Home Other Building Blocks 57-96-5
57-96-5,MFCD00057279
Catalog No.:AA003DC1

57-96-5 | 4-[2-(benzenesulfinyl)ethyl]-1,2-diphenylpyrazolidine-3,5-dione

Pack Size
Purity
Availability
Price(USD)
Quantity
  
25g
98%
in stock  
$19.00   $14.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003DC1
Chemical Name:
4-[2-(benzenesulfinyl)ethyl]-1,2-diphenylpyrazolidine-3,5-dione
CAS Number:
57-96-5
Molecular Formula:
C23H20N2O3S
Molecular Weight:
404.4815
MDL Number:
MFCD00057279
SMILES:
O=C1N(c2ccccc2)N(C(=O)C1CCS(=O)c1ccccc1)c1ccccc1
Properties
Properties
 
BP:
590.8 °C at 760 mmHg  
Form:
Solid  
MP:
136-137°  
Refractive Index:
1.6360 (estimate)  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
571  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  
XLogP3:
2.3  

Literature

Title: Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11).

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Discovery of small molecule human FPR1 receptor antagonists.

Journal: Bioorganic & medicinal chemistry letters 20110515

Title: Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110201

Title: Interactions of urate transporter URAT1 in human kidney with uricosuric drugs.

Journal: Nephrology (Carlton, Vic.) 20110201

Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: A combined spectroscopic and crystallographic approach to probing drug-human serum albumin interactions.

Journal: Bioorganic & medicinal chemistry 20101101

Title: Adherence with urate-lowering therapies for the treatment of gout.

Journal: Arthritis research & therapy 20090101

Title: Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

Journal: Journal of medicinal chemistry 20080612

Title: Uric acid lowering therapy: prescribing patterns in a large cohort of older adults.

Journal: Annals of the rheumatic diseases 20080501

Title: MRP7/ABCC10 expression is a predictive biomarker for the resistance to paclitaxel in non-small cell lung cancer.

Journal: Molecular cancer therapeutics 20080501

Title: 2-Substituted 4-, 5-, and 6-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones and 2-substituted 4,5-bis[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones as potent platelet aggregation inhibitors: design, synthesis, and SAR studies.

Journal: Bioorganic & medicinal chemistry letters 20080115

Title: HepaRG cells as an in vitro model for evaluation of cytochrome P450 induction in humans.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080101

Title: Design, synthesis, and structure-activity relationships of a novel series of 5-alkylidenepyridazin-3(2H)-ones with a non-cAMP-based antiplatelet activity.

Journal: Journal of medicinal chemistry 20071227

Title: Molecular epidemiology of malaria in Cameroon. XXVI. Twelve-year in vitro and molecular surveillance of pyrimethamine resistance and experimental studies to modulate pyrimethamine resistance.

Journal: The American journal of tropical medicine and hygiene 20070801

Title: Morin (3,5,7,2',4'-pentahydroxyflavone) exhibits potent inhibitory actions on urate transport by the human urate anion transporter (hURAT1) expressed in human embryonic kidney cells.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070601

Title: Block of CFTR-dependent chloride currents by inhibitors of multidrug resistance-associated proteins.

Journal: European journal of pharmacology 20070410

Title: Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070301

Title: Use of cryopreserved transiently transfected cells in high-throughput pregnane X receptor transactivation assay.

Journal: Journal of biomolecular screening 20070301

Title: In silico prediction of pregnane X receptor activators by machine learning approaches.

Journal: Molecular pharmacology 20070101

Title: Sulfinpyrazone C-glucuronidation is catalyzed selectively by human UDP-glucuronosyltransferase 1A9.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20061201

Title: Use of immortalized human hepatocytes to predict the magnitude of clinical drug-drug interactions caused by CYP3A4 induction.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20061001

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Clinical trials of uric acid lowering for coronary heart disease risk reduction.

