Home Other Building Blocks 89-84-9
89-84-9,MFCD00002279
Catalog No.:AA003FQD

89-84-9 | 2',4'-Dihydroxyacetophenone

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Purity
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Price(USD)
Quantity
  
10g
98%
in stock  
$13.00   $9.00
- +
25g
98%
in stock  
$21.00   $15.00
- +
100g
98%
in stock  
$51.00   $36.00
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500g
98%
in stock  
$107.00   $75.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003FQD
Chemical Name:
2',4'-Dihydroxyacetophenone
CAS Number:
89-84-9
Molecular Formula:
C8H8O3
Molecular Weight:
152.1473
MDL Number:
MFCD00002279
SMILES:
Oc1ccc(c(c1)O)C(=O)C
Properties
Properties
 
BP:
319.3 °C at 760 mmHg  
Form:
Solid  
MP:
143-144.5 °C(lit.)  
Refractive Index:
1.4945 (estimate)  
Stability:
Moisture Sensitive  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
155  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
1.7  

Upstream Synthesis Route

[1]JournalofOrganicChemistry,2015,vol.80,#17,p.8657-8667

[2]Patent:WO2004/5295,2004,A1,.Locationinpatent:Page80-81

[3]AnnalidiChimica(Rome,Italy),1958,vol.48,p.1329,1332,1333

[1]Patent:US4310693,1982,A,

[1]JournalofHeterocyclicChemistry,2015,vol.52,#2,p.562-572

[1]Patent:US2005/282781,2005,A1,.Locationinpatent:Page/Pagecolumn10

[1]Patent:US2005/282781,2005,A1,.Locationinpatent:Page/Pagecolumn10

Downstream Synthesis Route
3174-74-1    89-84-9   
1-(2-hydroxy-4-tetrahydropyran-4-yloxy-phenyl)-ethanone 

[1]JournaloftheAmericanChemicalSociety,1951,vol.73,p.3514

[2]JournaloftheAmericanChemicalSociety,1951,vol.73,p.3514

89-84-9    3847-57-2   
7-acetoxy-4-methyl-3-(4-nitro-phenyl)-coumarin 

[1]JournalOfScientificandIndustrialResearch,1954,vol.13B,p.316,318

[1]GazzettaChimicaItaliana,1913,vol.43I,p.170

[1]MonatsheftefurChemie,1952,vol.83,p.24,27,28

[1]Locationinpatent:experimentalpartSagrera,Gabriel;Bertucci,Ana;Vazquez,Alvaro;Seoane,Gustavo[BioorganicandMedicinalChemistry,2011,vol.19,#10,p.3060-3073]

[2]Serdiuk;Roshal[RSCAdvances,2015,vol.5,#124,p.102191-102203]

[3]Serdiuk,IlliaE.;Roshal,AlexanderD.;Błazejowski,Jerzy[JournalofPhysicalChemistryA,2016,vol.120,#25,p.4325-4337]

[4]CurrentPatentAssignee:SHENYANGPHARMACEUTICALUNIVERSITY-CN107827849,2018,ALocationinpatent:Paragraph0043;0044;0045

[5]Hu,Chun;Hu,Jian-Shu;Huang,Er-Fang;Jin,Li-Ping;Jin,Zhe;Wan,DavidChi-Cheong;Wang,Lin;Xie,Qian;Zhang,Bing-Qi[BioorganicChemistry,2020,vol.95]

[6]CurrentPatentAssignee:CLARIANTAG-US5726295,1998,A

[7]CurrentPatentAssignee:CLARIANTAG-US5726296,1998,A

[8]Gan,Li-She;Zeng,Lin-Wei;Li,Xiang-Rong;Zhou,Chang-Xin;Li,Jie[BioorganicandMedicinalChemistryLetters,2017,vol.27,#6,p.1441-1445]

[9]Dewick,PaulM.[SyntheticCommunications,1981,vol.11,#10,p.853-858]

[10]Tsukayama,Masao;Horie,Tokunaru;Fujimoto,Kunihiro;Nakayama,Mitsuru[Chemicalandpharmaceuticalbulletin,1986,vol.34,p.2369-2374]

