Home Other Building Blocks 133865-89-1
133865-89-1,MFCD00897036
Catalog No.:AA0038VE

133865-89-1 | Safinamide

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5mg
98%
in stock  
$7.00   $5.00
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250mg
98%
in stock  
$16.00   $11.00
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5g
98%
in stock  
$228.00   $160.00
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10g
98%
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$411.00   $288.00
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25g
98%
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$809.00   $567.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0038VE
Chemical Name:
Safinamide
CAS Number:
133865-89-1
Molecular Formula:
C17H19FN2O2
Molecular Weight:
302.3434
MDL Number:
MFCD00897036
SMILES:
NC(=O)[C@@H](NCc1ccc(cc1)OCc1cccc(c1)F)C
Properties
Computed Properties
 
Complexity:
346  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
2.2  

Literature

Title: 1,3-Dialkyl-substituted tetrahydropyrimido[1,2-f]purine-2,4-diones as multiple target drugs for the potential treatment of neurodegenerative diseases.

Journal: Bioorganic & medicinal chemistry 20131201

Title: A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency.

Journal: mBio 20130101

Title: Disposition and metabolism of safinamide, a novel drug for Parkinson's disease, in healthy male volunteers.

Journal: Pharmacology 20130101

Title: The effect of safinamide, a novel drug for Parkinson's disease, on pressor response to oral tyramine: a randomized, double-blind, clinical trial.

Journal: Clinical pharmacology and therapeutics 20121001

Title: Emerging therapies for Parkinson's disease.

Journal: Current opinion in neurology 20120801

Title: Managing the patient with newly diagnosed Parkinson disease.

Journal: Cleveland Clinic journal of medicine 20120701

Title: A randomized, double-blind, placebo-controlled trial of safinamide as add-on therapy in early Parkinson's disease patients.

Journal: Movement disorders : official journal of the Movement Disorder Society 20120101

Title: Novel reversible monoamine oxidase A inhibitors: highly potent and selective 3-(1H-pyrrol-3-yl)-2-oxazolidinones.

Journal: Journal of medicinal chemistry 20111208

Title: Pressor response to oral tyramine during co-administration with safinamide in healthy volunteers.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20111201

Title: Monoamine oxidase B inhibitors for the treatment of Parkinson's disease: a review of symptomatic and potential disease-modifying effects.

Journal: CNS drugs 20111201

Title: Lights and shadows on monoamine oxidase inhibition in neuroprotective pharmacological therapies.

Journal: Current topics in medicinal chemistry 20111101

Title: 3-Acetyl-2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoles: a new scaffold for the selective inhibition of monoamine oxidase B.

Journal: Journal of medicinal chemistry 20110922

Title: Medical management of Parkinson's disease: focus on neuroprotection.

Journal: Current neuropharmacology 20110601

Title: A validated chiral liquid chromatographic method for the enantiomeric separation of safinamide mesilate, a new anti-Parkinson drug.

Journal: Journal of pharmaceutical and biomedical analysis 20110428

Title: Available and emerging treatments for Parkinson's disease: a review.

Journal: Drug design, development and therapy 20110101

Title: Liposomes for Targeted Delivery of Active Agents against Neurodegenerative Diseases (Alzheimer's Disease and Parkinson's Disease).

Journal: Journal of drug delivery 20110101

Title: Safinamide in the treatment of Parkinson's disease.

Journal: Expert opinion on pharmacotherapy 20100901

Title: The Movement Disorder Society--14th International Congress of Parkinson's Disease and Movement Disorders.

Journal: IDrugs : the investigational drugs journal 20100801

Title: Two polymorphs of safinamide, a selective and reversible inhibitor of monoamine oxidase B.

Journal: Acta crystallographica. Section C, Crystal structure communications 20100601

Title: Merging the structural motifs of functionalized amino acids and alpha-aminoamides: compounds with significant anticonvulsant activities.

Journal: Journal of medicinal chemistry 20100513

Title: Recent advances in adjunctive therapy for epilepsy: focus on sodium channel blockers as third-generation antiepileptic drugs.

Journal: Drugs of today (Barcelona, Spain : 1998) 20100401

Title: Superpose3D: a local structural comparison program that allows for user-defined structure representations.

Journal: PloS one 20100101

Title: Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions.

Journal: Pharmacological reports : PR 20090101

Title: An expert opinion on safinamide in Parkinson's disease.

Journal: Expert opinion on investigational drugs 20080701

Title: Computational systems analysis of dopamine metabolism.

Journal: PloS one 20080101

Title: Monoamine oxidase-B inhibition in the treatment of Parkinson's disease.

Journal: Pharmacotherapy 20071201

Title: Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs.

Journal: Journal of medicinal chemistry 20071115

Title: Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase.

Journal: Journal of medicinal chemistry 20071004

Title: Safinamide for the treatment of Parkinson's disease, epilepsy and restless legs syndrome.

Journal: Current opinion in investigational drugs (London, England : 2000) 20070701

Title: Safinamide.

Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20070101

Title: Safinamide: from molecular targets to a new anti-Parkinson drug.

Journal: Neurology 20061010

Title: Symptom relief in Parkinson disease by safinamide: Biochemical and clinical evidence of efficacy beyond MAO-B inhibition.

Journal: Neurology 20061010

Title: New pharmacologic horizons in the treatment of Parkinson disease.

Journal: Neurology 20061010

Title: Bioassay of safinamide in biological fluids of humans and various animal species.

Journal: Arzneimittel-Forschung 20060101

Title: Voltage gated ion channels: targets for anticonvulsant drugs.

Journal: Current topics in medicinal chemistry 20050101

Title: Improvement of motor function in early Parkinson disease by safinamide.

Journal: Neurology 20040824

Title: Pharmacokinetics and pharmacodynamics of safinamide, a neuroprotectant with antiparkinsonian and anticonvulsant activity.

Journal: Pharmacological research 20040701

Title: Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class.

Journal: Journal of medicinal chemistry 20040325

Title: Safinamide: FCE 26743, NW 1015, PNU 151774, PNU 151774E.

Journal: Drugs in R&D 20040101

Title: Progress report on new antiepileptic drugs: a summary of the Seventh Eilat Conference (EILAT VII).

Journal: Epilepsy research 20040101

Title: Pressor response to intravenous tyramine in healthy subjects after safinamide, a novel neuroprotectant with selective, reversible monoamine oxidase B inhibition.

Journal: Clinical neuropharmacology 20030101

Title: Novel anticonvulsant medications in development.

Journal: Expert opinion on investigational drugs 20021001

Title: Progress report on new antiepileptic drugs: a summary of the Sixth Eilat Conference (EILAT VI).

Journal: Epilepsy research 20020901

Title: Safinamide (Newron Pharmaceuticals).

Journal: Current opinion in investigational drugs (London, England : 2000) 20010601

Title: Future prospects for the drug treatment of epilepsy.

Journal: CNS drugs 20010101

Title: Leonetti F, et al. Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase. J Med Chem, 2007, 50(20), 4909-4916.

Title: C Caccia, et al.Safinamide: from molecular targets to a new anti-Parkinson drug. Neurology. 2006 Oct 10;67(7 Suppl 2):S18-23.

Title: Michele Morari, et al. Safinamide Differentially Modulates In Vivo Glutamate and GABA Release in the Rat Hippocampus and Basal Ganglia.J Pharmacol Exp Ther. 2018 Feb;364(2):198-206.

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