[1]Patent:CN107936015,2018,A.Locationinpatent:Paragraph0007;0011;0039-0040;0046-0047;0053-0054;0060
[2]Patent:CN106117201,2016,A.Locationinpatent:Paragraph00312;0032;0033;0034;0035;0036;0037-0060
[3]Patent:CN104628724,2017,B.Locationinpatent:Paragraph0029;0030;0033;0034;0037;0038;0041;0042
[4]SyntheticCommunications,2013,vol.43,p.72-79
[5]Patent:CN106117200,2016,A.Locationinpatent:Paragraph0028;0046;0047;0048
[6]Patent:US2017/15663,2017,A1.Locationinpatent:Paragraph0149
[7]Patent:CN109627242,2019,A.Locationinpatent:Paragraph0035-0038;0041-0044
[8]Patent:WO2014/75648,2014,A1.Locationinpatent:Page/Pagecolumn15
[9]Patent:CN105254630,2016,A.Locationinpatent:Paragraph0061;0062;0063
[10]Patent:CN104892601,2017,B.Locationinpatent:Paragraph0020;0050-0051
[11]Patent:CN103694237,2016,B.Locationinpatent:Paragraph0120-0122
[12]Patent:US2017/313695,2017,A1.Locationinpatent:Paragraph0069
[13]Patent:WO2017/187245,2017,A1.Locationinpatent:Page/Pagecolumn14
[14]JournalofMedicinalChemistry,2007,vol.50,p.5339-5356
[15]Patent:WO2012/168364,2012,A1.Locationinpatent:Page/Pagecolumn19-20
[16]BioorganicandMedicinalChemistry,2016,vol.24,p.5646-5661
[17]BioorganicandMedicinalChemistry,2017,vol.25,p.2800-2810
[18]Patent:WO2014/72884,2014,A1.Locationinpatent:Page/Pagecolumn11
[19]Patent:CN107400131,2017,A.Locationinpatent:Paragraph0031;0057-0059
[20]Patent:CN107955002,2018,A.Locationinpatent:Paragraph0114;0117
[21]Patent:US2017/50964,2017,A1.Locationinpatent:Paragraph0751
[22]Patent:WO2015/111073,2015,A3.Locationinpatent:Page/Pagecolumn13
[23]Patent:WO2010/30983,2010,A2.Locationinpatent:Page/Pagecolumn32
[24]Patent:WO2013/119328,2013,A1.Locationinpatent:Paragraph0050
[25]Patent:WO2014/111954,2014,A1.Locationinpatent:Paragraph0135
[26]Patent:WO2015/162551,2015,A1.Locationinpatent:Page/Pagecolumn16-17
[27]Patent:WO2015/177801,2015,A1.Locationinpatent:Page/Pagecolumn27
[28]Patent:WO2016/20711,2016,A1
[29]Patent:WO2016/20711,2016,A1
[30]Patent:US2015/353541,2015,A1.Locationinpatent:Paragraph0135
[31]Patent:CN103896940,2016,B
[32]Patent:WO2017/13079,2017,A1.Locationinpatent:Paragraph00188
[33]Patent:CN104045637,2016,B
[34]MonatsheftefurChemie,2017,vol.148,p.1477-1482
[35]Patent:US2016/326171,2016,A1.Locationinpatent:Paragraph0183;0184
[36]Patent:US2016/326171,2016,A1
[37]Patent:US2016/326171,2016,A1
[38]Patent:US2016/326171,2016,A1
[1]Patent:WO2016/20711,2016,A1.Locationinpatent:Page/Pagecolumn22
[2]Patent:CN106188036,2016,A.Locationinpatent:Paragraph0054;0055;0085;0086
[3]Patent:US2003/181466,2003,A1
[4]Patent:CN103896940,2016,B
[1]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2010/30983,2010,A2Locationinpatent:Page/Pagecolumn33
[1]CurrentPatentAssignee:JIANGXIGUOYAOPHARMACEUTICAL-CN110003206,2019,ALocationinpatent:Paragraph0069-0072;0079-0081;0082;0085-0086
[2]Ramirez,Antonio;Mudryk,Boguslaw;Rossano,Lucius;Tummala,Srinivas[JournalofOrganicChemistry,2012,vol.77,#1,p.775-779]
[3]CurrentPatentAssignee:CHANGZHOUPHARMACEUTICALFACTORYCOLTD-CN116375703,2023,ALocationinpatent:Paragraph0060-0064
[1]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2013/119328,2013,A1Locationinpatent:Paragraph0044
[2]CurrentPatentAssignee:ZYDUSLIFESCIENCESLTD-WO2014/203275,2014,A2Locationinpatent:Page/Pagecolumn39-40
[3]CurrentPatentAssignee:GANSUHAOTIANCHEMEXPRESS-CN103342704,2016,BLocationinpatent:Paragraph0027;0028;0029;0037;0038
Title: Overview of the new oral anticoagulants: opportunities and challenges.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20150501
Title: The role of factor Xa inhibitors in venous thromboembolism treatment.
Journal: Vascular health and risk management 20150101
Title: The safety and efficacy of apixaban : where do we stand in 2013?
Journal: Expert opinion on drug safety 20130701
Title: A specific antidote for reversal of anticoagulation by direct and indirect inhibitors of coagulation factor Xa.
Journal: Nature medicine 20130401
Title: New anticoagulants for treatment of venous thromboembolism.
Journal: European journal of internal medicine 20121201
Title: Analysis of the projected utility of dabigatran, rivaroxaban, and apixaban and their future impact on existing Hematology and Cardiology Anticoagulation Clinics at The Johns Hopkins Hospital.
Journal: Journal of thrombosis and thrombolysis 20121101
Title: Interpretation of endpoints in a network meta-analysis of new oral anticoagulants following total hip or total knee replacement surgery.
Journal: Thrombosis and haemostasis 20121101
Title: Management consensus guidance for the use of rivaroxaban--an oral, direct factor Xa inhibitor.
Journal: Thrombosis and haemostasis 20121101
Title: [Concepts in anticoagulant therapy - past, present, and future].
Journal: Therapeutische Umschau. Revue therapeutique 20121101
Title: [New anticoagulants - direct factor Xa-inhibitors].
Journal: Therapeutische Umschau. Revue therapeutique 20121101
Title: [Laboratory diagnostic with regard to new anticoagulants - monitoring and influence on coagulation tests].
Journal: Therapeutische Umschau. Revue therapeutique 20121101
Title: [Clinical pharmacological aspects of new oral anticoagulants].
Journal: Therapeutische Umschau. Revue therapeutique 20121101
Title: How I treat anticoagulated patients undergoing an elective procedure or surgery.
Journal: Blood 20121011
Title: Apixaban strengthens its case in atrial fibrillation.
Journal: BMJ (Clinical research ed.) 20121010
Title: Cost-effectiveness of apixaban vs warfarin for secondary stroke prevention in atrial fibrillation.
Journal: Neurology 20121002
Title: Prevention of stroke in patients with atrial fibrillation: anticoagulant and antiplatelet options.
Journal: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20121001
Title: Adjusted indirect comparison of new oral anticoagulants for stroke prevention in atrial fibrillation.
Journal: QJM : monthly journal of the Association of Physicians 20121001
Title: Anticoagulants in atrial fibrillation patients with chronic kidney disease.
Journal: Nature reviews. Nephrology 20121001
Title: Atrial fibrillation in long term care.
Journal: Journal of the American Medical Directors Association 20121001
Title: New anticoagulants for stroke prophylaxis in atrial fibrillation: assessing the impact on medication adherence.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20121001
Title: New anticoagulants: A concise review.
Journal: The journal of trauma and acute care surgery 20121001
Title: [Prophylaxis of thromboembolic events following hip and knee replacement: dabigatran, rivaroxaban or apixaban in comparison to enoxaparin].
