53882-12-5,MFCD00864803
Catalog No.:AA003ABT

53882-12-5 | 2-[2-chloro-5-cyano-3-(oxaloamino)anilino]-2-oxoacetic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25mg
≥95%
in stock  
$139.00   $97.00
- +
50mg
≥95%
in stock  
$263.00   $184.00
- +
100mg
≥95%
in stock  
$495.00   $346.00
- +
250mg
≥95%
in stock  
$1,098.00   $768.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA003ABT
Chemical Name:
2-[2-chloro-5-cyano-3-(oxaloamino)anilino]-2-oxoacetic acid
CAS Number:
53882-12-5
Molecular Formula:
C11H6ClN3O6
Molecular Weight:
311.6348
MDL Number:
MFCD00864803
SMILES:
N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl
Properties
Computed Properties
 
Complexity:
489  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
4  
XLogP3:
0.5  

Literature

Title: GPR35 mediates lodoxamide-induced migration inhibitory response but not CXCL17-induced migration stimulatory response in THP-1 cells; is GPR35 a receptor for CXCL17?

Journal: British journal of pharmacology 20180101

Title: Ocular medicines in children: the regulatory situation related to clinical research.

Journal: BMC pediatrics 20120101

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Involvement of nitric oxide pathways in neurogenic pulmonary edema induced by vagotomy.

Journal: Clinics (Sao Paulo, Brazil) 20110601

Title: Eosinophils express muscarinic receptors and corticotropin-releasing factor to disrupt the mucosal barrier in ulcerative colitis.

Journal: Gastroenterology 20110501

Title: Safety and efficacy of lodoxamide in vernal keratoconjunctivitis.

Journal: JPMA. The Journal of the Pakistan Medical Association 20110301

Title: Multiple endpoint analysis of BAC-preserved and unpreserved antiallergic eye drops on a 3D-reconstituted corneal epithelial model.

Journal: Molecular vision 20110101

Title: Updates in the treatment of ocular allergies.

Journal: Journal of asthma and allergy 20100101

Title: Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1.

Journal: Biochemical pharmacology 20090615

Title: Immediate hypersensitivity elicits renin release from cardiac mast cells.

Journal: International archives of allergy and immunology 20080101

Title: Secondary bacterial keratitis associated with shield ulcer caused by vernal conjunctivitis.

Journal: Cornea 20060901

Title: Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion.

Journal: The Journal of clinical investigation 20060403

Title: A clinicopathological analysis of the efficacy of lodoxamide 0.1% eye drops on the conjunctiva of patients with vernal keratoconjunctivitis seen at Guinness Eye Centre, Lagos University Teaching Hospital.

Journal: The Nigerian postgraduate medical journal 20060301

Title: Efficacy and tolerability of newer antihistamines in the treatment of allergic conjunctivitis.

Journal: Drugs 20050101

Title: Topical treatments for seasonal allergic conjunctivitis: systematic review and meta-analysis of efficacy and effectiveness.

Journal: The British journal of general practice : the journal of the Royal College of General Practitioners 20040601

Title: Tear and serum eosinophil cationic protein levels in seasonal allergic conjunctivitis.

Journal: European journal of ophthalmology 20031001

Title: Effects of ketotifen 0.025% and lodoxamide 0.1% on eosinophil infiltration into the guinea pig conjunctiva in a model of allergic conjunctivitis.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20030401

Title: [In vitro effects of antiallergic eyedrops on complement activation induced by particulate matter].

Journal: Journal francais d'ophtalmologie 20030401

Title: Vernal keratoconjunctivitis in Thailand.

Journal: Asian Pacific journal of allergy and immunology 20030301

Title: Comparison of antiallergic drugs in an experimental model of ocular anaphylaxis.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20030101

Title: [Evaluation of the efficacy and safety of lodoxamide in patients with allergic eye diseases].

Journal: Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti 20020101

Title: Comparison of lodoxamide 0.1% ophthalmic solution and levocabastine 0.05% ophthalmic suspension in vernal keratoconjunctivitis.

