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822-06-0,MFCD00002047
Catalog No.:AA003DOI

822-06-0 | 1,6-Diisocyanatohexane

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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA003DOI
Chemical Name:
1,6-Diisocyanatohexane
CAS Number:
822-06-0
Molecular Formula:
C8H12N2O2
Molecular Weight:
168.1931
MDL Number:
MFCD00002047
SMILES:
O=C=NCCCCCCN=C=O
NSC Number:
11687
UN Number:
2281
Properties
Properties
 
BP:
255.0°C  
Form:
Liquid  
MP:
-55℃  
Storage:
2-8℃;  

Computed Properties
 
Complexity:
169  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
12  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
7  
XLogP3:
3.2  

Literature

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Title: DNA methylation modifies urine biomarker levels in 1,6-hexamethylene diisocyanate exposed workers: a pilot study.

Journal: Toxicology letters 20141201

Title: Gene expressions changes in bronchial epithelial cells: markers for respiratory sensitizers and exploration of the NRF2 pathway.

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Title: Transferability of aliphatic isocyanates from recently applied paints to the skin of auto body shop workers.

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Title: In vitro effect on cancer cells: synthesis and preparation of polyurethane membranes for controlled delivery of curcumin.

Journal: Journal of biomedical materials research. Part A 20111201

Title: Development of a sampling patch to measure dermal exposures to monomeric and polymeric 1,6-hexamethylene diisocyanate: a pilot study.

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Title: Environmental isocyanate-induced asthma: morphologic and pathogenetic aspects of an increasing occupational disease.

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Title: Hexamethylene diisocyanate asthma is associated with genetic polymorphisms of CD14, IL-13, and IL-4 receptor α.

Journal: The Journal of allergy and clinical immunology 20110801

Title: Biodegradable pH/temperature-sensitive oligo(β-amino ester urethane) hydrogels for controlled release of doxorubicin.

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Title: Repair of parastomal hernias with biologic grafts: a systematic review.

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Title: Synthesis, characterizations and biocompatibility of alternating block polyurethanes based on P3/4HB and PPG-PEG-PPG.

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Title: Synthesis of OH-group-containing, biodegradable polyurethane and protein fixation on its surface.

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Journal: Environmental health perspectives 20110601

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Title: Surface grafting thermoresponsive PEO-PPO-PEO chains.

Journal: Journal of tissue engineering and regenerative medicine 20110501

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Journal: International urogynecology journal 20110501

Title: Hemoglobin adducts in workers exposed to 1,6-hexamethylene diisocyanate.

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Title: Development of a biodegradable tissue adhesive based on functionalized 1,2-ethylene glycol bis(dilactic acid). II.

Journal: Journal of biomedical materials research. Part B, Applied biomaterials 20110401

Title: Biodegradable block poly(ester-urethane)s based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) copolymers.

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Title: Genetics of occupational asthma.

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Title: Development of a permeation panel to test dermal protective clothing against sprayed coatings.

Journal: The Annals of occupational hygiene 20110301

Title: Biological monitoring for isocyanates.

Journal: The Annals of occupational hygiene 20110301

Title: Use of aliphatic poly(amide urethane)s for the controlled release of 5-fluorouracil.

Journal: European journal of medicinal chemistry 20110301

Title: Field comparison of air sampling methods for monomeric and polymeric 1,6-hexamethylene diisocyanate.

Journal: Journal of occupational and environmental hygiene 20110301

Title: Design and characterization of novel β-cyclodextrin based copolymer materials.

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Title: Synthesis, properties, and light-induced shape memory effect of multiblock polyesterurethanes containing biodegradable segments and pendant cinnamamide groups.

Journal: Biomacromolecules 20110110

Title: Characterization of the degradation mechanisms of lysine-derived aliphatic poly(ester urethane) scaffolds.

Journal: Biomaterials 20110101

Title: Factors affecting variability in the urinary biomarker 1,6-hexamethylene diamine in workers exposed to 1,6-hexamethylene diisocyanate.