Journal: Der Unfallchirurg 20121001
Title: Antithrombotic treatment of atrial fibrillation: new insights.
Journal: Thrombosis research 20121001
Title: Oral direct factor Xa inhibitors.
Journal: Circulation research 20120928
Title: ACP Journal Club. Review: new oral anticoagulants reduced stroke and systemic embolism compared with warfarin in AF.
Journal: Annals of internal medicine 20120918
Title: New oral anticoagulants: a review of the literature with particular emphasis on patients with impaired renal function.
Journal: Drugs 20120910
Title: Apixaban and rivaroxaban safety after hip and knee arthroplasty: a meta-analysis.
Journal: Journal of cardiovascular pharmacology and therapeutics 20120901
Title: Novel oral anticoagulation in management of venous thromboembolism, atrial fibrillation, and acute coronary syndrome.
Journal: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20120901
Title: Antithrombotic options for atrial fibrillation in 2012.
Journal: Cardiovascular & hematological disorders drug targets 20120901
Title: Anticoagulants for the treatment of acute coronary syndrome in the era of new oral agents.
Journal: Coronary artery disease 20120901
Title: An indirect comparison of dabigatran, rivaroxaban and apixaban for atrial fibrillation.
Journal: Thrombosis and haemostasis 20120901
Title: [The ARISTOTLE study].
Journal: Giornale italiano di cardiologia (2006) 20120901
Title: Newer oral anticoagulants: a review of laboratory monitoring options and reversal agents in the hemorrhagic patient.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120901
Title: Systematic review and adjusted indirect comparison meta-analysis of oral anticoagulants in atrial fibrillation.
Journal: Circulation. Cardiovascular quality and outcomes 20120901
Title: The novel oral anticoagulants: an update for the interventional radiologist.
Journal: AJR. American journal of roentgenology 20120901
Title: [The new anticoagulants - their role in secondary prevention of thromboembolism after stroke].
Journal: Therapeutische Umschau. Revue therapeutique 20120901
Title: The promise of novel direct oral anticoagulants.
Journal: Best practice & research. Clinical haematology 20120901
Title: Apixaban. After hip or knee replacement: LMWH remains the standard treatment.
Journal: Prescrire international 20120901
Title: Apixaban in other situations?
Journal: Prescrire international 20120901
Title: Indirect comparisons of new oral anticoagulant drugs for efficacy and safety when used for stroke prevention in atrial fibrillation.
Journal: Journal of the American College of Cardiology 20120821
Title: Danger ahead: watch out for indirect comparisons!
Journal: Journal of the American College of Cardiology 20120821
Title: ACP Journal Club: review: factor Xa inhibitors reduce DVT more than LMWH in total knee or hip replacement.
Journal: Annals of internal medicine 20120821
Title: A new era of antithrombotic therapy in patients with atrial fibrillation.
Journal: The American journal of the medical sciences 20120801
Title: Dabigatran, rivaroxaban and apixaban versus enoxaparin for thomboprophylaxis after total knee or hip arthroplasty: pool-analysis of phase III randomized clinical trials.
Journal: Thrombosis research 20120801
Title: Therapeutic potential of apixaban in the prevention of venous thromboembolism in patients undergoing total knee replacement surgery.
Journal: Journal of thrombosis and thrombolysis 20120801
Title: Meta-analysis of efficacy and safety of new oral anticoagulants (dabigatran, rivaroxaban, apixaban) versus warfarin in patients with atrial fibrillation.
Journal: The American journal of cardiology 20120801
Title: Novel anticoagulants for non-valvular atrial fibrillation.
Journal: Heart, lung & circulation 20120801
Title: Novel oral anticoagulants in the treatment of acute coronary syndromes: is there any room for new anticoagulants?
Journal: Current clinical pharmacology 20120801
Title: Oral IIa and Xa inhibitors for prevention of stroke in atrial fibrillation: clinical studies and regulatory considerations.
Journal: Current clinical pharmacology 20120801
Title: Prevention and treatment of venous thromboembolism and pulmonary embolism: the role of novel oral anticoagulants.
Journal: Current clinical pharmacology 20120801
Title: Breakthroughs in anticoagulation: advent of the oral direct factor Xa inhibitors.
Journal: Journal of cardiothoracic and vascular anesthesia 20120801
Title: Anticoagulation-related intracranial hemorrhages.
Journal: Current atherosclerosis reports 20120801
Title: More light at the end of the tunnel - apixaban in atrial fibrillation.
Journal: Expert opinion on investigational drugs 20120801
Title: Comparison of efficacy and safety of dabigatran, rivaroxaban and apixaban in patients with atrial fibrillation using network meta-analysis.
Journal: International angiology : a journal of the International Union of Angiology 20120801
Title: Stroke risk and efficacy of apixaban in atrial fibrillation patients with moderate chronic kidney disease.
Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 20120801
Title: Emerging oral anticoagulants for stroke prevention in patients with non-valvular atrial fibrillation.
Journal: Minerva cardioangiologica 20120801
Title: The new oral anticoagulants: a challenge for hospital formularies.
Journal: Hospital practice (1995) 20120801
Title: Renal profiles of anticoagulants.
Journal: Journal of clinical pharmacology 20120701
Title: Apixaban: a novel oral inhibitor of factor Xa.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120701
Title: Cost-effectiveness of apixaban compared with aspirin for stroke prevention in atrial fibrillation among patients unsuitable for warfarin.
Journal: Circulation. Cardiovascular quality and outcomes 20120701
Title: Comparative efficacy and safety of new oral anticoagulants in patients with atrial fibrillation.
Journal: Circulation. Cardiovascular quality and outcomes 20120701
Title: Apixaban versus enoxaparin for thromboprophylaxis after total hip or knee arthroplasty: a meta-analysis of randomized controlled trials.
Journal: Chinese medical journal 20120701
Title: Apixaban: a review of its use in the prevention of venous thromboembolism after knee or hip replacement surgery.
Journal: Drugs 20120618
Title: New oral anticoagulants for venous thromboembolism: focus on factor Xa and thrombin inhibitors.
Journal: Current drug discovery technologies 20120601
Title: Apixaban: a new player in the anticoagulant class.
Journal: Current drug targets 20120601
Title: Novel oral anticoagulants after acute coronary syndromes.
Journal: Cardiovascular drugs and therapy 20120601
Title: Role of new anticoagulants for the prevention of venous thromboembolism after major orthopaedic surgery and in hospitalised acutely ill medical patients.
Journal: Thrombosis and haemostasis 20120601
Title: New anticoagulant drugs for treatment of venous thromboembolism and stroke prevention in atrial fibrillation.
Journal: Journal of internal medicine 20120601
Title: Novel antithrombotic agents for atrial fibrillation.
Journal: Pharmacology & therapeutics 20120601
Title: Long-term benefits of preventing venous thromboembolic events.
Journal: Current medical research and opinion 20120601
Title: [Pharmacology of the new oral anticoagulants].
Journal: Herz 20120601
Title: [Role of the new oral anticoagulants in comparison to vitamin K antagonists in practice].
Journal: Herz 20120601
Title: Apixaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of the ARISTOTLE trial.
Journal: The Lancet. Neurology 20120601
Title: Reducing the risk of recurrent stroke in patients with AF.
Journal: The Lancet. Neurology 20120601
Title: Current and future alternatives to warfarin for the prevention of stroke in atrial fibrillation.
Journal: Critical pathways in cardiology 20120601
Title: A guidance pathway for the selection of novel anticoagulants in the treatment of atrial fibrillation.
Journal: Critical pathways in cardiology 20120601
Title: The emergence of factor Xa inhibitors for the treatment of cardiovascular diseases: a patent review.
Journal: Expert opinion on therapeutic patents 20120601
Title: Novel oral anticoagulants for stroke prevention in atrial fibrillation: focus on apixaban.
