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583-08-4,MFCD00023578
Catalog No.:AA003F15

583-08-4 | Nicotinoyl-glycine

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1g
95%
in stock  
$45.00   $32.00
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5g
>98.0%(T)
in stock  
$115.00   $80.00
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25g
95%
in stock  
$328.00   $230.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003F15
Chemical Name:
Nicotinoyl-glycine
CAS Number:
583-08-4
Molecular Formula:
C8H8N2O3
Molecular Weight:
180.1607
MDL Number:
MFCD00023578
SMILES:
OC(=O)CNC(=O)c1cccnc1
NSC Number:
71273
Properties
Properties
 
BP:
512.5°C at 760 mmHg  
Form:
Solid  
MP:
256-258 °C (dec.);  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
206  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
-0.4  

Downstream Synthesis Route

[1]ArchivderPharmazie,1951,vol.284,p.6

[2]BioorganicandMedicinalChemistry,2016,vol.24,p.5368-5373

[1]BiochemischeZeitschrift,1930,vol.229,p.154,156

[1]ZeitschriftfurNaturforschung,TeilB:AnorganischeChemie,OrganischeChemie,1986,vol.41,p.367-370

70254-43-2    122-51-0    583-08-4   
N-(5,6-dihydro-2,5-dioxo-2H-pyrano<3,2-c>quinoline-3-yl)pyridine-2-carboxamide 

[1]Heterocycles,1995,vol.41,p.1299-1306

1076-38-6    122-51-0    583-08-4   
N-(2,5-dioxo-2H,5H-pyrano<3,2-c><1>benzopyran-3-yl)pyridine-3-carboxamide 

[1]Heterocycles,1995,vol.41,p.1299-1306

Literature

Title: Simultaneous quantification of niacin and its three main metabolites in human plasma by LC-MS/MS.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120901

Title: Beneficial metabolic effects of 2',3',5'-tri-acetyl-N6- (3-hydroxylaniline) adenosine in the liver and plasma of hyperlipidemic hamsters.

Journal: PloS one 20120101

Title: Assessment of potential pharmacokinetic interactions of ezetimibe/simvastatin and extended-release niacin tablets in healthy subjects.

Journal: European journal of clinical pharmacology 20110501

Title: Feedback modeling of non-esterified fatty acids in rats after nicotinic acid infusions.

Journal: Journal of pharmacokinetics and pharmacodynamics 20110201

Title: Pharmacokinetics and dose recommendations of Niaspan® in chronic kidney disease and dialysis patients.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110101

Title: Chemometric analysis of biofluids from mice experimentally infected with Schistosoma mansoni.

Journal: Parasites & vectors 20110101

Title: [Determination of nicacid and its metabolites in human plasma by HPLC-MS/MS].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20101101

Title: Simultaneous determination of niacin and its metabolites--nicotinamide, nicotinuric acid and N-methyl-2-pyridone-5-carboxamide--in human plasma by LC-MS/MS and its application to a human pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20101001

Title: Role of nicotinamide in DNA damage, mutagenesis, and DNA repair.

Journal: Journal of nucleic acids 20100101

Title: A comparison of the pharmacokinetics of two different formulations of extended-release niacin.

Journal: Current medical research and opinion 20090101

Title: Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM).

Journal: Bioorganic & medicinal chemistry 20081201

Title: Targeting multiple dyslipidemias with fixed combinations--focus on extended release niacin and simvastatin.

Journal: Vascular health and risk management 20081001

Title: Analysis of time-related metabolic fluctuations induced by ethionine in the rat.

Journal: Journal of proteome research 20071201

Title: The comparative bioavailability of an extended-release niacin and lovastatin fixed dose combination tablet versus extended-release niacin tablet, lovastatin tablet and a combination of extended-release niacin tablet and lovastatin tablet.

Journal: Biopharmaceutics & drug disposition 20070901

Title: Plasma and urine pharmacokinetics of niacin and its metabolites from an extended-release niacin formulation.

Journal: International journal of clinical pharmacology and therapeutics 20070801

Title: Nicotinic acid induces secretion of prostaglandin D2 in human macrophages: an in vitro model of the niacin flush.

Journal: Atherosclerosis 20070601

Title: Effect of the rate of niacin administration on the plasma and urine pharmacokinetics of niacin and its metabolites.

Journal: Journal of clinical pharmacology 20070601

Title: Azabicyclic amino acids by stereoselective dearomatizing cyclization of the enolates of N-nicotinoyl glycine derivatives.

Journal: Organic letters 20061109

Title: Simultaneous determination of niacin, niacinamide and nicotinuric acid in human plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20050104

Title: Simultaneous determination of nicotinic acid and its metabolites using hydrophilic interaction chromatography with tandem mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20050101

Title: Effects of excess nicotinamide administration on the urinary excretion of nicotinamide N-oxide and nicotinuric acid by rats.

Journal: Bioscience, biotechnology, and biochemistry 20040101

Title: Synthesis and asymmetric reducing performance of chitin/dihydronicotinamide conjugates having glycine or L-leucine spacer arms.

Journal: Biomacromolecules 20020101

Title: Inamadugu JK, et al. Simultaneous determination of niacin and its metabolites--nicotinamide, nicotinuric acid and N-methyl-2-pyridone-5-carboxamide--in human plasma by LC-MS/MS and its application to a human pharmacokinetic study. Biomed Chromatogr. 2010 Oct;24(10):1059-74.

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