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Title: Biomarkers predicting isocyanate-induced asthma.

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Title: Immune sensitization to methylene diphenyl diisocyanate (MDI) resulting from skin exposure: albumin as a carrier protein connecting skin exposure to subsequent respiratory responses.

Journal: Journal of occupational medicine and toxicology (London, England) 20110101

Title: Elimination kinetics of diisocyanates after specific inhalative challenges in humans: mass spectrometry analysis, as a basis for biomonitoring strategies.

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Title: Genetic variability in susceptibility to occupational respiratory sensitization.

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Title: Haptenation: chemical reactivity and protein binding.

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Title: Occupational exposure to HDI: progress and challenges in biomarker analysis.

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Title: Design and in vitro evaluation of a novel polymeric P-glycoprotein (P-gp) inhibitor.

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Title: Trends in pulmonary function and prevalence of asthma in hexamethylene diisocyanate workers during a 19-year period.

Journal: Journal of occupational and environmental medicine 20101001

Title: Chronic inhalation exposures of Fischer 344 rats to 1,6-hexamethylene diisocyanate did not reveal a carcinogenic potential.

Journal: Inhalation toxicology 20100801

Title: Urine 1,6-hexamethylene diamine (HDA) levels among workers exposed to 1,6-hexamethylene diisocyanate (HDI).

Journal: The Annals of occupational hygiene 20100801

Title: Development of a biodegradable tissue adhesive based on functionalized 1,2-ethylene glycol bis(dilactic acid). I.

Journal: Journal of biomedical materials research. Part B, Applied biomaterials 20100801

Title: Indoor air pollution evaluation with emphasize on HDI and biological assessment of HDA in the polyurethane factories.

Journal: Environmental monitoring and assessment 20100601

Title: Adsorption efficiency of respirator filter cartridges for isocyanates.

Journal: The Annals of occupational hygiene 20100601

Title: Preparation of degradable polymeric nanocapsules from hyperbranched poly (amine ester) grafted nanosilica templates.

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Journal: Amino acids 20100501

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Journal: Biomacromolecules 20100412

Title: Controlled release of 5-aminosalicylic acid (5-ASA) from new biodegradable polyurethanes.

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Title: Quantification and statistical modeling--part II: dermal concentrations of monomeric and polymeric 1,6-hexamethylene diisocyanate.

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Title: Synthesis, characterization and biocompatibility of biodegradable elastomeric poly(ether-ester urethane)s Based on Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) and Poly(ethylene glycol) via melting polymerization.

Journal: Journal of biomaterials science. Polymer edition 20090101

Title: Synthesis, characterization and cell compatibility of novel poly(ester urethane)s based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) and poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) prepared by melting polymerization.

Journal: Journal of biomaterials science. Polymer edition 20090101

Title: Magnetic resonance flow velocity and temperature mapping of a shape memory polymer foam device.

Journal: Biomedical engineering online 20090101

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Journal: Journal of hazardous materials 20081230

Title: The respiratory local lymph node assay as a tool to study respiratory sensitizers.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20081201

Title: Validation of transferability of DBA derivatization and LC-MS/MS determination method for isocyanates via an interlaboratory comparison.

Journal: The Annals of occupational hygiene 20081101

Title: Loading dependent swelling and release properties of novel biodegradable, elastic and environmental stimuli-sensitive polyurethanes.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20081021

Title: Immobilization of NaIO4-treated heparin on PEG-modified 316L SS surface for high anti-thrombin-III binding.

Journal: Journal of biomedical materials research. Part A 20080901

Title: Contact sensitization to 4,4'-diaminodiphenylmethane and to isocyanates among general dermatology patients.

Journal: Contact dermatitis 20080801

Title: Cyclodextrin conjugated magnetic colloidal nanoparticles as a nanocarrier for targeted anticancer drug delivery.

Journal: Nanotechnology 20080702

Title: Segmented poly(esterurethane urea)s from novel urea-diol chain extenders: synthesis, characterization and in vitro biological properties.