Journal: Advances in therapy 20120601
Title: Development and clinical applications of novel oral anticoagulants. Part I. Clinically approved drugs.
Journal: Discovery medicine 20120601
Title: Anticoagulant therapy for patients with ischaemic stroke.
Journal: Nature reviews. Neurology 20120508
Title: Dabigatran etexilate: a review of its use for the prevention of venous thromboembolism after total hip or knee replacement surgery.
Journal: Drugs 20120507
Title: A randomised assessment of the pharmacokinetic, pharmacodynamic and safety interaction between apixaban and enoxaparin in healthy subjects.
Journal: Thrombosis and haemostasis 20120501
Title: A randomized phase II trial of apixaban for the prevention of thromboembolism in patients with metastatic cancer.
Journal: Journal of thrombosis and haemostasis : JTH 20120501
Title: Reversal of antithrombotic agents.
Journal: American journal of hematology 20120501
Title: Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors.
Journal: American journal of hematology 20120501
Title: Implementing the new oral anticoagulants into the hospital formulary.
Journal: American journal of hematology 20120501
Title: Novel oral anticoagulants--key messages for the angiologist.
Journal: VASA. Zeitschrift fur Gefasskrankheiten 20120501
Title: Newer oral anticoagulant agents: a new era in medicine.
Journal: Current cardiology reviews 20120501
Title: Current trial-associated outcomes with warfarin in prevention of stroke in patients with nonvalvular atrial fibrillation: a meta-analysis.
Journal: Archives of internal medicine 20120423
Title: New oral anticoagulants in atrial fibrillation and acute coronary syndromes: ESC Working Group on Thrombosis-Task Force on Anticoagulants in Heart Disease position paper.
Journal: Journal of the American College of Cardiology 20120417
Title: Novel anticoagulants for atrial fibrillation: a critical appraisal.
Journal: Angiology 20120401
Title: New oral anticoagulants for atrial fibrillation: a review of clinical trials.
Journal: Clinical therapeutics 20120401
Title: [Novel oral anticoagulants and their use in the perioperative setting].
Journal: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20120401
Title: Practical use of apixaban in the prevention of venous thromboembolism after total knee or hip replacement.
Journal: Drugs of today (Barcelona, Spain : 1998) 20120401
Title: Preventing venous thromboembolic events after total hip arthroplasty: new developments in clinical practice.
Journal: Hospital practice (1995) 20120401
Title: Net clinical benefit of new oral anticoagulants (dabigatran, rivaroxaban, apixaban) versus no treatment in a 'real world' atrial fibrillation population: a modelling analysis based on a nationwide cohort study.
Journal: Thrombosis and haemostasis 20120301
Title: Old and new oral anticoagulants for venous thromboembolism and atrial fibrillation: a review of the literature.
Journal: Thrombosis research 20120301
Title: Apixaban versus aspirin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a predefined subgroup analysis from AVERROES, a randomised trial.
Journal: The Lancet. Neurology 20120301
Title: Critique of apixaban versus warfarin in patients with atrial fibrillation.
Journal: Stroke 20120301
Title: What's the 'go to' anticoagulant for stroke prevention in atrial fibrillation?
Journal: Thrombosis and haemostasis 20120301
Title: New directions in anticoagulation.
Journal: The American journal of medicine 20120301
Title: Prevention of stroke in atrial fibrillation: cautious optimism.
Journal: The Lancet. Neurology 20120301
Title: A new generation of oral direct anticoagulants.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20120301
Title: Apixaban: an oral direct factor-xa inhibitor.
Journal: Advances in therapy 20120301
Title: Review of atrial fibrillation outcome trials of oral anticoagulant and antiplatelet agents.
Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20120301
Title: Highlights of the American Heart Association Scientific Sessions 2011: a focus on ATLAS-TIMI 51, TRACER and PALLAS.
Journal: Expert review of cardiovascular therapy 20120301
Title: The efficacy and safety of postoperative autologous transfusion of filtered shed blood and anticoagulant prophylaxis in total knee arthroplasty patients.
Journal: Knee surgery & related research 20120301
Title: Oral direct factor Xa inhibitors for stroke prevention in atrial fibrillation.
Journal: Nature reviews. Cardiology 20120227
Title: Rational approaches to improving selectivity in drug design.
Journal: Journal of medicinal chemistry 20120223
Title: Apixaban versus enoxaparin in medically ill patients.
Journal: The New England journal of medicine 20120223
Title: Oral factor Xa inhibitors for the long-term management of ACS.
Journal: Nature reviews. Cardiology 20120221
Title: Anticoagulant management in the cardiovascular setting.
Journal: Fundamental & clinical pharmacology 20120201
Title: Rivaroxaban for the prevention and treatment of venous thromboembolism.
Journal: Fundamental & clinical pharmacology 20120201
Title: New anticoagulants for the prevention of stroke in atrial fibrillation.
Journal: Fundamental & clinical pharmacology 20120201
Title: Cost-effectiveness of pharmacologic and invasive therapies for stroke prophylaxis in atrial fibrillation.
Journal: Journal of cardiovascular medicine (Hagerstown, Md.) 20120201
Title: The year in Cardiothoracic and Vascular Anesthesia: selected highlights from 2011.
Journal: Journal of cardiothoracic and vascular anesthesia 20120201
Title: The king is dead (warfarin): direct thrombin and factor Xa inhibitors: the next Diadochian War?
Journal: International journal of stroke : official journal of the International Stroke Society 20120201
Title: Direct thrombin inhibitors and factor Xa inhibitors in patients with cerebrovascular disease.
Journal: Expert review of neurotherapeutics 20120201
Title: Apixaban for the prevention of stroke in atrial fibrillation.
Journal: Expert review of cardiovascular therapy 20120201
Title: Active online assessment of patients using new oral anticoagulants: bleeding risk, compliance, and coagulation analysis.
Journal: Seminars in thrombosis and hemostasis 20120201
Title: Prevention of VTE in orthopedic surgery patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines.
Journal: Chest 20120201
Title: Apixaban versus enoxaparin for thromboprophylaxis after hip or knee replacement: pooled analysis of major venous thromboembolism and bleeding in 8464 patients from the ADVANCE-2 and ADVANCE-3 trials.
Journal: The Journal of bone and joint surgery. British volume 20120201
Title: Apixaban reduced stroke and systemic embolism compared with warfarin in atrial fibrillation.
Journal: Annals of internal medicine 20120117
Title: Apixaban versus warfarin in atrial fibrillation.
Journal: The New England journal of medicine 20120105
Title: Apixaban versus warfarin in atrial fibrillation.
Journal: The New England journal of medicine 20120105
Title: Concerns about studies investigating new anticoagulant drugs for stroke prevention in atrial fibrillation.
Journal: Journal of neurology 20120101
Title: [Anticoagulation in atrial fibrillation: a new era has begun].
Journal: Hamostaseologie 20120101
Title: [Anticoagulation for atrial fibrillation : the future has begun].
Journal: Der Internist 20120101
Title: [Apixaban: pharmacology and action profile].
Journal: Deutsche medizinische Wochenschrift (1946) 20120101
Title: New frontiers for stroke prevention in atrial fibrillation.
Journal: Cerebrovascular diseases (Basel, Switzerland) 20120101
Title: ARISTOTLE RE-LYs on the ROCKET. What's new in stroke prevention in patients with atrial fibrillation?
Journal: Cardiology journal 20120101
Title: Anticoagulation prophylaxis in orthopedic surgery: an efficiency frontier approach.
Journal: Postgraduate medicine 20120101
Title: New oral antithrombotics: focus on dabigatran, an oral, reversible direct thrombin inhibitor for the prevention and treatment of venous and arterial thromboembolic disorders.
Journal: Vascular health and risk management 20120101
Title: I recently heard that there are alternative medications to the blood thinner warfarin. What are they, and how are they different?
