

Journal: Developmental dynamics : an official publication of the American Association of Anatomists 20080101

Title: Evidence for a major role of endogenous fibroblast growth factor-2 in apoptotic cortex-induced subventricular zone cell proliferation.

Journal: The European journal of neuroscience 20071201

Title: Activation of fibroblast growth factor receptor by axotomy, through downstream p38 in dorsal root ganglion, contributes to neuropathic pain.

Journal: Neuroscience 20071130

Title: Mechanism for FGF-1 to regulate biogenesis of apoE-HDL in astrocytes.

Journal: Journal of lipid research 20070901

Title: The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and notch signaling in the somite segmentation clock.

Journal: Developmental cell 20070801

Title: Oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells.

Journal: Development (Cambridge, England) 20070701

Title: Acute intermittent nicotine treatment induces fibroblast growth factor-2 in the subventricular zone of the adult rat brain and enhances neuronal precursor cell proliferation.

Journal: Neuroscience 20070316

Title: FGF is essential for both condensation and mesenchymal-epithelial transition stages of pronephric kidney tubule development.

Journal: Developmental biology 20060901

Title: Cell aggregation-induced FGF8 elevation is essential for P19 cell neural differentiation.

Journal: Molecular biology of the cell 20060701

Title: The accelerating effect of histamine on the cutaneous wound-healing process through the action of basic fibroblast growth factor.

Journal: The Journal of investigative dermatology 20060601

Title: FGF signaling is necessary for establishing gut tube domains along the anterior-posterior axis in vivo.

Journal: Mechanisms of development 20060101

Title: FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies.

Journal: Oncogene 20051215

Title: The hyaluronan-binding protease upregulates ERK1/2 and PI3K/Akt signalling pathways in fibroblasts and stimulates cell proliferation and migration.

Journal: Cellular signalling 20051201

Title: The fibroblast growth factor receptors, FGFR-1 and FGFR-2, mediate two independent signalling pathways in human retinal pigment epithelial cells.

Journal: Biochemical and biophysical research communications 20051111

Title: Regulation of neurokinin-1 receptor messenger RNA expression in synovial fibroblasts of patients with rheumatoid arthritis.

Journal: Neuropeptides 20051001

Title: A synthetic NCAM-derived peptide, FGL, protects hippocampal neurons from ischemic insult both in vitro and in vivo.

Journal: The European journal of neuroscience 20051001

Title: Oncogenic tyrosine kinase of malignant hemopathy targets the centrosome.

Journal: Cancer research 20050815

Title: Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin prevents synovial sarcoma proliferation via apoptosis in in vitro models.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050801

Title: FGF signal regulates gastrulation cell movements and morphology through its target NRH.

Journal: Developmental biology 20050601

Title: Tissue interaction between the retinal pigment epithelium and the choroid triggers retinal regeneration of the newt Cynops pyrrhogaster.

Journal: Developmental biology 20050401

Title: Disruption of fibroblast growth factor signal pathway inhibits the growth of synovial sarcomas: potential application of signal inhibitors to molecular target therapy.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050401

Title: Zebrafish Polycomb group gene ph2alpha is required for epiboly and tailbud formation acting downstream of FGF signaling.

Journal: Biochemical and biophysical research communications 20050325

Title: Transforming property of TEL-FGFR3 mediated through PI3-K in a T-cell lymphoma that subsequently progressed to AML.

Journal: Blood 20050301

Title: [Activation of HIF-1 by bFGF in breast cancer: role of PI-3K and MEK1/ERK pathways].

Journal: Zhonghua yi xue za zhi 20041117

Title: Fgf signaling is required for zebrafish tooth development.

Journal: Developmental biology 20041001

Title: Hedgehog and Fgf signaling pathways regulate the development of tphR-expressing serotonergic raphe neurons in zebrafish embryos.

Journal: Journal of neurobiology 20040905

Title: Fibroblast growth factor-1 improves cardiac functional recovery and enhances cell survival after ischemia and reperfusion: a fibroblast growth factor receptor, protein kinase C, and tyrosine kinase-dependent mechanism.

