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Home Other Building Blocks 5437-25-2
5437-25-2,MFCD00871017
Catalog No.:AA003B30

5437-25-2 | 9H-Purine-2,6-dithiol

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
95%
in stock  
$24.00   $17.00
- +
5g
95%
in stock  
$113.00   $79.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003B30
Chemical Name:
9H-Purine-2,6-dithiol
CAS Number:
5437-25-2
Molecular Formula:
C5H4N4S2
Molecular Weight:
184.2421
MDL Number:
MFCD00871017
SMILES:
S=c1[nH]c(=S)c2c([nH]1)[nH]cn2
Properties
Properties
 
BP:
498.1°C at 760 mmHg  
Form:
Solid  
MP:
>350 °C(lit.)  
Refractive Index:
1.5605 (estimate)  
Solubility:
slightly soluble  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
217  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
XLogP3:
0.5  

Downstream Synthesis Route

[1]Beaman[JournaloftheAmericanChemicalSociety,1954,vol.76,p.5633,5635,5636]

[2]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-US2697709,1952,A

[1]JournaloftheAmericanChemicalSociety,1954,vol.76,p.6073,6076

[1]Stanovnik,Branko;Tisler,Miha;Hribar,Alenka;Barlin,GordonB.;Brown,DesmondJ.[AustralianJournalofChemistry,1981,vol.34,#8,p.1729-1738]

Literature

Title: 2,6-Dithiopurine, a nucleophilic scavenger, protects against mutagenesis in mouse skin treated in vivo with 2-(chloroethyl) ethyl sulfide, a mustard gas analog.

Journal: Toxicology and applied pharmacology 20120901

Title: Cell signalling by reactive lipid species: new concepts and molecular mechanisms.

Journal: The Biochemical journal 20120315

Title: Protection against 2-chloroethyl ethyl sulfide (CEES)-induced cytotoxicity in human keratinocytes by an inducer of the glutathione detoxification pathway.

Journal: Toxicology and applied pharmacology 20110901

Title: 2,6-Dithiopurine blocks toxicity and mutagenesis in human skin cells exposed to sulfur mustard analogues, 2-chloroethyl ethyl sulfide and 2-chloroethyl methyl sulfide.

Journal: Chemical research in toxicology 20100315

Title: Acacia Senegal gum exudate offers protection against cyclophosphamide-induced urinary bladder cytotoxicity.

Journal: Oxidative medicine and cellular longevity 20090101

Title: Mixed effects of 2,6-dithiopurine against cyclophosphamide mediated bladder and lung toxicity in mice.

Journal: Toxicology 19980116

Title: Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii.

Journal: Biochemical pharmacology 19951109

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SDS
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