Journal: DukeMedicine healthnews 20120101
Title: Increased atherothrombotic burden in patients with diabetes mellitus and acute coronary syndrome: a review of antiplatelet therapy.
Journal: Cardiology research and practice 20120101
Title: A new era for anticoagulation in atrial fibrillation. Which anticoagulant should we choose for long‑term prevention of thromboembolic complications in patients with atrial fibrillation?
Journal: Polskie Archiwum Medycyny Wewnetrznej 20120101
Title: Upcoming oral factor Xa inhibitors for venous thromboembolism prophylaxis in patients undergoing major orthopedic surgery: rivaroxaban (Xarelto) and apixaban (Eliquis) review.
Journal: Connecticut medicine 20120101
Title: Improving prevention and treatment of venous thromboembolism: clinical trial results.
Journal: Journal of medical economics 20120101
Title: Stroke Prevention in Atrial Fibrillation: Where are We Now?
Journal: Clinical Medicine Insights. Cardiology 20120101
Title: Cost considerations in the management of atrial fibrillation - impact of dronedarone.
Journal: ClinicoEconomics and outcomes research : CEOR 20120101
Title: Focused 2012 update of the Canadian Cardiovascular Society atrial fibrillation guidelines: recommendations for stroke prevention and rate/rhythm control.
Journal: The Canadian journal of cardiology 20120101
Title: Medical cost reductions associated with the usage of novel oral anticoagulants vs warfarin among atrial fibrillation patients, based on the RE-LY, ROCKET-AF, and ARISTOTLE trials.
Journal: Journal of medical economics 20120101
Title: Current status of new anticoagulants in the management of venous thromboembolism.
Journal: Advances in hematology 20120101
Title: Costs and clinical consequences of suboptimal atrial fibrillation management.
Journal: ClinicoEconomics and outcomes research : CEOR 20120101
Title: Efficacy and safety of venous thromboembolism prophylaxis with apixaban in major orthopedic surgery.
Journal: Therapeutics and clinical risk management 20120101
Title: Oral anticoagulants. New oral anticoagulants for atrial fibrillation: the factor Xa inhibitors rivaroxaban and apixaban.
Journal: Reviews in cardiovascular medicine 20120101
Title: The economic impact of enoxaparin versus unfractionated heparin for prevention of venous thromboembolism in acute ischemic stroke patients.
Journal: ClinicoEconomics and outcomes research : CEOR 20120101
Title: Preventing stroke in atrial fibrillation patients - clinical utility of oral anticoagulants.
Journal: Journal of blood medicine 20120101
Title: Anticoagulant and antiplatelet therapy in patients with atrial fibrillation and coronary artery disease.
Journal: Thrombosis 20120101
Title: [New antithrombotic drugs].
Journal: Duodecim; laaketieteellinen aikakauskirja 20120101
Title: Advances in the diagnosis and treatment of acute pulmonary embolism.
Journal: F1000 medicine reports 20120101
Title: Reviewing the medical literature: five notable articles in general internal medicine from 2010 and 2011.
Journal: Open medicine : a peer-reviewed, independent, open-access journal 20120101
Title: Assessment of female sex as a risk factor in atrial fibrillation in Sweden: nationwide retrospective cohort study.
Journal: BMJ (Clinical research ed.) 20120101
Title: Non-pharmacological therapy for atrial fibrillation: managing the left atrial appendage.
Journal: Cardiology research and practice 20120101
Title: Newer anticoagulants for the prevention of venous thromboembolism.
Journal: The National medical journal of India 20120101
Title: Emerging anticoagulants.
Journal: Current medicinal chemistry 20120101
Title: Dabigatran, rivaroxaban, or apixaban versus enoxaparin for thromboprophylaxis after total hip or knee replacement: systematic review, meta-analysis, and indirect treatment comparisons.
Journal: BMJ (Clinical research ed.) 20120101
Title: Health technology assessment and its role in the future development of the Indian healthcare sector.
Journal: Perspectives in clinical research 20120101
Title: [Apixaban].
Journal: Hamostaseologie 20120101
Title: [New anticoagulants: dabigatran, rivaroxaban and apixaban].
Journal: Gaceta medica de Mexico 20120101
Title: An evidence-based review of apixaban and its potential in the prevention of stroke in patients with atrial fibrillation.
Journal: Core evidence 20120101
Title: Emerging anticoagulant therapies for atrial fibrillation: new options, new challenges.
Journal: Current medicinal chemistry 20120101
Title: Safety and efficacy of apixaban in the treatment of atrial fibrillation.
Journal: Clinical Medicine Insights. Cardiology 20120101
Title: Perioperative stroke risk in nonvascular surgery.
Journal: Cerebrovascular diseases (Basel, Switzerland) 20120101
Title: Vitamin K antagonists. Ready to be replaced?
Journal: Hamostaseologie 20120101
Title: Understanding the new emerging oral anticoagulants for venous thromboembolism prophylaxis.
Journal: Orthopedic nursing 20120101
Title: Rivaroxaban in atrial fibrillation.
Journal: Vascular health and risk management 20120101
Title: Prevention of stroke and systemic embolization in atrial fibrillation: a Canadian perspective.
Journal: Polskie Archiwum Medycyny Wewnetrznej 20120101
Title: Stroke prevention in atrial fibrillation: understanding the new oral anticoagulants dabigatran, rivaroxaban, and apixaban.
Journal: Thrombosis 20120101
Title: [New oral anticoagulants for atrial fibrillation: a neurologist's view].
Journal: Nederlands tijdschrift voor geneeskunde 20120101
Title: Management of venous thromboembolism in patients with advanced gastrointestinal cancers: what is the role of novel oral anticoagulants?
Journal: Thrombosis 20120101
Title: Coronary and mortality risk of novel oral antithrombotic agents: a meta-analysis of large randomised trials.
Journal: BMJ open 20120101
Title: Cost-effectiveness of apixaban compared with warfarin for stroke prevention in atrial fibrillation.
Journal: PloS one 20120101
Title: Left atrial appendage exclusion for stroke prevention in atrial fibrillation.
Journal: Cardiology research and practice 20120101
Title: Apixaban versus enoxaparin for thromboprophylaxis in medically ill patients.
Journal: The New England journal of medicine 20111208
Title: Antiplatelet agents and anticoagulants for hypertension.
Journal: The Cochrane database of systematic reviews 20111207
Title: In people with atrial fibrillation unsuitable for warfarin, apixaban reduces the risk of stroke compared with aspirin, with no difference in major bleeding.
Journal: Evidence-based medicine 20111201
Title: [Thrombosis prophylaxis in surgery. What is the evidence?].
Journal: Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen 20111201
Title: Antithrombotic therapy in nonvalvular atrial fibrillation: a narrative review.
Journal: Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20111201
Title: Clinical trials update from the European Society of Cardiology Meeting 2011: ARISTOTLE, SMART-AV: QLV substudy, SHIFT: echocardiography and quality of life substudies, European CRT Survey, and Basic Science Update.
Journal: European journal of heart failure 20111201
Title: [Pharmacologic heterogeneity of new anticoagulants].
Journal: Journal des maladies vasculaires 20111201
Title: [ADOPT study. Longer thrombosis prevention in internal medicine patients has no advantage].
Journal: MMW Fortschritte der Medizin 20111201
Title: Antithrombotic therapy for secondary stroke prevention.
Journal: Continuum (Minneapolis, Minn.) 20111201
Title: Apixaban after acute coronary syndrome.
Journal: The New England journal of medicine 20111110
Title: External and internal validity of open label or double-blind trials in oral anticoagulation: better, worse or just different?
Journal: Journal of thrombosis and haemostasis : JTH 20111101
Title: Therapeutic potential of apixaban in the prevention of venous thromboembolism in patients undergoing total knee replacement surgery.
