Title: Effect of the Catechol-O-Methyltransferase Inhibitors Tolcapone and Entacapone on Fatty Acid Metabolism in HepaRG Cells.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20180801
Title: The catechol-O-methyltransferase inhibitors tolcapone and entacapone uncouple and inhibit the mitochondrial respiratory chain in HepaRG cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20170801
Title: Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals.
Journal: Chemical research in toxicology 20170515
Title: Utilization of human nuclear receptors as an early counter screen for off-target activity: a case study with a compendium of 615 known drugs.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20150601
Title: A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140101
Title: Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140101
Title: Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131201
Title: Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration.
Journal: Brain research 20130225
Title: Real-time concurrent monitoring of apoptosis, cytosolic calcium, and mitochondria permeability transition for hypermulticolor high-content screening of drug-induced mitochondrial dysfunction-mediated hepatotoxicity.
Journal: Toxicology letters 20121017
Title: Genetic vs. pharmacological inactivation of COMT influences cannabinoid-induced expression of schizophrenia-related phenotypes.
Journal: The international journal of neuropsychopharmacology 20121001
Title: The liver toxicity biomarker study phase I: markers for the effects of tolcapone or entacapone.
Journal: Toxicologic pathology 20120801
Title: Dopamine, corticostriatal connectivity, and intertemporal choice.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120704
Title: Levodopa infusion combined with entacapone or tolcapone in Parkinson disease: a pilot trial.
Journal: European journal of neurology 20120601
Title: Ultraviolet B radiation differentially modifies catechol-O-methyltransferase activity in keratinocytes and melanoma cells.
Journal: Photodermatology, photoimmunology & photomedicine 20120601
Title: The ethics of elective psychopharmacology.
Journal: The international journal of neuropsychopharmacology 20120501
Title: Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice.
Journal: Behavioural brain research 20120317
Title: COMT Val(158)Met genotype determines the direction of cognitive effects produced by catechol-O-methyltransferase inhibition.
Journal: Biological psychiatry 20120315
Title: Characterization of non-nitrocatechol pan and isoform specific catechol-O-methyltransferase inhibitors and substrates.
Journal: ACS chemical neuroscience 20120215
Title: Bioanalytical chromatographic methods for the determination of catechol-O-methyltransferase inhibitors in rodents and human samples: a review.
Journal: Analytica chimica acta 20120113
Title: Quantitative prediction of intestinal glucuronidation of drugs in rats using in vitro metabolic clearance data.
Journal: Drug metabolism and pharmacokinetics 20120101
Title: Dissociable effects of monoamine reuptake inhibitors on distinct forms of impulsive behavior in rats.
Journal: Psychopharmacology 20120101
Title: Neurocognitive correlates of apathy and anxiety in Parkinson's disease.
Journal: Parkinson's disease 20120101
Title: The dopamine augmenter L-DOPA does not affect positive mood in healthy human volunteers.
Journal: PloS one 20120101
Title: Risk of falls in Parkinson's disease: a cross-sectional study of 160 patients.
Journal: Parkinson's disease 20120101
Title: A systematic review of catechol-0-methyltransferase inhibitors: efficacy and safety in clinical practice.
Journal: Clinical neuropharmacology 20120101
Title: [A combined preparation stalevo in Parkinson's disease: a 5-year experience of continuous dopaminergic stimulation].
Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20120101
Title: Diverse facets of COMT: from a plausible predictive marker to a potential drug target for schizophrenia.
Journal: Current molecular medicine 20111201
Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Journal: PLoS computational biology 20111201
Title: 2'-Deoxyguanosine as a surrogate trapping agent for DNA reactive drug metabolites.
Journal: Toxicology letters 20111110
Title: Orientation and cellular distribution of membrane-bound catechol-O-methyltransferase in cortical neurons: implications for drug development.
Journal: The Journal of biological chemistry 20111007
Title: A within-subject comparison of 6-[18F]fluoro-m-tyrosine and 6-[18F]fluoro-L-dopa in Parkinson's disease.
Journal: Movement disorders : official journal of the Movement Disorder Society 20110901
Title: Development of a highly sensitive cytotoxicity assay system for CYP3A4-mediated metabolic activation.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110801
Title: Dopaminergic drugs and the risk of hip or femur fracture: a population-based case-control study.
