Home Amines 1056634-68-4
1056634-68-4,MFCD16038899
Catalog No.:AA003860

1056634-68-4 | N-(Cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]benzamide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$19.00   $14.00
- +
5mg
98%(HPLC)powder
in stock  
$34.00   $24.00
- +
25mg
98%(HPLC)powder
in stock  
$91.00   $64.00
- +
100mg
98%(HPLC)powder
in stock  
$274.00   $192.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003860
Chemical Name:
N-(Cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]benzamide
CAS Number:
1056634-68-4
Molecular Formula:
C23H22N6O2
Molecular Weight:
414.4598
MDL Number:
MFCD16038899
SMILES:
N#CCNC(=O)c1ccc(cc1)c1ccnc(n1)Nc1ccc(cc1)N1CCOCC1
Properties
Computed Properties
 
Complexity:
615  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
2.6  

Literature

Title: Momelotinib therapy for myelofibrosis: a 7-year follow-up.

Journal: Blood cancer journal 20180301

Title: Momelotinib versus best available therapy in patients with myelofibrosis previously treated with ruxolitinib (SIMPLIFY 2): a randomised, open-label, phase 3 trial.

Journal: The Lancet. Haematology 20180201

Title: The effect of quercetin nanoparticle on cervical cancer progression by inducing apoptosis, autophagy and anti-proliferation via JAK2 suppression.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20160801

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Current outlook on molecular pathogenesis and treatment of myeloproliferative neoplasms.

Journal: Molecular diagnosis & therapy 20121001

Title: Liquid chromatography-tandem mass spectrometric assay for the JAK2 inhibitor CYT387 in plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120501

Title: Liquid chromatography-tandem mass spectrometric assay for the VEGFR inhibitor cediranib and its primary human metabolite cediranib-N⁺-glucuronide in plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120501

Title: JAK2 inhibitors and their impact in myeloproliferative neoplasms.

Journal: Hematology (Amsterdam, Netherlands) 20120401

Title: New generation small-molecule inhibitors in myeloproliferative neoplasms.

Journal: Current opinion in hematology 20120301

Title: Incyte comes of age with JAK inhibitor approval.

Journal: Nature biotechnology 20120109

Title: The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells.

Journal: Leukemia 20111201

Title: Targeting myeloproliferative neoplasms with JAK inhibitors.

Journal: Current opinion in hematology 20110301

Title: CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms.

Journal: Blood 20100624

Title: Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs).

Journal: Bioorganic & medicinal chemistry letters 20091015

Title: CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients.

Journal: Leukemia 20090801

Title: Pardanani A, et al. CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients. Leukemia, 2009, 23(8), 1441-1445.

Title: Monaghan KA, et al. The novel JAK inhibitor CYT387 suppresses multiple signalling pathways, prevents proliferation and induces apoptosis in phenotypically diverse myeloma cells. Leukemia, 2011, 25(12), 1891-1899.

Title: Tyner JW, et al. CYT387, a novel JAK2 inhibitor, induces hematologic responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms. Blood, 2010, 115(25), 5232-5240.

Title: Kitajima S, et al.Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS.Cancer Cell. 2018 Sep 10;34(3):439-452.e6. doi: 10.1016/j.ccell.2018.08.009.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 1056634-68-4
Tags:1056634-68-4 Molecular Formula|1056634-68-4 MDL|1056634-68-4 SMILES|1056634-68-4 N-(Cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]benzamide