Journal: Current medical research and opinion 20111101
Title: [New anticoagulants. Characteristics, monitoring and management of bleeding].
Journal: Medizinische Klinik, Intensivmedizin und Notfallmedizin 20111101
Title: [Current status and future of anti-Xa inhibitors].
Journal: Rinsho shinkeigaku = Clinical neurology 20111101
Title: [New anticoagulants].
Journal: La Revue du praticien 20111101
Title: Apixaban: first global approval.
Journal: Drugs 20111022
Title: Trial watch: apixaban beats warfarin in stroke trial.
Journal: Nature reviews. Drug discovery 20111014
Title: Apixaban in acute coronary syndromes.
Journal: Cardiovascular therapeutics 20111001
Title: Inhibitors of propagation of coagulation: factors V and X.
Journal: British journal of clinical pharmacology 20111001
Title: Anticoagulating obese patients in the modern era.
Journal: British journal of haematology 20111001
Title: RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome.
Journal: European heart journal 20111001
Title: New and emerging anticoagulant therapy for atrial fibrillation and acute coronary syndrome.
Journal: Pharmacotherapy 20111001
Title: The role of apixaban for venous and arterial thromboembolic disease.
Journal: The Annals of pharmacotherapy 20111001
Title: Novel oral anticoagulants for VTE prevention in orthopedic surgery: overview of phase 3 trials.
Journal: Orthopedics 20111001
Title: The new oral anticoagulants.
Journal: Clinical medicine (London, England) 20111001
Title: Apixaban for stroke prevention in atrial fibrillation: a review of the clinical trial evidence.
Journal: Hospital practice (1995) 20111001
Title: [New antithrombotic drugs for the treatment of venous thromboembolism].
Journal: Revue des maladies respiratoires 20111001
Title: CSAR benchmark exercise of 2010: combined evaluation across all submitted scoring functions.
Journal: Journal of chemical information and modeling 20110926
Title: [Atrial fibrillation: what the GP needs to know].
Journal: MMW Fortschritte der Medizin 20110922
Title: [Modern risk assessment and stroke prevention in atrial fibrillation].
Journal: Praxis 20110921
Title: A new era for anticoagulation in atrial fibrillation.
Journal: The New England journal of medicine 20110915
Title: Apixaban versus warfarin in patients with atrial fibrillation.
Journal: The New England journal of medicine 20110915
Title: [Anticoagulation in atrial fibrillation. Standard in stroke prevention is eliminated].
Journal: MMW Fortschritte der Medizin 20110915
Title: Atrial fibrillation: ARISTOTLE reveals superiority of apixaban over warfarin in patients with atrial fibrillation.
Journal: Nature reviews. Cardiology 20110913
Title: Preclinical pharmacokinetics and pharmacodynamics of apixaban, a potent and selective factor Xa inhibitor.
Journal: European journal of drug metabolism and pharmacokinetics 20110901
Title: Emerging options in the treatment of deep vein thrombosis and pulmonary embolism.
Journal: Blood reviews 20110901
Title: Prevention of venous thromboembolism after major orthopedic surgery: indirect comparison of three new oral anticoagulants.
Journal: Journal of thrombosis and haemostasis : JTH 20110901
Title: Update on anti-coagulation in atrial fibrillation.
Journal: QJM : monthly journal of the Association of Physicians 20110901
Title: [The AVERROES study].
Journal: Giornale italiano di cardiologia (2006) 20110901
Title: [Thromboembolic prophylaxis 2011: is warfarin on the wane?].
Journal: Giornale italiano di cardiologia (2006) 20110901
Title: Apixaban with antiplatelet therapy after acute coronary syndrome.
Journal: The New England journal of medicine 20110825
Title: New antithrombotic drugs and European approval processes.
Journal: Lancet (London, England) 20110820
Title: [The new Anticoagulants - Relevant Facts for the GP].
Journal: Praxis 20110810
Title: [Apixaban for prevention of thrombosis in hip replacement].
Journal: Praxis 20110810
Title: ['Xa-tra-xa': opportunities and open questions about new anticoagulants].
Journal: Praxis 20110810
Title: Apixaban inhibition of factor Xa: Microscopic rate constants and inhibition mechanism in purified protein systems and in human plasma.
Journal: Journal of enzyme inhibition and medicinal chemistry 20110801
Title: Novel oral anticoagulants: focus on stroke prevention and treatment of venous thrombo-embolism.
Journal: European heart journal 20110801
Title: Chromogenic laboratory assays to measure the factor Xa-inhibiting properties of apixaban--an oral, direct and selective factor Xa inhibitor.
Journal: Journal of thrombosis and thrombolysis 20110801
Title: New anticoagulants for prevention of stroke in patients with atrial fibrillation.
Journal: Journal of cardiovascular electrophysiology 20110801
Title: Apixaban in atrial fibrillation: from bleeding cows to 21st century medicinal chemistry.
Journal: Stroke 20110801
Title: Role of emerging antithrombotic therapy in the prevention of cardioembolic complications in patients with atrial fibrillation.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20110801
Title: Novel oral anticoagulants in development: Dabigatran, Rivaroxaban, and Apixaban.
Journal: American journal of therapeutics 20110701
Title: Clinical trials of direct thrombin and factor Xa inhibitors in atrial fibrillation.
Journal: Current opinion in cardiology 20110701
Title: Recent progress in anticoagulant therapy: oral direct inhibitors of thrombin and factor Xa.
Journal: Journal of thrombosis and haemostasis : JTH 20110701
Title: [New anticoagulants in the prevention and treatment of venous thromboembolism].
Journal: Orvosi hetilap 20110619
Title: Apixaban in patients with atrial fibrillation.
Journal: The New England journal of medicine 20110616
Title: Apixaban in patients with atrial fibrillation.
Journal: The New England journal of medicine 20110616
Title: The unmet need of patients with atrial fibrillation: AVERROES and the novel oral anticoagulants.
Journal: International journal of stroke : official journal of the International Stroke Society 20110601
Title: [New oral anticoagulants for treatment of venous thromboembolism].
Journal: Deutsche medizinische Wochenschrift (1946) 20110601
Title: What's new in stroke? The top 10 studies of 2009-2011: part II.
Journal: Polskie Archiwum Medycyny Wewnetrznej 20110601
Title: ACP journal club. Apixaban reduced VTE and did not increase major bleeding compared with enoxaparin in hip replacement.
Journal: Annals of internal medicine 20110517
Title: Update on pharmacologic approaches to prevent thromboembolism in atrial fibrillation: are thrombin and factor Xa inhibitors the ultimate answer?
Journal: Current vascular pharmacology 20110501
Title: Is there evidence to support the use of direct Factor Xa inhibitors in coronary artery disease?
Journal: Reviews on recent clinical trials 20110501
Title: Modelling and simulation as research tools in paediatric drug development.
Journal: European journal of clinical pharmacology 20110501
Title: Laboratory assessment of new anticoagulants.
Journal: Clinical chemistry and laboratory medicine 20110501
Title: Preclinical discovery of apixaban, a direct and orally bioavailable factor Xa inhibitor.
Journal: Journal of thrombosis and thrombolysis 20110501
Title: Risk-benefit ratio assessment for stroke prevention in intermediate risk atrial fibrillation patients: will TEE-based aspirin treatment fill the gap?
Journal: Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 20110501
Title: [New oral anticoagulant drugs: dabigatran, rivaroxaban and apixaban. Present and future].
Journal: Medecine sciences : M/S 20110501
Title: [The new anticoagulants].
Journal: Harefuah 20110501
Title: ACP Journal Club. Apixaban reduced stroke and systemic embolism compared with aspirin in adults with AF for whom VKA therapy was unsuitable.
Journal: Annals of internal medicine 20110419
Title: [Current and future therapies for prophylaxis of thromboembolism in atrial fibrillation].