Journal: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110701
Title: Species independence in brain tissue binding using brain homogenates.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110701
Title: Tolcapone, COMT polymorphisms and pharmacogenomic treatment of schizophrenia.
Journal: Pharmacogenomics 20110401
Title: Meta-analysis of the comparative efficacy and safety of adjuvant treatment to levodopa in later Parkinson's disease.
Journal: Movement disorders : official journal of the Movement Disorder Society 20110301
Title: D-Isomer of gly-tyr-pro-cys-pro-his-pro peptide: a novel and sensitive in vitro trapping agent to detect reactive metabolites by electrospray mass spectrometry.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20110201
Title: Kleptomania treated with tolcapone, a catechol-O-methyl-transferase (COMT) inhibitor.
Journal: Progress in neuro-psychopharmacology & biological psychiatry 20110115
Title: Sub-optimal performance in the 5-choice serial reaction time task in rats was sensitive to methylphenidate, atomoxetine and d-amphetamine, but unaffected by the COMT inhibitor tolcapone.
Journal: Neuroscience research 20110101
Title: Rotigotine effects on early morning motor function and sleep in Parkinson's disease: a double-blind, randomized, placebo-controlled study (RECOVER).
Journal: Movement disorders : official journal of the Movement Disorder Society 20110101
Title: Relation of subjective quality of life to motor symptom profile in Parkinson's disease.
Journal: Parkinson's disease 20110101
Title: Available and emerging treatments for Parkinson's disease: a review.
Journal: Drug design, development and therapy 20110101
Title: Once-daily pramipexole for the treatment of early and advanced idiopathic Parkinson's disease: implications for patients.
Journal: Neuropsychiatric disease and treatment 20110101
Title: Network neighbors of drug targets contribute to drug side-effect similarity.
Journal: PloS one 20110101
Title: Impact of external cue validity on driving performance in Parkinson's disease.
Journal: Parkinson's disease 20110101
Title: Factor analysis of attentional set-shifting performance in young and aged mice.
Journal: Behavioral and brain functions : BBF 20110101
Title: Identification and categorization of liver toxicity markers induced by a related pair of drugs.
Journal: International journal of molecular sciences 20110101
Title: Pharmacologic safety concerns in Parkinson's disease: facts and insights.
Journal: The International journal of neuroscience 20110101
Title: Liposomes for Targeted Delivery of Active Agents against Neurodegenerative Diseases (Alzheimer's Disease and Parkinson's Disease).
Journal: Journal of drug delivery 20110101
Title: Drug-resistant tuberculosis: emerging treatment options.
Journal: Clinical pharmacology : advances and applications 20110101
Title: Activation of nitrofurazone by azoreductases: multiple activities in one enzyme.
Journal: Scientific reports 20110101
Title: Comparison of in vitro cell models in predicting in vivo brain entry of drugs.
Journal: International journal of pharmaceutics 20101215
Title: Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20101201
Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201
Title: Systemic catechol-O-methyl transferase inhibition enables the D1 agonist radiotracer R-[11C]SKF 82957.
Journal: Nuclear medicine and biology 20101001
Title: Drug therapies for Parkinson's disease: A database analysis of patient compliance and persistence.
Journal: The American journal of geriatric pharmacotherapy 20100801
Title: Transdermal rotigotine for the perioperative management of Parkinson's disease.
Journal: Journal of neural transmission (Vienna, Austria : 1996) 20100701
Title: Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity.
Journal: The Journal of biological chemistry 20100514
Title: Pharmacokinetic-pharmacodynamic modeling of levodopa in patients with advanced Parkinson disease.
Journal: Clinical neuropharmacology 20100501
Title: Replacing a dopamine agonist by the COMT-inhibitor tolcapone as an adjunct to L-dopa in the treatment of Parkinson's disease: a randomized, multicenter, open-label, parallel-group study.
Journal: Clinical neuropharmacology 20100501
Title: Discovery of a long-acting, peripherally selective inhibitor of catechol-O-methyltransferase.
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Title: Impaired transmethylation potential in Parkinson's disease patients treated with L-Dopa.
Journal: Neuroscience letters 20100114
Title: Capture compound mass spectrometry sheds light on the molecular mechanisms of liver toxicity of two Parkinson drugs.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20100101
Title: Tolcapone improves sleep in patients with advanced Parkinson's disease (PD).