[11]Arakawa,Yoshihito;Chiji,Hideyuki;Izawa,Masao[AgriculturalandBiologicalChemistry,1983,vol.47,#9,p.2029-2034]

[12]Gulatietal.[JournaloftheChemicalSociety,1934,p.1765]

[13]vanHeerden,F.R.etal.[JournaloftheChemicalSociety.PerkintransactionsI,1978,p.137-145]

[14]Manners,G.D.;Jurd,L.[Phytochemistry,1979,vol.18,p.1037-1042]

[15]Tillekeratne;Sherette;Grossman;Hupe;Hupe;Hudson[BioorganicandMedicinalChemistryLetters,2001,vol.11,#20,p.2763-2767]

[16]Locationinpatent:schemeortableTang,Jian;Qian,Keduo;Zhang,Bei-Na;Chen,Ying;Xia,Peng;Yu,Donglei;Xia,Yi;Yang,Zheng-Yu;Chen,Chin-Ho;Morris-Natschke,SusanL.;Lee,Kuo-Hsiung[BioorganicandMedicinalChemistry,2010,vol.18,#12,p.4363-4373]

[17]Ma,Ya-Tuan;Fan,Hua-Fang;Gao,Yu-Qi;Li,He;Zhang,An-Ling;Gao,Jin-Ming[ChemicalBiologyandDrugDesign,2013,vol.81,#4,p.545-552]

[18]Dejon,Lisa;Mohammed,Hamdoon;Du,Peng;Jacob,Claus;Speicher,Andreas[MedChemComm,2013,vol.4,#12,p.1580-1583]

[19]CurrentPatentAssignee:NOVARTISAG;Novartis(w/oSandoz)-GB377464,1932,A

[20]Hu,Deyu;Huang,Maoxi;Jiang,Donghao;Li,Miao;Song,Baoan;Zan,Ningning[Bioorganicandmedicinalchemistryletters,2020,vol.30,#5]

Literature

Title: Application of high-resolution ESI and MALDI mass spectrometry to metabolite profiling of small interfering RNA duplex.

Journal: Journal of mass spectrometry : JMS 20120801

Title: Bioactive metabolites from biotransformation of paeonol by the white-rot basidiomycete Coriolus versicolor.

Journal: Natural product communications 20110801

Title: Growth inhibitory activities of oxyprenylated and non-prenylated naturally occurring phenylpropanoids in cancer cell lines.

Journal: Bioorganic & medicinal chemistry letters 20110715

Title: Setup for human sera MALDI profiling: the case of rhEPO treatment.

Journal: Electrophoresis 20110601

Title: Spectrophotometric investigation of the complexation mechanism of Al(III) by 2,4-dihydroxy-acetophenone.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20100915

Title: Bis{2-(5-hydr-oxy-2-[1-(hydroxy-imino)eth-yl]phenolato-κO,N}nickel(II) N,N-dimethyl-formamide disolvate.

Journal: Acta crystallographica. Section E, Structure reports online 20091101

Title: Concomitant polymorphism and conformational isomerism in 4-acetylresorcinol.

Journal: Acta crystallographica. Section C, Crystal structure communications 20090601

Title: Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20090201

Title: Molecular modeling and inhibition of phospholipase A2 by polyhydroxy phenolic compounds.

Journal: European journal of medicinal chemistry 20090101

Title: [Determination of four acetophenones in Radix Cynanchi bungei by high performance liquid chromatography-photodiode array detection].

Journal: Se pu = Chinese journal of chromatography 20090101

Title: Antifungal agent and other constituents from Cynanchum otophyllum.

Journal: Natural product research 20070301

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: Suppression by flavonoids of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells: structure-activity relationship.

Journal: Japanese journal of cancer research : Gann 20000701

Title: Steroid hormone activity of flavonoids and related compounds.

Journal: Breast cancer research and treatment 20000701

Title: 2,4'-Dihydroxyacetophenone dioxygenase (EC 1.13.11.41) from Alcaligenes sp. 4HAP: a novel enzyme with an atypical dioxygenase sequence.

Journal: The Biochemical journal 19991201

Title: Li XJ, et al. Bioactive metabolites from biotransformation of paeonol by the white-rot basidiomycete Coriolus versicolor. Nat Prod Commun. 2011 Aug;6(8):1129-30.

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