Journal: MMW Fortschritte der Medizin 20110414
Title: The potential role of new oral anticoagulants in the prevention and treatment of thromboembolism.
Journal: Pharmacology & therapeutics 20110401
Title: What do the RE-LY, AVERROES and ROCKET-AF trials tell us for stroke prevention in atrial fibrillation?
Journal: Thrombosis and haemostasis 20110401
Title: New oral anticoagulants.
Journal: Journal of thrombosis and thrombolysis 20110401
Title: Drug and dietary interactions of warfarin and novel oral anticoagulants: an update.
Journal: Journal of thrombosis and thrombolysis 20110401
Title: Investigational factor Xa inhibitors for thrombosis and acute coronary syndromes.
Journal: Expert opinion on investigational drugs 20110401
Title: Arrhythmias: apixaban triumphs over aspirin for stroke prevention in patients with atrial fibrillation.
Journal: Nature reviews. Cardiology 20110401
Title: Apixaban vs. enoxaparin after hip replacement.
Journal: The New England journal of medicine 20110324
Title: Apixaban in patients with atrial fibrillation.
Journal: The New England journal of medicine 20110303
Title: Italian intersociety consensus statement on antithrombotic prophylaxis in hip and knee replacement and in femoral neck fracture surgery.
Journal: Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology 20110301
Title: Effects on fibrin network porosity of anticoagulants with different modes of action and reversal by activated coagulation factor concentrate.
Journal: British journal of haematology 20110301
Title: Changing anticoagulant paradigms for atrial fibrillation: dabigatran, apixaban and rivaroxaban.
Journal: Expert opinion on pharmacotherapy 20110301
Title: Apixaban versus enoxaparin in patients with total knee arthroplasty. A meta-analysis of randomised trials.
Journal: Thrombosis and haemostasis 20110201
Title: Tissue distribution and elimination of [14C]apixaban in rats.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110201
Title: New anticoagulant agents in acute coronary syndromes.
Journal: Heart (British Cardiac Society) 20110201
Title: Novel anticoagulants: a discussion of clinical use in the treatment and prevention of venous thromboembolism.
Journal: Phlebology 20110201
Title: [New oral anticoagulants in atrial fibrillation].
Journal: Der Nervenarzt 20110201
Title: New anticoagulants: pharmacology and clinical studies.
Journal: Wiener medizinische Wochenschrift (1946) 20110201
Title: New oral anticoagulants and outpatient prophylaxis of venous thromboembolism.
Journal: The American journal of managed care 20110201
Title: Apixaban decreases coagulation activity in patients with acute deep-vein thrombosis.
Journal: Thrombosis and haemostasis 20110101
Title: Factor Xa and thrombin as targets for new oral anticoagulants.
Journal: Thrombosis research 20110101
Title: Novel oral factor Xa and thrombin inhibitors in the management of thromboembolism.
Journal: Annual review of medicine 20110101
Title: New oral anticoagulants: should they replace heparins and warfarin?
Journal: Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20110101
Title: [Summary of the article: Lassen MR, Gallus A, Borris LC et al. Apixaban vs enoxaparin for thromboprophylaxis after hip replacement. N Engl J Med, 2010; 363: 2487-2498].
Journal: Kardiologia polska 20110101
Title: Heparin-induced thrombocytopenia in the ICU: an overview.
Journal: Critical care (London, England) 20110101
Title: The pathology and treatment of cardiac arrhythmias: focus on atrial fibrillation.
Journal: Vascular health and risk management 20110101
Title: New oral anticoagulants for venous thromboembolism prophylaxis in orthopaedic surgery.
Journal: Instructional course lectures 20110101
Title: [Drug prevention of pulmonary embolism in orthopedic practice: traditional and novel approaches].
Journal: Kardiologiia 20110101
Title: Safety and efficacy of the oral direct factor xa inhibitor apixaban in Japanese patients with non-valvular atrial fibrillation. -The ARISTOTLE-J study-.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20110101
Title: Thrombin inhibitor or factor xa inhibitor? -Opening of a New Era of antithrombotic management-.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20110101
Title: Battle of oral anticoagulants in the field of atrial fibrillation scrutinized from a clinical practice (the real world) perspective.
Journal: Thrombosis journal 20110101
Title: Antithrombotic medication for cardioembolic stroke prevention.
Journal: Stroke research and treatment 20110101
Title: Management of patients with atrial fibrillation: specific considerations for the old age.
Journal: Cardiology research and practice 20110101
Title: Evaluation of marine brown algae and sponges from Brazil as anticoagulant and antiplatelet products.
Journal: Marine drugs 20110101
Title: Tissue factor, blood coagulation, and beyond: an overview.
Journal: International journal of inflammation 20110101
Title: Prophylaxis for deep vein thrombosis and pulmonary embolism in the surgical patient.
Journal: Advances in surgery 20110101
Title: [The new oral anticoagulants in surgery].
Journal: Revista medica del Instituto Mexicano del Seguro Social 20110101
Title: European Society of Cardiology congress 2011.
Journal: Cardiovascular journal of Africa 20110101
Title: Role of factor xa inhibitors in cancer-associated thrombosis: any new data?
Journal: Advances in hematology 20110101
Title: Emerging therapies for acute coronary syndromes.
Journal: Frontiers in pharmacology 20110101
Title: Dabigatran etexilate versus warfarin in management of non-valvular atrial fibrillation in UK context: quantitative benefit-harm and economic analyses.
Journal: BMJ (Clinical research ed.) 20110101
Title: Venous thromboembolism: classification, risk factors, diagnosis, and management.
Journal: ISRN hematology 20110101
Title: Preoperative versus postoperative initiation of thromboprophylaxis following major orthopedic surgery: safety and efficacy of postoperative administration supported by recent trials of new oral anticoagulants.
Journal: Thrombosis journal 20110101
Title: Gene-drug interaction in stroke.
Journal: Stroke research and treatment 20110101
Title: Cardiac arrest caused by multiple recurrent pulmonary embolism.
Journal: Case reports in medicine 20110101
Title: The case for an elderly targeted stroke management.
Journal: Frontiers in neurology 20110101
Title: Deep vein thrombosis: a clinical review.
Journal: Journal of blood medicine 20110101
Title: Apixaban versus enoxaparin for thromboprophylaxis after hip replacement.
Journal: The New England journal of medicine 20101223
Title: Therapeutic potential of oral factor Xa inhibitors.
Journal: The New England journal of medicine 20101223
Title: Novel anticoagulants for stroke prevention in atrial fibrillation: current clinical evidence and future developments.
Journal: Journal of the American College of Cardiology 20101214
Title: [New oral anticoagulants: better than vitamin K antagonists?].
Journal: Der Internist 20101201
Title: Clinical laboratory measurement of direct factor Xa inhibitors: anti-Xa assay is preferable to prothrombin time assay.
Journal: Thrombosis and haemostasis 20101201
Title: New synthetic antithrombotic agents for venous thromboembolism: pentasaccharides, direct thrombin inhibitors, direct Xa inhibitors.
Journal: Clinics in chest medicine 20101201
Title: Effect of apixaban, an oral and direct factor Xa inhibitor, on coagulation activity biomarkers following acute coronary syndrome.
Journal: Thrombosis and haemostasis 20101101
Title: Intracerebral hemorrhage: Pick your poison.
Journal: Cleveland Clinic journal of medicine 20101101
Title: [Novel anticoagulants for stroke prevention in atrial fibrillation].
Journal: Deutsche medizinische Wochenschrift (1946) 20101101
Title: [New oral anticoagulants from the perspective of trauma surgery].
Journal: Der Unfallchirurg 20101101
Title: New options for stroke prevention in atrial fibrillation.
Journal: The American journal of managed care 20101101
Title: New antithrombotics for atrial fibrillation.
Journal: Cardiovascular therapeutics 20101001
Title: Emerging antithrombotic agents: what does the intensivist need to know?