Journal: The American journal of medicine 20060401

Title: Pyridazines part 41: synthesis, antiplatelet activity and SAR of 2,4,6-substituted 5-(3-oxo-3-phenylprop-1-en-1-yl)- or 5-(3-phenylprop-2-enoyl)pyridazin-3(2H)-ones.

Journal: Bioorganic & medicinal chemistry letters 20060215

Title: Macrophage uptake and recycling of ascorbic acid: response to activation by lipopolysaccharide.

Journal: Free radical biology & medicine 20051201

Title: Prediction of CYP2C9-mediated drug-drug interactions: a comparison using data from recombinant enzymes and human hepatocytes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20051101

Title: Combined effects of GSTP1 and MRP1 in melanoma drug resistance.

Journal: British journal of cancer 20050725

Title: Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2.

Journal: Biochimica et biophysica acta 20050630

Title: High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands.

Journal: Journal of biomolecular screening 20050601

Title: UDP-glucuronosyltransferases and clinical drug-drug interactions.

Journal: Pharmacology & therapeutics 20050401

Title: Ascorbate uptake in pig coronary artery endothelial cells.

Journal: Molecular and cellular biochemistry 20050301

Title: Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux.

Journal: British journal of pharmacology 20041201

Title: Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter.

Journal: Journal of the American Society of Nephrology : JASN 20041101

Title: Effect of a selective CYP2C9 inhibitor on the pharmacokinetics of nateglinide in healthy subjects.

Journal: European journal of clinical pharmacology 20040801

Title: Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects.

Journal: Molecular pharmacology 20040401

Title: Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20040301

Title: Pyridazines. Part 36: Synthesis and antiplatelet activity of 5-substituted-6-phenyl-3(2H)-pyridazinones.

Journal: Bioorganic & medicinal chemistry letters 20040119

Title: Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity.

Journal: The Journal of pharmacology and experimental therapeutics 20040101

Title: Differential effects of glucose on dehydroascorbic acid transport and intracellular ascorbate accumulation in astrocytes and skeletal myocytes.

Journal: Brain research 20031212

Title: Potential roles of P-gp and calcium channels in loperamide and diphenoxylate transport.

Journal: Toxicology and applied pharmacology 20031115

Title: Identification and prediction of promiscuous aggregating inhibitors among known drugs.

Journal: Journal of medicinal chemistry 20031009

Title: Functional expression of the multidrug resistance protein 1 in microglia.

Journal: The Journal of pharmacology and experimental therapeutics 20031001

Title: UV or X-irradiation increases the cytoplasmic accumulation of rhodamine 123 in various cancer cell lines.

Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20030801

Title: Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10).

Journal: Molecular pharmacology 20030201

Title: Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes.

Journal: Archives of biochemistry and biophysics 20030101

Title: Accumulation of intracellular ascorbate from dehydroascorbic acid by astrocytes is decreased after oxidative stress and restored by propofol.

Journal: Glia 20020801

Title: CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20020701

Title: Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.

Journal: Cancer research 20020601

Title: Free radical scavenging properties of sulfinpyrazone.

Journal: Free radical research 20020601

Title: Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2).

Journal: Pharmacology 20020101

Title: Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3).

Journal: The Journal of biological chemistry 20011207

Title: Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity.

Journal: The Journal of biological chemistry 20011012

Title: Resistance to mitoxantrone in multidrug-resistant MCF7 breast cancer cells: evaluation of mitoxantrone transport and the role of multidrug resistance protein family proteins.

Journal: Cancer research 20010715

Title: Metabolism of sulfinpyrazone sulfide and sulfinpyrazone by human liver microsomes and cDNA-expressed cytochrome P450s.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20010501

Title: A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 19990301

Title: Acute renal failure due to sulfinpyrazone.

Journal: The American journal of the medical sciences 19980501

Title: Development of an in vitro reporter gene assay to assess xenobiotic induction of the human CYP3A4 gene.

Journal: European journal of drug metabolism and pharmacokinetics 19970101

Title: Antiplatelet therapy in the prevention of stroke.

