Home Other Building Blocks 585-86-4
585-86-4,MFCD00150767
Catalog No.:AA003913

585-86-4 | 4-O-beta-D-Galactopyranosyl-D-glucitol

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
98%
in stock  
$231.00   $162.00
- +
500mg
98%
in stock  
$777.00   $544.00
- +
1g
98%
in stock  
$1,256.00   $879.00
- +
5g
98%
in stock  
$5,449.00   $3,814.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003913
Chemical Name:
4-O-beta-D-Galactopyranosyl-D-glucitol
CAS Number:
585-86-4
Molecular Formula:
C12H24O11
Molecular Weight:
344.3124
MDL Number:
MFCD00150767
SMILES:
OC[C@H]([C@H]([C@@H]([C@H](CO)O)O)O[C@@H]1O[C@H](CO)[C@@H]([C@@H]([C@H]1O)O)O)O
NSC Number:
760415
Properties
Computed Properties
 
Complexity:
343  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
9  
Rotatable Bond Count:
8  
XLogP3:
-5.2  

Downstream Synthesis Route

[1]CurrentPatentAssignee:INTERNATIONALFLAVORS&FRAGRANCESINC-WO2007/125176,2007,A1Locationinpatent:Page/Pagecolumn16-17;24

[2]CurrentPatentAssignee:INTERNATIONALFLAVORS&FRAGRANCESINC-WO2007/125176,2007,A1Locationinpatent:Page/Pagecolumn24

[3]CurrentPatentAssignee:INTERNATIONALFLAVORS&FRAGRANCESINC-WO2007/125176,2007,A1Locationinpatent:Page/Pagecolumn16-17;24

[4]CurrentPatentAssignee:SHANDONGLVJIANBIOLOGTECHNOLOGY-CN103980329,2016,BLocationinpatent:Paragraph0023-0024

[5]Ishikawa,Hiroki;Kida,Michio;Kuriyama,Wataru;Matsumura,Kazuhiko;Touge,Taichiro[OrganicProcessResearchandDevelopment,2022]

[1]Patent:WO2007/125176,2007,A1.Locationinpatent:Page/Pagecolumn17-18;20-21;24-25

[2]Patent:WO2007/125176,2007,A1.Locationinpatent:Page/Pagecolumn24-25

[3]Patent:WO2007/125176,2007,A1.Locationinpatent:Page/Pagecolumn24-25

[4]Patent:WO2007/125176,2007,A1.Locationinpatent:Page/Pagecolumn24-25

[5]Patent:WO2007/125176,2007,A1.Locationinpatent:Page/Pagecolumn24-25

[6]Patent:WO2007/125176,2007,A1.Locationinpatent:Page/Pagecolumn24-25

[7]Patent:WO2007/125176,2007,A1.Locationinpatent:Page/Pagecolumn24-25

[1]Patent:WO2007/125176,2007,A1.Locationinpatent:Page/Pagecolumn18-19

CASUnavailable 
  585-86-4    1647064-28-5 

[1]CurrentPatentAssignee:ChengYi;GaoYouheng;ChenYuchao;ZhengPinjing-CN104292289,2017,BLocationinpatent:Paragraph0069;0075;0076;0085;0086

Literature

Title: Improved bioavailability of inhibitors of Trypanosoma cruzi trans-sialidase: PEGylation of lactose analogs with multiarm polyethyleneglycol.

Journal: Glycobiology 20121001

Title: Gut microbiota of healthy elderly NSAID users is selectively modified with the administration of Lactobacillus acidophilus NCFM and lactitol.

Journal: Age (Dordrecht, Netherlands) 20120801

Title: Osmotic and stimulant laxatives for the management of childhood constipation.

Journal: The Cochrane database of systematic reviews 20120711

Title: Freeze-thaw stability of duck surimi-like materials with different cryoprotectants added.

Journal: Poultry science 20120701

Title: [Hepatic encephalopathy and liver transplantation].

Journal: Magyar sebeszet 20120401

Title: Revision and update on clinical practice guideline for liver cirrhosis.

Journal: The Korean journal of hepatology 20120301

Title: Aging of the human metaorganism: the microbial counterpart.

Journal: Age (Dordrecht, Netherlands) 20120201

Title: The effect of alternative sweeteners on batter rheology and cake properties.

