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88899-55-2,MFCD06795130
Catalog No.:AA00397Y

88899-55-2 | (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one

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1mg
≥95%
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$252.00   $176.00
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5mg
≥95%
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$1,108.00   $775.00
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00397Y
Chemical Name:
(3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
CAS Number:
88899-55-2
Molecular Formula:
C35H58O9
Molecular Weight:
622.8296
MDL Number:
MFCD06795130
SMILES:
CO[C@H]1/C=C/C=C(\C)/C[C@H](C)[C@H](O)[C@@H](/C=C(/C=C(/C(=O)O[C@@H]1[C@H]([C@H]([C@@H]([C@@]1(O)C[C@@H](O)[C@@H]([C@H](O1)C(C)C)C)C)O)C)\OC)\C)C C35H58O9
Properties
Computed Properties
 
Complexity:
1060  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
12  
Defined Bond Stereocenter Count:
4  
Heavy Atom Count:
44  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
7  
XLogP3:
6  

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Journal: Biological chemistry 20100501

Title: Lysosome dysfunction triggers Atg7-dependent neural apoptosis.

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Title: Initiation of purinergic signaling by exocytosis of ATP-containing vesicles in liver epithelium.

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Journal: Brain research 20100208

Title: Selective and specific internalization of clostridial C3 ADP-ribosyltransferases into macrophages and monocytes.

Journal: Cellular microbiology 20100201

Title: Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation.

Journal: Cancer research 20100201

Title: Pigment epithelium-derived factor inhibits lysosomal degradation of Bcl-xL and apoptosis in HepG2 cells.

Journal: The American journal of pathology 20100101

Title: Novel application of low pH-dependent fluorescent dyes to examine colitis.

Journal: BMC gastroenterology 20100101

Title: Vacuolar ATPase regulates surfactant secretion in rat alveolar type II cells by modulating lamellar body calcium.

Journal: PloS one 20100101

Title: Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption--implications for osteoclast quality.

Journal: BMC musculoskeletal disorders 20100101

Title: 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.

Journal: BMC cancer 20100101

Title: Vacuolar ATPase-mediated cellular concentration and retention of quinacrine: a model for the distribution of lipophilic cationic drugs to autophagic vacuoles.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20091201

Title: Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of the human ATP-binding cassette transporter ABCG2.

Journal: The FEBS journal 20091201

Title: Vacuolisation of human microvascular endothelial cells by enterohaemorrhagic Escherichia coli.

Journal: Thrombosis and haemostasis 20091201

Title: Serum deprivation induced autophagy and predominantly an AIF-dependent apoptosis in hippocampal HT22 neurons.

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Title: Rapid flow cytometric method for measuring senescence associated beta-galactosidase activity in human fibroblasts.

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Title: Aggregated LDL in contact with macrophages induces local increases in free cholesterol levels that regulate local actin polymerization.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20091001

Title: Inhibitors of the V0 subunit of the vacuolar H+-ATPase prevent segregation of lysosomal- and secretory-pathway proteins.

Journal: Journal of cell science 20091001

Title: Mechanism of insulin uptake in rat alveolar type II and type I-like epithelial cells.

Journal: Biological & pharmaceutical bulletin 20091001

Title: An unusual organelle in Cryptococcus neoformans links luminal pH and capsule biosynthesis.

Journal: Fungal genetics and biology : FG & B 20090901

Title: Endoplasmic reticulum stress induces autophagy in renal proximal tubular cells.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090901

Title: Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpins.

Journal: The Journal of biological chemistry 20090821

Title: The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells.

Journal: International journal of cancer 20090801

Title: NAADP receptors mediate calcium signaling stimulated by endothelin-1 and norepinephrine in renal afferent arterioles.

Journal: American journal of physiology. Renal physiology 20090801

Title: Vacuolar H+-ATPase inhibitors overcome Bcl-xL-mediated chemoresistance through restoration of a caspase-independent apoptotic pathway.

Journal: Cancer science 20090801

Title: Intracellular sequestration of amiodarone: role of vacuolar ATPase and macroautophagic transition of the resulting vacuolar cytopathology.

Journal: British journal of pharmacology 20090801

Title: Microbial toxin's effect on mitochondrial survival by increasing K+ uptake.

Journal: Toxicology and industrial health 20090801

Title: A designer biomimetic vector with a chimeric architecture for targeted gene transfer.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20090701

Title: Extrasynaptic release of GABA by retinal dopaminergic neurons.

Journal: Journal of neurophysiology 20090701

Title: Murine norovirus-1 entry into permissive macrophages and dendritic cells is pH-independent.

Journal: Virus research 20090701

Title: Vaccinia virus strain differences in cell attachment and entry.

Journal: Virology 20090620

Title: 4'-Epidoxorubicin to re-explore anthracycline degradation in cardiomyocytes.

