[1]ChemMedChem,2014,vol.9,p.311-322
[2]BioorganicandMedicinalChemistryLetters,2016,vol.26,p.3694-3699
[1]ChemMedChem,2014,vol.9,p.311-322
[2]BioorganicandMedicinalChemistryLetters,2016,vol.26,p.3694-3699
[1]Roecker,AnthonyJ.;Mercer,SwatiP.;Schreier,JohnD.;Cox,ChristopherD.;Fraley,MarkE.;Steen,JustinT.;Lemaire,Wei;Bruno,JosephG.;Harrell,C.Meacham;Garson,SusanL.;Gotter,AnthonyL.;Fox,StevenV.;Stevens,Joanne;Tannenbaum,PamelaL.;Prueksaritanont,Thomayant;Cabalu,TamaraD.;Cui,Donghui;Stellabott,Joyce;Hartman,GeorgeD.;Young,StevenD.;Winrow,ChristopherJ.;Renger,JohnJ.;Coleman,PaulJ.[ChemMedChem,2014,vol.9,#2,p.311-322]
Title: Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man.
Journal: Scientific reports 20160101
Title: Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
Journal: Bioorganic & medicinal chemistry letters 20141015
Title: Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
Journal: ChemMedChem 20140201
Title: Roecker AJ et al. Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia. ChemMedChem. 2014 Feb;9(2):311-22.
Title: Gotter AL et al. Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man. Sci Rep. 2016 Jun 3;6:27147.
Title: Laura A Grafe, et al. Orexin 2 receptor regulation of the hypothalamic-pituitary-adrenal (HPA) response to acute and repeated stress. Neuroscience. 2017 Apr 21;348:313-323.