Journal: Current opinion in critical care 20101001
Title: Factor Xa inhibitors: next-generation antithrombotic agents.
Journal: Journal of medicinal chemistry 20100909
Title: Role of orally available antagonists of factor Xa in the treatment and prevention of thromboembolic disease: focus on rivaroxaban.
Journal: Journal of clinical pharmacology 20100901
Title: New antithrombotic agents--insights from clinical trials.
Journal: Nature reviews. Cardiology 20100901
Title: Quantification of apixaban's therapeutic utility in prevention of venous thromboembolism: selection of phase III trial dose.
Journal: Clinical pharmacology and therapeutics 20100901
Title: Novel oral anticoagulants: implications in the perioperative setting.
Journal: Anesthesiology 20100901
Title: Antithrombotic and anticoagulant profiles of TAK-442, a novel factor Xa inhibitor, in a rabbit model of venous thrombosis.
Journal: Journal of cardiovascular pharmacology 20100801
Title: Apixaban, a direct factor Xa inhibitor, inhibits tissue-factor induced human platelet aggregation in vitro: comparison with direct inhibitors of factor VIIa, XIa and thrombin.
Journal: Thrombosis and haemostasis 20100801
Title: Treatment of thromboembolism in cancer patients.
Journal: Expert opinion on pharmacotherapy 20100801
Title: [Do orally active factor Xa (FXa) inhibitors have potential as innovative new anticoagulants? Future perspective from preclinical data].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20100801
Title: Oral factor Xa inhibitors for the prevention of stroke in atrial fibrillation.
Journal: Current opinion in cardiology 20100701
Title: [A new deal with new anticoagulants?].
Journal: Journal des maladies vasculaires 20100601
Title: Effect of the direct factor Xa inhibitor apixaban in rat models of thrombosis and hemostasis.
Journal: Journal of cardiovascular pharmacology 20100601
Title: Old versus new anticoagulants: focus on pharmacology.
Journal: Recent patents on cardiovascular drug discovery 20100601
Title: Drug and dietary interactions of the new and emerging oral anticoagulants.
Journal: International journal of clinical practice 20100601
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20100601
Title: Novel oral anticoagulants. Part II: direct thrombin inhibitors.
Journal: Expert review of hematology 20100601
Title: Emerging anticoagulants for venous thromboembolism prevention.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100515
Title: Primary prevention of venous thromboembolism in medical and surgical oncology patients.
Journal: British journal of cancer 20100413
Title: Antithrombotic treatment failures in antiphospholipid syndrome: the new anticoagulants?
Journal: Lupus 20100401
Title: VTE prophylaxis for the medical patient: where do we stand? - a focus on cancer patients.
Journal: Thrombosis research 20100401
Title: Potential of new anticoagulants in patients with cancer.
Journal: Thrombosis research 20100401
Title: Health trends.
Journal: The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20100401
Title: Novel oral anticoagulants for prophylaxis and treatment of venous thromboembolism: part I (Factor Xa inhibitors).
Journal: Expert review of hematology 20100401
Title: Apixaban to prevent venous thromboembolism after knee replacement.
Journal: Lancet (London, England) 20100306
Title: Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): a randomised double-blind trial.
Journal: Lancet (London, England) 20100306
Title: In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20100301
Title: Comparative efficacy and safety of the novel oral anticoagulants dabigatran, rivaroxaban and apixaban in preclinical and clinical development.
Journal: Thrombosis and haemostasis 20100301
Title: Antithrombotic drugs for patients with ischaemic stroke and transient ischaemic attack to prevent recurrent major vascular events.
Journal: The Lancet. Neurology 20100301
Title: Apixaban for reduction in stroke and other ThromboemboLic events in atrial fibrillation (ARISTOTLE) trial: design and rationale.
Journal: American heart journal 20100301
Title: Rationale and design of AVERROES: apixaban versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K antagonist treatment.
Journal: American heart journal 20100301
Title: [Pulmonary circulation: contributions of the year 2009].
Journal: Archivos de bronconeumologia 20100301
Title: Recent advances in the management of venous thromboembolism.
Journal: The Korean journal of hematology 20100301
Title: Phenyltriazolinones as potent factor Xa inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20100215
Title: New oral anticoagulants: a practical guide for clinicians.
Journal: Journal of thrombosis and thrombolysis 20100201
Title: The new oral anticoagulants.
Journal: Blood 20100107
Title: Metabolism, pharmacokinetics and pharmacodynamics of the factor Xa inhibitor apixaban in rabbits.
Journal: Journal of thrombosis and thrombolysis 20100101
Title: Apixaban: an emerging oral factor Xa inhibitor.
Journal: Journal of thrombosis and thrombolysis 20100101
Title: New oral anticoagulants in development: potential for improved safety profiles.
Journal: Reviews in neurological diseases 20100101
Title: Forecasting drug utilization and expenditure in a metropolitan health region.
Journal: BMC health services research 20100101
Title: New options with dabigatran etexilate in anticoagulant therapy.
Journal: Vascular health and risk management 20100101
Title: New anticoagulants for the prevention of venous thromboembolism.
Journal: Drug design, development and therapy 20100101
Title: Novel anticoagulant therapy: principle and practice.
Journal: Methods in molecular biology (Clifton, N.J.) 20100101
Title: Prevention strategies for cardioembolic stroke: present and future perspectives.
Journal: The open neurology journal 20100101
Title: New anticoagulants for the prevention of thromboembolism.
Journal: Current pharmaceutical design 20100101
Title: Pharmacologic properties of the new oral anticoagulants: a clinician-oriented review with a focus on perioperative management.
Journal: Current pharmaceutical design 20100101
Title: Post-operative thromboprophylaxis: new oral thrombin and factor X inhibitors and their place in clinical practice.
Journal: F1000 medicine reports 20100101
Title: Newer antithrombotic drugs.
Journal: Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 20100101
Title: Simplifying thromboprophylaxis could improve outcomes in orthopaedic surgery.
Journal: Thrombosis 20100101
Title: New oral anticoagulants for thromboprophylaxis after elective total hip and knee arthroplasty.
Journal: Thrombosis 20100101
Title: Emerging antithrombotic agents for thromboprophylaxis, clinical potential and patient considerations.
Journal: Journal of blood medicine 20100101
Title: Oral factor Xa inhibitors for thromboprophylaxis in major orthopedic surgery: a review.
Journal: Internal and emergency medicine 20091201
Title: Oral anticoagulation with Factor Xa and thrombin inhibitors: Is there an alternative to warfarin?
Journal: Discovery medicine 20091201
Title: Apixaban or enoxaparin for thromboprophylaxis.
Journal: The New England journal of medicine 20091119
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20091101
Title: New antithrombotic drugs: potential for use in oncology.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20091010
Title: New anticoagulants and regional anesthesia.
Journal: Current opinion in anaesthesiology 20091001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20091001
Title: Oral anticoagulation with factor Xa and thrombin inhibitors: on the threshold of change.
Journal: Current opinion in hematology 20090901
Title: [New developments in antithrombotic care].
Journal: Revue medicale de Bruxelles 20090901
Title: Apixaban or enoxaparin for thromboprophylaxis after knee replacement.
Journal: The New England journal of medicine 20090806
Title: Comparative metabolism of 14C-labeled apixaban in mice, rats, rabbits, dogs, and humans.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090801
Title: Favorable therapeutic index of the direct factor Xa inhibitors, apixaban and rivaroxaban, compared with the thrombin inhibitor dabigatran in rabbits.
Journal: Journal of thrombosis and haemostasis : JTH 20090801
Title: Recent developments in the use of oral anticoagulants.
Journal: Expert opinion on pharmacotherapy 20090801
Title: Novel anticoagulants in clinical development: focus on factor Xa and direct thrombin inhibitors.