Journal: Archives of gerontology and geriatrics 20100101
Title: Quality of life in Parkinson's disease patients following adjunctive tolcapone therapy: results of an open-label, multicenter, community-based trial.
Journal: CNS spectrums 20100101
Title: Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models.
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Title: Carbidopa/levodopa/entacapone: the evidence for its place in the treatment of Parkinson's disease.
Journal: Core evidence 20100101
Title: Dual beneficial effects of (-)-epigallocatechin-3-gallate on levodopa methylation and hippocampal neurodegeneration: in vitro and in vivo studies.
Journal: PloS one 20100101
Title: Binding of protein kinase inhibitors to synapsin I inferred from pair-wise binding site similarity measurements.
Journal: PloS one 20100101
Title: Levodopa in the treatment of Parkinson's disease: an old drug still going strong.
Journal: Clinical interventions in aging 20100101
Title: Therapeutic interventions and adjustments in the management of Parkinson disease: role of combined carbidopa/levodopa/entacapone (Stalevo).
Journal: Neuropsychiatric disease and treatment 20100101
Title: The dopamine metabolite 3-methoxytyramine is a neuromodulator.
Journal: PloS one 20100101
Title: Toxicology and safety of COMT inhibitors.
Journal: International review of neurobiology 20100101
Title: Problems with the present inhibitors and a relevance of new and improved COMT inhibitors in Parkinson's disease.
Journal: International review of neurobiology 20100101
Title: COMT Val158Met Polymorphism Modulates Cognitive Effects of Dietary Intervention.
Journal: Frontiers in aging neuroscience 20100101
Title: Treatment of advanced Parkinson's disease.
Journal: Parkinson's disease 20100101
Title: Membrane-Bound Catechol-O-Methyl Transferase in Cortical Neurons and Glial Cells is Intracellularly Oriented.
Journal: Frontiers in psychiatry 20100101
Title: Tolcapone effects on gating, working memory, and mood interact with the synonymous catechol-O-methyltransferase rs4818c/g polymorphism.
Journal: Biological psychiatry 20091201
Title: Management of antiparkinsonian therapy during chronic subthalamic stimulation in Parkinson's disease.
Journal: Parkinsonism & related disorders 20091201
Title: Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study.
Journal: Biological psychiatry 20090915
Title: Identification of metabolite profiles of the catechol-O-methyl transferase inhibitor tolcapone in rat urine using LC/MS-based metabonomics analysis.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090815
Title: Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis.
Journal: PLoS computational biology 20090701
Title: Metabolism of protocatechuic acid influences fatty acid oxidation in rat heart: new anti-angina mechanism implication.
Journal: Biochemical pharmacology 20090315
Title: 'Bad guys' among the antiparkinsonian drugs.
Journal: Psychiatria Danubina 20090301
Title: Physiological and pathological role of alpha-synuclein in Parkinson's disease through iron mediated oxidative stress; the role of a putative iron-responsive element.
Journal: International journal of molecular sciences 20090301
Title: Tolcapone in elderly patients with Parkinson's disease: a prospective open-label multicenter non-interventional trial.
Journal: Archives of gerontology and geriatrics 20090101
Title: Tolcapone enhances food-evoked dopamine efflux and executive memory processes mediated by the rat prefrontal cortex.
Journal: Psychopharmacology 20090101
Title: The liver toxicity biomarker study: phase I design and preliminary results.
Journal: Toxicologic pathology 20090101
Title: Information about ADRs explored by pharmacovigilance approaches: a qualitative review of studies on antibiotics, SSRIs and NSAIDs.
Journal: BMC clinical pharmacology 20090101
Title: Tolcapone: review of its pharmacology and use as adjunctive therapy in patients with Parkinson's disease.
Journal: Clinical interventions in aging 20090101
Title: A review of ropinirole prolonged release in Parkinson's disease.
Journal: Clinical interventions in aging 20090101
Title: Levodopa/carbidopa and entacapone in the treatment of Parkinson's disease: efficacy, safety and patient preference.
Journal: Patient preference and adherence 20090101
Title: Possible treatment concepts for the levodopa-related hyperhomocysteinemia.
Journal: Cardiovascular psychiatry and neurology 20090101
Title: Antiparkinsonian therapy modifications in PD patients after STN DBS: a retrospective observational analysis.
Journal: Parkinsonism & related disorders 20081201
Title: Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition.