Journal: Chemical research in toxicology 20090601

Title: Efficient polyethylenimine-mediated gene delivery proceeds via a caveolar pathway in HeLa cells.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20090521

Title: Autophagy protects neuron from Abeta-induced cytotoxicity.

Journal: Autophagy 20090501

Title: Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells.

Journal: Biochemical and biophysical research communications 20090501

Title: Functional significance and morphological characterization of starvation-induced autophagy in the adult heart.

Journal: The American journal of pathology 20090501

Title: Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells.

Journal: The Journal of clinical investigation 20090501

Title: Influenza A virus H5N1 entry into host cells is through clathrin-dependent endocytosis.

Journal: Science in China. Series C, Life sciences 20090501

Title: Identification of a chemical probe for NAADP by virtual screening.

Journal: Nature chemical biology 20090401

Title: Neutralization of endomembrane compartments in epithelial MDCK cells affects proteoglycan synthesis in the apical secretory pathway.

Journal: The Biochemical journal 20090315

Title: Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells.

Journal: International journal of cancer 20090301

Title: The effect of bafilomycin A1 and protease inhibitors on the degradation and recycling of a Class 5-mutant LDLR.

Journal: Acta biochimica et biophysica Sinica 20090301

Title: Major SNP (Q141K) variant of human ABC transporter ABCG2 undergoes lysosomal and proteasomal degradations.

Journal: Pharmaceutical research 20090201

Title: Total synthesis of bafilomycin A1.

Journal: Angewandte Chemie (International ed. in English) 20090101

Title: Analysis of hemagglutinin-mediated entry tropism of H5N1 avian influenza.

Journal: Virology journal 20090101

Title: Differential role of autophagy in CD4 T cells and macrophages during X4 and R5 HIV-1 infection.

Journal: PloS one 20090101

Title: Oligoethylenimine-grafted polypropylenimine dendrimers as degradable and biocompatible synthetic vectors for gene delivery.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20081208

Title: Mechanism of basic calcium phosphate crystal-stimulated matrix metalloproteinase-13 expression by osteoarthritic synovial fibroblasts: inhibition by prostaglandin E2.

Journal: Annals of the rheumatic diseases 20081201

Title: Initiation of motility by steelhead (Oncorhynchus mykiss) sperm: membrane ion exchangers and pH sensitivity.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20081201

Title: Soapwort saponins trigger clathrin-mediated endocytosis of saporin, a type I ribosome-inactivating protein.

Journal: Chemico-biological interactions 20081125

Title: Lysosomal cathepsin B participates in the podosome-mediated extracellular matrix degradation and invasion via secreted lysosomes in v-Src fibroblasts.

Journal: Cancer research 20081115

Title: Biodegradable poly(ester amine) based on glycerol dimethacrylate and polyethylenimine as a gene carrier.

Journal: The journal of gene medicine 20081101

Title: Evidence for nickel/proton antiport activity at the tonoplast of the hyperaccumulator plant Alyssum lesbiacum.

Journal: Plant biology (Stuttgart, Germany) 20081101

Title: Glutamate transporter-mediated glutamate secretion in the mammalian pineal gland.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20081022

Title: Metabolic stress induces the lysosomal degradation of neuropilin-1 but not neuropilin-2.

Journal: The Journal of biological chemistry 20081017

Title: The proton pump inhibitor inhibits cell growth and induces apoptosis in human hepatoblastoma.

Journal: Pediatric surgery international 20081001

Title: Does bafilomycin A1 block the fusion of autophagosomes with lysosomes?

Journal: Autophagy 20081001

Title: Toll-like receptor-mediated activation of neutrophils by influenza A virus.

Journal: Blood 20080901

Title: Conditioning the heart induces formation of signalosomes that interact with mitochondria to open mitoKATP channels.

Journal: American journal of physiology. Heart and circulatory physiology 20080901

Title: Intravesicular calcium release mediates the motion and exocytosis of secretory organelles: a study with adrenal chromaffin cells.

Journal: The Journal of biological chemistry 20080815

Title: Pregnancy-upregulated nonubiquitous calmodulin kinase induces ligand-independent EGFR degradation.

Journal: American journal of physiology. Cell physiology 20080801

Title: Receptor-independent, vacuolar ATPase-mediated cellular uptake of histamine receptor-1 ligands: possible origin of pharmacological distortions and side effects.

Journal: Toxicology and applied pharmacology 20080615

Title: A determination of the steady state lysosomal pH of bloodstream stage African trypanosomes.

Journal: Molecular and biochemical parasitology 20080601

Title: Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimod.

Journal: Molecular immunology 20080601

Title: Ubiquitin-mediated proteasomal degradation of non-synonymous SNP variants of human ABC transporter ABCG2.

Journal: The Biochemical journal 20080501

Title: Intense pseudotransport of a cationic drug mediated by vacuolar ATPase: procainamide-induced autophagic cell vacuolization.