Journal: Journal of cardiovascular medicine (Hagerstown, Md.) 20090801
Title: Use of emerging oral anticoagulants in clinical practice: translating results from clinical trials to orthopedic and general surgical patient populations.
Journal: Annals of surgery 20090801
Title: Factor Xa inhibitors--new anticoagulants for secondary haemostasis.
Journal: Hamostaseologie 20090801
Title: New anticoagulants: focus on venous thromboembolism.
Journal: Current vascular pharmacology 20090701
Title: New anticoagulants for atrial fibrillation.
Journal: Seminars in thrombosis and hemostasis 20090701
Title: Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial.
Journal: Circulation 20090609
Title: 3-(3-Chloro-anilino)-1-(3,5-dimethyl-1H-pyrazol-1-yl)propan-1-one.
Journal: Acta crystallographica. Section E, Structure reports online 20090601
Title: Rivaroxaban -- an oral, direct Factor Xa inhibitor: lessons from a broad clinical study programme.
Journal: European journal of haematology 20090501
Title: Discovery of betrixaban (PRT054021), N-(5-chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide, a highly potent, selective, and orally efficacious factor Xa inhibitor.
Journal: Bioorganic & medicinal chemistry letters 20090415
Title: Sulfation of o-demethyl apixaban: enzyme identification and species comparison.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090401
Title: Apixaban, an oral direct factor Xa inhibitor, inhibits human clot-bound factor Xa activity in vitro.
Journal: Thrombosis and haemostasis 20090401
Title: [Advances in antithrombotic treatment--antithrombotics with anti-Xa effect].
Journal: Vnitrni lekarstvi 20090301
Title: The novel anticoagulants: entering a new era.
Journal: Swiss medical weekly 20090207
Title: New anticoagulants - towards the development of an 'ideal' anticoagulant.
Journal: VASA. Zeitschrift fur Gefasskrankheiten 20090201
Title: Laboratory monitoring of anticoagulation: where do we stand?
Journal: Seminars in thrombosis and hemostasis 20090201
Title: Highly efficacious factor Xa inhibitors containing alpha-substituted phenylcycloalkyl P4 moieties.
Journal: Bioorganic & medicinal chemistry letters 20090115
Title: Apixaban metabolism and pharmacokinetics after oral administration to humans.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20090101
Title: Comparative pharmacodynamics and pharmacokinetics of oral direct thrombin and factor xa inhibitors in development.
Journal: Clinical pharmacokinetics 20090101
Title: In the pipeline: new oral anticoagulants for the prevention of venous thromboembolism.
Journal: Orthopedics 20090101
Title: New oral anticoagulants: not quite there yet.
Journal: Polskie Archiwum Medycyny Wewnetrznej 20090101
Title: Old and new anticoagulant agents for the prevention and treatment of patients with ischemic stroke.
Journal: Cerebrovascular diseases (Basel, Switzerland) 20090101
Title: Use of anticoagulants in elderly patients: practical recommendations.
Journal: Clinical interventions in aging 20090101
Title: Selecting the optimal antithrombotic regimen for patients with acute coronary syndromes undergoing percutaneous coronary intervention.
Journal: Vascular health and risk management 20090101
Title: The prevention and treatment of venous thromboembolism with LMWHs and new anticoagulants.
Journal: Vascular health and risk management 20090101
Title: Apixaban, an oral direct Factor Xa inhibitor: awaiting the verdict.
Journal: Expert opinion on investigational drugs 20081201
Title: Emergence of new oral antithrombotics: a critical appraisal of their clinical potential.
Journal: Vascular health and risk management 20081201
Title: [New oral anticoagulants: molecular characteristics, mechanisms of action, pharmacokinetics and pharmacodynamics].
Journal: Medicina clinica 20081101
Title: Arterial antithrombotic and bleeding time effects of apixaban, a direct factor Xa inhibitor, in combination with antiplatelet therapy in rabbits.
Journal: Journal of thrombosis and haemostasis : JTH 20081001
Title: Apixaban, an oral, direct inhibitor of activated Factor Xa.
Journal: Current opinion in investigational drugs (London, England : 2000) 20080901
Title: New developments in anticoagulation for atrial fibrillation.
Journal: Current treatment options in cardiovascular medicine 20080901
Title: Efficacy and safety of the oral direct factor Xa inhibitor apixaban for symptomatic deep vein thrombosis. The Botticelli DVT dose-ranging study.
Journal: Journal of thrombosis and haemostasis : JTH 20080801
Title: New compounds in the management of venous thromboembolism after orthopedic surgery: focus on rivaroxaban.
Journal: Vascular health and risk management 20080801
Title: Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies.
Journal: Journal of thrombosis and haemostasis : JTH 20080501
Title: Structure-activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties.
Journal: Bioorganic & medicinal chemistry letters 20080501
Title: New anticoagulants for treatment of venous thromboembolism.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20080301
Title: Update on atrial fibrillation: part I.
Journal: Clinical cardiology 20080201
Title: [New anticoagulants].
Journal: Hamostaseologie 20080201
Title: Current and future prospects for anticoagulant therapy: inhibitors of factor Xa and factor IIa.
Journal: Seminars in thrombosis and hemostasis 20080201
Title: The laboratory diagnosis and clinical management of patients with heparin-induced thrombocytopenia: an update.
Journal: Seminars in thrombosis and hemostasis 20080201
Title: New oral anticoagulants in atrial fibrillation.
Journal: European heart journal 20080101
Title: The top 4 advances in antithrombotic care in the last year.
Journal: Thrombosis research 20080101
Title: Brave new world: the current and future use of novel anticoagulants.
Journal: Thrombosis research 20080101
Title: Gateways to clinical trials. July-August 2008.
Journal: Methods and findings in experimental and clinical pharmacology 20080101
Title: Controversies in the antiphospholipid syndrome: can we ever stop warfarin?
Journal: Journal of autoimmune diseases 20080101
Title: New issues in oral anticoagulants.
Journal: Hematology. American Society of Hematology. Education Program 20080101
Title: Oral factor Xa inhibitors for venous thromboembolism prevention in major orthopedic surgery: a review.
Journal: Pathophysiology of haemostasis and thrombosis 20080101
Title: The efficacy and safety of apixaban, an oral, direct factor Xa inhibitor, as thromboprophylaxis in patients following total knee replacement.
Journal: Journal of thrombosis and haemostasis : JTH 20071201
Title: Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa.
Journal: Journal of medicinal chemistry 20071101
Title: SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa.
Journal: Bioorganic & medicinal chemistry letters 20070815
Title: Beyond unfractionated heparin and warfarin: current and future advances.
Journal: Circulation 20070731
Title: Oral, direct factor Xa inhibitors in development for the prevention and treatment of thromboembolic diseases.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20070601
Title: Investigational treatments of venous thromboembolism.
Journal: Expert opinion on investigational drugs 20070401
Title: Stroke in atrial fibrillation: update on pathophysiology, new antithrombotic therapies, and evolution of procedures and devices.
Journal: Annals of medicine 20070101
Title: Oral anticoagulants in development: focus on thromboprophylaxis in patients undergoing orthopaedic surgery.
Journal: Drugs 20060101
Title: Pinto DJ, et al. Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo,4-cpyridine-3-carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa. J Med Chem. 2007 Nov 1;50(22):5339-56.
Title: Wong PC, et al. Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies. J Thromb Haemost. 2008 May;6(5):820-9
Title: Zhang D, et al. Metabolism, pharmacokinetics and pharmacodynamics of the factor Xa inhibitor apixaban in rabbits. J Thromb Thrombolysis. 2010 Jan;29(1):70-80
Title: He K, et al. Preclinical pharmacokinetics and pharmacodynamics of apixaban, a potent and selective factor Xa inhibitor. Eur J Drug Metab Pharmacokinet. 2011 Sep;36(3):129-39
