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930-35-8,MFCD00014536
Catalog No.:AA003AXJ

930-35-8 | 1,3-Dithiole-2-thione

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1g
>97.0%(GC)
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$50.00   $35.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003AXJ
Chemical Name:
1,3-Dithiole-2-thione
CAS Number:
930-35-8
Molecular Formula:
C3H2S3
Molecular Weight:
134.2430
MDL Number:
MFCD00014536
SMILES:
S=c1sccs1
Properties
Properties
 
BP:
235.5°C at 760 mmHg  
Form:
Solid  
MP:
48-50 °C(lit.)  
Refractive Index:
1.7000 (estimate)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
84.2  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
6  
Hydrogen Bond Acceptor Count:
3  
XLogP3:
2  

Literature

Title: Dietary modulation of the biotransformation and genotoxicity of aflatoxin B(1).

Journal: Toxicology 20120928

Title: Dithiolethiones inhibit NF-κB activity via covalent modification in human estrogen receptor-negative breast cancer.

Journal: Cancer research 20120501

Title: 6,6-Dimethyl-2H,5H,6H,7H-1,3-dithiolo[4,5-f][1,5,3]dithia-silepin-2-one.

Journal: Acta crystallographica. Section E, Structure reports online 20120401

Title: 2-Methyl-sulfanyl-5,6-dihydro-2H-1,3-dithiolo[4,5-b][1,4]dioxin-2-ium tetra-fluoro-borate.

Journal: Acta crystallographica. Section E, Structure reports online 20120401

Title: Mechanism of chemical activation of Nrf2.

Journal: PloS one 20120101

Title: The yin and yang of nrf2-regulated selenoproteins in carcinogenesis.

Journal: International journal of cell biology 20120101

Title: The antioxidant 3H-1,2-dithiole-3-thione potentiates advanced glycation end-product-induced oxidative stress in SH-SY5Y cells.

Journal: Experimental diabetes research 20120101

Title: 2-Sulfanylidene-1,3-dithiolo[4,5-b]naphtho-[2,3-e][1,4]dithiine-5,10-dione.

Journal: Acta crystallographica. Section E, Structure reports online 20111101

Title: 5,6-Dihydro-2H-1,3-dithiolo[4,5-b][1,4]dioxine-2-thione.

Journal: Acta crystallographica. Section E, Structure reports online 20110601

Title: S-diclofenac protects against doxorubicin-induced cardiomyopathy in mice via ameliorating cardiac gap junction remodeling.

Journal: PloS one 20110101

Title: 5,6-Diamino-1,3-benzodithiole-2-thione.

Journal: Acta crystallographica. Section E, Structure reports online 20101201

Title: New aryldithiolethione derivatives as potent histone deacetylase inhibitors.

Journal: Bioorganic & medicinal chemistry 20100615

Title: 4,6,7,9,10,12,13,15,16,18-Decahydro-1,3-dithiolo[4,5-l][1,4,7,10,15]trioxadithia-cyclo-hepta-decine-2-thione.

Journal: Acta crystallographica. Section E, Structure reports online 20100601

Title: Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells.

Journal: Lung cancer (Amsterdam, Netherlands) 20100501

Title: Modulation of thiol homeostasis induced by H2S-releasing aspirin.

Journal: Free radical biology & medicine 20100501

Title: HPLC determination of novel dithiolethione containing drugs and its application for in vivo studies in rats.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100201

Title: PSMB7 is associated with anthracycline resistance and is a prognostic biomarker in breast cancer.

Journal: British journal of cancer 20100119

Title: Redox-active tetrathiafulvalene and dithiolene compounds derived from allylic 1,4-diol rearrangement products of disubstituted 1,3-dithiole derivatives.

Journal: Beilstein journal of organic chemistry 20100101

Title: Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity.

Journal: Oncogene 20091029

Title: Therapeutic potential of dithiolethiones for hepatic diseases.

Journal: Pharmacology & therapeutics 20091001

Title: Oltipraz and dithiolethione congeners inhibit hypoxia-inducible factor-1alpha activity through p70 ribosomal S6 kinase-1 inhibition and H2O2-scavenging effect.