Journal: Journal of the science of food and agriculture 20120115

Title: [Diagnostics and treatment of hepatic encephalopathy].

Journal: Deutsche medizinische Wochenschrift (1946) 20120101

Title: Beta glucan: health benefits in obesity and metabolic syndrome.

Journal: Journal of nutrition and metabolism 20120101

Title: Comparison of a Chinese Herbal Medicine (CCH1) and Lactulose as First-Line Treatment of Constipation in Long-Term Care: A Randomized, Double-Blind, Double-Dummy, and Placebo-Controlled Trial.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Biological activity of SE-10, granulated powder of Sasa senanensis Rehder leaf extract.

Journal: In vivo (Athens, Greece) 20120101

Title: Management of hepatic encephalopathy by traditional chinese medicine.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Lactulose for minimal hepatic encephalopathy in patients with extrahepatic portal vein obstruction.

Journal: Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 20120101

Title: The end-organ impairment in liver cirrhosis: appointments for critical care.

Journal: Critical care research and practice 20120101

Title: Transcriptional analysis of prebiotic uptake and catabolism by Lactobacillus acidophilus NCFM.

Journal: PloS one 20120101

Title: [Influence of lactitol and lactulose on adhesion properties of Bacillus subtilis probiotic strains].

Journal: Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993) 20120101

Title: Proteome reference map of Lactobacillus acidophilus NCFM and quantitative proteomics towards understanding the prebiotic action of lactitol.

Journal: Proteomics 20110901

Title: Comparative and functional genomics of Rhodococcus opacus PD630 for biofuels development.

Journal: PLoS genetics 20110901

Title: Prolonging the viability of Lactobacillus plantarum through the addition of prebiotics into the medium.

Journal: Journal of food science 20110801

Title: Effects of xylitol on metabolic parameters and visceral fat accumulation.

Journal: Journal of clinical biochemistry and nutrition 20110701

Title: Starches, sugars and obesity.

Journal: Nutrients 20110301

Title: Metabolic responses to high glycemic index and low glycemic index meals: a controlled crossover clinical trial.

Journal: Nutrition journal 20110101

Title: Constipation in children: novel insight into epidemiology, pathophysiology and management.

Journal: Journal of neurogastroenterology and motility 20110101

Title: Profile of hepatic encephalopathy in children with cirrhosis and response to lactulose.

Journal: Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 20110101

Title: Longevity in mice is promoted by probiotic-induced suppression of colonic senescence dependent on upregulation of gut bacterial polyamine production.

Journal: PloS one 20110101

Title: Barcoded pyrosequencing reveals that consumption of galactooligosaccharides results in a highly specific bifidogenic response in humans.

Journal: PloS one 20110101

Title: Management of hepatic encephalopathy.

Journal: International journal of hepatology 20110101

Title: A capillary blood ammonia bedside test following glutamine load to improve the diagnosis of hepatic encephalopathy in cirrhosis.

Journal: BMC gastroenterology 20110101

Title: Successful drug development despite adverse preclinical findings part 2: examples.

Journal: Journal of toxicologic pathology 20101201

Title: Differences between reversible (self-association) and irreversible aggregation of rHuG-CSF in carbohydrate and polyol formulations.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20101101

Title: Lactitol or lactulose in the treatment of chronic constipation: result of a systematic.

Journal: Journal of the Indian Medical Association 20101101

Title: Current and emerging strategies for treating hepatic encephalopathy.

Journal: Critical care nursing clinics of North America 20100901

Title: Synthesis of PEGylated lactose analogs for inhibition studies on T.cruzi trans-sialidase.

Journal: Glycoconjugate journal 20100701

Title: Pharmacotherapy for hepatic encephalopathy.

Journal: Drugs 20100618

Title: Synbiotic effects of lactitol and Lactobacillus acidophilus NCFM™ in a semi-continuous colon fermentation model.

Journal: Beneficial microbes 20100601

Title: Xylo-oligosaccharides and lactitol promote the growth of Bifidobacterium lactis and Lactobacillus species in pure cultures.

Journal: Beneficial microbes 20100601

Title: Freeze-drying of proteins with glass-forming oligosaccharide-derived sugar alcohols.

Journal: International journal of pharmaceutics 20100415

Title: Idiopathic proximal hemimegacolon in an adult woman.

