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35543-24-9,MFCD00078965
Catalog No.:AA003DQD

35543-24-9 | Buflomedil HCl

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Purity
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25mg
98%
in stock  
$6.00   $4.00
- +
100mg
98%
in stock  
$8.00   $6.00
- +
1g
98%
in stock  
$21.00   $15.00
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5g
98%
in stock  
$58.00   $41.00
- +
10g
98%
in stock  
$95.00   $67.00
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25g
98%
in stock  
$195.00   $137.00
- +
100g
98%
in stock  
$483.00   $338.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003DQD
Chemical Name:
Buflomedil HCl
CAS Number:
35543-24-9
Molecular Formula:
C17H26ClNO4
Molecular Weight:
343.8456
MDL Number:
MFCD00078965
SMILES:
COc1cc(OC)cc(c1C(=O)CCC[NH+]1CCCC1)OC.[Cl-]
NSC Number:
759291
Properties
Properties
 
BP:
454.5°C at 760 mmHg  
Form:
Solid  
MP:
194-196°C  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
330  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
8  

Literature

Title: Safety profile assessment of buflomedil: an overview of adverse reactions between 1975 and 2011.

Journal: Pharmacoepidemiology and drug safety 20121101

Title: [Microbial transformation of buflomedil by Cunninghamella blakesleana AS 3.153].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120701

Title: The value of population pharmacokinetics and simulation for postmarketing safety evaluation of dosing guidelines for drugs with a narrow therapeutic index: buflomedil as a case study.

Journal: Fundamental & clinical pharmacology 20120401

Title: Vasoactive agent buflomedil up-regulated expression of vascular endothelial growth factor in a rat model of sciatic nerve crush injury.

Journal: Indian journal of pharmacology 20120101

Title: Safety of subcutaneous microinjections (mesotherapy) in musicians.

Journal: Medical problems of performing artists 20110601

Title: Effects of buflomedil on skin blood flow in patients with type 2 diabetes mellitus without overt micro- or macroangiopathy.

Journal: International angiology : a journal of the International Union of Angiology 20110401

Title: Buflomedil: still too many fatal cardiac and neurological events.

Journal: Prescrire international 20110401

Title: A controlled trial of a prostacyclin and rt-PA in the treatment of severe frostbite.

Journal: The New England journal of medicine 20110113

Title: Influence of pharmacological treatment on blood flow and muscle perfusion in patients with obliterative atheromatosis assessed with isotopic methods. A pilot study.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20101201

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: [Addition of antithrombosis in situ in the case of digital replantation: preliminary prospective study of 13 cases].

Journal: Chirurgie de la main 20101001

Title: [Multicentric study of thrombosis prevention in upper-extremity microsurgery. Survey at the Fesum centers].

Journal: Chirurgie de la main 20100401

Title: Effects of buflomedil and pentoxifylline on hamster skin-flap microcirculation: prediction of flap viability using orthogonal polarization spectral imaging.

Journal: Clinics (Sao Paulo, Brazil) 20090801

Title: Buflomedil: potential new indications for an old agent.

Journal: International angiology : a journal of the International Union of Angiology 20090601

Title: Pharmacologic therapy for intermittent claudication.

Journal: Pharmacotherapy 20090501

Title: Cutaneous granulomatous reaction from mesotherapy.

Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20090201

Title: Bias in benefit-risk appraisal in older products: the case of buflomedil for intermittent claudication.

Journal: Drug safety 20090101

Title: Letter by De Backer et al regarding article, 'Oral buflomedil in the prevention of cardiovascular events in patients with peripheral arterial obstructive disease: a randomized, placebo-controlled, 4-year study'.

Journal: Circulation 20080902

Title: Simultaneous FTIR spectroscopic imaging and visible photography to monitor tablet dissolution and drug release.

Journal: Pharmaceutical research 20080401

Title: The use of buflomedil in reduction mammaplasty for a previously irradiated breast: a case report.