Journal: Toxicology and applied pharmacology 20080501

Title: An endosomolytic Tat peptide produced by incorporation of histidine and cysteine residues as a nonviral vector for DNA transfection.

Journal: Biomaterials 20080501

Title: Lipid droplet changes in proliferating and quiescent 3T3 fibroblasts.

Journal: Histochemistry and cell biology 20080501

Title: Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.

Journal: Nature chemical biology 20080501

Title: A mathematical model of the proton balance in the outer mantle epithelium of Anodonta cygnea L.

Journal: The Journal of membrane biology 20080501

Title: A method to measure cardiac autophagic flux in vivo.

Journal: Autophagy 20080401

Title: Analysis of the mechanism of antibody-dependent enhancement of feline infectious peritonitis virus infection: aminopeptidase N is not important and a process of acidification of the endosome is necessary.

Journal: The Journal of general virology 20080401

Title: Biochemical and functional characterization of the actin-binding activity of the B subunit of yeast vacuolar H+-ATPase.

Journal: The Journal of experimental biology 20080401

Title: Impaired acid secretion in cortical collecting duct intercalated cells from H-K-ATPase-deficient mice: role of HKalpha isoforms.

Journal: American journal of physiology. Renal physiology 20080301

Title: Vesicular release of glutamate from hippocampal neurons in culture: an immunocytochemical assay.

Journal: Experimental brain research 20080201

Title: Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.

Journal: Traffic (Copenhagen, Denmark) 20080201

Title: The relative contribution of mannose salvage pathways to glycosylation in PMI-deficient mouse embryonic fibroblast cells.

Journal: The FEBS journal 20080201

Title: Acute effectors of GLUT1 glucose transporter subcellular targeting in CIT3 mouse mammary epithelial cells.

Journal: Pediatric research 20080101

Title: Phagocytosis-induced apoptosis of macrophages is linked to uptake, killing and degradation of bacteria.

Journal: European journal of immunology 20080101

Title: Induction of apoptosis by epigallocatechin gallate and autophagy inhibitors in a mouse macrophage-like cell line.

Journal: Anticancer research 20080101

Title: Low-affinity transport of FITC-albumin in alveolar type II epithelial cell line RLE-6TN.

Journal: Drug metabolism and pharmacokinetics 20080101

Title: Methods to investigate autophagy during starvation and regeneration in hydra.

Journal: Methods in enzymology 20080101

Title: Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways.

Journal: ACS nano 20080101

Title: Endoplasmic reticulum-associated degradation of growth hormone receptor in Janus kinase 2-deficient cells.

Journal: Endocrinology 20071201

Title: Involvement of vesicular H+-ATPase in insulin-stimulated glucose transport in 3T3-F442A adipocytes.

Journal: Endocrine journal 20071201

Title: Depolarization of isolated horizontal cells of fish acidifies their immediate surrounding by activating V-ATPase.

Journal: The Journal of physiology 20071201

Title: Involvement of Na+/H+ exchangers in induction of cyclooxygenase-2 by vacuolar-type (H+)-ATPase inhibitors in RAW 264 cells.

Journal: FEBS letters 20071002

Title: A dimethylmaleic acid-melittin-polylysine conjugate with reduced toxicity, pH-triggered endosomolytic activity and enhanced gene transfer potential.

Journal: The journal of gene medicine 20070901

Title: Replication-competent recombinant vesicular stomatitis virus encoding hepatitis C virus envelope proteins.

Journal: Journal of virology 20070801

Title: Bafilomycin A1 is a potassium ionophore that impairs mitochondrial functions.

Journal: Journal of bioenergetics and biomembranes 20070801

Title: NAADP mobilizes calcium from the endoplasmic reticular Ca(2+) store in T-lymphocytes.

Journal: The Journal of biological chemistry 20070629

Title: Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies.

Journal: The Journal of biological chemistry 20070622

Title: Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1.

Journal: The Journal of biological chemistry 20070420

Title: An envelope-determined endocytic route of viral entry allows HIV-1 to escape from secreted phospholipase A2 entry blockade.

Journal: Journal of molecular biology 20070330

Title: Angiotensin II increases chloride absorption in the cortical collecting duct in mice through a pendrin-dependent mechanism.

Journal: American journal of physiology. Renal physiology 20070301

Title: ATP6V0C competes with von Hippel-Lindau protein in hypoxia-inducible factor 1alpha (HIF-1alpha) binding and mediates HIF-1alpha expression by bafilomycin A1.

Journal: Molecular pharmacology 20070301

Title: Vacuolar-type H+-ATPase-mediated acidosis promotes in vitro osteoclastogenesis via modulation of cell migration.

Journal: International journal of molecular medicine 20070301

Title: Vesicular release of glutamate from unmyelinated axons in white matter.

Journal: Nature neuroscience 20070301

Title: Chitosan-graft-polyethylenimine as a gene carrier.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20070212

Title: Inhibition of bone resorption in cultures of mouse calvariae by apicularen A.