Journal: Journal of neurogastroenterology and motility 20100401

Title: Recombinant human granulocyte colony stimulating factor pre-screening and screening of stabilizing carbohydrates and polyols.

Journal: International journal of pharmaceutics 20100315

Title: Standards of medical care in diabetes--2010.

Journal: Diabetes care 20100101

Title: Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults.

Journal: PloS one 20100101

Title: Sugar alcohols, caries incidence, and remineralization of caries lesions: a literature review.

Journal: International journal of dentistry 20100101

Title: Microbial and bioconversion production of D-xylitol and its detection and application.

Journal: International journal of biological sciences 20100101

Title: Duodenal administered seal oil for patients with subjective food hypersensitivity: an explorative open pilot study.

Journal: International journal of general medicine 20100101

Title: Constipation in adults.

Journal: BMJ clinical evidence 20100101

Title: Polyols as filler-binders for disintegrating tablets prepared by direct compaction.

Journal: Drug development and industrial pharmacy 20090601

Title: [Elderly hereditary hemorrhagic telangiectasia female with portosystemic encephalopathy].

Journal: Rinsho shinkeigaku = Clinical neurology 20090501

Title: Influence of a combination of Lactobacillus acidophilus NCFM and lactitol on healthy elderly: intestinal and immune parameters.

Journal: The British journal of nutrition 20090201

Title: Standards of medical care in diabetes--2009.

Journal: Diabetes care 20090101

Title: Suppressive response of confections containing the extractive from leaves of Morus Alba on postprandial blood glucose and insulin in healthy human subjects.

Journal: Nutrition & metabolism 20090101

Title: Current trends in the treatment of hepatic encephalopathy.

Journal: Therapeutics and clinical risk management 20090101

Title: The role of rifaximin in the treatment and chemoprophylaxis of travelers' diarrhea.

Journal: Therapeutics and clinical risk management 20090101

Title: Some putative prebiotics increase the severity of Salmonella enterica serovar Typhimurium infection in mice.

Journal: BMC microbiology 20090101

Title: Sensory properties and color measurements of dietary chocolates with different compositions during storage for up to 360 days.

Journal: Sensors (Basel, Switzerland) 20090101

Title: Intestinal metabolism of weaned piglets fed a typical United States or European diet with or without supplementation of tributyrin and lactitol.

Journal: Journal of animal science 20081101

Title: Treatment of minimal hepatic encephalopathy.

Journal: Hepatology research : the official journal of the Japan Society of Hepatology 20081101

Title: Rifaximin for the treatment of hepatic encephalopathy.

Journal: Pharmacotherapy 20080801

Title: Roles of probiotics and prebiotics in colon cancer prevention: Postulated mechanisms and in-vivo evidence.

Journal: International journal of molecular sciences 20080501

Title: Characteristic fragmentation patterns of the trimethylsilyl and trimethylsilyl-oxime derivatives of various saccharides as obtained by gas chromatography coupled to ion-trap mass spectrometry.

Journal: Journal of chromatography. A 20080104

Title: Human lactobacilli as supplementation of clindamycin to patients with bacterial vaginosis reduce the recurrence rate; a 6-month, double-blind, randomized, placebo-controlled study.

Journal: BMC women's health 20080101

Title: Xylitol-supplemented nutrition enhances bacterial killing and prolongs survival of rats in experimental pneumococcal sepsis.

Journal: BMC microbiology 20080101

Title: [Influence of the bifidobacteria and lactitol containing products on lypoperoxidation processes and intestinal microflora].

Journal: Voprosy pitaniia 20080101

Title: Relevance of the diversity among members of the Trypanosoma cruzi trans-sialidase family analyzed with camelids single-domain antibodies.

Journal: PloS one 20080101

Title: Prophylactic antibiotic treatment is superior to therapy on-demand in experimental necrotising pancreatitis.

Journal: Critical care (London, England) 20080101

Title: Accuracy of drug advertisements in medical journals under new law regulating the marketing of pharmaceutical products in Switzerland.

Journal: BMC medical informatics and decision making 20080101

Title: Ecological characterization of the colonic microbiota of normal and diarrheic dogs.

Journal: Interdisciplinary perspectives on infectious diseases 20080101

Title: [Prebiotic lactitol as a component of biopreparation from aerobic bacilli].