Journal: Archives of toxicology 20081201
Title: Improvement of prepulse inhibition and executive function by the COMT inhibitor tolcapone depends on COMT Val158Met polymorphism.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20081201
Title: Does COMT val158met affect behavioral phenotypes: yes, no, maybe?
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20081201
Title: Clinical experience of tolcapone in advanced Parkinson's disease.
Journal: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20081201
Title: Suppression of beta oscillations in the subthalamic nucleus following cortical stimulation in humans.
Journal: The European journal of neuroscience 20081001
Title: Current management of the cognitive dysfunction in Parkinson's disease: how far have we come?
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Title: Parkinson's disease and dopaminergic therapy--differential effects on movement, reward and cognition.
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Title: Current approaches to the treatment of Parkinson's disease.
Journal: Neuropsychiatric disease and treatment 20080801
Title: Clinical insights into pharmacogenetics and schizophrenia, part 2.
Journal: The Journal of clinical psychiatry 20080601
Title: Current status of symptomatic medical therapy in Parkinson's disease.
Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20080401
Title: Update on the use of pramipexole in the treatment of Parkinson's disease.
Journal: Neuropsychiatric disease and treatment 20080401
Title: Knowledge creation about ADRs--turning the perspective from the rear mirror to the projector?
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Title: COMT inhibition with tolcapone in the treatment algorithm of patients with Parkinson's disease (PD): relevance for motor and non-motor features.
Journal: Neuropsychiatric disease and treatment 20080201
Title: Drugs for Parkinson’s disease: levodopa is still the gold standard.
Journal: Neuropsychiatric disease and treatment 20080201
Title: Rasagiline in treatment of Parkinson's disease.
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Title: Evidence-based efficacy comparison of tolcapone and entacapone as adjunctive therapy in Parkinson's disease.
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Title: Impact of newer pharmacological treatments on quality of life in patients with Parkinson's disease.
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Title: Computational systems analysis of dopamine metabolism.
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Title: Real-life evaluations of compliance with mandatory drug safety monitoring exemplified with tolcapone in Parkinson's disease.
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Title: Role of tolcapone in the treatment of Parkinson's disease.
Journal: Expert review of neurotherapeutics 20071201
Title: Novel screening assay for antioxidant protection against peroxyl radical-induced loss of protein function.
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Title: Safety and tolerability of adjunctive tolcapone treatment in patients with early Parkinson's disease.
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Title: Rasagiline - a novel MAO B inhibitor in Parkinson's disease therapy.
Journal: Therapeutics and clinical risk management 20070601
Title: Continuous levodopa for advanced Parkinson's disease.
Journal: Neuropsychiatric disease and treatment 20070601
Title: Tolcapone improves cognition and cortical information processing in normal human subjects.
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Title: The endophenotype concept in psychiatric genetics.
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Title: Entacapone to tolcapone switch: Multicenter double-blind, randomized, active-controlled trial in advanced Parkinson's disease.
Journal: Movement disorders : official journal of the Movement Disorder Society 20070101
Title: Increased catechol-O-methyltransferase activity and protein expression in OX-42-positive cells in the substantia nigra after lipopolysaccharide microinfusion.
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Title: Treatment of cognitive deficits associated with schizophrenia: potential role of catechol-O-methyltransferase inhibitors.
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Title: Medical management of levodopa-associated motor complications in patients with Parkinson's disease.
Journal: CNS drugs 20070101
Title: Catechol-O-methyltransferase and its inhibitors in Parkinson's disease.
Journal: CNS drug reviews 20070101
Title: Results from a 2-year centralized tolcapone liver enzyme monitoring program.
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Title: Tolcapone: an efficacy and safety review (2007).
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Title: New strategies in motor parkinsonism.
Journal: Parkinsonism & related disorders 20070101
Title: [Tolcapone in the management of Parkinson's disease].
Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20070101
Title: Utility of tolcapone in fluctuating Parkinson's disease.
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Title: Tolcapone in the management of Parkinson's disease.
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Title: Bioactivation and hepatotoxicity of nitroaromatic drugs.
Journal: Current drug metabolism 20061001
Title: Understanding Parkinson's disease: an update on current diagnostic and treatment strategies.
Journal: Journal of the American Medical Directors Association 20060901
Title: Tolcapone decreases plasma levels of S-adenosyl-L-homocysteine and homocysteine in treated Parkinson's disease patients.