Journal: Acta biomaterialia 20080701

Title: Size-separated sampling and analysis of isocyanates in workplace aerosols--Part II: aging of aerosols from thermal degradation of polyurethane.

Journal: The Annals of occupational hygiene 20080701

Title: Synthesis of (Dex-HMDI)-g-PEIs as effective and low cytotoxic nonviral gene vectors.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20080604

Title: Preparation and surface characterization of HMDI-activated 316L stainless steel for coronary artery stents.

Journal: Journal of biomedical materials research. Part A 20080601

Title: Gene expression profiling of in vitro cultured macrophages after exposure to the respiratory sensitizer hexamethylene diisocyanate.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20080601

Title: Human innate immune responses to hexamethylene diisocyanate (HDI) and HDI-albumin conjugates.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20080601

Title: Identification of a glycine motif required for packing in EmrE, a multidrug transporter from Escherichia coli.

Journal: The Journal of biological chemistry 20080502

Title: Comparative assessment of early acute lung injury in mice and rats exposed to 1,6-hexamethylene diisocyanate-polyisocyanate aerosols.

Journal: Toxicology 20080502

Title: Quantitative monitoring of dermal and inhalation exposure to 1,6-hexamethylene diisocyanate monomer and oligomers.

Journal: Journal of environmental monitoring : JEM 20080401

Title: Active single-drop microextraction for the determination of gaseous diisocyanates.

Journal: Journal of chromatography. A 20080328

Title: Surface modification of medical-grade polyurethane by cyanurchloride-activated tetraether lipid (a new approach for bacterial antiadhesion).

Journal: Journal of biomedical materials research. Part A 20080301

Title: Skin exposure to aliphatic polyisocyanates in the auto body repair and refinishing industry: II. A quantitative assessment.

Journal: The Annals of occupational hygiene 20080301

Title: Synthesis of beta-cyclodextrin and starch based polymers for sorption of azo dyes from aqueous solutions.

Journal: Bioresource technology 20080201

Title: FTIR and molecular mechanics studies of H-bonds in aliphatic polyurethane and polyamide-66 model molecules.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080201

Title: The use of long-chain plant polyprenols as a means to modify the biological properties of new biodegradable polyurethane scaffolds for tissue engineering. A pilot study.

Journal: Journal of materials science. Materials in medicine 20080101

Title: Development of a biodegradable bioadhesive containing urethane groups.

Journal: Journal of materials science. Materials in medicine 20080101

Title: Gold nanoparticles induce surface morphological transformation in polyurethane and affect the cellular response.

Journal: Biomacromolecules 20080101

Title: Respiratory symptoms, sensitization, and exposure response relationships in spray painters exposed to isocyanates.

Journal: American journal of respiratory and critical care medicine 20071201

Title: Metal complexes of crosslinked chitosans Part II. An investigation of their hydrolysis to chitooligosaccharides using chitosanase.

Journal: International journal of biological macromolecules 20071201

Title: Thermoplastic biodegradable polyurethanes: the effect of chain extender structure on properties and in-vitro degradation.

Journal: Biomaterials 20071201

Title: Th2 Cytokines in Skin Draining Lymph Nodes and Serum IgE Do Not Predict Airway Hypersensitivity to Intranasal Isocyanate Exposure in Mice.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20071101

Title: Neuronal modulation of lung injury induced by polymeric hexamethylene diisocyanate in mice.

Journal: Toxicology and applied pharmacology 20071001

Title: Comparative assessment of air pollution-related health risks in Houston.

Journal: Environmental health perspectives 20071001

Title: Use of beta-cyclodextrin and starch based polymers for sorption of Congo red from aqueous solutions.

Journal: Journal of hazardous materials 20070905

Title: Diisocyanate conjugate and immunoassay characteristics influence detection of specific antibodies in HDI-exposed workers.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20070701

Title: New cyclodextrin bioconjugates for active tumour targeting.

Journal: Journal of drug targeting 20070701

Title: Transport behavior of n-alkane penetrants into castor oil based polyurethane-polyester nonwoven fabric composites.