Journal: Planta medica 20070201

Title: Estrogen decrease in tight junctional resistance involves matrix-metalloproteinase-7-mediated remodeling of occludin.

Journal: Endocrinology 20070101

Title: Biosynthetic origin of the methoxyl extender unit in bafilomycin and concanamycin using stereospecifically labeled precursors.

Journal: The Journal of antibiotics 20070101

Title: Conjugated polythiophene probes target lysosome-related acidic vacuoles in cultured primary cells.

Journal: Molecular and cellular probes 20070101

Title: Inhibition of betanodavirus infection by inhibitors of endosomal acidification.

Journal: Archives of virology 20070101

Title: The effects of repeated exposure to sub-toxic doses of plecomacrolide antibiotics on the endocrine pancreas.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20061201

Title: Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1alpha.

Journal: Molecular pharmacology 20061201

Title: Cell entry and cAMP imaging of anthrax edema toxin.

Journal: The EMBO journal 20061115

Title: Osteoclasts play a part in pain due to the inflammation adjacent to bone.

Journal: Bone 20061101

Title: Nitric oxide production by the vacuolar-type (H+)-ATPase inhibitors bafilomycin A1 and concanamycin A and its possible role in apoptosis in RAW 264.7 cells.

Journal: The Journal of pharmacology and experimental therapeutics 20061101

Title: Suppression of proinflammatory cytokine production in macrophages by lansoprazole.

Journal: Pediatric surgery international 20061101

Title: pH dependence and inhibition by extracellular calcium of proton currents via plasmalemmal vacuolar-type H+-ATPase in murine osteoclasts.

Journal: The Journal of physiology 20061015

Title: Bafilomycin A1-sensitive pathway is required for the maturation of cystic fibrosis transmembrane conductance regulator.

Journal: Biochimica et biophysica acta 20061001

Title: CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels.

Journal: Biochemical and biophysical research communications 20060714

Title: Chronic high glucose inhibits albumin reabsorption by lysosomal alkalinization in cultured porcine proximal tubular epithelial cells (LLC-PK1).

Journal: Diabetes research and clinical practice 20060601

Title: Role of urease in megasome formation and Helicobacter pylori survival in macrophages.

Journal: Journal of leukocyte biology 20060601

Title: Dynamic life and death interactions between Mycobacterium smegmatis and J774 macrophages.

Journal: Cellular microbiology 20060601

Title: Effects of bafilomycin A1, a vacuolar type H+ ATPase inhibitor, on the thermosensitivity of a human pancreatic cancer cell line.

Journal: International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20060601

Title: Palmitoyl protein thioesterase 1 (PPT1) deficiency causes endocytic defects connected to abnormal saposin processing.

Journal: Experimental cell research 20060515

Title: Inhibition of vacuolar-type (H+)-ATPase by the cytostatic macrolide apicularen A and its role in apicularen A-induced apoptosis in RAW 264.7 cells.

Journal: FEBS letters 20060515

Title: Defective one- or two-electron reduction of the anticancer anthracycline epirubicin in human heart. Relative importance of vesicular sequestration and impaired efficiency of electron addition.

Journal: The Journal of biological chemistry 20060421

Title: Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation.

Journal: The Journal of biological chemistry 20060421

Title: FGF-1 and FGF-2 require the cytosolic chaperone Hsp90 for translocation into the cytosol and the cell nucleus.

Journal: The Journal of biological chemistry 20060421

Title: Ca2+ release triggered by NAADP in hepatocyte microsomes.

Journal: The Biochemical journal 20060415

Title: Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons.

Journal: Molecular pharmacology 20060401

Title: Development of a concise and diversity-oriented approach for the synthesis of plecomacrolides via the diene-ene RCM.

Journal: Organic letters 20060316

Title: Cathepsin B-mediated yolk protein degradation during killifish oocyte maturation is blocked by an H+-ATPase inhibitor: effects on the hydration mechanism.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20060201

Title: Proton pump-rich cell secretes acid in skin of zebrafish larvae.

Journal: American journal of physiology. Cell physiology 20060201

Title: Calcium mobilization by nicotinic acid adenine dinucleotide phosphate (NAADP) in rat astrocytes.

Journal: Cell calcium 20060201

Title: Glia re-sealed particles freshly prepared from adult rat brain are competent for exocytotic release of glutamate.

Journal: Journal of neurochemistry 20060201

Title: Human macrophages do not require phagosome acidification to mediate fungistatic/fungicidal activity against Histoplasma capsulatum.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20060201

Title: GTP uptake into rat brain synaptic vesicles.

Journal: Brain research 20060127

Title: Intragranular pH rapidly modulates exocytosis in adrenal chromaffin cells.

Journal: Journal of neurochemistry 20060101

Title: H+-ATPase activity in selective disruption of H+-K+-ATPase alpha 1 gene of mice under normal and K-depleted conditions.