Journal: European journal of clinical pharmacology 20060601
Title: Practice Parameter: treatment of Parkinson disease with motor fluctuations and dyskinesia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology.
Journal: Neurology 20060411
Title: Optimal design for multivariate response pharmacokinetic models.
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Title: Tolcapone: new drug. In Parkinson's disease: unacceptable risk of severe hepatitis.
Journal: Prescrire international 20060401
Title: Lateralized semantic priming: modulation by levodopa, semantic distance, and participants' magical beliefs.
Journal: Neuropsychiatric disease and treatment 20060301
Title: Pharmacokinetic optimisation in the treatment of Parkinson's disease : an update.
Journal: Clinical pharmacokinetics 20060101
Title: Synthesis and biological evaluation of a novel series of 'ortho-nitrated' inhibitors of catechol-O-methyltransferase.
Journal: Journal of medicinal chemistry 20051215
Title: Two patients with COMT inhibitor-induced hepatic dysfunction and UGT1A9 genetic polymorphism.
Journal: Neurology 20051213
Title: Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice.
Journal: Nature neuroscience 20051101
Title: [Serious tolpcapone-induced hepatitis 17 months after commencing treatment].
Journal: Revue neurologique 20051101
Title: Gastrointestinal bleeding and massive liver damage in neuroleptic malignant syndrome.
Journal: Therapeutics and clinical risk management 20050901
Title: Rapid simultaneous determination of metabolic clearance of multiple compounds catalyzed in vitro by recombinant human UDP-glucuronosyltransferases.
Journal: Analytical biochemistry 20050601
Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.
Journal: Chemical research in toxicology 20050601
Title: The effect of nicotine in combination with various dopaminergic drugs on nigrostriatal dopamine in rats.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20050601
Title: Evidence-based medical review update: pharmacological and surgical treatments of Parkinson's disease: 2001 to 2004.
Journal: Movement disorders : official journal of the Movement Disorder Society 20050501
Title: UDP-glucuronosyltransferases and clinical drug-drug interactions.
Journal: Pharmacology & therapeutics 20050401
Title: The role of physicochemical properties of entacapone and tolcapone on their efficacy during local intrastriatal administration.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050401
Title: The combination of liquid chromatography/tandem mass spectrometry and chip-based infusion for improved screening and characterization of drug metabolites.
Journal: Rapid communications in mass spectrometry : RCM 20050101
Title: Tolcapone: a review of its use in the management of Parkinson's disease.
Journal: CNS drugs 20050101
Title: Tolcapone in Parkinson's disease: liver toxicity and clinical efficacy.
Journal: Expert opinion on drug safety 20050101
Title: Role of COMT inhibitors and dopamine agonists in the treatment of motor fluctuations.
Journal: Movement disorders : official journal of the Movement Disorder Society 20050101
Title: Oxidative stress mediated idiosyncratic drug toxicity.
Journal: Drug metabolism reviews 20050101
Title: [Tolcapone treatment of late stages of Parkinson's disease].
Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101
Title: [Comparison of the safety of the medicinal product in the European Union and the United States, tolcapone (Tasmar) -- COMT inhibitor as the analyzed example].
Journal: Neurologia i neurochirurgia polska 20050101
Title: Synthesis, biological evaluation, and molecular modeling studies of a novel, peripherally selective inhibitor of catechol-O-methyltransferase.
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Title: Assessment of catechol induction and glucuronidation in rat liver microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20041201
Title: Catechol-O-methyltransferase inhibitors versus active comparators for levodopa-induced complications in Parkinson's disease.
Journal: The Cochrane database of systematic reviews 20041018
Title: Catechol-O-methyltransferase inhibitors for levodopa-induced complications in Parkinson's disease.
Journal: The Cochrane database of systematic reviews 20041018
Title: Clinical advantages of COMT inhibition with entacapone - a review.
Journal: Journal of neural transmission (Vienna, Austria : 1996) 20041001
Title: SL25.1131 [3(S),3a(S)-3-methoxymethyl-7-[4,4,4-trifluorobutoxy]-3,3a,4,5-tetrahydro-1,3-oxazolo[3,4-a]quinolin-1-one], a new, reversible, and mixed inhibitor of monoamine oxidase-A and monoamine oxidase-B: biochemical and behavioral profile.