Journal: European journal of ophthalmology 20010101

Title: [Evaluation of efficacy and safety of sterile solution of lodoxamide in patients with ocular allergy].

Journal: Oftalmologia (Bucharest, Romania : 1990) 20010101

Title: Lodoxamide as adjuvant therapy in patients with dry eye.

Journal: Collegium antropologicum 20010101

Title: Mechanisms and comparison of anti-allergic efficacy of topical lodoxamide and cromolyn sodium treatment in vernal keratoconjunctivitis.

Journal: Ophthalmology 20000701

Title: Lodoxamide versus spaglumic acid: a comparative double-blind trial on patients suffering from seasonal allergic conjunctivitis induced by Parietaria pollen.

Journal: Allergologia et immunopathologia 19970101

Title: Lodoxamide in vernal keratoconjunctivitis.

Journal: The Annals of pharmacotherapy 19960501

Title: Watt GD, et al. Protective effect opf lodoxamide tromethamine on allergen inhalation challenge. J Allergy Clin Immunol. 1980 Oct;66(4):286-94.

Title: Capron M,et al. Inhibitory effects of lodoxamide on eosinophil activation. Int Arch Allergy Immunol. 1998 Jun;116(2):140-6.

Title: Barr ML, et al. Addition of a mast cell stabilizing compound to organ preservation solutions decreases lung reperfusion injury. J Thorac Cardiovasc Surg. 1998 Mar;115(3):631-6; discussion 636-7.

Title: Mann JS, et al. Inhaled lodoxamide tromethamine in the treatment of perennial asthma: a double-blind placebo-controlled study. J Allergy Clin Immunol. 1985 Jul;76(1):83-90.

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Tags:53882-12-5 Molecular Formula|53882-12-5 MDL|53882-12-5 SMILES|53882-12-5 2-[2-chloro-5-cyano-3-(oxaloamino)anilino]-2-oxoacetic acid
Catalog No.: AA003ABT
53882-12-5,MFCD00864803
53882-12-5 | 2-[2-chloro-5-cyano-3-(oxaloamino)anilino]-2-oxoacetic acid
Pack Size: 25mg
Purity: ≥95%
in stock
$139.00 $97.00
Pack Size: 50mg
Purity: ≥95%
in stock
$263.00 $184.00
Pack Size: 100mg
Purity: ≥95%
in stock
$495.00 $346.00
Pack Size: 250mg
Purity: ≥95%
in stock
$1,098.00 $768.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA003ABT
Chemical Name: 2-[2-chloro-5-cyano-3-(oxaloamino)anilino]-2-oxoacetic acid
CAS Number: 53882-12-5
Molecular Formula: C11H6ClN3O6
Molecular Weight: 311.6348
MDL Number: MFCD00864803
SMILES: N#Cc1cc(NC(=O)C(=O)O)c(c(c1)NC(=O)C(=O)O)Cl
Properties
Complexity: 489  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 21  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 4  
Rotatable Bond Count: 4  
XLogP3: 0.5  
Literature fold

Title: GPR35 mediates lodoxamide-induced migration inhibitory response but not CXCL17-induced migration stimulatory response in THP-1 cells; is GPR35 a receptor for CXCL17?

Journal: British journal of pharmacology20180101

Title: Ocular medicines in children: the regulatory situation related to clinical research.

Journal: BMC pediatrics20120101

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology20111201

Title: Involvement of nitric oxide pathways in neurogenic pulmonary edema induced by vagotomy.

Journal: Clinics (Sao Paulo, Brazil)20110601

Title: Eosinophils express muscarinic receptors and corticotropin-releasing factor to disrupt the mucosal barrier in ulcerative colitis.

Journal: Gastroenterology20110501

Title: Safety and efficacy of lodoxamide in vernal keratoconjunctivitis.

