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1797983-09-5,MFCD26142638
Catalog No.:AA003AOD

1797983-09-5 | GSK-J4 Hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$14.00   $10.00
- +
10mg
98%
in stock  
$51.00   $36.00
- +
25mg
98%
in stock  
$85.00   $60.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003AOD
Chemical Name:
GSK-J4 Hydrochloride
CAS Number:
1797983-09-5
Molecular Formula:
C24H28ClN5O2
Molecular Weight:
453.9644
MDL Number:
MFCD26142638
SMILES:
CCOC(=O)CCNc1cc(nc(n1)c1ccccn1)N1CCc2c(CC1)cccc2.Cl
Properties
Computed Properties
 
Complexity:
546  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  

Literature

Title: Kruidenier L, et al. A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature. 2012 Aug 16;488(7411):404-8.

Title: Majumder S, et al. Shifts in podocyte histone H3K27me3 regulate mouse and human glomerular disease. J Clin Invest. 2018 Jan 2;128(1):483-499.

Title: Donas C, et al. The histone demethylase inhibitor GSK-J4 limits inflammation through the induction of a tolerogenic phenotype on DCs. J Autoimmun. 2016 Dec;75:105-117.

Title: Yapp C, et al. H3K27me3 demethylases regulate in vitro chondrogenesis and chondrocyte activity in osteoarthritis. Arthritis Res Ther. 2016 Jul 7;18(1):158

Title: Kamikawa YF, et al. Histone demethylation maintains Prdm14 and Tsix expression and represses xIst in embryonic stem cells. PLoS One. 2015 May 20;10(5):e0125626

Title: Heinemann B, et al. Inhibition of demethylases by GSK-J1/J4. Nature. 2014 Oct 2;514(7520):E1-2

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SDS
Tags:1797983-09-5 Molecular Formula|1797983-09-5 MDL|1797983-09-5 SMILES|1797983-09-5 GSK-J4 Hydrochloride