Journal: The Journal of laboratory and clinical medicine 20060101

Title: Autophagy, bafilomycin and cell death: the 'a-B-cs' of plecomacrolide-induced neuroprotection.

Journal: Autophagy 20060101

Title: Subunit a of the yeast V-ATPase participates in binding of bafilomycin.

Journal: The Journal of biological chemistry 20051209

Title: Inhibition of the vacuolar H(+)-pump with bafilomycin A1 does not induce acrosome reaction or activate proacrosin in mouse spermatozoa.

Journal: Biochemical and biophysical research communications 20051202

Title: Proteolytic processing of the ovine prion protein in cell cultures.

Journal: Biochemical and biophysical research communications 20051111

Title: Nano neodymium oxide induces massive vacuolization and autophagic cell death in non-small cell lung cancer NCI-H460 cells.

Journal: Biochemical and biophysical research communications 20051111

Title: Neuronal zinc stores are modulated by non-steroidal anti-inflammatory drugs: an optical analysis in cultured hippocampal neurons.

Journal: Brain research 20051102

Title: Gene delivery with low molecular weight linear polyethylenimines.

Journal: The journal of gene medicine 20051001

Title: A vacuolar ATPase inhibitor, FR167356, prevents bone resorption in ovariectomized rats with high potency and specificity: potential for clinical application.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20050901

Title: Ca2+ accumulation into acidic organelles mediated by Ca2+- and vacuolar H+-ATPases in human platelets.

Journal: The Biochemical journal 20050815

Title: Mechanisms behind Pb-induced disruption of Na+ and Cl- balance in rainbow trout (Oncorhynchus mykiss).

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20050801

Title: Characterization of vacuolar transport of the endogenous alkaloid berberine in Coptis japonica.

Journal: Plant physiology 20050801

Title: Synergistic effect of poly(ethylenimine) on the transfection efficiency of galactosylated chitosan/DNA complexes.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20050720

Title: V-ATPase expression during development of Artemia franciscana embryos: potential role for proton gradients in anoxia signaling.

Journal: The Journal of experimental biology 20050701

Title: V-ATPase inhibition prevents recovery from anoxia in Artemia franciscana embryos: quiescence signaling through dissipation of proton gradients.

Journal: The Journal of experimental biology 20050701

Title: Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis.

Journal: The journal of gene medicine 20050501

Title: Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells.

Journal: International journal of oncology 20050501

Title: Direct measurement of acid efflux from isolated guinea pig pancreatic ducts.

Journal: Pancreas 20050501

Title: Vglut1 and ZnT3 co-targeting mechanisms regulate vesicular zinc stores in PC12 cells.

Journal: Journal of cell science 20050501

Title: pH-dependent intraluminal organization of mucin granules in live human mucous/goblet cells.

Journal: The Journal of biological chemistry 20050429

Title: Glycosaminoglycans modulate activation, activity, and stability of tripeptidyl-peptidase I in vitro and in vivo.

Journal: The Journal of biological chemistry 20050304

Title: Insertion of targeting domains into the envelope glycoprotein of Moloney murine leukemia virus (MoMLV)-based vectors modulates the route of mCAT-1-mediated viral entry.

Journal: Virus research 20050301

Title: Nicotinic acid adenine dinucleotide phosphate potentiates neurite outgrowth.

Journal: The Journal of biological chemistry 20050218

Title: Role of H+-ATPase-mediated acidification in sorting and release of the regulated secretory protein chromogranin A: evidence for a vesiculogenic function.

Journal: The Journal of biological chemistry 20050204

Title: In vitro gene delivery using polyamidoamine dendrimers with a trimesyl core.

Journal: Biomacromolecules 20050101

Title: Lysosome-sarcoplasmic reticulum junctions. A trigger zone for calcium signaling by nicotinic acid adenine dinucleotide phosphate and endothelin-1.

Journal: The Journal of biological chemistry 20041224

Title: Burkholderia cepacia complex isolates survive intracellularly without replication within acidic vacuoles of Acanthamoeba polyphaga.

Journal: Cellular microbiology 20041201

Title: H+-ATPase of crude homogenate of the outer mantle epithelium of Anodonta cygnea.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20041201

Title: A fluorescent probe of polyamine transport accumulates into intracellular acidic vesicles via a two-step mechanism.

Journal: The Journal of biological chemistry 20041119

Title: Dopamine recruits D1A receptors to Na-K-ATPase-rich caveolar plasma membranes in rat renal proximal tubules.

Journal: American journal of physiology. Renal physiology 20041101

Title: The ability of chloroquine to prevent tat-induced cytokine secretion by monocytes is implicated in its in vivo anti-human immunodeficiency virus type 1 activity.

Journal: Journal of virology 20041101

Title: Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes.

Journal: The Journal of biological chemistry 20041022

Title: Distinct profiles of refilling of inhibitory neurotransmitters into presynaptic terminals projecting to spinal neurones in immature rats.