Journal: Journal of the American College of Cardiology 20040901

Title: Screening of FGF target genes in Xenopus by microarray: temporal dissection of the signalling pathway using a chemical inhibitor.

Journal: Genes to cells : devoted to molecular & cellular mechanisms 20040801

Title: Interactions between FGF and Wnt signals and Tbx3 gene expression in mammary gland initiation in mouse embryos.

Journal: Journal of anatomy 20040701

Title: Targeting FGFR3 in multiple myeloma: inhibition of t(4;14)-positive cells by SU5402 and PD173074.

Journal: Leukemia 20040501

Title: Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma.

Journal: British journal of haematology 20040301

Title: Inhibition of FGF signaling causes expansion of the endoderm in Xenopus.

Journal: Biochemical and biophysical research communications 20040227

Title: Regulation of segmental patterning by retinoic acid signaling during Xenopus somitogenesis.

Journal: Developmental cell 20040201

Title: An early Fgf signal required for gene expression in the zebrafish hindbrain primordium.

Journal: Brain research. Developmental brain research 20040131

Title: Fibroblast growth factor receptor-1 is essential for in vitro cardiomyocyte development.

Journal: Circulation research 20030905

Title: Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos.

Journal: Current biology : CB 20030617

Title: Preferential neurotrophic activity of fibroblast growth factor-20 for dopaminergic neurons through fibroblast growth factor receptor-1c.

Journal: Journal of neuroscience research 20030515

Title: Effect of angiogenesis inhibitors on oestrogen-mediated endometrial endothelial cell proliferation in the ovariectomized mouse.

Journal: Reproduction (Cambridge, England) 20030301

Title: Ventral axial organs regulate expression of myotomal Fgf-8 that influences rib development.

Journal: Developmental biology 20030301

Title: Gene expression profiles of mouse submandibular gland development: FGFR1 regulates branching morphogenesis in vitro through BMP- and FGF-dependent mechanisms.

Journal: Development (Cambridge, England) 20021201

Title: Fibroblast growth factor (FGF)-23 inhibits renal phosphate reabsorption by activation of the mitogen-activated protein kinase pathway.

Journal: The Journal of biological chemistry 20020802

Title: Regulated lens regeneration from isolated pigmented epithelial cells of newt iris in culture in response to FGF2/4.

Journal: Differentiation; research in biological diversity 20020501

Title: The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins.

Journal: Blood 20011215

Title: The status of Wnt signalling regulates neural and epidermal fates in the chick embryo.

Journal: Nature 20010517

Title: Identification of substituted 3-[(4,5,6, 7-tetrahydro-1H-indol-2-yl)methylene]-1,3-dihydroindol-2-ones as growth factor receptor inhibitors for VEGF-R2 (Flk-1/KDR), FGF-R1, and PDGF-Rbeta tyrosine kinases.

Journal: Journal of medicinal chemistry 20000713

Title: Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases.

Journal: Journal of medicinal chemistry 19991216

Title: Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases.

Journal: Journal of medicinal chemistry 19980702

Title: Sun L, et al. Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenylindolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J Med Chem. 1999 Dec 16;42(25):5120-30.

Title: Kachel P, et al. Phosphorylation of pyruvate kinase M2 and lactate dehydrogenase A by fibroblast growth factor receptor 1 in benign and malignant thyroid tissue. BMC Cancer. 2015 Mar 18;15:140.

Title: Trzcińska-Daneluti AM, et al. RNA Interference Screen to Identify Kinases That Suppress Rescue of ΔF508-CFTR. Mol Cell Proteomics. 2015 Jun;14(6):1569-83.

Title: Izikki M, et al. Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents. J Clin Invest. 2009 Mar;119(3):512-23.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:215543-92-3 Molecular Formula|215543-92-3 MDL|215543-92-3 SMILES|215543-92-3 2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid