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121-54-0,MFCD00149978
Catalog No.:AA0039PH

121-54-0 | Benzethonium chloride

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25g
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$9.00   $7.00
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100g
99+%
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$28.00   $20.00
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500g
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0039PH
Chemical Name:
Benzethonium chloride
CAS Number:
121-54-0
Molecular Formula:
C27H42ClNO2
Molecular Weight:
448.0809
MDL Number:
MFCD00149978
SMILES:
CC(CC(c1ccc(cc1)OCCOCC[N+](Cc1ccccc1)(C)C)(C)C)(C)C.[Cl-]
Properties
Computed Properties
 
Complexity:
466  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
12  

Literature

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Journal: Archives of toxicology 20180601

Title: Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131201

Title: Synthesis, self-aggregation and biological properties of alkylphosphocholine and alkylphosphohomocholine derivatives of cetyltrimethylammonium bromide, cetylpyridinium bromide, benzalkonium bromide (C16) and benzethonium chloride.

Journal: European journal of medicinal chemistry 20130801

Title: Mechanism of HERG potassium channel inhibition by tetra-n-octylammonium bromide and benzethonium chloride.

Journal: Toxicology and applied pharmacology 20130301

Title: Visual and confocal microscopic interpretation of patch tests to benzethonium chloride and benzalkonium chloride.

Journal: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 20120801

Title: Comparative study on toxic effects induced by oral or intravascular administration of commonly used disinfectants and surfactants in rats.

Journal: Journal of applied toxicology : JAT 20120701

Title: High prevalence of qacA/B carriage among clinical isolates of meticillin-resistant Staphylococcus aureus in Malaysia.

Journal: The Journal of hospital infection 20120701

Title: Biocomposite films based on alginate and organically modified clay.

Journal: International journal of biological macromolecules 20120501

Title: Bactericidal activity of topical antiseptics and their gargles against Bordetella pertussis.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20120401

Title: Identification of specific pluripotent stem cell death--inducing small molecules by chemical screening.

Journal: Stem cell reviews 20120301

Title: A novel flow cytometric HTS assay reveals functional modulators of ATP binding cassette transporter ABCB6.

Journal: PloS one 20120101

Title: Sensitization prevalence for benzalkonium chloride and benzethonium chloride.

Journal: Dermatitis : contact, atopic, occupational, drug 20120101

Title: Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.

Journal: Journal of medicinal chemistry 20110714

Title: Synthesis and antimycobacterial activities of non-purine analogs of 6-aryl-9-benzylpurines: Imidazopyridines, pyrrolopyridines, benzimidazoles, and indoles.

Journal: Bioorganic & medicinal chemistry 20110601

Title: Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.

Journal: Toxicology and applied pharmacology 20110501

Title: Stimulation of suicidal erythrocyte death by benzethonium.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

Title: Convergent synthesis of fluorescence-labeled probes of Annonaceous acetogenins and visualization of their cell distribution.

Journal: Bioorganic & medicinal chemistry 20101215

Title: Benzethonium increases the cytotoxicity of S(+)-ketamine in lymphoma, neuronal, and glial cells.

Journal: Anesthesia and analgesia 20101201

Title: Magnetic 'fishing' assay to screen small-molecule mixtures for modulators of protein-protein interactions.

Journal: Analytical chemistry 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents.

Journal: Leukemia research 20100701

Title: Effects of high-dose major components in oral disinfectants on the cell cycle and apoptosis in primary human gingival fibroblasts in vitro.

Journal: Dental materials journal 20100101

Title: A facile synthesis of highly water-soluble, core-shell organo-silica nanoparticles with controllable size via sol-gel process.

Journal: Journal of colloid and interface science 20091215

Title: Direct quantitative bioanalysis of drugs in dried blood spot samples using a thin-layer chromatography mass spectrometer interface.

Journal: Analytical chemistry 20091215

Title: Is paromomycin an effective and safe treatment against cutaneous leishmaniasis? A meta-analysis of 14 randomized controlled trials.

Journal: PLoS neglected tropical diseases 20090201

Title: Synthesis of C4-fluorinated solamins and their growth inhibitory activity against human cancer cell lines.

Journal: Bioorganic & medicinal chemistry letters 20081215

Title: The enhancement effect of three sugar alcohols on the fungicidal effect of benzethonium chloride toward Candida albicans.

Journal: Journal of dentistry 20081101

Title: Kinetics of 14carbon dioxide excretion from 14C-urea by oral commensal flora.

Journal: Journal of gastroenterology and hepatology 20081001

Title: Validation of a quantitative NMR method for suspected counterfeit products exemplified on determination of benzethonium chloride in grapefruit seed extracts.

Journal: Journal of pharmaceutical and biomedical analysis 20080805

Title: Rapid antibacterial activity of 2 novel hand soaps: evaluation of the risk of development of bacterial resistance to the antibacterial agents.

Journal: Infection control and hospital epidemiology 20080801

Title: Is secondary wavelength always necessary in turbidimetric urine protein measurements?

Journal: Clinical biochemistry 20080501

Title: Effects of nonionic and ionic surfactants on survival, oxidative stress, and cholinesterase activity of planarian.

Journal: Chemosphere 20080201

Title: [Survey of synthetic disinfectants in grapefruit seed extract and its compounded products].

Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20080201

Title: Synthesis of annonaceous acetogenins from muricatacin.

Journal: Bioscience, biotechnology, and biochemistry 20071001

Title: Displacement chromatography of proteins on hydrophobic charge induction adsorbent column.

Journal: Journal of chromatography. A 20070921

Title: Simultaneous identification and quantification by liquid chromatography of benzethonium chloride, methyl paraben and triclosan in commercial products labeled as grapefruit seed extract.

Journal: Die Pharmazie 20070801

Title: Aqueous micellar two-phase system composed of hyamine-type hydrophobically modified ethylene oxide and application for cytochrome P450 BM-3 separation.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070601

Title: Leishmania major: in vitro and in vivo anti-leishmanial activity of paromomycin ointment (Leshcutan) combined with the immunomodulator Imiquimod.

Journal: Experimental parasitology 20070601

Title: Adverse effects by artificial grapefruit seed extract products in patients on warfarin therapy.

Journal: European journal of clinical pharmacology 20070601

Title: Metastin (KiSS-1) mimetics identified from peptide structure-activity relationship-derived pharmacophores and directed small molecule database screening.

Journal: Journal of medicinal chemistry 20070208

Title: Evaluation of an alcohol-based surgical hand disinfectant containing a synergistic combination of farnesol and benzethonium chloride for immediate and persistent activity against resident hand flora of volunteers and with a novel in vitro pig skin model.

Journal: Infection control and hospital epidemiology 20070201

Title: Strong interference of hemoglobin concentration on CSF total protein measurement using the trichloroacetic acid precipitation method.

Journal: Clinical chemistry and laboratory medicine 20070101

Title: Cutaneous leishmaniasis.

Journal: Clinics in dermatology 20070101

Title: Cationic surfactants induce apoptosis in normal and cancer cells.

Journal: Annals of the New York Academy of Sciences 20070101

Title: Determination of benzethonium chloride in anthrax vaccine adsorbed by HPLC.

Journal: Biologicals : journal of the International Association of Biological Standardization 20061201

Title: A siderophore biosynthesis gene cluster from the fish pathogen Photobacterium damselae subsp. piscicida is structurally and functionally related to the Yersinia high-pathogenicity island.

Journal: Microbiology (Reading, England) 20061101

Title: Otitis externa: Review and clinical update.

Journal: American family physician 20061101

Title: Benzethonium chloride: a novel anticancer agent identified by using a cell-based small-molecule screen.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060915

Title: Efficacy of an alcohol-based healthcare hand rub containing synergistic combination of farnesol and benzethonium chloride.

Journal: International journal of hygiene and environmental health 20060901

Title: Hexadecyl-phosphorylcholine ointment for treatment of cutaneous leishmaniasis: an animal trial.

Journal: Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit 20060901

Title: Cytotoxic effects of dental desensitizers on human gingival fibroblasts.

Journal: Journal of biomedical materials research. Part B, Applied biomaterials 20060701

Title: [Properties of benzethonium chloride in micellar solutions and the effect of added sodium chloride].

Journal: Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20060701

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Natural cis-solamin is a mixture of two tetra-epimeric diastereoisomers: biosynthetic implications for Annonaceous acetogenins.

Journal: Organic & biomolecular chemistry 20060407

Title: Ormosil nanocomposite materials as modifiers for acrylic coating systems.

Journal: Journal of nanoscience and nanotechnology 20060201

Title: Effect of addition of hemolysate on urine and cerebrospinal fluid assays for protein.

Journal: Clinical chemistry 20060101

Title: In vitro short-time killing activity of povidone-iodine (Isodine Gargle) in the presence of oral organic matter.

Journal: Dermatology (Basel, Switzerland) 20060101

Title: The effect on shear bond strength of different antimicrobial agents after acid etching.

Journal: European journal of orthodontics 20051001

Title: A toxicity index of skin and wound cleansers used on in vitro fibroblasts and keratinocytes.

Journal: Advances in skin & wound care 20050901

Title: Oxidative cyclization of diols derived from 1,5-dienes: formation of enantiopure cis-tetrahydrofurans by using catalytic osmium tetroxide; formal synthesis of (+)-cis-solamin.

Journal: Angewandte Chemie (International ed. in English) 20050725

Title: Comparative efficacy of hand hygiene agents in the reduction of bacteria and viruses.

Journal: American journal of infection control 20050301

Title: In vitro analysis of the digestive enzymes amylase and alpha-glucosidase in the midguts of Locusta migratoria L. in response to the myosuppressin, SchistoFLRFamide.

Journal: Journal of insect physiology 20050101

Title: Effect of desensitizers on the bond strength of a self-etching adhesive system to caries-affected dentin on the gingival wall.

Journal: Operative dentistry 20050101

Title: Cerumen removal products.

Journal: Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners 20050101

Title: New strategy for the construction of a monotetrahydrofuran ring in Annonaceous acetogenin based on a ruthenium ring-closing metathesis: application to the synthesis of Solamin.

Journal: The Journal of organic chemistry 20040820

Title: Comparison of the effectiveness of two topical paromomycin treatments versus meglumine antimoniate for New World cutaneous leishmaniasis.

Journal: Acta tropica 20040701

Title: Peptidergic innervation of the crop and the effects of an ingested nonpeptidal agonist on longevity in female Musca domestica (Diptera: Muscidae).

Journal: Journal of medical entomology 20040701

Title: Total synthesis and preliminary biological evaluation of cis-solamin isomers.

Journal: The Journal of organic chemistry 20040514

Title: The effects of test variables on the efficacy of hand hygiene agents.

Journal: American journal of infection control 20040401

Title: Comparative analysis of antibiotic and antimicrobial biocide susceptibility data in clinical isolates of methicillin-sensitive Staphylococcus aureus, methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa between 1989 and 2000.

Journal: Journal of applied microbiology 20040101

Title: A nonpeptide provides insight into mechanisms that regulate Drosophila melanogaster heart contractions.

Journal: Peptides 20031001

Title: Synthesis of cis-solamin using a permanganate-mediated oxidative cyclization.

Journal: Organic letters 20021017

Title: Total synthesis of cis-solamin.

Journal: Organic letters 20020404

Title: In vitro evaluation of skin sensitivity of povidone-iodine and other antiseptics using a three-dimensional human skin model.

Journal: Dermatology (Basel, Switzerland) 20020101

Title: Randomized, controlled, double-blind trial of topical treatment of cutaneous leishmaniasis with paromomycin plus methylbenzethonium chloride ointment in Guatemala.

Journal: The American journal of tropical medicine and hygiene 20011101

Title: Ketamine and its preservative, benzethonium chloride, both inhibit human recombinant alpha7 and alpha4beta2 neuronal nicotinic acetylcholine receptors in Xenopus oocytes.

Journal: British journal of pharmacology 20011001

Title: Identification of benzethonium chloride in commercial grapefruit seed extracts.

Journal: Journal of agricultural and food chemistry 20010701

Title: Effectiveness of manual cleaning and disinfection of gastroendoscopes with 3% glutaraldehyde for decreasing risk of transmission of hepatitis C virus.

Journal: The American journal of gastroenterology 20010601

Title: [Appraisal of fungistatic and fungicidal activities of quaternary compounds towards yeasts belonging to the genera Candida and Cryptococcus].

Journal: Annales pharmaceutiques francaises 20010401

Title: Antiseptic treatment of methicillin-resistant Staphylococcus aureus conjunctivitis.

Journal: The Journal of infection 20010201

Title: Maintaining intact skin during handwashing: the first line of defense against the chain of septic flow.

Journal: The Journal of practical nursing 20010101

Title: Successful topical treatment of murine cutaneous leishmaniasis with a combination of paromomycin (Aminosidine) and gentamicin.

Journal: The Journal of parasitology 19990401

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