Journal: The Journal of physiology 20041015

Title: Inhibition of bicarbonate reabsorption in the rat proximal tubule by activation of luminal P2Y1 receptors.

Journal: American journal of physiology. Renal physiology 20041001

Title: Identification and characterization of the Pasteurella multocida toxin translocation domain.

Journal: Molecular microbiology 20041001

Title: Mobilization and fusion of a non-recycling pool of synaptic vesicles under conditions of endocytic blockade.

Journal: Neuropharmacology 20041001

Title: Biosynthetic investigations of the V-type ATPase inhibitors bafilomycin A1, B1 and concanamycin A.

Journal: The Journal of antibiotics 20041001

Title: Molecular mechanisms of TNF-alpha-induced ceramide formation in human glioma cells: P53-mediated oxidant stress-dependent and -independent pathways.

Journal: Cell death and differentiation 20040901

Title: V-type ATPase is involved in biogenesis of GLUT4 vesicles.

Journal: American journal of physiology. Endocrinology and metabolism 20040901

Title: Group IB secretory phospholipase A2 promotes matrix metalloproteinase-2-mediated cell migration via the phosphatidylinositol 3-kinase and Akt pathway.

Journal: The Journal of biological chemistry 20040827

Title: The bafilomycin/concanamycin binding site in subunit c of the V-ATPases from Neurospora crassa and Saccharomyces cerevisiae.

Journal: The Journal of biological chemistry 20040806

Title: Transmembrane reorientation of the substrate-binding site in vesicular acetylcholine transporter.

Journal: Biochemistry 20040713

Title: Up-regulation of low-density lipoprotein receptor in human hepatocytes is induced by sequestration of free cholesterol in the endosomal/lysosomal compartment.

Journal: Biochemical pharmacology 20040615

Title: Mild heat shock induces autophagic growth arrest, but not apoptosis in U251-MG and U87-MG human malignant glioma cells.

Journal: Journal of neuro-oncology 20040601

Title: Proteinases participating in the processing and activation of prolegumain in primary cultured rat macrophages.

Journal: Biological chemistry 20040601

Title: Salicylihalamide A inhibits the V0 sector of the V-ATPase through a mechanism distinct from bafilomycin A1.

Journal: The Journal of biological chemistry 20040507

Title: Important role for the V-type H(+)-ATPase and the Golgi apparatus in the recycling of PTH/PTHrP receptor.

Journal: American journal of physiology. Endocrinology and metabolism 20040501

Title: Characterization of osteoclasts from patients harboring a G215R mutation in ClC-7 causing autosomal dominant osteopetrosis type II.

Journal: The American journal of pathology 20040501

Title: Processing and activation of latent heparanase occurs in lysosomes.

Journal: Journal of cell science 20040501

Title: Release of intact and fragmented osteocalcin molecules from bone matrix during bone resorption in vitro.

Journal: The Journal of biological chemistry 20040430

Title: Involvement of membrane GABA transporter in alpha-latrotoxin-stimulated [3H]GABA release.

Journal: Neurochemistry international 20040401

Title: Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells.

Journal: Cell death and differentiation 20040401

Title: The membrane potential of the intraerythrocytic malaria parasite Plasmodium falciparum.

Journal: The Journal of biological chemistry 20040319

Title: Lactosylated polyethylenimine for gene transfer into airway epithelial cells: role of the sugar moiety in cell delivery and intracellular trafficking of the complexes.

Journal: The journal of gene medicine 20040301

Title: Endocytic trafficking in actively resorbing osteoclasts.

Journal: Journal of cell science 20040227

Title: Inhibitory effect of Toll-like receptor 4 on fusion between phagosomes and endosomes/lysosomes in macrophages.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20040215

Title: Synergism in gene delivery by small PEIs and three different nonviral vectors.

Journal: International journal of pharmaceutics 20040211

Title: Recycling, degradation and sensitivity to the synergistic anion of transferrin in the receptor-independent route of iron uptake by human hepatoma (HuH-7) cells.

Journal: The international journal of biochemistry & cell biology 20040201

Title: Correction of defective early tyrosinase processing by bafilomycin A1 and monensin in pink-eyed dilution melanocytes.

Journal: Pigment cell research 20040201

Title: Modulation of mature cystic fibrosis transmembrane regulator protein by the PDZ domain protein CAL.

Journal: The Journal of biological chemistry 20040116

Title: Sodium and chloride transport in soft water and hard water acclimated zebrafish (Danio rerio).

Journal: Biochimica et biophysica acta 20031230

Title: Synthesis of the c14-c25 subunit of bafilomycin A1.

Journal: The Journal of organic chemistry 20031226

Title: Cellular vacuolation and mitochondrial cytochrome c release are independent outcomes of Helicobacter pylori vacuolating cytotoxin activity that are each dependent on membrane channel formation.