Journal: Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993) 20080101

Title: The treatment of hepatic encephalopathy.

Journal: Metabolic brain disease 20071201

Title: The trans-sialidase from Trypanosoma cruzi efficiently transfers alpha-(2-->3)-linked N-glycolylneuraminic acid to terminal beta-galactosyl units.

Journal: Carbohydrate research 20071126

Title: Suppressive effect of partially hydrolyzed guar gum on transitory diarrhea induced by ingestion of maltitol and lactitol in healthy humans.

Journal: European journal of clinical nutrition 20070901

Title: Effects of low doses of lactitol on faecal microflora, pH, short chain fatty acids and gastrointestinal symptomology.

Journal: European journal of nutrition 20070901

Title: [A case of recurrent pneumatosis cystoides intestinalis associated with recurrent pneumoperitoneum].

Journal: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20070901

Title: A study of the properties of tablets from the mixtures of directly compressible starch and directly compressible lactitol.

Journal: Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20070701

Title: Characterization of the bga1-encoded glycoside hydrolase family 35 beta-galactosidase of Hypocrea jecorina with galacto-beta-D-galactanase activity.

Journal: The FEBS journal 20070401

Title: Threshold for transitory diarrhea induced by ingestion of xylitol and lactitol in young male and female adults.

Journal: Journal of nutritional science and vitaminology 20070201

Title: Effects of lactitol on intestinal microflora and plasma endotoxin in patients with chronic viral hepatitis.

Journal: The Journal of infection 20070101

Title: Anemia impairs small intestinal absorption measured by intestinal permeability in children.

Journal: European annals of allergy and clinical immunology 20070101

Title: Effect of oral lactulose on clinical and immunohistochemical parameters in patients with inflammatory bowel disease: a pilot study.

Journal: BMC gastroenterology 20070101

Title: Constipation in adults.

Journal: BMJ clinical evidence 20070101

Title: Molecular mobility and dynamic site heterogeneity in amorphous lactose and lactitol from erythrosin B phosphorescence.

Journal: Biophysical chemistry 20060920

Title: The trans-sialidase from Trypanosoma cruzi triggers apoptosis by target cell sialylation.

Journal: Cellular microbiology 20060701

Title: Prevention of first overt episode of hepatic encephalopathy after TIPS: no easy task.

Journal: Hepatology (Baltimore, Md.) 20060501

Title: Direct simultaneous determination of eight sweeteners in foods by capillary isotachophoresis.

Journal: Journal of separation science 20060501

Title: Carbohydrate preference, acid tolerance and bile tolerance in five strains of Bifidobacterium.

Journal: Journal of applied microbiology 20060401

Title: Management of hepatic encephalopathy: focus on antibiotic therapy.

Journal: Digestion 20060101

Title: [The diagnostics and therapy of hepatic encephalopathy. Recommendations of of the working group on portal hypertension in the Czech Hepatology Society and the J. E. Purkinje Czech Medical Society].

Journal: Vnitrni lekarstvi 20060101

Title: Short-chain fatty acid formation in the hindgut of rats fed oligosaccharides varying in monomeric composition, degree of polymerisation and solubility.

Journal: The British journal of nutrition 20051101

Title: Dietary lactitol fermentation increases circulating peptide YY and glucagon-like peptide-1 in rats and humans.

Journal: Nutrition (Burbank, Los Angeles County, Calif.) 20051001

Title: Attenuated response of the serum triglyceride concentration to ingestion of a chocolate containing polydextrose and lactitol in place of sugar.

Journal: Bioscience, biotechnology, and biochemistry 20051001

Title: [Intestinal function tests].

Journal: Praxis 20050914

Title: Comparison of rifaximin and lactulose for the treatment of hepatic encephalopathy: a prospective randomized study.

Journal: Yonsei medical journal 20050630

Title: Pharmacological prophylaxis of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt: a randomized controlled study.

Journal: Journal of hepatology 20050501

Title: Maximum permissive dosage of lactose and lactitol for transitory diarrhea, and utilizable capacity for lactose in Japanese female adults.

Journal: Journal of nutritional science and vitaminology 20050401

Title: [Pneumatosis intestinalis in 9 children with an oncologic disease].