Journal: The Journal of pharmacology and experimental therapeutics 20040901
Title: Drug treatment of Parkinson's disease.
Journal: Dialogues in clinical neuroscience 20040901
Title: Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex.
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Title: [Treatment in Parkinson disease].
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Title: Differences in toxicity of the catechol-O-methyl transferase inhibitors, tolcapone and entacapone to cultured human neuroblastoma cells.
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Title: Safety and tolerability of COMT inhibitors.
Journal: Neurology 20040113
Title: [A comparative study of efficacy of dopamine receptors agonists and catechol-O-methyltransferase in the treatment of late stages of Parkinson's disease].
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Title: Cerebrospinal fluid 3,4-dihydroxyphenylacetic acid level after tolcapone administration as an indicator of nigrostriatal degeneration.
Journal: Experimental neurology 20030901
Title: Modifications of plasma and platelet levels of L-DOPA and its direct metabolites during treatment with tolcapone or entacapone in patients with Parkinson's disease.
Journal: Journal of neural transmission (Vienna, Austria : 1996) 20030801
Title: Prevention and treatment of motor fluctuations.
Journal: Parkinsonism & related disorders 20030801
Title: The psychometric properties of the Parkinson's Impact Scale (PIMS) as a measure of quality of life in Parkinson's disease.
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Title: Hepatotoxic profile of catechol-O-methyltransferase inhibitors in Parkinson's disease.
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Title: Molecular modeling and metabolic studies of the interaction of catechol-O-methyltransferase and a new nitrocatechol inhibitor.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20030301
Title: Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat.
Journal: The Journal of pharmacology and experimental therapeutics 20030201
Title: Rapid screening and characterization of drug metabolites using a new quadrupole-linear ion trap mass spectrometer.
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Title: In vitro metabolism of tolcapone to reactive intermediates: relevance to tolcapone liver toxicity.
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Title: The relevance of preclinical studies for the treatment of Parkinson's disease.
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Title: Effects of peripheral and central catechol-O-methyltransferase inhibition on striatal extracellular levels of dopamine: a microdialysis study in freely moving rats.
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Title: Advances in the pharmacological management of Parkinson disease.
Journal: Journal of neural transmission. Supplementum 20030101
Title: Tissue histopathology, clinical chemistry and behaviour of adult Comt-gene-disrupted mice.
Journal: Journal of applied toxicology : JAT 20030101
Title: Tolcapone-related liver dysfunction: implications for use in Parkinson's disease therapy.
Journal: Drug safety 20030101
Title: Mechanisms of idiosyncratic drug reactions: the case of felbamate.
Journal: Chemico-biological interactions 20021110
Title: Different toxicological profile of two COMT inhibitors in vivo: the role of uncoupling effects.
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Title: Effects of entacapone and tolcapone on mitochondrial membrane potential.
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Title: [The usefulness of dopaminergic drugs in traumatic brain injury].
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Title: Entacapone in the management of Parkinson's disease.
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Title: Entacapone does not induce conformational changes in liver mitochondria or skeletal muscle in vivo.
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Title: Different modes of action of catecholamine-O-methyltransferase inhibitors entacapone and tolcapone on adenylyl cyclase activity in vitro.
Journal: Journal of neural transmission (Vienna, Austria : 1996) 20020501
Title: 18F-dopa PET evidence that tolcapone acts as a central COMT inhibitor in Parkinson's disease.
Journal: Synapse (New York, N.Y.) 20020301
Title: Characterization of catechol glucuronidation in rat liver.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20020201
Title: Catechol-O-methyltransferase and Parkinson's disease.
Journal: Acta medica Okayama 20020201
Title: Synthesis of 1-(3,4-dihydroxy-5-nitrophenyl)-2-phenyl-ethanone and derivatives as potent and long-acting peripheral inhibitors of catechol-O-methyltransferase.
Journal: Journal of medicinal chemistry 20020131
Title: COMT-inhibition increases serum levels of dihydroxyphenylacetic acid (DOPAC) in patients with advanced Parkinson's disease.
Journal: Journal of neural transmission (Vienna, Austria : 1996) 20020101
Title: Dopaminergic transmission in the rat striatum in vivo in conditions of pharmacological modulation.
Journal: Neuroscience and behavioral physiology 20020101
Title: COMT inhibitors: management of Parkinson's disease.
