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1116235-97-2,MFCD19443644
Catalog No.:AA003A74

1116235-97-2 | Gsk1838705a

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥95%
in stock  
$173.00   $121.00
- +
10mg
≥95%
in stock  
$329.00   $230.00
- +
25mg
98%
in stock  
$497.00   $348.00
- +
100mg
99% (HPLC)
in stock  
$1,752.00   $1,227.00
- +
500mg
99% (HPLC)
in stock  
$5,515.00   $3,861.00
- +
1000mg
99% (HPLC)
in stock  
$8,787.00   $6,151.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA003A74
Chemical Name:
Gsk1838705a
CAS Number:
1116235-97-2
Molecular Formula:
C27H29FN8O3
Molecular Weight:
532.5694
MDL Number:
MFCD19443644
SMILES:
CNC(=O)c1c(cccc1F)Nc1nc(Nc2cc3c(cc2OC)CCN3C(=O)CN(C)C)nc2c1cc[nH]2
Properties
Computed Properties
 
Complexity:
867  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
8  
XLogP3:
3.8  

Downstream Synthesis Route

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2009/20990,2009,A1Locationinpatent:Page/Pagecolumn360-362

1116235-97-2   
C26H27FN8O3 

[1]SolingapuramSai,KiranKumar;Prabhakaran,Jaya;Sattiraju,Anirudh;Mann,J.John;Mintz,Akiva;Kumar,J.S.Dileep[BioorganicandMedicinalChemistryLetters,2017,vol.27,#13,p.2895-2897]

Literature

Title: Comprehensive analysis of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111030

Title: Anaplastic Lymphoma Kinase: role in specific tumours, and development of small molecule inhibitors for cancer therapy.

Journal: Cancer letters 20101228

Title: Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.

Journal: Chemistry & biology 20101124

Title: The emerging pathogenic and therapeutic importance of the anaplastic lymphoma kinase gene.

Journal: European journal of cancer (Oxford, England : 1990) 20100901

Title: GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers.

Journal: Molecular cancer therapeutics 20091001

Title: Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity.

Journal: Bioorganic & medicinal chemistry letters 20090115

Title: Sabbatini P, et al.GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers.Mol Cancer Ther. 2009 Oct;8(10):2811-20.

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SDS
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Tags:1116235-97-2 Molecular Formula|1116235-97-2 MDL|1116235-97-2 SMILES|1116235-97-2 Gsk1838705a
Catalog No.: AA003A74
1116235-97-2,MFCD19443644
1116235-97-2 | Gsk1838705a
Pack Size： 5mg
Purity： ≥95%
in stock
$173.00 $121.00
Pack Size： 10mg
Purity： ≥95%
in stock
$329.00 $230.00
Pack Size： 25mg
Purity： 98%
in stock
$497.00 $348.00
Pack Size： 100mg
Purity： 99% (HPLC)
in stock
$1,752.00 $1,227.00
Pack Size： 500mg
Purity： 99% (HPLC)
in stock
$5,515.00 $3,861.00
Pack Size： 1000mg
Purity： 99% (HPLC)
in stock
$8,787.00 $6,151.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA003A74
Chemical Name: Gsk1838705a
CAS Number: 1116235-97-2
Molecular Formula: C27H29FN8O3
Molecular Weight: 532.5694
MDL Number: MFCD19443644
SMILES: CNC(=O)c1c(cccc1F)Nc1nc(Nc2cc3c(cc2OC)CCN3C(=O)CN(C)C)nc2c1cc[nH]2
Properties
Complexity: 867  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 39  
Hydrogen Bond Acceptor Count: 9  
Hydrogen Bond Donor Count: 4  
Rotatable Bond Count: 8  
XLogP3: 3.8  
Downstream Synthesis Route
1116236-02-2    1116235-97-2 

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2009/20990,2009,A1Locationinpatent:Page/Pagecolumn360-362

1116235-97-2   
C26H27FN8O3 

[1]SolingapuramSai,KiranKumar;Prabhakaran,Jaya;Sattiraju,Anirudh;Mann,J.John;Mintz,Akiva;Kumar,J.S.Dileep[BioorganicandMedicinalChemistryLetters,2017,vol.27,#13,p.2895-2897]

Literature fold

Title: Comprehensive analysis of kinase inhibitor selectivity.

Journal: Nature biotechnology20111030

Title: Anaplastic Lymphoma Kinase: role in specific tumours, and development of small molecule inhibitors for cancer therapy.

Journal: Cancer letters20101228

Title: Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.

Journal: Chemistry & biology20101124

Title: The emerging pathogenic and therapeutic importance of the anaplastic lymphoma kinase gene.

Journal: European journal of cancer (Oxford, England : 1990)20100901

Title: GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers.

Journal: Molecular cancer therapeutics20091001

Title: Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity.

Journal: Bioorganic & medicinal chemistry letters20090115

Title: Sabbatini P, et al.GSK1838705A inhibits the insulin-like growth factor-1 receptor and anaplastic lymphoma kinase and shows antitumor activity in experimental models of human cancers.Mol Cancer Ther. 2009 Oct;8(10):2811-20.

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