Journal: The Journal of biological chemistry 20031128

Title: Identification of a new chondropsin class of antitumor compound that selectively inhibits V-ATPases.

Journal: The Journal of biological chemistry 20031107

Title: Characterization of the functional coupling of bovine brain vacuolar-type H(+)-translocating ATPase. Effect of divalent cations, phospholipids, and subunit H (SFD).

Journal: The Journal of biological chemistry 20031107

Title: Profibrillin-1 maturation by human dermal fibroblasts: proteolytic processing and molecular chaperones.

Journal: Journal of cellular biochemistry 20031015

Title: Wortmannin alters the intracellular trafficking of the bradykinin B2 receptor: role of phosphoinositide 3-kinase and Rab5.

Journal: The Biochemical journal 20031001

Title: Vacuolar H+-ATPase inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1.

Journal: Journal of biochemistry 20030901

Title: The host cell chaperone Hsp90 is essential for translocation of the binary Clostridium botulinum C2 toxin into the cytosol.

Journal: The Journal of biological chemistry 20030822

Title: Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis.

Journal: The Journal of biological chemistry 20030815

Title: Cell alkalosis elevates cytosolic Ca2+ in rabbit resident alveolar macrophages.

Journal: Clinical science (London, England : 1979) 20030701

Title: Amyloid-beta increases acetylcholinesterase expression in neuroblastoma cells by reducing enzyme degradation.

Journal: Journal of neurochemistry 20030701

Title: Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine.

Journal: Oncogene 20030619

Title: Distribution and serotonin-induced activation of vacuolar-type H+-ATPase in the salivary glands of the blowfly Calliphora vicina.

Journal: The Journal of experimental biology 20030601

Title: Channel formation by the binding component of Clostridium botulinum C2 toxin: glutamate 307 of C2II affects channel properties in vitro and pH-dependent C2I translocation in vivo.

Journal: Biochemistry 20030513

Title: Increase in secretion of glial cell line-derived neurotrophic factor from glial cell lines by inhibitors of vacuolar ATPase.

Journal: Neurochemistry international 20030501

Title: Secretion of acid and base equivalents by intact distal airways.

Journal: American journal of physiology. Lung cellular and molecular physiology 20030501

Title: Induction of autophagic cell death in malignant glioma cells by arsenic trioxide.

Journal: Cancer research 20030501

Title: Phosphocitrate inhibits calcium hydroxyapatite induced mitogenesis and upregulation of matrix metalloproteinase-1, interleukin-1beta and cyclooxygenase-2 mRNA in human breast cancer cell lines.

Journal: Breast cancer research and treatment 20030501

Title: Proton pump inhibitors control osteoclastic resorption of calcium phosphate implants and stimulate increased local reparative bone growth.

Journal: The Journal of craniofacial surgery 20030501

Title: An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway.

Journal: The Journal of biological chemistry 20030418

Title: Effects of Bafilomycin A1: an inhibitor of vacuolar H (+)-ATPases on endocytosis and apoptosis in RAW cells and RAW cell-derived osteoclasts.

Journal: Journal of cellular biochemistry 20030415

Title: Presentation by recycling MHC class II molecules of an influenza hemagglutinin-derived epitope that is revealed in the early endosome by acidification.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20030401

Title: Isolation of small agranular synaptic vesicles of rat brain by gel filtration chromatography.

Journal: Journal of biochemistry 20030401

Title: Remodeling of endosomes during lysosome biogenesis involves 'kiss and run' fusion events regulated by rab5.

Journal: Journal of cell science 20030301

Title: Increased tumour extracellular pH induced by Bafilomycin A1 inhibits tumour growth and mitosis in vivo and alters 5-fluorouracil pharmacokinetics.

Journal: European journal of cancer (Oxford, England : 1990) 20030301

Title: In bafilomycin A1-resistant cells, bafilomycin A1 raised lysosomal pH and both prodigiosins and concanamycin A inhibited growth through apoptosis.

Journal: FEBS letters 20030227

Title: Different synergistic roles of small polyethylenimine and Dosper in gene delivery.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20030214

Title: Localization and characterization of phenamil-sensitive Na+ influx in isolated rainbow trout gill epithelial cells.

Journal: The Journal of experimental biology 20030201

Title: Specific biological functions of vacuolar-type H(+)-ATPase and lysosomal cysteine proteinase, cathepsin K, in osteoclasts.

Journal: The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology 20030201

Title: Inhibition of the yeast V-type ATPase by cytosolic ADP.

Journal: FEBS letters 20030130

Title: Receptor occupancy limits synaptic depression at climbing fiber synapses.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030115

Title: Storage and release of ATP from astrocytes in culture.

Journal: The Journal of biological chemistry 20030110

Title: Intracellular pH regulation in U937 human monocytes: roles of V-ATPase and Na+/H+ exchange.