Journal: Movement disorders : official journal of the Movement Disorder Society 20020101
Title: DA agonists -- ergot derivatives: bromocriptine: management of Parkinson's disease.
Journal: Movement disorders : official journal of the Movement Disorder Society 20020101
Title: Pharmacogenetic analysis of adverse drug effect reveals genetic variant for susceptibility to liver toxicity.
Journal: The pharmacogenomics journal 20020101
Title: Approaching disturbed sleep in late Parkinson's Disease: first step toward a proposal for a revised UPDRS.
Journal: Parkinsonism & related disorders 20011001
Title: Randomized trial of tolcapone versus pergolide as add-on to levodopa therapy in Parkinson's disease patients with motor fluctuations.
Journal: Movement disorders : official journal of the Movement Disorder Society 20010901
Title: Effect of intracerebral 6-nitronoradrenaline, an endogenous catechol-O-methyltransferase (COMT) inhibitor, on striatal dopamine metabolism in anaesthetised rats.
Journal: Journal of neuroscience methods 20010815
Title: D1-like dopamine receptor activation and natriuresis by nitrocatechol COMT inhibitors.
Journal: Kidney international 20010501
Title: Tolcapone increases plasma catecholamine levels in patients with Parkinson's disease.
Journal: Parkinsonism & related disorders 20010401
Title: Molecular mechanisms controlling the rate and specificity of catechol O-methylation by human soluble catechol O-methyltransferase.
Journal: Molecular pharmacology 20010201
Title: [Pharmacological treatments of Parkinson's disease].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20010201
Title: Gait analysis in advanced Parkinson's disease--effect of levodopa and tolcapone.
Journal: The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques 20010201
Title: Possible applications for dopaminergic agents following traumatic brain injury: part 2.
Journal: The Journal of head trauma rehabilitation 20010201
Title: Comparative toxicological study on the hepatic safety of entacapone and tolcapone in the rat.
Journal: Journal of neural transmission (Vienna, Austria : 1996) 20010101
Title: Catechol-O-methyltransferase decreases levodopa toxicity in vitro.
Journal: Clinical neuropharmacology 20010101
Title: The central catechol-O-methyltransferase inhibitor tolcapone increases striatal hydroxyl radical production in L-DOPA/carbidopa treated rats.
Journal: Journal of neural transmission (Vienna, Austria : 1996) 20010101
Title: Catechol-O-methyltransferase inhibitors in the management of Parkinson's disease.
Journal: Seminars in neurology 20010101
Title: Pharmacokinetic-pharmacodynamic relationship of levodopa with and without tolcapone in patients with Parkinson's disease.
Journal: Clinical pharmacokinetics 20010101
Title: Switch-over from tolcapone to entacapone in severe Parkinson's disease patients.
Journal: European neurology 20010101
Title: Comparison of two dosages of tolcapone added to levodopa in nonfluctuating patients with PD.
Journal: Clinical neuropharmacology 20010101
Title: Long-term comparative experience with tolcapone and entacapone in advanced Parkinson's disease.
Journal: Clinical neuropharmacology 20010101
Title: Neuroleptic malignant-like syndrome and acute hepatitis during tolcapone and clozapine medication.
Journal: European neurology 20010101
Title: A preclinical re-evaluation of the safety profile of tolcapone.
Journal: Functional neurology 20010101
Title: COMT inhibition and safety.
Journal: Functional neurology 20010101
Title: Tolcapone-related fulminant hepatitis: electron microscopy shows mitochondrial alterations.
Journal: Digestive diseases and sciences 20000901
Title: Population pharmacokinetics of levodopa in patients with Parkinson's disease treated with tolcapone.
Journal: Clinical pharmacology and therapeutics 20000601
Title: Clinical pharmacology, therapeutic use and potential of COMT inhibitors in Parkinson's disease.
Journal: Drugs 20000601
Title: Neuroleptic malignant-like syndrome in an elderly patient caused by abrupt withdrawal of tolcapone, a-catechol-o-methyl transferase inhibitor.
Journal: The American journal of medicine 20000415
Title: Tolcapone increases maximum concentration of levodopa.
Journal: Journal of neural transmission (Vienna, Austria : 1996) 20000101
Title: Effect of tolcapone on the haemodynamic effects and tolerability of desipramine.
Journal: European neurology 20000101
Title: [Akathisia secondary to tolcapone. Report of a case].