Journal: Journal of hazardous materials 20070625

Title: Slow curing of aliphatic polyisocyanate paints in automotive refinishing: a potential source for skin exposure.

Journal: Journal of occupational and environmental hygiene 20070601

Title: The effect of monomers on the formulation of polymeric nanocapsules based on polyureas and polyamides.

Journal: International journal of pharmaceutics 20070420

Title: Developments in laboratory diagnostics for isocyanate asthma.

Journal: Current opinion in allergy and clinical immunology 20070401

Title: Modification of gelatin by reaction with 1,6-diisocyanatohexane.

Journal: Macromolecular bioscience 20070308

Title: Isosteric heats of sorption of 1-naphthol and phenol from aqueous solutions by beta-cyclodextrin polymers.

Journal: Journal of colloid and interface science 20070301

Title: Skin exposure to isocyanates: reasons for concern.

Journal: Environmental health perspectives 20070301

Title: Determination of pulmonary irritant threshold concentrations of hexamethylene-1,6-diisocyanate (HDI) prepolymers by bronchoalveolar lavage in acute rat inhalation studies according to TRGS 430.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070201

Title: New biodegradable thermogelling copolymers having very low gelation concentrations.

Journal: Biomacromolecules 20070201

Title: Isocyanate exposure in bathtub refinishing: à propos a case of occupational asthma.

Journal: International journal of occupational medicine and environmental health 20070101

Title: Nerve regeneration using tubular scaffolds from biodegradable polyurethane.

Journal: Acta neurochirurgica. Supplement 20070101

Title: Cytokine and chemokine dynamics differ between rats and mice after collagen implantation.

Journal: Journal of tissue engineering and regenerative medicine 20070101

Title: Fabrication and in vitro deployment of a laser-activated shape memory polymer vascular stent.

Journal: Biomedical engineering online 20070101

Title: Abstracts of papers presented at the 2007 pittsburgh conference.

Journal: Journal of automated methods & management in chemistry 20070101

Title: Cytokeratin autoantibodies: useful serologic markers for toluene diisocyanate-induced asthma.

Journal: Yonsei medical journal 20061231

Title: Diisocyanate asthma and gene-environment interactions with IL4RA, CD-14, and IL-13 genes.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20061201

Title: Effects of simple and complex motion patterns on gene expression of chondrocytes seeded in 3D scaffolds.

Journal: Tissue engineering 20061101

Title: Dermal, inhalation, and internal exposure to 1,6-HDI and its oligomers in car body repair shop workers and industrial spray painters.

Journal: Occupational and environmental medicine 20060901

Title: Modeling dermal exposure--an illustration for spray painting applications.

Journal: Journal of occupational and environmental hygiene 20060901

Title: Evaluation of antibody binding to diisocyanate protein conjugates in a general population.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060901

Title: Assessing isocyanate exposures in polyurethane industry sectors using biological and air monitoring methods.

Journal: The Annals of occupational hygiene 20060801

Title: Subacute inhalation exposure of rats to 1,6-hexamethylene diisocyanate with recovery period.

Journal: Inhalation toxicology 20060801

Title: Determination of airborne isocyanates generated during the thermal degradation of car paint in body repair shops.

Journal: The Annals of occupational hygiene 20060601

Title: Circulating autoantibodies in patients with aspirin-intolerant asthma: an epiphenomenon related to airway inflammation.

Journal: Journal of Korean medical science 20060601

Title: Tape-strip sampling for measuring dermal exposure to 1,6-hexamethylene diisocyanate.

Journal: Scandinavian journal of work, environment & health 20060601

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Journal: Journal of occupational and environmental hygiene 20050901

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Journal: Journal of molecular biology 20050218

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Journal: Journal of biomaterials science. Polymer edition 20050101

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Journal: Journal of cellular physiology 20040401

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Journal: The Analyst 20040401

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Tags:822-06-0 Molecular Formula|822-06-0 MDL|822-06-0 SMILES|822-06-0 1,6-Diisocyanatohexane