Journal: Drugs 19910101

Title: Interaction of sulfonamide and sulfone compounds with Toxoplasma gondii dihydropteroate synthase.

Journal: The Journal of clinical investigation 19900201

Title: Plasmapheresis and antiplatelet agents in the treatment of the hemolytic uremic syndrome secondary to mitomycin.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 19860501

Title: Interference by sulphinpyrazone with the antihypertensive effects of oxprenolol.

Journal: European journal of clinical pharmacology 19860101

Title: [Acute tubulo-interstitial nephropathy associated with ingestion of sulfinpyrazone].

Journal: Presse medicale (Paris, France : 1983) 19850223

Title: Sulfinpyrazone: risk for renal insufficiency.

Journal: Archives of internal medicine 19840301

Title: [Acute interstitial nephritis and kidney failure requiring dialysis after sulfinpyrazone therapy].

Journal: Acta medica Austriaca 19840101

Title: Acute renal failure secondary to sulfinpyrazone treatment after myocardial infarction.

Journal: Nephron 19840101

Title: Transcoronary platelet thromboxane A2 formation without platelet trapping in patients with coronary stenosis-effect of sulphinpyrazone treatment.

Journal: Thrombosis and haemostasis 19831230

Title: Sulfinpyrazone-associated acute renal failure.

Journal: Clinical nephrology 19830701

Title: Decrease in renal function due to sulphinpyrazone treatment early after myocardial infarction.

Journal: Clinical nephrology 19830301

Title: Oliguric acute renal failure after treatment with sulfinpyrazone.

Journal: Clinical nephrology 19830101

Title: [Sulfinpyrazone-associated renal failure (author's transl)].

Journal: Deutsche medizinische Wochenschrift (1946) 19820709

Title: Non oliguric acute renal failure after treatment with sulfinpyrazone.

Journal: Clinical nephrology 19820501

Title: Acute renal failure following sulfinpyrazone therapy.

Journal: South Dakota journal of medicine 19820401

Title: Sulphinpyrazone--induced decrease in renal function: a review of reports with discussion of pathogenesis.

Journal: Acta clinica Belgica 19820101

Title: Renal dysfunction due to anturane.

Journal: The New England journal of medicine 19811105

Title: Acute renal dysfunction due to sulfinpyrazone therapy in post-myocardial infarction cardiomegaly: reversible hypersensitive interstitial nephritis.

Journal: American heart journal 19810801

Title: Renal dysfunction due to anturan.

Journal: The New England journal of medicine 19810709

Title: Effects of sulfinpyrazone, aspirin and propranolol on the isoproterenol-induced myocardial necrosis.

Journal: Japanese heart journal 19810701

Title: Sulfinpyrazone induced uric acid urolithiasis with acute renal failure.

Journal: Connecticut medicine 19810701

Title: Sulphinpyrazone-induced acute renal failure.

Journal: British medical journal (Clinical research ed.) 19810221

Title: [Acute renal failure induced by sulfinpyrazone (author's transl)].

Journal: Nephrologie 19810101

Title: Are agents affecting platelet functions clinically useful?

Journal: The American journal of medicine 19761201

Title: Abnormalities of urinary sediment and renal failure following sulfinpyrazone therapy.

Journal: Archives of internal medicine 19760901

Title: Acute myelomonocytic leukaemia and multiple myeloma after sulphinpyrazone and colchicine treatment of gout.

Journal: British medical journal 19760710

Title: Margulies EH, White AM, Sherry S. Sulfinpyrazone: a review of its pharmacological properties and therapeutic use. Drugs. 1980;20(3):179‐197.

Title: Rüegg M. Antithrombotic effects of sulfinpyrazone in animals: influence on fibrinolysis and sodium arachidonate-induced pulmonary embolism. Pharmacology. 1976;14(6):522‐536.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 57-96-5
Tags:57-96-5 Molecular Formula|57-96-5 MDL|57-96-5 SMILES|57-96-5 4-[2-(benzenesulfinyl)ethyl]-1,2-diphenylpyrazolidine-3,5-dione