Journal: Gaceta medica de Mexico 20000101
Title: Vitiligo associated with tolcapone and levodopa in a patient with Parkinson's disease.
Journal: The Annals of pharmacotherapy 19991101
Title: Open study of the catechol-O-methyltransferase inhibitor tolcapone in major depressive disorder.
Journal: Journal of clinical psychopharmacology 19990801
Title: Effects of tolcapone upon soluble and membrane-bound brain and liver catechol-O-methyltransferase.
Journal: Brain research 19990306
Title: Tolcapone, a selective catechol-O-methyltransferase inhibitor for treatment of Parkinson's disease.
Journal: Pharmacotherapy 19990101
Title: Efficacy and tolerability of tolcapone compared with bromocriptine in levodopa-treated parkinsonian patients. Tolcapone Study Group.
Journal: Movement disorders : official journal of the Movement Disorder Society 19990101
Title: Pharmacokinetics and pharmacodynamics of L-Dopa after acute and 6-week tolcapone administration in patients with Parkinson's disease.
Journal: Clinical neuropharmacology 19990101
Title: Inhibition of catechol-O-methyltransferase (COMT) in the brain does not affect the action of dopamine and levodopa: an in vitro electrophysiological evidence from rat mesencephalic dopamine neurons.
Journal: Journal of neural transmission (Vienna, Austria : 1996) 19990101
Title: Randomized, placebo-controlled study of tolcapone in patients with fluctuating Parkinson disease treated with levodopa-carbidopa. Tolcapone Fluctuator Study Group III.
Journal: Archives of neurology 19980801
Title: Pharmacokinetics and pharmacodynamics after oral and intravenous administration of tolcapone, a novel adjunct to Parkinson's disease therapy.
Journal: European journal of clinical pharmacology 19980701
Title: Tolcapone in stable Parkinson's disease: efficacy and safety of long-term treatment. Tolcapone Stable Study Group.
Journal: Neurology 19980501
Title: Tolcapone in stable Parkinson's disease: efficacy and safety of long-term treatment. The Tolcapone Stable Study Group.
Journal: Neurology 19970901
Title: Optimizing levodopa pharmacokinetics with multiple tolcapone doses in the elderly.
Journal: Clinical pharmacology and therapeutics 19970901
Title: Ontogenic aspects of liver and kidney catechol-O-methyltransferase sensitivity to tolcapone.
Journal: British journal of pharmacology 19960201
Title: Multiple-dose clinical pharmacology of the catechol-O-methyl-transferase inhibitor tolcapone in elderly subjects.
Journal: European journal of clinical pharmacology 19960101
Title: Effects of the catechol-O-methyltransferase inhibitor tolcapone in Parkinson's disease: correlations between concentrations of dopaminergic substances in the plasma and cerebrospinal fluid and clinical improvement.
Journal: Neuroscience letters 19950616
Title: Acute administration of levodopa-benserazide and tolcapone, a COMT inhibitor, Parkinson's disease.
Journal: Clinical neuropharmacology 19950601
Title: Integrated pharmacokinetics and pharmacodynamics of the novel catechol-O-methyltransferase inhibitor tolcapone during first administration to humans.
Journal: Clinical pharmacology and therapeutics 19950501
Title: Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme.
Journal: Biochemistry 19950404
Title: Beneficial effects of co-administration of catechol-O-methyltransferase inhibitors and L-dihydroxyphenylalanine in rat models of depression.
Journal: European journal of pharmacology 19950214
Title: The COMT inhibitor tolcapone potentiates the anticataleptic effect of Madopar in MPP(+)-lesioned mice.
Journal: Experientia 19941015
Title: Tolcapone: a potential new antidepressant detected in a novel animal model of depression.
Journal: Behavioural pharmacology 19940601
Title: Attenuation of haloperidol-induced catalepsy by noradrenaline and L-threo-DOPS.
Journal: Journal of neural transmission. Parkinson's disease and dementia section 19930101
Title: Behavioural and neurochemical effects of Ro 40-7592, a new COMT inhibitor with a potential therapeutic activity in Parkinson's disease.
Journal: Journal of neural transmission. Parkinson's disease and dementia section 19900101
Title: Ro 40-7592: inhibition of COMT in rat brain and extracerebral tissues.
Journal: Journal of neural transmission. Supplementum 19900101