Journal: Nederlands tijdschrift voor geneeskunde 20050319

Title: [Nonabsorbable disaccharides for the treatment of hepatic encephalopathy--a systemic review of randomized clinical trials--a secondary publication].

Journal: Ugeskrift for laeger 20050110

Title: Oxalate degradation by intestinal lactic acid bacteria in dogs and cats.

Journal: Veterinary microbiology 20040714

Title: Lactose derivatives are inhibitors of Trypanosoma cruzi trans-sialidase activity toward conventional substrates in vitro and in vivo.

Journal: Glycobiology 20040701

Title: Effect of sugar alcohols on gut function and body composition in normal and cecectomized rats.

Journal: Experimental animals 20040701

Title: Combination of polydextrose and lactitol affects microbial ecosystem and immune responses in rat gastrointestinal tract.

Journal: The British journal of nutrition 20040601

Title: Constipation in adults.

Journal: Clinical evidence 20040601

Title: Non-absorbable disaccharides for hepatic encephalopathy: systematic review of randomised trials.

Journal: BMJ (Clinical research ed.) 20040501

Title: Antagonistic activity of lactic acid bacteria as probiotics against selected bacteria of the Enterobaceriacae family in the presence of polyols and their galactosyl derivatives.

Journal: Biotechnology letters 20040201

Title: Nonabsorbable disaccharides for hepatic encephalopathy.

Journal: The Cochrane database of systematic reviews 20040101

Title: Sugar alcohols: what is the evidence for caries-preventive and caries-therapeutic effects?

Journal: Caries research 20040101

Title: Effects of hyperosmolar agents--lactulose, lactitol, sodium phosphate and polyethylene glycol--on cecal coliform bacteria during traditional bowel cleansing: an experimental study in rats.

Journal: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20040101

Title: Review: lactulose or lactitol may improve hepatic encephalopathy but may be less effective than antibiotics.

Journal: ACP journal club 20040101

Title: Health potential of polyols as sugar replacers, with emphasis on low glycaemic properties.

Journal: Nutrition research reviews 20031201

Title: [Compressibility of directly compressed forms of lactitol].

Journal: Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20030901

Title: Effects of lactulose and lactitol on coliform bacteria and bacterial translocation in the caecum during 72-h starvation in rats.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20030701

Title: Cyclic treatment of chronic hepatic encephalopathy with rifaximin. Results of a double-blind clinical study.

Journal: Minerva gastroenterologica e dietologica 20030301

Title: Comparison of rifaximin and lactitol in the treatment of acute hepatic encephalopathy: results of a randomized, double-blind, double-dummy, controlled clinical trial.

Journal: Journal of hepatology 20030101

Title: Chemoenzymatically synthesized glycoconjugate polymers.

Journal: Biomacromolecules 20030101

Title: Interaction of methylparaben preservative with selected sugars and sugar alcohols.

Journal: Journal of pharmaceutical sciences 20020701

Title: Sugar alcohols enhance calcium transport from rat small and large intestine epithelium in vitro.

Journal: Digestive diseases and sciences 20020601

Title: Tributyrin and lactitol synergistically enhanced the trophic status of the intestinal mucosa and reduced histamine levels in the gut of nursery pigs.

Journal: Journal of animal science 20020301

Title: Structural changes in natural actomyosin and surimi from ling cod (Ophiodon elongatus) during frozen storage in the absence or presence of cryoprotectants.

Journal: Journal of agricultural and food chemistry 20011001

Title: Intestinal permeability in children: variation with age and reliability in the diagnosis of cow's milk allergy.

Journal: Acta paediatrica (Oslo, Norway : 1992) 20010501

Title: Lactitol or lactulose in the treatment of chronic hepatic encephalopathy: results of a meta-analysis.

Journal: Hepatology (Baltimore, Md.) 19920201

Title: Lactulose inhibits endotoxin induced tumour necrosis factor production by monocytes. An in vitro study.

Journal: Gut 19900201

Title: Maydeo A, et al. Lactitol or lactulose in the treatment of chronic constipation: result of a systematic. J Indian Med Assoc. 2010 Nov;108(11):789-92.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:585-86-4 Molecular Formula|585-86-4 MDL|585-86-4 SMILES|585-86-4 4-O-beta-D-Galactopyranosyl-D-glucitol