Journal: JPMA. The Journal of the Pakistan Medical Association20110301

Title: Multiple endpoint analysis of BAC-preserved and unpreserved antiallergic eye drops on a 3D-reconstituted corneal epithelial model.

Journal: Molecular vision20110101

Title: Updates in the treatment of ocular allergies.

Journal: Journal of asthma and allergy20100101

Title: Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1.

Journal: Biochemical pharmacology20090615

Title: Immediate hypersensitivity elicits renin release from cardiac mast cells.

Journal: International archives of allergy and immunology20080101

Title: Secondary bacterial keratitis associated with shield ulcer caused by vernal conjunctivitis.

Journal: Cornea20060901

Title: Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion.

Journal: The Journal of clinical investigation20060403

Title: A clinicopathological analysis of the efficacy of lodoxamide 0.1% eye drops on the conjunctiva of patients with vernal keratoconjunctivitis seen at Guinness Eye Centre, Lagos University Teaching Hospital.

Journal: The Nigerian postgraduate medical journal20060301

Title: Efficacy and tolerability of newer antihistamines in the treatment of allergic conjunctivitis.

Journal: Drugs20050101

Title: Topical treatments for seasonal allergic conjunctivitis: systematic review and meta-analysis of efficacy and effectiveness.

Journal: The British journal of general practice : the journal of the Royal College of General Practitioners20040601

Title: Tear and serum eosinophil cationic protein levels in seasonal allergic conjunctivitis.

Journal: European journal of ophthalmology20031001

Title: Effects of ketotifen 0.025% and lodoxamide 0.1% on eosinophil infiltration into the guinea pig conjunctiva in a model of allergic conjunctivitis.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics20030401

Title: [In vitro effects of antiallergic eyedrops on complement activation induced by particulate matter].

Journal: Journal francais d'ophtalmologie20030401

Title: Vernal keratoconjunctivitis in Thailand.

Journal: Asian Pacific journal of allergy and immunology20030301

Title: Comparison of antiallergic drugs in an experimental model of ocular anaphylaxis.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde20030101

Title: [Evaluation of the efficacy and safety of lodoxamide in patients with allergic eye diseases].

Journal: Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti20020101

Title: Comparison of lodoxamide 0.1% ophthalmic solution and levocabastine 0.05% ophthalmic suspension in vernal keratoconjunctivitis.

Journal: European journal of ophthalmology20010101

Title: [Evaluation of efficacy and safety of sterile solution of lodoxamide in patients with ocular allergy].

Journal: Oftalmologia (Bucharest, Romania : 1990)20010101

Title: Lodoxamide as adjuvant therapy in patients with dry eye.

Journal: Collegium antropologicum20010101

Title: Mechanisms and comparison of anti-allergic efficacy of topical lodoxamide and cromolyn sodium treatment in vernal keratoconjunctivitis.

Journal: Ophthalmology20000701

Title: Lodoxamide versus spaglumic acid: a comparative double-blind trial on patients suffering from seasonal allergic conjunctivitis induced by Parietaria pollen.

Journal: Allergologia et immunopathologia19970101

Title: Lodoxamide in vernal keratoconjunctivitis.

Journal: The Annals of pharmacotherapy19960501

Title: Watt GD, et al. Protective effect opf lodoxamide tromethamine on allergen inhalation challenge. J Allergy Clin Immunol. 1980 Oct;66(4):286-94.

Title: Capron M,et al. Inhibitory effects of lodoxamide on eosinophil activation. Int Arch Allergy Immunol. 1998 Jun;116(2):140-6.

Title: Barr ML, et al. Addition of a mast cell stabilizing compound to organ preservation solutions decreases lung reperfusion injury. J Thorac Cardiovasc Surg. 1998 Mar;115(3):631-6; discussion 636-7.

Title: Mann JS, et al. Inhaled lodoxamide tromethamine in the treatment of perennial asthma: a double-blind placebo-controlled study. J Allergy Clin Immunol. 1985 Jul;76(1):83-90.

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