Journal: Aesthetic plastic surgery 20080301

Title: Oral buflomedil in the prevention of cardiovascular events in patients with peripheral arterial obstructive disease: a randomized, placebo-controlled, 4-year study.

Journal: Circulation 20080212

Title: Buflomedil in peripheral arterial disease: trials and tribulations.

Journal: Circulation 20080212

Title: Buflomedil for intermittent claudication.

Journal: The Cochrane database of systematic reviews 20080123

Title: Buflomedil for intermittent claudication.

Journal: The Cochrane database of systematic reviews 20071017

Title: Buflomedil: still seizures and cardiac disorders. Too many patients are exposed to an unjustified risk of serious adverse effects.

Journal: Prescrire international 20070201

Title: Comparison between intravenous iloprost and vasoactive drugs in limb ischemia IIB severe. A retrospective analysis.

Journal: Minerva cardioangiologica 20060601

Title: The effects of prostaglandin E-1 in patients with intermittent claudication.

Journal: Cardiovascular & hematological disorders drug targets 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Assemblage of novel release modules for the development of adaptable drug delivery systems.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20060310

Title: Facilitated column selection in pharmaceutical analyses using a simple column classification system.

Journal: Journal of chromatography. A 20060106

Title: Buflomedil and pentoxifylline in the viability of dorsal cutaneous flaps of rats treated with nicotine.

Journal: Journal of plastic, reconstructive & aesthetic surgery : JPRAS 20060101

Title: [Severe peripheral ischemia of rare origin].

Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20060101

Title: Effect of loading on a swelling-controlled drug delivery system studied by optical techniques.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20050103

Title: Protective effect of buflomedil in a rat model of moderate cerebral ischemia.

Journal: Arzneimittel-Forschung 20050101

Title: Inhibitory effect of buflomedil on prostate alpha1A adrenoceptor in the Wistar rat.

Journal: Neuroscience letters 20040902

Title: [Secondary prevention and conservative therapy of obliterative arteriosclerosis].

Journal: Orvosi hetilap 20040516

Title: Suicide by buflomedil HCl: a case report.

Journal: Journal of clinical forensic medicine 20040201

Title: [Suicidal buflomedil intoxication].

Journal: Archiv fur Kriminologie 20040101

Title: Rapid HPLC measurement of buflomedil in plasma in poisoning cases.

Journal: Biomedical chromatography : BMC 20021001

Title: Rheological and biochemical examination of red blood cells after treatment with different pharmacological and toxic substances.

Journal: Clinical hemorheology and microcirculation 20020101

Title: [Sudden hearing loss. Clinical case].

Journal: Anales otorrinolaringologicos ibero-americanos 20020101

Title: Clinical and hemorheological effects of buflomedil in diabetic subjects with intermittent claudication.

Journal: International angiology : a journal of the International Union of Angiology 20011201

Title: [Retrograde venous perfusion (RVP in ulcero-mutilating neuropathy].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20011001

Title: [Clinical study of the effect of buflomedil on peripheral neuropathy in diabetic patients].

Journal: Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 20010628

Title: [Myoclonic coma and severe cardiac insufficiency in a patient with arteritis].

Journal: La Revue de medecine interne 20010601

Title: Effects of buflomedil on early carotid atherosclerosis in Type 2 diabetic patients.

Journal: International angiology : a journal of the International Union of Angiology 20010601

Title: Heparin protects local skin microcirculation in 210 minutes-long intravital microscopy observations under general anaesthesia.

Journal: European journal of medical research 20010420

Title: Translocation of drug particles in HPMC matrix gel layer: effect of drug solubility and influence on release rate.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20010223

Title: Buflomedil for intermittent claudication.

Journal: The Cochrane database of systematic reviews 20010101

Title: Ticlopidine-pentoxifylline combination in the treatment of atherosclerosis and the prevention of cerebrovascular accidents.

Journal: The Journal of international medical research 19890101

Title: [Emetic and catalepsy-inducing actions of buflomedil].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 19881201

Title: http://www.medscape.com/viewarticle/753768

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