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16816-67-4,MFCD07357235
Catalog No.:AA003864

16816-67-4 | D-Pantethine syrup

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
95%
in stock  
$24.00   $17.00
- +
5g
95%
in stock  
$64.00   $45.00
- +
25g
95%
in stock  
$197.00   $138.00
- +
100g
98 - 101% (Assay on anhydrous basis)
in stock  
$600.00   $420.00
- +
250g
98 - 101% (Assay on anhydrous basis)
in stock  
$1,258.00   $880.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003864
Chemical Name:
D-Pantethine syrup
CAS Number:
16816-67-4
Molecular Formula:
C22H42N4O8S2
Molecular Weight:
554.7209
MDL Number:
MFCD07357235
SMILES:
OCC([C@H](C(=O)NCCC(=O)NCCSSCCNC(=O)CCNC(=O)[C@@H](C(CO)(C)C)O)O)(C)C
Properties
Computed Properties
 
Complexity:
652  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
8  
Rotatable Bond Count:
19  
XLogP3:
-2.2  

Downstream Synthesis Route

[1]Moffatt,J.G.;Khorana,H.G.[JournaloftheAmericanChemicalSociety,1961,vol.83,p.663-675]

[2]Mouterde,LouisM.M.;Stewart,JonD.[OrganicProcessResearchandDevelopment,2016,vol.20,#5,p.954-959]

[3]Rath,ChristopherM.;Benton,BretM.;DeVicente,Javier;Drumm,JosephE.;Geng,Mei;Li,Cindy;Moreau,RobertJ.;Shen,Xiaoyu;Skepper,ColinK.;Steffek,Micah;Takeoka,Kenneth;Wang,Lisha;Wei,Jun-Rong;Xu,Wenjian;Zhang,Qiong;Feng,BrianY.[ACSInfectiousDiseases,2018,vol.4,#3,p.391-402]

[1]Taguchi,Y.etal.[BulletinoftheChemicalSocietyofJapan,1976,vol.49,p.1122-1125]

[2]Kopelevich,V.M.etal.[PharmaceuticalChemistryJournal,1967,#11,p.629-630][Khimiko-FarmatsevticheskiiZhurnal,1967,#11,p.26-27]

[3]Mouterde,LouisM.M.;Stewart,JonD.[OrganicProcessResearchandDevelopment,2016,vol.20,#5,p.954-959]

[1]Locationinpatent:experimentalpartYan,Xuxu;Akinnusi,T.Olukayode;Larsen,AaronT.;Auclair,Karine[OrganicandBiomolecularChemistry,2011,vol.9,#5,p.1538-1546]

[2]Heine;Sundaram;Beudert,Matthias;Martin;Hertweck[ChemicalScience,2016,vol.7,#8,p.4848-4855]

[3]Yi,Dongqi;Acharya,Atanu;Gumbart,JamesC.;Gutekunst,WillR.;Agarwal,Vinayak[JournaloftheAmericanChemicalSociety,2021,vol.143,#20,p.7617-7622]

[4]Locationinpatent:experimentalpartBorgaro,JanineG.;Chang,Andrew;MacHutta,CarlA.;Zhang,Xujie;Tonge,PeterJ.[Biochemistry,2011,vol.50,#49,p.10678-10686]

[5]Zheng;Hu;Cassady;Paige;Geahlen[JournalofPharmaceuticalSciences,1994,vol.83,#2,p.233-238]

[6]Locationinpatent:experimentalpartWu,Jiang;Zheng,YujunGeorge[HeterocyclicCommunications,2010,vol.16,#4-6,p.231-234]

[7]CurrentPatentAssignee:NORTH-WESTUNIVERSITY(SOUTHAFRICA)-WO2012/17400,2012,A1Locationinpatent:Page/Pagecolumn18

[8]Mouterde,LouisM.M.;Stewart,JonD.[OrganicProcessResearchandDevelopment,2016,vol.20,#5,p.954-959]

[9]CurrentPatentAssignee:KOREAINSTITUTEOFOCEANSCIENCETECHNOLOGY-KR101695375,2017,B1Locationinpatent:Paragraph0066

[10]CurrentPatentAssignee:KOREAINSTITUTEOFOCEANSCIENCETECHNOLOGY-US2018/185257,2018,A1Locationinpatent:Paragraph0060

[11]CurrentPatentAssignee:KOREAINSTITUTEOFOCEANSCIENCETECHNOLOGY-EP3549574,2019,A1Locationinpatent:Paragraph0022;0051

[12]Begley,TadhgP.;Wang,Yuanyou[JournaloftheAmericanChemicalSociety,2020,vol.142,#22,p.9944-9954]

CASUnavailable 
  16816-67-4 

[1]Wittleetal.[JournaloftheAmericanChemicalSociety,1953,vol.75,p.1694,1698]

[1]Gao,Feng;Yan,Xuxu;Shakya,Tushar;Baettig,OliverM.;Ait-Mohand-Brunet,Samia;Berghuis,AlbertM.;Wright,GerardD.;Auclair,Karine[JournalofMedicinalChemistry,2006,vol.49,#17,p.5273-5281]

Literature

Title: Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation.

Journal: Vascular health and risk management 20140101

Title: The role of nutraceutical supplements in the treatment of dyslipidemia.

Journal: Journal of clinical hypertension (Greenwich, Conn.) 20120201

Title: Impaired Coenzyme A metabolism affects histone and tubulin acetylation in Drosophila and human cell models of pantothenate kinase associated neurodegeneration.

Journal: EMBO molecular medicine 20111201

Title: Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk North American subjects: a triple-blinded placebo and diet-controlled investigation.

Journal: Nutrition research (New York, N.Y.) 20110801

Title: Comparison of the effects of pantethine and fursultiamine on plasma gastrointestinal peptide levels in healthy volunteers.

Journal: Biological & pharmaceutical bulletin 20110101

Title: Pantethine. Monograph.

Journal: Alternative medicine review : a journal of clinical therapeutic 20100901

Title: Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injury.

Journal: BMC neuroscience 20100101

Title: Current medical aspects of pantethine.

Journal: Ideggyogyaszati szemle 20090730

Title: Topical apolipoprotein A-1 may have a beneficial effect on the corneal epithelium in a mouse model of dry eye: a pilot study.

Journal: Eye & contact lens 20080901

Title: An Arabidopsis mutant impaired in coenzyme A biosynthesis is sugar dependent for seedling establishment.

Journal: Plant physiology 20060301

Title: Dietary and nutraceutical options for managing the hypertriglyceridemic patient.

Journal: Progress in cardiovascular nursing 20060101

Title: Inhibition of acetyl-CoA carboxylase by cystamine may mediate the hypotriglyceridemic activity of pantethine.

Journal: Medical hypotheses 20010301

Title: Can drugs or micronutrients prevent cataract?

Journal: Drugs & aging 20010101

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