Journal: Molecular cancer therapeutics 20091001

Title: Structural and vibrational studies of molecular conductors using quantum mechanical methods: 1,3-Dithiole-2-thione, 1,3-dithiole-2-one, 1,3-dioxole-2-one and 1,3-dioxole-2-thione.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090915

Title: Hydrogen peroxide is a second messenger in phase 2 enzyme induction by cancer chemopreventive dithiolethiones.

Journal: Chemical research in toxicology 20090817

Title: 4,6,7,9,10,12-Hexahydro-1,3-dithiolo[4,5-f][1,4,9]oxadithia-cyclo-undecine-2-thione.

Journal: Acta crystallographica. Section E, Structure reports online 20090701

Title: Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090315

Title: Chemical genomics of cancer chemopreventive dithiolethiones.

Journal: Carcinogenesis 20090301

Title: 3-(2-Thioxo-1,3-dithiol-4-ylsulfan-yl)-propane-nitrile.

Journal: Acta crystallographica. Section E, Structure reports online 20081101

Title: New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity.

Journal: Bioorganic & medicinal chemistry letters 20080315

Title: An Hg2+-gated chiral molecular switch created by using binaphthalene molecules with two anthracene units and two 1,3-dithiole-2-thione (1,3-dithiole-2-one) units.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

Title: Induction of Nrf2-regulated genes by 3H-1, 2-dithiole-3-thione through the ERK signaling pathway in murine keratinocytes.

Journal: European journal of pharmacology 20071222

Title: Identification of a novel class of dithiolethiones that prevent hepatic insulin resistance via the adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway.

Journal: Hepatology (Baltimore, Md.) 20070901

Title: Tissue specific increase of the catalytic subunits of the 26S proteasome by indirect antioxidant dithiolethione in mice: enhanced activity for degradation of abnormal protein.

Journal: Life sciences 20070606

Title: Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target.

Journal: PLoS medicine 20070601

Title: Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid.

Journal: British journal of pharmacology 20070501

Title: The thiol antioxidant 1,2-dithiole-3-thione stimulates the expression of heat shock protein 70 in dopaminergic PC12 cells.

Journal: Neuroscience letters 20070406

Title: Thiolated pi-extended tetrathiafulvalenes: versatile multifunctional pi-systems.

Journal: The Journal of organic chemistry 20070216

Title: The nature of the chemical bond in linear three-body systems: from i3- to mixed chalcogen/halogen and trichalcogen moieties.

Journal: Bioinorganic chemistry and applications 20070101

Title: The chemopreventive efficacy of inhaled oltipraz particulates in the B[a]P-induced A/J mouse lung adenoma model.

Journal: Carcinogenesis 20060801

Title: The antioxidant anethole dithiolethione inhibits monoamine oxidase-B but not monoamine oxidase A activity in extracts of cultured astrocytes.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20060501

Title: Reactions Between Chalcogen Donors and Dihalogens/Interalogens: Typology of Products and Their Characterization by FT-Raman Spectroscopy.

Journal: Bioinorganic chemistry and applications 20060101

Title: 1,3-Dithiole-2-thione derivatives featuring an anthracene unit: new selective chemodosimeters for Hg(II) ion.

Journal: Chemical communications (Cambridge, England) 20050428

Title: Safety and efficacy of weekly oral oltipraz in chronic smokers.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20050401

Title: NF-kappaB activation by the chemopreventive dithiolethione oltipraz is exerted through stimulation of MEKK3 signaling.

Journal: The Journal of biological chemistry 20040618

Title: Evaluation of the cancer chemopreventive potency of dithiolethione analogs of oltipraz.

Journal: Carcinogenesis 20031201

Title: Essential role of phosphatidylinositol 3-kinase-dependent CCAAT/enhancer binding protein beta activation in the induction of glutathione S-transferase by oltipraz.

Journal: Journal of the National Cancer Institute 20030101

Title: Chemoprotective potential of phase 2 enzyme inducers.

Journal: Expert review of anticancer therapy 20021001

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