Journal: Immunobiology 20030101

Title: Insulin-stimulated cytosol alkalinization facilitates optimal activation of glucose transport in cardiomyocytes.

Journal: American journal of physiology. Endocrinology and metabolism 20021201

Title: Activation of D2-like receptors causes recruitment of tyrosine-phosphorylated NKA alpha 1-subunits in kidney.

Journal: American journal of physiology. Renal physiology 20021201

Title: Rapid trafficking of membrane type 1-matrix metalloproteinase to the cell surface regulates progelatinase a activation.

Journal: Laboratory investigation; a journal of technical methods and pathology 20021201

Title: Clostridium perfringens iota toxin. Mapping of the Ia domain involved in docking with Ib and cellular internalization.

Journal: The Journal of biological chemistry 20021115

Title: Hydralazine reduces the quantal size of secretory events by displacement of catecholamines from adrenomedullary chromaffin secretory vesicles.

Journal: Circulation research 20021101

Title: The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase (V-ATPase) interacts with the H subunit and is required for V-ATPase function.

Journal: The Journal of biological chemistry 20021011

Title: Inhibition of vacuolation toxin activity of Helicobacter pylori by iodine, nitrite and potentiation by sodium chloride, sterigmatocystin and fluoride.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20021001

Title: Inhibition of weak-base amine-induced lysis of lysosomes by cytosol.

Journal: Journal of biochemistry 20021001

Title: In-vitro characterisation of the phagocytosis and fate of anthrax spores in macrophages and the effects of anti-PA antibody.

Journal: Journal of medical microbiology 20021001

Title: Enhanced expression of the human vacuolar H+-ATPase c subunit gene (ATP6L) in response to anticancer agents.

Journal: The Journal of biological chemistry 20020927

Title: Vesicle transmembrane potential is required for translocation to the cytosol of externally added FGF-1.

Journal: The EMBO journal 20020902

Title: Plasmalemmal H+ extruders in mammalian alveolar macrophages.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20020901

Title: Characterization of berberine transport into Coptis japonica cells and the involvement of ABC protein.

Journal: Journal of experimental botany 20020901

Title: Mechanisms of acid secretion in pseudobranch cells of rainbow trout (Oncorhynchus mykiss).

Journal: The Journal of experimental biology 20020901

Title: Properties of the V-type ATPase from the excretory system of the usherhopper, Poekilocerus bufonius.

Journal: Insect biochemistry and molecular biology 20020901

Title: Influence of ANG II on cytoplasmic sodium in cultured rabbit nonpigmented ciliary epithelium.

Journal: American journal of physiology. Cell physiology 20020801

Title: The internal pH of synaptic-like microvesicles in rat pinealocytes in culture.

Journal: Journal of neurochemistry 20020801

Title: Analysis of the infectious entry pathway of human papillomavirus type 33 pseudovirions.

Journal: Virology 20020801

Title: The Vibrio cholerae haemolysin anion channel is required for cell vacuolation and death.

Journal: Cellular microbiology 20020701

Title: Total synthesis of (-)-bafilomycin A(1).

Journal: Journal of the American Chemical Society 20020619

Title: Studies on the synthesis of bafilomycin A(1): stereochemical aspects of the fragment assembly aldol reaction for construction of the C(13)-C25) segment.

Journal: The Journal of organic chemistry 20020614

Title: V-type H+-ATPase in the human eccrine sweat duct: immunolocalization and functional demonstration.

Journal: American journal of physiology. Cell physiology 20020601

Title: Environmental factors in the etiology of type 1 diabetes.

Journal: American journal of medical genetics 20020530

Title: Abnormal acidification of melanoma cells induces tyrosinase retention in the early secretory pathway.

Journal: The Journal of biological chemistry 20020426

Title: Copper uptake across rainbow trout gills: mechanisms of apical entry.

Journal: The Journal of experimental biology 20020401

Title: Acidocalcisomes are functionally linked to the contractile vacuole of Dictyostelium discoideum.

Journal: The Journal of biological chemistry 20020308

Title: Mutations in subunit C of the vacuolar ATPase confer resistance to bafilomycin and identify a conserved antibiotic binding site.

Journal: The Journal of biological chemistry 20020208

Title: Inhibition of protein phosphatase-1 is linked to phosphorylation of p53 and apoptosis.

Journal: Apoptosis : an international journal on programmed cell death 20020201

Title: Dynamics of lysosomal cholesterol in Niemann-Pick type C and normal human fibroblasts.

Journal: Journal of lipid research 20020201

Title: pH-dependent regulation of lysosomal calcium in macrophages.

Journal: Journal of cell science 20020201

Title: Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experiments.

Journal: Pharmaceutical research 20020201

Title: Transcytosis of iota-toxin across polarized CaCo-2 cells.

Journal: Molecular microbiology 20020201

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Tags:88899-55-2 Molecular Formula|88899-55-2 MDL|88899-55-2 SMILES|88899-55-2 (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one